Incidental Mutation 'R1302:Gpr153'
ID 158412
Institutional Source Beutler Lab
Gene Symbol Gpr153
Ensembl Gene ENSMUSG00000042804
Gene Name G protein-coupled receptor 153
Synonyms PGR1, 1110065N12Rik
MMRRC Submission 039368-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1302 (G1)
Quality Score 103
Status Not validated
Chromosome 4
Chromosomal Location 152358689-152369794 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 152364400 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 152 (T152M)
Ref Sequence ENSEMBL: ENSMUSP00000101276 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055754] [ENSMUST00000105650] [ENSMUST00000105651]
AlphaFold Q8K0Z9
Predicted Effect probably damaging
Transcript: ENSMUST00000055754
AA Change: T152M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052742
Gene: ENSMUSG00000042804
AA Change: T152M

DomainStartEndE-ValueType
Pfam:7tm_1 24 298 1.2e-14 PFAM
low complexity region 501 518 N/A INTRINSIC
low complexity region 605 617 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000105650
AA Change: T152M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101275
Gene: ENSMUSG00000042804
AA Change: T152M

DomainStartEndE-ValueType
Pfam:7tm_1 24 297 5.4e-18 PFAM
low complexity region 478 495 N/A INTRINSIC
low complexity region 582 594 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000105651
AA Change: T152M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000101276
Gene: ENSMUSG00000042804
AA Change: T152M

DomainStartEndE-ValueType
Pfam:7tm_1 24 297 5.3e-17 PFAM
low complexity region 501 518 N/A INTRINSIC
low complexity region 605 617 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144035
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.3%
  • 20x: 86.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810004N23Rik A T 8: 125,566,607 (GRCm39) I271N probably damaging Het
5031439G07Rik A G 15: 84,837,477 (GRCm39) Y279H probably damaging Het
Abcg2 T A 6: 58,662,802 (GRCm39) M548K probably damaging Het
Acat1 T C 9: 53,500,525 (GRCm39) D257G possibly damaging Het
Adamts4 G A 1: 171,080,752 (GRCm39) G360R probably damaging Het
Akr1c12 T C 13: 4,322,328 (GRCm39) D238G probably damaging Het
Ankrd1 C T 19: 36,092,403 (GRCm39) G275S probably damaging Het
Ascc3 T A 10: 50,480,890 (GRCm39) M1K probably null Het
Atf7ip2 T C 16: 10,058,472 (GRCm39) S304P possibly damaging Het
Casp4 T A 9: 5,328,518 (GRCm39) C333* probably null Het
Ccdc68 G A 18: 70,072,033 (GRCm39) V37M probably damaging Het
Cda T A 4: 138,078,502 (GRCm39) I87F probably damaging Het
Chst1 A T 2: 92,443,864 (GRCm39) D112V probably damaging Het
Chtf18 T C 17: 25,938,132 (GRCm39) D967G probably damaging Het
Col5a1 A G 2: 27,895,248 (GRCm39) R1106G probably damaging Het
Coro1b T G 19: 4,199,376 (GRCm39) F12V probably damaging Het
Ctif G T 18: 75,654,749 (GRCm39) P259Q probably benign Het
Duox1 A T 2: 122,177,760 (GRCm39) I1515F probably benign Het
Eme2 G A 17: 25,111,892 (GRCm39) S263F probably damaging Het
Flt1 A G 5: 147,501,050 (GRCm39) Y1328H possibly damaging Het
Frem2 T C 3: 53,562,959 (GRCm39) D516G probably benign Het
Gin1 A T 1: 97,703,314 (GRCm39) K46* probably null Het
Gle1 C G 2: 29,842,564 (GRCm39) probably null Het
Gm11146 T G 16: 77,398,970 (GRCm39) I5L unknown Het
H1f8 A T 6: 115,924,610 (GRCm39) R39* probably null Het
Hdlbp A T 1: 93,351,107 (GRCm39) probably null Het
Ifi207 A T 1: 173,562,861 (GRCm39) L95Q possibly damaging Het
Ikzf3 G T 11: 98,407,746 (GRCm39) P32T probably benign Het
Ints10 T A 8: 69,279,964 (GRCm39) V697E probably damaging Het
Krt14 A G 11: 100,094,173 (GRCm39) S474P probably damaging Het
L3mbtl3 T A 10: 26,203,667 (GRCm39) I388F unknown Het
Ldha A C 7: 46,497,063 (GRCm39) Q7P probably damaging Het
Lrwd1 A G 5: 136,161,267 (GRCm39) S232P probably benign Het
Med1 G T 11: 98,048,275 (GRCm39) D840E possibly damaging Het
Med23 T A 10: 24,764,320 (GRCm39) probably null Het
Naip5 G A 13: 100,358,099 (GRCm39) P1046S possibly damaging Het
Ndufa4l2 A T 10: 127,351,301 (GRCm39) M31L probably benign Het
Nlrp4f A G 13: 65,342,371 (GRCm39) S425P possibly damaging Het
Nova1 A T 12: 46,767,581 (GRCm39) H113Q unknown Het
Npc1 T C 18: 12,328,142 (GRCm39) K1056E probably benign Het
Nrbp1 A G 5: 31,407,233 (GRCm39) H354R probably benign Het
Ogfod3 A G 11: 121,074,300 (GRCm39) F250L probably damaging Het
Pclo A G 5: 14,731,647 (GRCm39) D3383G unknown Het
Pde1b T A 15: 103,436,026 (GRCm39) D457E probably benign Het
Pkd1 C G 17: 24,787,210 (GRCm39) S581R probably benign Het
Pno1 T A 11: 17,154,545 (GRCm39) Q212L probably benign Het
Polr3b C T 10: 84,468,350 (GRCm39) P112L probably damaging Het
Pomk T A 8: 26,473,102 (GRCm39) I284F probably damaging Het
Rapgef4 A T 2: 71,875,504 (GRCm39) D119V probably benign Het
Rprm A T 2: 53,975,165 (GRCm39) L51Q probably benign Het
Spata31e5 A T 1: 28,815,421 (GRCm39) D870E probably benign Het
Taok3 A C 5: 117,337,108 (GRCm39) S58R possibly damaging Het
Tmprss9 T A 10: 80,730,963 (GRCm39) S830T probably benign Het
Tnfrsf1a G A 6: 125,333,879 (GRCm39) C44Y probably damaging Het
Ubr5 A T 15: 38,041,723 (GRCm39) D235E possibly damaging Het
Vapb C A 2: 173,613,330 (GRCm39) F76L possibly damaging Het
Vmn2r72 T C 7: 85,387,465 (GRCm39) I700V probably damaging Het
Wwc1 G A 11: 35,734,984 (GRCm39) R964W probably damaging Het
Zfp644 A T 5: 106,782,765 (GRCm39) V1203D probably damaging Het
Other mutations in Gpr153
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Gpr153 APN 4 152,366,423 (GRCm39) unclassified probably benign
IGL01368:Gpr153 APN 4 152,367,451 (GRCm39) missense probably benign 0.40
IGL01568:Gpr153 APN 4 152,366,825 (GRCm39) splice site probably null
IGL01672:Gpr153 APN 4 152,364,370 (GRCm39) nonsense probably null
R0735:Gpr153 UTSW 4 152,363,830 (GRCm39) nonsense probably null
R0925:Gpr153 UTSW 4 152,366,331 (GRCm39) missense probably benign
R1829:Gpr153 UTSW 4 152,366,849 (GRCm39) missense possibly damaging 0.70
R2041:Gpr153 UTSW 4 152,367,810 (GRCm39) missense probably benign
R4698:Gpr153 UTSW 4 152,366,240 (GRCm39) missense probably damaging 1.00
R5069:Gpr153 UTSW 4 152,364,340 (GRCm39) missense probably damaging 0.99
R5623:Gpr153 UTSW 4 152,366,398 (GRCm39) missense possibly damaging 0.89
R5800:Gpr153 UTSW 4 152,364,534 (GRCm39) nonsense probably null
R5940:Gpr153 UTSW 4 152,367,832 (GRCm39) missense probably benign 0.12
R6773:Gpr153 UTSW 4 152,363,757 (GRCm39) missense probably damaging 1.00
R6944:Gpr153 UTSW 4 152,363,820 (GRCm39) missense probably damaging 1.00
R7486:Gpr153 UTSW 4 152,366,858 (GRCm39) missense probably benign 0.01
R8170:Gpr153 UTSW 4 152,364,634 (GRCm39) missense probably damaging 1.00
R8699:Gpr153 UTSW 4 152,363,558 (GRCm39) start gained probably benign
R8701:Gpr153 UTSW 4 152,363,558 (GRCm39) start gained probably benign
R8732:Gpr153 UTSW 4 152,363,558 (GRCm39) start gained probably benign
R9047:Gpr153 UTSW 4 152,364,664 (GRCm39) missense probably damaging 1.00
R9383:Gpr153 UTSW 4 152,367,516 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GAGGTACAAGGCTCTGCCATGATG -3'
(R):5'- CCCGTGATCTGTAGCGAAGTTCTG -3'

Sequencing Primer
(F):5'- CTCTGCCATGATGGCTGG -3'
(R):5'- AGGCTCTGAGCCATCAATG -3'
Posted On 2014-02-18