Mutagenetix > Incidental Mutation

Incidental Mutation 'P0157:Prl8a6'

15788

Institutional Source

Beutler Lab

Gene Symbol

Prl8a6

Ensembl Gene

ENSMUSG00000021345

Gene Name

prolactin family 8, subfamily a, member 6

Synonyms

Prlpc, PLP-Ca, PLP-calpha, Prlpc1

MMRRC Submission

038296-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.061) question?

Stock #

P0157 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

27616664-27622671 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 27620162 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000105984 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018392] [ENSMUST00000080762] [ENSMUST00000110355]

AlphaFold

Q9DAY2

Predicted Effect

probably benign
Transcript: ENSMUST00000018392

SMART Domains

Protein: ENSMUSP00000018392
Gene: ENSMUSG00000021345

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	16	239	2.8e-56	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000080762

SMART Domains

Protein: ENSMUSP00000079584
Gene: ENSMUSG00000021345

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	86	1.9e-13	PFAM
Pfam:Hormone_1	83	205	2.4e-36	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000110355

SMART Domains

Protein: ENSMUSP00000105984
Gene: ENSMUSG00000021345

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	240	1e-58	PFAM

Coding Region Coverage

1x: 67.6%
3x: 53.1%
10x: 28.4%
20x: 14.6%

Validation Efficiency

82% (18/22)

Allele List at MGI

Other mutations in this stock

Total: 2 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrl2	G	T	3: 148,564,699 (GRCm39)	Q290K	probably damaging	Het
Or52h9	T	A	7: 104,202,714 (GRCm39)	I196N	probably damaging	Het

Other mutations in Prl8a6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0115:Prl8a6	UTSW	13	27,617,084 (GRCm39)	missense	probably benign	0.07
R0481:Prl8a6	UTSW	13	27,617,084 (GRCm39)	missense	probably benign	0.07
R0514:Prl8a6	UTSW	13	27,616,990 (GRCm39)	nonsense	probably null
R2209:Prl8a6	UTSW	13	27,619,369 (GRCm39)	missense	probably benign	0.03
R2329:Prl8a6	UTSW	13	27,621,050 (GRCm39)	missense	probably benign
R3876:Prl8a6	UTSW	13	27,617,015 (GRCm39)	nonsense	probably null
R5259:Prl8a6	UTSW	13	27,620,179 (GRCm39)	nonsense	probably null
R5800:Prl8a6	UTSW	13	27,619,453 (GRCm39)	missense	probably benign
R5921:Prl8a6	UTSW	13	27,621,171 (GRCm39)	missense	probably damaging	1.00
R6901:Prl8a6	UTSW	13	27,621,030 (GRCm39)	missense	possibly damaging	0.87
R7182:Prl8a6	UTSW	13	27,621,153 (GRCm39)	missense	probably damaging	1.00
R7230:Prl8a6	UTSW	13	27,617,021 (GRCm39)	missense	probably benign	0.00

Posted On

2013-01-04