Incidental Mutation 'P0029:Zfp418'
ID 15798
Institutional Source Beutler Lab
Gene Symbol Zfp418
Ensembl Gene ENSMUSG00000034538
Gene Name zinc finger protein 418
Synonyms A230102I05Rik
MMRRC Submission 038282-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # P0029 (G1)
Quality Score
Status Validated
Chromosome 7
Chromosomal Location 7174352-7186559 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 7177636 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 50 (Y50C)
Ref Sequence ENSEMBL: ENSMUSP00000057159 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051435]
AlphaFold Q8BFS8
Predicted Effect probably damaging
Transcript: ENSMUST00000051435
AA Change: Y50C

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000057159
Gene: ENSMUSG00000034538
AA Change: Y50C

DomainStartEndE-ValueType
KRAB 25 78 2.58e-17 SMART
low complexity region 196 211 N/A INTRINSIC
ZnF_C2H2 256 278 6.32e-3 SMART
ZnF_C2H2 284 306 2.57e-3 SMART
ZnF_C2H2 312 334 1.56e-2 SMART
ZnF_C2H2 340 362 1.36e-2 SMART
ZnF_C2H2 368 390 1.82e-3 SMART
ZnF_C2H2 396 418 1.04e-3 SMART
ZnF_C2H2 424 446 2.75e-3 SMART
ZnF_C2H2 452 474 4.47e-3 SMART
ZnF_C2H2 480 502 1.58e-3 SMART
ZnF_C2H2 508 530 8.6e-5 SMART
ZnF_C2H2 536 558 7.78e-3 SMART
ZnF_C2H2 564 586 1.5e-4 SMART
ZnF_C2H2 592 614 4.54e-4 SMART
ZnF_C2H2 620 642 5.59e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209387
Meta Mutation Damage Score 0.6000 question?
Coding Region Coverage
  • 1x: 79.5%
  • 3x: 61.6%
  • 10x: 20.9%
  • 20x: 5.8%
Validation Efficiency 87% (20/23)
Allele List at MGI
Other mutations in this stock
Total: 5 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp6v1c1 T C 15: 38,687,146 (GRCm39) probably benign Het
Dnah8 T A 17: 30,984,694 (GRCm39) Y3131N probably damaging Het
Itpr2 A C 6: 146,280,987 (GRCm39) M223R probably damaging Het
Lmna A T 3: 88,391,224 (GRCm39) H506Q possibly damaging Het
Txnip A G 3: 96,467,679 (GRCm39) probably null Het
Other mutations in Zfp418
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01783:Zfp418 APN 7 7,184,448 (GRCm39) missense possibly damaging 0.72
IGL02351:Zfp418 APN 7 7,177,690 (GRCm39) splice site probably benign
IGL02358:Zfp418 APN 7 7,177,690 (GRCm39) splice site probably benign
R4355_Zfp418_487 UTSW 7 7,175,161 (GRCm39) missense probably benign 0.02
R5592_zfp418_571 UTSW 7 7,184,314 (GRCm39) missense possibly damaging 0.72
R0018:Zfp418 UTSW 7 7,185,449 (GRCm39) missense probably benign 0.06
R0018:Zfp418 UTSW 7 7,185,449 (GRCm39) missense probably benign 0.06
R1065:Zfp418 UTSW 7 7,184,561 (GRCm39) missense probably benign 0.18
R1168:Zfp418 UTSW 7 7,185,500 (GRCm39) missense possibly damaging 0.91
R1660:Zfp418 UTSW 7 7,184,789 (GRCm39) missense probably benign 0.04
R1937:Zfp418 UTSW 7 7,185,401 (GRCm39) missense possibly damaging 0.71
R2266:Zfp418 UTSW 7 7,185,807 (GRCm39) missense probably benign 0.18
R3119:Zfp418 UTSW 7 7,184,688 (GRCm39) missense possibly damaging 0.53
R4355:Zfp418 UTSW 7 7,175,161 (GRCm39) missense probably benign 0.02
R4539:Zfp418 UTSW 7 7,184,276 (GRCm39) missense probably benign 0.18
R4735:Zfp418 UTSW 7 7,185,561 (GRCm39) missense probably damaging 0.96
R4756:Zfp418 UTSW 7 7,185,762 (GRCm39) missense possibly damaging 0.89
R4763:Zfp418 UTSW 7 7,184,444 (GRCm39) missense possibly damaging 0.53
R4810:Zfp418 UTSW 7 7,185,846 (GRCm39) missense possibly damaging 0.82
R5347:Zfp418 UTSW 7 7,185,534 (GRCm39) missense probably benign 0.40
R5592:Zfp418 UTSW 7 7,184,314 (GRCm39) missense possibly damaging 0.72
R5640:Zfp418 UTSW 7 7,184,980 (GRCm39) nonsense probably null
R5974:Zfp418 UTSW 7 7,185,199 (GRCm39) missense possibly damaging 0.95
R6209:Zfp418 UTSW 7 7,185,096 (GRCm39) missense possibly damaging 0.51
R6218:Zfp418 UTSW 7 7,185,627 (GRCm39) missense possibly damaging 0.73
R6502:Zfp418 UTSW 7 7,185,599 (GRCm39) missense possibly damaging 0.86
R6619:Zfp418 UTSW 7 7,184,895 (GRCm39) missense probably damaging 0.98
R7205:Zfp418 UTSW 7 7,184,562 (GRCm39) missense probably benign 0.33
R7299:Zfp418 UTSW 7 7,185,827 (GRCm39) missense possibly damaging 0.61
R7492:Zfp418 UTSW 7 7,184,396 (GRCm39) missense possibly damaging 0.53
R7774:Zfp418 UTSW 7 7,185,776 (GRCm39) missense possibly damaging 0.51
R7826:Zfp418 UTSW 7 7,185,668 (GRCm39) missense probably benign 0.32
R7974:Zfp418 UTSW 7 7,185,167 (GRCm39) missense possibly damaging 0.61
R8002:Zfp418 UTSW 7 7,184,873 (GRCm39) missense probably benign 0.04
R8182:Zfp418 UTSW 7 7,184,658 (GRCm39) missense probably benign 0.00
R8298:Zfp418 UTSW 7 7,185,814 (GRCm39) nonsense probably null
R8773:Zfp418 UTSW 7 7,185,797 (GRCm39) missense probably benign 0.06
R9280:Zfp418 UTSW 7 7,184,408 (GRCm39) missense possibly damaging 0.53
R9318:Zfp418 UTSW 7 7,185,435 (GRCm39) missense probably damaging 0.98
R9404:Zfp418 UTSW 7 7,185,104 (GRCm39) missense possibly damaging 0.71
R9648:Zfp418 UTSW 7 7,185,171 (GRCm39) missense probably benign 0.29
Posted On 2013-01-04