Mutagenetix > Incidental Mutations

Incidental Mutation 'R1301:Mroh9'

158342

Institutional Source

Beutler Lab

Gene Symbol

Mroh9

Ensembl Gene

ENSMUSG00000071890

Gene Name

maestro heat-like repeat family member 9

Synonyms

4921528O07Rik, Armc11

MMRRC Submission

039367-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1301 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

163024302-163085670 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 163043983 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000094365 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000096608]

AlphaFold

G5E8L9

Predicted Effect

probably null
Transcript: ENSMUST00000096608

SMART Domains

Protein: ENSMUSP00000094365
Gene: ENSMUSG00000071890

Domain	Start	End	E-Value	Type
SCOP:d1gw5b_	231	716	2e-8	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000195132

Meta Mutation Damage Score

0.9475

Coding Region Coverage

1x: 98.7%
3x: 97.5%
10x: 93.3%
20x: 82.6%

Validation Efficiency

96% (67/70)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ano1	A	G	7: 144,633,689	W447R	possibly damaging	Het
Blm	T	A	7: 80,455,417	K103*	probably null	Het
Camta2	A	G	11: 70,676,404	I675T	probably benign	Het
Catsperz	G	A	19: 6,925,082	R15C	probably damaging	Het
Chd1l	T	C	3: 97,603,648		probably benign	Het
Corin	C	A	5: 72,304,933	E844D	possibly damaging	Het
Cyb5rl	T	G	4: 107,080,907	M127R	probably damaging	Het
Dcdc2a	A	T	13: 25,102,586	N164I	possibly damaging	Het
Dnah6	A	G	6: 73,208,545		probably null	Het
Emilin2	T	C	17: 71,255,965		probably benign	Het
Epb41l2	T	A	10: 25,443,902	V211D	probably damaging	Het
Fbxo47	C	T	11: 97,868,601	M166I	probably benign	Het
Gm13124	T	A	4: 144,565,065	I24L	probably benign	Het
Gm4450	G	A	3: 98,446,866	Q106*	probably null	Het
Golm1	T	C	13: 59,638,373	D335G	probably damaging	Het
Gpn1	T	A	5: 31,503,429	M188K	probably damaging	Het
Gpr84	T	A	15: 103,309,219	S144C	probably damaging	Het
Grm8	G	T	6: 27,981,201	Q237K	possibly damaging	Het
Gsdmd	C	A	15: 75,867,059		probably null	Het
Hmgcr	G	A	13: 96,659,020	T347I	probably damaging	Het
Hsd17b7	T	A	1: 169,961,205		probably benign	Het
Klhl7	T	G	5: 24,159,491	W508G	probably damaging	Het
Lrp2	C	A	2: 69,428,604	D4581Y	probably damaging	Het
Lrrc7	T	C	3: 158,135,331	N1357D	probably benign	Het
Macf1	T	C	4: 123,486,658		probably benign	Het
Mroh7	T	C	4: 106,720,495	T329A	probably damaging	Het
Mta2	A	G	19: 8,949,186		probably benign	Het
Myo3a	A	T	2: 22,267,095		probably benign	Het
Nrip2	A	G	6: 128,407,389	D153G	probably benign	Het
Nup133	T	C	8: 123,917,417		probably benign	Het
Nup210	C	T	6: 91,042,347	V259M	possibly damaging	Het
Olfr1338	C	T	4: 118,753,619	M308I	probably benign	Het
Olfr1466	A	T	19: 13,341,847	I30F	probably benign	Het
Olfr1499	A	T	19: 13,815,362	V76D	probably damaging	Het
Otog	C	T	7: 46,289,689	R2048C	probably damaging	Het
Paqr7	T	C	4: 134,507,813	L327P	probably damaging	Het
Parl	A	G	16: 20,286,926	S249P	probably damaging	Het
Phc1	A	G	6: 122,325,874	I230T	probably benign	Het
Pitpnm1	T	G	19: 4,110,831		probably null	Het
Plpp1	A	G	13: 112,834,943	Y48C	probably damaging	Het
Pxdc1	A	G	13: 34,628,887	F194L	probably benign	Het
Rp1	A	T	1: 4,345,936	V1651D	possibly damaging	Het
Serpinb1c	T	A	13: 32,896,960	R47*	probably null	Het
Sis	T	C	3: 72,946,582	T521A	possibly damaging	Het
Slc16a9	A	G	10: 70,282,478	D209G	probably benign	Het
Slc26a4	A	T	12: 31,525,568	C706*	probably null	Het
Slc37a2	A	G	9: 37,236,881	V325A	probably benign	Het
Speg	T	A	1: 75,401,501	D784E	probably damaging	Het
Sycp1	T	C	3: 102,920,622	I270V	probably benign	Het
Tatdn2	T	A	6: 113,704,115	F309I	probably damaging	Het
Tmem206	T	C	1: 191,348,435	V284A	probably damaging	Het
Tmem67	T	C	4: 12,089,400		probably benign	Het
Trpm1	T	A	7: 64,203,053		probably null	Het
Wrn	T	C	8: 33,292,686	R496G	probably damaging	Het
Zfhx2	A	G	14: 55,063,397	V2299A	probably benign	Het
Zfp819	T	A	7: 43,617,100	S260T	possibly damaging	Het

Other mutations in Mroh9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00593:Mroh9	APN	1	163045781	missense	possibly damaging	0.89
IGL00705:Mroh9	APN	1	163079503	missense	probably damaging	1.00
IGL00788:Mroh9	APN	1	163024658	missense	probably benign	0.06
IGL00795:Mroh9	APN	1	163060622	missense	probably damaging	1.00
IGL00815:Mroh9	APN	1	163039131	missense	probably damaging	1.00
IGL01025:Mroh9	APN	1	163047866	missense	possibly damaging	0.67
IGL01303:Mroh9	APN	1	163080575	missense	probably benign	0.00
IGL01526:Mroh9	APN	1	163055603	missense	probably damaging	0.99
IGL01680:Mroh9	APN	1	163047982	splice site	probably null
IGL01823:Mroh9	APN	1	163055609	missense	probably benign	0.39
IGL02024:Mroh9	APN	1	163062502	missense	possibly damaging	0.65
IGL02213:Mroh9	APN	1	163058079	missense	probably damaging	1.00
IGL02455:Mroh9	APN	1	163075580	missense	probably benign	0.03
IGL02546:Mroh9	APN	1	163080576	missense	probably benign	0.04
IGL03059:Mroh9	APN	1	163024636	missense	possibly damaging	0.95
IGL03061:Mroh9	APN	1	163026502	missense	probably damaging	1.00
IGL03071:Mroh9	APN	1	163039197	missense	probably damaging	1.00
R0048:Mroh9	UTSW	1	163062487	missense	probably damaging	0.97
R0048:Mroh9	UTSW	1	163062487	missense	probably damaging	0.97
R0441:Mroh9	UTSW	1	163060762	missense	probably damaging	1.00
R0506:Mroh9	UTSW	1	163060636	missense	possibly damaging	0.90
R0629:Mroh9	UTSW	1	163060636	missense	possibly damaging	0.90
R0751:Mroh9	UTSW	1	163066124	missense	possibly damaging	0.84
R1481:Mroh9	UTSW	1	163026509	missense	probably damaging	1.00
R1618:Mroh9	UTSW	1	163024541	missense	probably benign	0.00
R1647:Mroh9	UTSW	1	163046056	missense	probably damaging	1.00
R1648:Mroh9	UTSW	1	163046056	missense	probably damaging	1.00
R1668:Mroh9	UTSW	1	163024592	missense	possibly damaging	0.52
R1795:Mroh9	UTSW	1	163056778	missense	probably damaging	0.97
R1796:Mroh9	UTSW	1	163045710	missense	probably damaging	1.00
R1857:Mroh9	UTSW	1	163039145	missense	probably damaging	0.98
R1869:Mroh9	UTSW	1	163026513	missense	probably damaging	0.97
R1923:Mroh9	UTSW	1	163076291	missense	probably damaging	1.00
R2325:Mroh9	UTSW	1	163026530	splice site	probably null
R2511:Mroh9	UTSW	1	163038945	missense	probably benign	0.13
R2912:Mroh9	UTSW	1	163044003	missense	probably damaging	1.00
R2913:Mroh9	UTSW	1	163044003	missense	probably damaging	1.00
R2919:Mroh9	UTSW	1	163056772	missense	probably damaging	1.00
R2973:Mroh9	UTSW	1	163056769	missense	probably damaging	1.00
R3912:Mroh9	UTSW	1	163066069	missense	probably damaging	0.97
R4034:Mroh9	UTSW	1	163080553	critical splice donor site	probably null
R4551:Mroh9	UTSW	1	163044093	missense	probably damaging	0.98
R4656:Mroh9	UTSW	1	163066024	missense	probably damaging	1.00
R4662:Mroh9	UTSW	1	163055593	missense	probably damaging	0.97
R4743:Mroh9	UTSW	1	163024492	missense	probably benign	0.05
R4890:Mroh9	UTSW	1	163026524	missense	probably damaging	1.00
R5128:Mroh9	UTSW	1	163060760	missense	probably damaging	1.00
R5129:Mroh9	UTSW	1	163060760	missense	probably damaging	1.00
R5147:Mroh9	UTSW	1	163060760	missense	probably damaging	1.00
R5157:Mroh9	UTSW	1	163044121	missense	probably damaging	0.96
R5324:Mroh9	UTSW	1	163060760	missense	probably damaging	1.00
R5325:Mroh9	UTSW	1	163060760	missense	probably damaging	1.00
R5340:Mroh9	UTSW	1	163080587	start gained	probably benign
R6005:Mroh9	UTSW	1	163075677	missense	probably damaging	0.99
R6182:Mroh9	UTSW	1	163066043	nonsense	probably null
R6414:Mroh9	UTSW	1	163074702	missense	probably damaging	1.00
R6477:Mroh9	UTSW	1	163076304	missense	probably damaging	1.00
R6540:Mroh9	UTSW	1	163038972	missense	possibly damaging	0.87
R6541:Mroh9	UTSW	1	163058038	missense	possibly damaging	0.78
R6643:Mroh9	UTSW	1	163075561	missense	probably damaging	1.00
R6811:Mroh9	UTSW	1	163046041	missense	possibly damaging	0.86
R6830:Mroh9	UTSW	1	163076366	missense	probably benign
R7026:Mroh9	UTSW	1	163060682	missense	probably benign	0.00
R7052:Mroh9	UTSW	1	163038956	missense	possibly damaging	0.92
R7068:Mroh9	UTSW	1	163039181	missense	probably damaging	1.00
R7350:Mroh9	UTSW	1	163076289	critical splice donor site	probably null
R7545:Mroh9	UTSW	1	163074708	missense	possibly damaging	0.56
R7615:Mroh9	UTSW	1	163046032	missense	probably benign	0.40
R7743:Mroh9	UTSW	1	163024553	missense	probably benign
R7808:Mroh9	UTSW	1	163039109	missense	probably damaging	1.00
R8024:Mroh9	UTSW	1	163039233	missense	probably benign	0.02
R8062:Mroh9	UTSW	1	163038975	missense	probably damaging	1.00
R8145:Mroh9	UTSW	1	163062527	missense	probably benign	0.00
R8426:Mroh9	UTSW	1	163024725	missense	probably damaging	0.98
R8458:Mroh9	UTSW	1	163055681	missense	probably damaging	1.00
R8555:Mroh9	UTSW	1	163072026	splice site	probably null
R8960:Mroh9	UTSW	1	163055627	missense	probably benign	0.25
R9040:Mroh9	UTSW	1	163062500	missense	probably benign	0.06
R9125:Mroh9	UTSW	1	163047843	missense	probably benign	0.19
R9154:Mroh9	UTSW	1	163062461	missense
RF003:Mroh9	UTSW	1	163058061	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGTAGAAGGATTTACACCCACCCAG -3'
(R):5'- AGCAAGGACATTACCTTGTAGAGCAAC -3'

Sequencing Primer
(F):5'- AGCCCAGGTCCAGTGTTAATC -3'
(R):5'- GCACAGTGTTGGTATATTCCCAAG -3'

Posted On

2014-02-18