Incidental Mutation 'R1295:Vmn2r6'
| ID |
158045 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r6
|
| Ensembl Gene |
ENSMUSG00000090581 |
| Gene Name |
vomeronasal 2, receptor 6 |
| Synonyms |
EG620718, EG667069 |
| MMRRC Submission |
039361-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.184)
|
| Stock # |
R1295 (G1)
|
| Quality Score |
218 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
64537561-64565298 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 64538273 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Serine
at position 677
(F677S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135148
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000165012]
[ENSMUST00000176481]
|
| AlphaFold |
H3BK29 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000165012
AA Change: F588S
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000131831
Gene: ENSMUSG00000090581
AA Change: F588S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
1 |
416 |
1.4e-72 |
PFAM |
|
Pfam:Peripla_BP_6
|
58 |
244 |
1.2e-10 |
PFAM |
|
Pfam:NCD3G
|
458 |
511 |
1.8e-17 |
PFAM |
|
Pfam:7tm_3
|
542 |
779 |
3.9e-76 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176481
AA Change: F677S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000135148
Gene: ENSMUSG00000090581
AA Change: F677S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
88 |
505 |
9.8e-77 |
PFAM |
|
Pfam:Peripla_BP_6
|
142 |
331 |
3.4e-10 |
PFAM |
|
Pfam:NCD3G
|
547 |
600 |
5.4e-17 |
PFAM |
|
Pfam:7tm_3
|
633 |
867 |
3.9e-47 |
PFAM |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.4%
- 10x: 93.1%
- 20x: 82.0%
|
| Validation Efficiency |
98% (81/83) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ackr2 |
A |
G |
9: 121,908,717 (GRCm38) |
S53G |
possibly damaging |
Het |
| Adgrb1 |
T |
A |
15: 74,550,039 (GRCm38) |
L886Q |
probably damaging |
Het |
| Adprhl1 |
G |
A |
8: 13,248,624 (GRCm38) |
T102M |
probably damaging |
Het |
| Akap6 |
A |
C |
12: 52,887,029 (GRCm38) |
K435Q |
probably damaging |
Het |
| Aldh7a1 |
T |
C |
18: 56,546,950 (GRCm38) |
|
probably null |
Het |
| Amfr |
T |
C |
8: 93,974,804 (GRCm38) |
R507G |
probably benign |
Het |
| Ap1m1 |
T |
A |
8: 72,251,875 (GRCm38) |
|
probably null |
Het |
| Arhgap29 |
A |
G |
3: 121,992,395 (GRCm38) |
H275R |
probably benign |
Het |
| Arhgef17 |
C |
A |
7: 100,881,269 (GRCm38) |
E428* |
probably null |
Het |
| Atm |
A |
T |
9: 53,456,530 (GRCm38) |
V2431E |
probably damaging |
Het |
| Atn1 |
G |
T |
6: 124,747,787 (GRCm38) |
P161Q |
unknown |
Het |
| Atp13a2 |
T |
C |
4: 140,993,802 (GRCm38) |
S99P |
probably damaging |
Het |
| Ccar1 |
C |
A |
10: 62,783,882 (GRCm38) |
|
probably null |
Het |
| Cdk18 |
T |
C |
1: 132,119,960 (GRCm38) |
|
probably benign |
Het |
| Cep85 |
A |
G |
4: 134,167,400 (GRCm38) |
W32R |
probably damaging |
Het |
| Col5a3 |
A |
G |
9: 20,808,418 (GRCm38) |
F215S |
unknown |
Het |
| Decr1 |
T |
C |
4: 15,919,207 (GRCm38) |
N312S |
possibly damaging |
Het |
| Diaph3 |
A |
T |
14: 87,007,399 (GRCm38) |
W178R |
probably damaging |
Het |
| Dync2h1 |
A |
G |
9: 7,075,752 (GRCm38) |
|
probably benign |
Het |
| Ehd3 |
C |
A |
17: 73,828,186 (GRCm38) |
D352E |
probably damaging |
Het |
| Enpp6 |
T |
G |
8: 47,065,500 (GRCm38) |
I221S |
probably benign |
Het |
| Fam186a |
T |
C |
15: 99,939,789 (GRCm38) |
|
probably benign |
Het |
| Gm5435 |
G |
T |
12: 82,495,784 (GRCm38) |
|
noncoding transcript |
Het |
| Gm6990 |
T |
A |
19: 56,755,334 (GRCm38) |
|
noncoding transcript |
Het |
| Gpr22 |
A |
C |
12: 31,709,514 (GRCm38) |
I203S |
probably benign |
Het |
| Gpr61 |
A |
G |
3: 108,150,481 (GRCm38) |
V288A |
possibly damaging |
Het |
| Grik3 |
G |
A |
4: 125,704,564 (GRCm38) |
|
probably benign |
Het |
| Gstcd |
T |
C |
3: 133,005,628 (GRCm38) |
N431D |
probably damaging |
Het |
| Haao |
T |
A |
17: 83,838,838 (GRCm38) |
Q69L |
probably benign |
Het |
| Hist1h1b |
T |
C |
13: 21,779,999 (GRCm38) |
S186G |
probably benign |
Het |
| Ift140 |
G |
T |
17: 25,088,933 (GRCm38) |
|
probably null |
Het |
| Ikbke |
A |
G |
1: 131,270,226 (GRCm38) |
V381A |
probably benign |
Het |
| Ing1 |
A |
C |
8: 11,561,501 (GRCm38) |
I38L |
probably benign |
Het |
| Ing1 |
T |
A |
8: 11,561,502 (GRCm38) |
I38N |
probably damaging |
Het |
| Itga4 |
A |
G |
2: 79,322,689 (GRCm38) |
M907V |
possibly damaging |
Het |
| Kcnk12 |
C |
T |
17: 87,746,373 (GRCm38) |
G287D |
probably damaging |
Het |
| Kmt2e |
A |
C |
5: 23,502,404 (GRCm38) |
H1655P |
probably damaging |
Het |
| Mbtd1 |
A |
G |
11: 93,910,359 (GRCm38) |
Y122C |
probably damaging |
Het |
| Mslnl |
T |
C |
17: 25,743,240 (GRCm38) |
L204P |
probably damaging |
Het |
| Muc6 |
T |
C |
7: 141,651,879 (GRCm38) |
E112G |
probably benign |
Het |
| Nav3 |
T |
A |
10: 109,692,102 (GRCm38) |
D2240V |
probably damaging |
Het |
| Ndufaf3 |
T |
C |
9: 108,566,693 (GRCm38) |
T9A |
probably damaging |
Het |
| Numb |
C |
A |
12: 83,796,161 (GRCm38) |
|
probably benign |
Het |
| Prodh2 |
T |
C |
7: 30,494,089 (GRCm38) |
V79A |
probably damaging |
Het |
| Psmb2 |
A |
G |
4: 126,687,032 (GRCm38) |
Y73C |
probably damaging |
Het |
| Rmnd5a |
G |
A |
6: 71,398,455 (GRCm38) |
L80F |
probably benign |
Het |
| Rnf19a |
G |
T |
15: 36,244,101 (GRCm38) |
Y604* |
probably null |
Het |
| Ros1 |
T |
A |
10: 52,087,932 (GRCm38) |
E1744V |
possibly damaging |
Het |
| Rpusd2 |
T |
C |
2: 119,036,927 (GRCm38) |
F219L |
probably benign |
Het |
| Sall2 |
T |
C |
14: 52,313,725 (GRCm38) |
N671S |
probably damaging |
Het |
| Sele |
T |
A |
1: 164,050,810 (GRCm38) |
S239R |
probably damaging |
Het |
| Serpina3b |
T |
C |
12: 104,130,879 (GRCm38) |
F140L |
probably damaging |
Het |
| Stxbp1 |
A |
T |
2: 32,794,636 (GRCm38) |
S594T |
probably benign |
Het |
| Sufu |
G |
A |
19: 46,454,720 (GRCm38) |
|
probably benign |
Het |
| Tbx2 |
A |
G |
11: 85,834,766 (GRCm38) |
E181G |
probably damaging |
Het |
| Thumpd2 |
A |
G |
17: 81,055,888 (GRCm38) |
V50A |
probably damaging |
Het |
| Tmem56 |
A |
G |
3: 121,207,291 (GRCm38) |
V231A |
probably benign |
Het |
| Ttn |
C |
A |
2: 76,743,245 (GRCm38) |
R17441L |
probably damaging |
Het |
| Usp34 |
A |
G |
11: 23,384,477 (GRCm38) |
Y1157C |
probably damaging |
Het |
| Vmn1r9 |
T |
C |
6: 57,071,537 (GRCm38) |
V199A |
probably damaging |
Het |
| Vmn2r84 |
C |
T |
10: 130,389,139 (GRCm38) |
A501T |
probably benign |
Het |
| Wapl |
C |
T |
14: 34,724,769 (GRCm38) |
P605S |
probably damaging |
Het |
| Zfp598 |
A |
G |
17: 24,679,649 (GRCm38) |
N474S |
probably benign |
Het |
| Zfyve26 |
A |
G |
12: 79,274,920 (GRCm38) |
L975P |
probably damaging |
Het |
| Zp3r |
C |
T |
1: 130,591,444 (GRCm38) |
G255D |
probably damaging |
Het |
|
| Other mutations in Vmn2r6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01547:Vmn2r6
|
APN |
3 |
64,538,104 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01968:Vmn2r6
|
APN |
3 |
64,556,345 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02009:Vmn2r6
|
APN |
3 |
64,537,902 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
IGL02039:Vmn2r6
|
APN |
3 |
64,556,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02652:Vmn2r6
|
APN |
3 |
64,556,328 (GRCm38) |
missense |
probably benign |
0.24 |
|
IGL02737:Vmn2r6
|
APN |
3 |
64,556,490 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
IGL02808:Vmn2r6
|
APN |
3 |
64,556,496 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03066:Vmn2r6
|
APN |
3 |
64,565,153 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03331:Vmn2r6
|
APN |
3 |
64,538,007 (GRCm38) |
missense |
probably damaging |
1.00 |
|
BB010:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
BB020:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
R0010:Vmn2r6
|
UTSW |
3 |
64,559,545 (GRCm38) |
nonsense |
probably null |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0206:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0208:Vmn2r6
|
UTSW |
3 |
64,539,912 (GRCm38) |
missense |
probably benign |
|
|
R0427:Vmn2r6
|
UTSW |
3 |
64,559,587 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0466:Vmn2r6
|
UTSW |
3 |
64,556,302 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1018:Vmn2r6
|
UTSW |
3 |
64,556,840 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1104:Vmn2r6
|
UTSW |
3 |
64,538,066 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R1186:Vmn2r6
|
UTSW |
3 |
64,565,067 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1245:Vmn2r6
|
UTSW |
3 |
64,556,790 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1473:Vmn2r6
|
UTSW |
3 |
64,538,158 (GRCm38) |
nonsense |
probably null |
|
|
R1498:Vmn2r6
|
UTSW |
3 |
64,556,469 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1925:Vmn2r6
|
UTSW |
3 |
64,556,277 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R2044:Vmn2r6
|
UTSW |
3 |
64,537,841 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R2069:Vmn2r6
|
UTSW |
3 |
64,556,098 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R2253:Vmn2r6
|
UTSW |
3 |
64,559,718 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2261:Vmn2r6
|
UTSW |
3 |
64,556,669 (GRCm38) |
missense |
probably benign |
0.24 |
|
R2262:Vmn2r6
|
UTSW |
3 |
64,556,669 (GRCm38) |
missense |
probably benign |
0.24 |
|
R2350:Vmn2r6
|
UTSW |
3 |
64,556,352 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2680:Vmn2r6
|
UTSW |
3 |
64,538,286 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R2846:Vmn2r6
|
UTSW |
3 |
64,556,790 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R2860:Vmn2r6
|
UTSW |
3 |
64,547,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2861:Vmn2r6
|
UTSW |
3 |
64,547,339 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3766:Vmn2r6
|
UTSW |
3 |
64,556,508 (GRCm38) |
missense |
probably benign |
0.19 |
|
R3870:Vmn2r6
|
UTSW |
3 |
64,556,621 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4018:Vmn2r6
|
UTSW |
3 |
64,556,472 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4024:Vmn2r6
|
UTSW |
3 |
64,538,250 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4026:Vmn2r6
|
UTSW |
3 |
64,538,250 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R4227:Vmn2r6
|
UTSW |
3 |
64,537,948 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4526:Vmn2r6
|
UTSW |
3 |
64,537,724 (GRCm38) |
missense |
probably benign |
0.32 |
|
R4570:Vmn2r6
|
UTSW |
3 |
64,559,647 (GRCm38) |
missense |
probably benign |
0.31 |
|
R4894:Vmn2r6
|
UTSW |
3 |
64,547,408 (GRCm38) |
missense |
probably benign |
|
|
R4934:Vmn2r6
|
UTSW |
3 |
64,556,345 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5057:Vmn2r6
|
UTSW |
3 |
64,537,786 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5059:Vmn2r6
|
UTSW |
3 |
64,537,623 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R5148:Vmn2r6
|
UTSW |
3 |
64,556,594 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5155:Vmn2r6
|
UTSW |
3 |
64,538,514 (GRCm38) |
missense |
probably benign |
0.44 |
|
R5179:Vmn2r6
|
UTSW |
3 |
64,537,990 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5256:Vmn2r6
|
UTSW |
3 |
64,556,842 (GRCm38) |
missense |
probably benign |
0.33 |
|
R5861:Vmn2r6
|
UTSW |
3 |
64,556,033 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5950:Vmn2r6
|
UTSW |
3 |
64,565,231 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6081:Vmn2r6
|
UTSW |
3 |
64,556,532 (GRCm38) |
missense |
probably benign |
0.25 |
|
R6173:Vmn2r6
|
UTSW |
3 |
64,559,755 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6190:Vmn2r6
|
UTSW |
3 |
64,538,003 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6240:Vmn2r6
|
UTSW |
3 |
64,556,805 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6433:Vmn2r6
|
UTSW |
3 |
64,547,380 (GRCm38) |
nonsense |
probably null |
|
|
R6645:Vmn2r6
|
UTSW |
3 |
64,556,876 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6791:Vmn2r6
|
UTSW |
3 |
64,538,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7265:Vmn2r6
|
UTSW |
3 |
64,556,774 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7503:Vmn2r6
|
UTSW |
3 |
64,539,951 (GRCm38) |
nonsense |
probably null |
|
|
R7562:Vmn2r6
|
UTSW |
3 |
64,556,520 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7584:Vmn2r6
|
UTSW |
3 |
64,565,262 (GRCm38) |
missense |
probably benign |
0.07 |
|
R7611:Vmn2r6
|
UTSW |
3 |
64,565,142 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7759:Vmn2r6
|
UTSW |
3 |
64,556,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7834:Vmn2r6
|
UTSW |
3 |
64,538,022 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7933:Vmn2r6
|
UTSW |
3 |
64,559,803 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7982:Vmn2r6
|
UTSW |
3 |
64,559,820 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8024:Vmn2r6
|
UTSW |
3 |
64,559,824 (GRCm38) |
missense |
probably benign |
0.40 |
|
R8074:Vmn2r6
|
UTSW |
3 |
64,547,643 (GRCm38) |
intron |
probably benign |
|
|
R8169:Vmn2r6
|
UTSW |
3 |
64,539,889 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8337:Vmn2r6
|
UTSW |
3 |
64,556,105 (GRCm38) |
nonsense |
probably null |
|
|
R8736:Vmn2r6
|
UTSW |
3 |
64,559,800 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8962:Vmn2r6
|
UTSW |
3 |
64,556,155 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9139:Vmn2r6
|
UTSW |
3 |
64,556,856 (GRCm38) |
missense |
probably benign |
0.12 |
|
R9206:Vmn2r6
|
UTSW |
3 |
64,559,611 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9295:Vmn2r6
|
UTSW |
3 |
64,556,063 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9332:Vmn2r6
|
UTSW |
3 |
64,547,250 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9616:Vmn2r6
|
UTSW |
3 |
64,538,303 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9663:Vmn2r6
|
UTSW |
3 |
64,556,128 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R9685:Vmn2r6
|
UTSW |
3 |
64,556,660 (GRCm38) |
missense |
probably benign |
0.19 |
|
X0020:Vmn2r6
|
UTSW |
3 |
64,538,450 (GRCm38) |
missense |
probably benign |
|
|
X0066:Vmn2r6
|
UTSW |
3 |
64,547,378 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Vmn2r6
|
UTSW |
3 |
64,556,325 (GRCm38) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATGGGGTGCATGGATATTAGCCG -3'
(R):5'- TCAAGAACAGCTCAAGTTGAGGTGTG -3'
Sequencing Primer
(F):5'- GCCGAGTTTTAGATATGGAAATCCTG -3'
(R):5'- ataGATTTCCAGTAAATCCTGTTGAG -3'
|
| Posted On |
2014-02-18 |
Incidental Mutation