Incidental Mutation 'R1302:H1f8'
ID 158420
Institutional Source Beutler Lab
Gene Symbol H1f8
Ensembl Gene ENSMUSG00000042279
Gene Name H1.8 linker histone
Synonyms H1foo, H1-8, H1oo
MMRRC Submission 039368-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1302 (G1)
Quality Score 171
Status Not validated
Chromosome 6
Chromosomal Location 115921899-115927197 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 115924610 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 39 (R39*)
Ref Sequence ENSEMBL: ENSMUSP00000123797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037831] [ENSMUST00000161617] [ENSMUST00000161969] [ENSMUST00000162084] [ENSMUST00000205177]
AlphaFold Q8VIK3
Predicted Effect probably null
Transcript: ENSMUST00000037831
AA Change: R39*
SMART Domains Protein: ENSMUSP00000036951
Gene: ENSMUSG00000042279
AA Change: R39*

DomainStartEndE-ValueType
low complexity region 4 24 N/A INTRINSIC
H15 43 110 8.84e-11 SMART
low complexity region 123 146 N/A INTRINSIC
low complexity region 182 197 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000161617
AA Change: R39*
SMART Domains Protein: ENSMUSP00000125701
Gene: ENSMUSG00000042279
AA Change: R39*

DomainStartEndE-ValueType
low complexity region 4 24 N/A INTRINSIC
H15 43 110 8.84e-11 SMART
low complexity region 123 146 N/A INTRINSIC
low complexity region 182 197 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000161969
AA Change: R39*
SMART Domains Protein: ENSMUSP00000123797
Gene: ENSMUSG00000042279
AA Change: R39*

DomainStartEndE-ValueType
low complexity region 4 24 N/A INTRINSIC
H15 43 110 8.84e-11 SMART
low complexity region 123 146 N/A INTRINSIC
low complexity region 182 197 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162084
Predicted Effect probably benign
Transcript: ENSMUST00000205177
SMART Domains Protein: ENSMUSP00000144958
Gene: ENSMUSG00000042279

DomainStartEndE-ValueType
low complexity region 11 26 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.3%
  • 20x: 86.2%
Validation Efficiency
MGI Phenotype FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes and the encoded protein is expressed only in oocytes. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a targeted mutation exhibit no detectable abnormalities. Oocytes develop normally and no defects in fertility or litter sizes are observed. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810004N23Rik A T 8: 125,566,607 (GRCm39) I271N probably damaging Het
5031439G07Rik A G 15: 84,837,477 (GRCm39) Y279H probably damaging Het
Abcg2 T A 6: 58,662,802 (GRCm39) M548K probably damaging Het
Acat1 T C 9: 53,500,525 (GRCm39) D257G possibly damaging Het
Adamts4 G A 1: 171,080,752 (GRCm39) G360R probably damaging Het
Akr1c12 T C 13: 4,322,328 (GRCm39) D238G probably damaging Het
Ankrd1 C T 19: 36,092,403 (GRCm39) G275S probably damaging Het
Ascc3 T A 10: 50,480,890 (GRCm39) M1K probably null Het
Atf7ip2 T C 16: 10,058,472 (GRCm39) S304P possibly damaging Het
Casp4 T A 9: 5,328,518 (GRCm39) C333* probably null Het
Ccdc68 G A 18: 70,072,033 (GRCm39) V37M probably damaging Het
Cda T A 4: 138,078,502 (GRCm39) I87F probably damaging Het
Chst1 A T 2: 92,443,864 (GRCm39) D112V probably damaging Het
Chtf18 T C 17: 25,938,132 (GRCm39) D967G probably damaging Het
Col5a1 A G 2: 27,895,248 (GRCm39) R1106G probably damaging Het
Coro1b T G 19: 4,199,376 (GRCm39) F12V probably damaging Het
Ctif G T 18: 75,654,749 (GRCm39) P259Q probably benign Het
Duox1 A T 2: 122,177,760 (GRCm39) I1515F probably benign Het
Eme2 G A 17: 25,111,892 (GRCm39) S263F probably damaging Het
Flt1 A G 5: 147,501,050 (GRCm39) Y1328H possibly damaging Het
Frem2 T C 3: 53,562,959 (GRCm39) D516G probably benign Het
Gin1 A T 1: 97,703,314 (GRCm39) K46* probably null Het
Gle1 C G 2: 29,842,564 (GRCm39) probably null Het
Gm11146 T G 16: 77,398,970 (GRCm39) I5L unknown Het
Gpr153 C T 4: 152,364,400 (GRCm39) T152M probably damaging Het
Hdlbp A T 1: 93,351,107 (GRCm39) probably null Het
Ifi207 A T 1: 173,562,861 (GRCm39) L95Q possibly damaging Het
Ikzf3 G T 11: 98,407,746 (GRCm39) P32T probably benign Het
Ints10 T A 8: 69,279,964 (GRCm39) V697E probably damaging Het
Krt14 A G 11: 100,094,173 (GRCm39) S474P probably damaging Het
L3mbtl3 T A 10: 26,203,667 (GRCm39) I388F unknown Het
Ldha A C 7: 46,497,063 (GRCm39) Q7P probably damaging Het
Lrwd1 A G 5: 136,161,267 (GRCm39) S232P probably benign Het
Med1 G T 11: 98,048,275 (GRCm39) D840E possibly damaging Het
Med23 T A 10: 24,764,320 (GRCm39) probably null Het
Naip5 G A 13: 100,358,099 (GRCm39) P1046S possibly damaging Het
Ndufa4l2 A T 10: 127,351,301 (GRCm39) M31L probably benign Het
Nlrp4f A G 13: 65,342,371 (GRCm39) S425P possibly damaging Het
Nova1 A T 12: 46,767,581 (GRCm39) H113Q unknown Het
Npc1 T C 18: 12,328,142 (GRCm39) K1056E probably benign Het
Nrbp1 A G 5: 31,407,233 (GRCm39) H354R probably benign Het
Ogfod3 A G 11: 121,074,300 (GRCm39) F250L probably damaging Het
Pclo A G 5: 14,731,647 (GRCm39) D3383G unknown Het
Pde1b T A 15: 103,436,026 (GRCm39) D457E probably benign Het
Pkd1 C G 17: 24,787,210 (GRCm39) S581R probably benign Het
Pno1 T A 11: 17,154,545 (GRCm39) Q212L probably benign Het
Polr3b C T 10: 84,468,350 (GRCm39) P112L probably damaging Het
Pomk T A 8: 26,473,102 (GRCm39) I284F probably damaging Het
Rapgef4 A T 2: 71,875,504 (GRCm39) D119V probably benign Het
Rprm A T 2: 53,975,165 (GRCm39) L51Q probably benign Het
Spata31e5 A T 1: 28,815,421 (GRCm39) D870E probably benign Het
Taok3 A C 5: 117,337,108 (GRCm39) S58R possibly damaging Het
Tmprss9 T A 10: 80,730,963 (GRCm39) S830T probably benign Het
Tnfrsf1a G A 6: 125,333,879 (GRCm39) C44Y probably damaging Het
Ubr5 A T 15: 38,041,723 (GRCm39) D235E possibly damaging Het
Vapb C A 2: 173,613,330 (GRCm39) F76L possibly damaging Het
Vmn2r72 T C 7: 85,387,465 (GRCm39) I700V probably damaging Het
Wwc1 G A 11: 35,734,984 (GRCm39) R964W probably damaging Het
Zfp644 A T 5: 106,782,765 (GRCm39) V1203D probably damaging Het
Other mutations in H1f8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00334:H1f8 APN 6 115,924,588 (GRCm39) unclassified probably benign
IGL00864:H1f8 APN 6 115,925,587 (GRCm39) missense probably damaging 0.99
R0050:H1f8 UTSW 6 115,924,729 (GRCm39) missense probably damaging 1.00
R0050:H1f8 UTSW 6 115,924,729 (GRCm39) missense probably damaging 1.00
R0056:H1f8 UTSW 6 115,923,934 (GRCm39) unclassified probably benign
R0081:H1f8 UTSW 6 115,926,942 (GRCm39) missense probably benign
R0559:H1f8 UTSW 6 115,924,760 (GRCm39) missense probably damaging 1.00
R1476:H1f8 UTSW 6 115,924,701 (GRCm39) missense possibly damaging 0.61
R1824:H1f8 UTSW 6 115,925,719 (GRCm39) missense probably null 0.97
R3778:H1f8 UTSW 6 115,926,708 (GRCm39) critical splice donor site probably null
R3928:H1f8 UTSW 6 115,925,757 (GRCm39) missense probably benign 0.12
R3929:H1f8 UTSW 6 115,925,757 (GRCm39) missense probably benign 0.12
R6316:H1f8 UTSW 6 115,925,876 (GRCm39) critical splice donor site probably null
R8356:H1f8 UTSW 6 115,925,745 (GRCm39) missense probably benign
R8456:H1f8 UTSW 6 115,925,745 (GRCm39) missense probably benign
R8869:H1f8 UTSW 6 115,926,911 (GRCm39) missense probably benign 0.00
R9628:H1f8 UTSW 6 115,924,700 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ATACCCTTGGGCAGCTAACCTACC -3'
(R):5'- GCCAGTTTCCAGAGCTTGCTTCAAC -3'

Sequencing Primer
(F):5'- tgggaggcagaggcagg -3'
(R):5'- AACAGGTACTTGAAACGGGTGG -3'
Posted On 2014-02-18