Incidental Mutation 'R1457:Olfr1045'
ID 158540
Institutional Source Beutler Lab
Gene Symbol Olfr1045
Ensembl Gene ENSMUSG00000075198
Gene Name olfactory receptor 1045
Synonyms MOR185-2, GA_x6K02T2Q125-47672825-47671878
MMRRC Submission 039512-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.167) question?
Stock # R1457 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 86195910-86203009 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 86198252 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 167 (S167P)
Ref Sequence ENSEMBL: ENSMUSP00000148982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099904] [ENSMUST00000215763]
AlphaFold Q7TR80
Predicted Effect probably damaging
Transcript: ENSMUST00000099904
AA Change: S167P

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000097488
Gene: ENSMUSG00000075198
AA Change: S167P

Pfam:7tm_4 31 307 3.2e-43 PFAM
Pfam:7tm_1 41 290 5.7e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215763
AA Change: S167P

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216885
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.7%
  • 20x: 87.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010300C02Rik A T 1: 37,626,012 (GRCm38) Y268* probably null Het
Abca14 A T 7: 120,289,460 (GRCm38) I1210F probably benign Het
Ankrd17 T C 5: 90,285,846 (GRCm38) H688R possibly damaging Het
Arhgap24 T A 5: 102,664,106 (GRCm38) N66K probably damaging Het
Atp1a1 C T 3: 101,590,466 (GRCm38) G335D probably damaging Het
Cacna1g C T 11: 94,459,555 (GRCm38) R488H possibly damaging Het
Cacna1h A T 17: 25,397,620 (GRCm38) V149E probably damaging Het
Cd22 G T 7: 30,873,170 (GRCm38) P338Q probably benign Het
Cntln G T 4: 85,096,839 (GRCm38) M1122I probably benign Het
Cntrl A G 2: 35,122,756 (GRCm38) N302S probably benign Het
Cog8 T C 8: 107,052,896 (GRCm38) R250G probably damaging Het
Creld2 T C 15: 88,823,753 (GRCm38) C232R probably damaging Het
Cyp2b23 G A 7: 26,673,149 (GRCm38) P347L probably damaging Het
Dnah5 T C 15: 28,403,542 (GRCm38) probably null Het
Eml6 C T 11: 30,024,459 (GRCm38) V40I probably damaging Het
Epb42 C T 2: 121,029,967 (GRCm38) probably null Het
Fcrla A G 1: 170,921,004 (GRCm38) L190P probably damaging Het
Galnt18 A T 7: 111,779,428 (GRCm38) Y40* probably null Het
Gdf7 A T 12: 8,298,073 (GRCm38) M416K probably damaging Het
Gm11232 T A 4: 71,756,919 (GRCm38) probably null Het
Gpam T A 19: 55,088,176 (GRCm38) N198Y probably damaging Het
Grip1 C T 10: 119,986,350 (GRCm38) S327F possibly damaging Het
Hey2 C T 10: 30,834,356 (GRCm38) A134T probably benign Het
Kat6a T C 8: 22,938,652 (GRCm38) I1341T probably benign Het
Kcnd3 T C 3: 105,668,186 (GRCm38) L542P probably benign Het
Lars G A 18: 42,210,050 (GRCm38) R1101C probably damaging Het
Lman2 T C 13: 55,351,251 (GRCm38) D234G probably benign Het
Map3k19 A C 1: 127,817,898 (GRCm38) I1273R probably damaging Het
Matn1 T A 4: 130,950,019 (GRCm38) F180I possibly damaging Het
Meikin T A 11: 54,370,941 (GRCm38) L61* probably null Het
Mroh2b G T 15: 4,925,684 (GRCm38) D720Y probably damaging Het
Myh13 T C 11: 67,331,046 (GRCm38) I199T probably damaging Het
Myh4 T A 11: 67,248,461 (GRCm38) S535T probably damaging Het
Myo5a T C 9: 75,213,065 (GRCm38) M1715T probably damaging Het
Nat8 A T 6: 85,830,989 (GRCm38) V54D probably damaging Het
Nbea A G 3: 56,085,327 (GRCm38) V286A probably damaging Het
Ndnf A G 6: 65,704,014 (GRCm38) K426E possibly damaging Het
Nup210l T A 3: 90,190,972 (GRCm38) N1410K possibly damaging Het
Oca2 A T 7: 56,321,521 (GRCm38) T399S probably damaging Het
Olfr118 A T 17: 37,672,925 (GRCm38) K301* probably null Het
Olfr250 G A 9: 38,368,196 (GRCm38) V217I probably benign Het
Olfr366 A C 2: 37,219,659 (GRCm38) T57P possibly damaging Het
Olfr644 A T 7: 104,068,459 (GRCm38) C191S probably damaging Het
Olfr652 T A 7: 104,565,071 (GRCm38) N283K probably damaging Het
Otogl A C 10: 107,878,152 (GRCm38) probably null Het
Pde4b C T 4: 102,605,176 (GRCm38) T511I probably damaging Het
Proser3 A G 7: 30,539,747 (GRCm38) probably null Het
Psmd12 G A 11: 107,479,646 (GRCm38) V24M probably damaging Het
Rbm17 A T 2: 11,593,461 (GRCm38) M170K probably benign Het
Rims2 C T 15: 39,511,314 (GRCm38) T1064I possibly damaging Het
Ripor3 C T 2: 167,992,653 (GRCm38) V281M probably damaging Het
Rreb1 C A 13: 37,946,928 (GRCm38) Q1353K possibly damaging Het
Sgo2a A G 1: 58,015,806 (GRCm38) D383G probably benign Het
Sik3 C T 9: 46,221,148 (GRCm38) T1346M probably damaging Het
Slx1b A T 7: 126,692,796 (GRCm38) V63E probably damaging Het
Son A G 16: 91,657,086 (GRCm38) D907G probably damaging Het
Src G A 2: 157,469,212 (GRCm38) V401M probably damaging Het
St3gal4 T C 9: 35,054,757 (GRCm38) K24E possibly damaging Het
Stat6 A G 10: 127,658,245 (GRCm38) K647R probably damaging Het
Tbl1xr1 G A 3: 22,193,169 (GRCm38) probably null Het
Tlk2 G A 11: 105,256,952 (GRCm38) probably null Het
Tmbim6 T A 15: 99,401,615 (GRCm38) I3K probably benign Het
Tmeff2 A T 1: 51,181,867 (GRCm38) I334F probably damaging Het
Ttn T C 2: 76,840,315 (GRCm38) probably null Het
Ubl7 T A 9: 57,914,611 (GRCm38) I81N probably damaging Het
Ugt1a10 A G 1: 88,055,711 (GRCm38) Y77C probably damaging Het
Uqcrfs1 A G 13: 30,540,907 (GRCm38) C217R probably damaging Het
Usp50 T C 2: 126,761,634 (GRCm38) T331A probably benign Het
Vmn1r65 A G 7: 6,009,157 (GRCm38) V26A probably benign Het
Wdfy3 A C 5: 101,917,579 (GRCm38) V1241G possibly damaging Het
Wtap A C 17: 12,981,744 (GRCm38) probably null Het
Zbtb40 C A 4: 136,984,837 (GRCm38) A1187S possibly damaging Het
Zfp57 T C 17: 37,006,098 (GRCm38) S20P probably damaging Het
Zfp592 A G 7: 81,024,479 (GRCm38) D397G probably damaging Het
Zfp747 A T 7: 127,374,504 (GRCm38) S165T probably benign Het
Zfp949 C T 9: 88,569,838 (GRCm38) T487I probably damaging Het
Zscan4d A G 7: 11,164,994 (GRCm38) C119R probably damaging Het
Other mutations in Olfr1045
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01350:Olfr1045 APN 2 86,197,805 (GRCm38) makesense probably null
IGL01914:Olfr1045 APN 2 86,198,672 (GRCm38) missense probably benign 0.45
IGL01991:Olfr1045 APN 2 86,198,533 (GRCm38) missense probably benign 0.23
IGL02623:Olfr1045 APN 2 86,198,019 (GRCm38) missense probably damaging 1.00
R0325:Olfr1045 UTSW 2 86,198,711 (GRCm38) missense possibly damaging 0.51
R0730:Olfr1045 UTSW 2 86,198,725 (GRCm38) missense probably benign 0.14
R2037:Olfr1045 UTSW 2 86,197,832 (GRCm38) missense probably benign
R2121:Olfr1045 UTSW 2 86,197,996 (GRCm38) missense possibly damaging 0.88
R2271:Olfr1045 UTSW 2 86,197,817 (GRCm38) missense probably benign 0.00
R3836:Olfr1045 UTSW 2 86,198,662 (GRCm38) missense probably benign 0.02
R4669:Olfr1045 UTSW 2 86,197,933 (GRCm38) missense possibly damaging 0.90
R6082:Olfr1045 UTSW 2 86,198,317 (GRCm38) missense probably damaging 0.97
R7326:Olfr1045 UTSW 2 86,198,573 (GRCm38) missense probably damaging 1.00
R7463:Olfr1045 UTSW 2 86,197,838 (GRCm38) missense probably benign
R7523:Olfr1045 UTSW 2 86,198,045 (GRCm38) missense probably damaging 0.99
R7842:Olfr1045 UTSW 2 86,198,172 (GRCm38) nonsense probably null
R7919:Olfr1045 UTSW 2 86,198,265 (GRCm38) nonsense probably null
R9763:Olfr1045 UTSW 2 86,197,837 (GRCm38) missense probably benign 0.10
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2014-03-14