Incidental Mutation 'P0157:Prl8a6'
ID15788
Institutional Source Beutler Lab
Gene Symbol Prl8a6
Ensembl Gene ENSMUSG00000021345
Gene Nameprolactin family 8, subfamily a, member 6
SynonymsPrlpc1, PLP-Ca, PLP-calpha, Prlpc
MMRRC Submission 038296-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #P0157 (G1)
Quality Score
Status Validated
Chromosome13
Chromosomal Location27432681-27438688 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 27436179 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000105984 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018392] [ENSMUST00000080762] [ENSMUST00000110355]
Predicted Effect probably benign
Transcript: ENSMUST00000018392
SMART Domains Protein: ENSMUSP00000018392
Gene: ENSMUSG00000021345

DomainStartEndE-ValueType
Pfam:Hormone_1 16 239 2.8e-56 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080762
SMART Domains Protein: ENSMUSP00000079584
Gene: ENSMUSG00000021345

DomainStartEndE-ValueType
Pfam:Hormone_1 17 86 1.9e-13 PFAM
Pfam:Hormone_1 83 205 2.4e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110355
SMART Domains Protein: ENSMUSP00000105984
Gene: ENSMUSG00000021345

DomainStartEndE-ValueType
Pfam:Hormone_1 17 240 1e-58 PFAM
Coding Region Coverage
  • 1x: 67.6%
  • 3x: 53.1%
  • 10x: 28.4%
  • 20x: 14.6%
Validation Efficiency 82% (18/22)
Allele List at MGI
Other mutations in this stock
Total: 2 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl2 G T 3: 148,859,063 Q290K probably damaging Het
Olfr651 T A 7: 104,553,507 I196N probably damaging Het
Other mutations in Prl8a6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0115:Prl8a6 UTSW 13 27433101 missense probably benign 0.07
R0481:Prl8a6 UTSW 13 27433101 missense probably benign 0.07
R0514:Prl8a6 UTSW 13 27433007 nonsense probably null
R2209:Prl8a6 UTSW 13 27435386 missense probably benign 0.03
R2329:Prl8a6 UTSW 13 27437067 missense probably benign
R3876:Prl8a6 UTSW 13 27433032 nonsense probably null
R5259:Prl8a6 UTSW 13 27436196 nonsense probably null
R5800:Prl8a6 UTSW 13 27435470 missense probably benign
R5921:Prl8a6 UTSW 13 27437188 missense probably damaging 1.00
R6901:Prl8a6 UTSW 13 27437047 missense possibly damaging 0.87
R7182:Prl8a6 UTSW 13 27437170 missense probably damaging 1.00
R7230:Prl8a6 UTSW 13 27433038 missense probably benign 0.00
Posted On2013-01-04