Incidental Mutation 'R1444:Il10rb'
ID 158737
Institutional Source Beutler Lab
Gene Symbol Il10rb
Ensembl Gene ENSMUSG00000022969
Gene Name interleukin 10 receptor, beta
Synonyms 6620401D04Rik, D21S58h, Il10r2, CRF2-4, D16H21S58, Crfb4
MMRRC Submission 039499-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1444 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 91203166-91222718 bp(+) (GRCm39)
Type of Mutation splice site (2336 bp from exon)
DNA Base Change (assembly) T to G at 91218675 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000023691] [ENSMUST00000156133]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000023691
AA Change: V236G

PolyPhen 2 Score 0.752 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000023691
Gene: ENSMUSG00000022969
AA Change: V236G

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
FN3 23 100 4.6e-2 SMART
FN3 114 204 7.1e-3 SMART
transmembrane domain 228 250 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000144215
SMART Domains Protein: ENSMUSP00000120485
Gene: ENSMUSG00000022969

DomainStartEndE-ValueType
Pfam:Tissue_fac 7 65 1.7e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152729
Predicted Effect probably benign
Transcript: ENSMUST00000156133
SMART Domains Protein: ENSMUSP00000120227
Gene: ENSMUSG00000022969

DomainStartEndE-ValueType
low complexity region 39 48 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000160764
SMART Domains Protein: ENSMUSP00000123997
Gene: ENSMUSG00000093701

DomainStartEndE-ValueType
FN3 2 92 5.1e1 SMART
FN3 110 187 9.09e0 SMART
FN3 201 291 1.39e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161517
SMART Domains Protein: ENSMUSP00000125579
Gene: ENSMUSG00000093701

DomainStartEndE-ValueType
Pfam:Interfer-bind 1 100 7.5e-20 PFAM
Meta Mutation Damage Score 0.2802 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.4%
  • 20x: 86.1%
Validation Efficiency 98% (59/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
PHENOTYPE: Most mice homozygous for a knock-out allele develop moderate to severe colitis without small intestinal involvement and splenomegaly with a hyperproliferative splenic red pulp. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik A T 8: 73,205,230 (GRCm39) D347V probably damaging Het
A630010A05Rik T A 16: 14,427,558 (GRCm39) F82I possibly damaging Het
Acad9 T A 3: 36,132,657 (GRCm39) F297L possibly damaging Het
Adgrl3 A T 5: 81,660,200 (GRCm39) Y323F probably damaging Het
Brca2 T A 5: 150,465,915 (GRCm39) M1893K probably benign Het
Cactin A T 10: 81,158,270 (GRCm39) probably null Het
Cadm4 A G 7: 24,203,046 (GRCm39) *389W probably null Het
Calr4 A G 4: 109,103,438 (GRCm39) T183A possibly damaging Het
Card10 A T 15: 78,672,041 (GRCm39) probably benign Het
Cdh6 C A 15: 13,091,924 (GRCm39) G14C probably benign Het
Cds1 A G 5: 101,946,245 (GRCm39) Y148C probably damaging Het
Chd1l C T 3: 97,490,047 (GRCm39) E503K probably benign Het
Cr1l A T 1: 194,813,510 (GRCm39) L35Q probably damaging Het
Daam2 T C 17: 49,787,779 (GRCm39) R445G possibly damaging Het
Ddn G A 15: 98,704,485 (GRCm39) T269M probably damaging Het
Epb41 G A 4: 131,733,382 (GRCm39) S176L probably benign Het
Ephx2 T C 14: 66,344,769 (GRCm39) D167G probably damaging Het
Erbb4 G A 1: 68,293,759 (GRCm39) R711C probably damaging Het
Flg2 T A 3: 93,109,620 (GRCm39) H549Q unknown Het
Gje1 A G 10: 14,592,380 (GRCm39) probably null Het
Heatr5b G A 17: 79,060,622 (GRCm39) H2018Y probably benign Het
Heatr5b A T 17: 79,062,856 (GRCm39) probably benign Het
Hectd3 G T 4: 116,853,593 (GRCm39) R189L probably benign Het
Hsd3b6 T C 3: 98,715,237 (GRCm39) T52A probably benign Het
Kcnc2 T C 10: 112,291,506 (GRCm39) probably benign Het
Lpl T A 8: 69,345,399 (GRCm39) D134E probably damaging Het
Lrit1 T C 14: 36,783,928 (GRCm39) F419L probably benign Het
Mmp8 T C 9: 7,567,264 (GRCm39) C422R probably benign Het
Myo18b A G 5: 112,923,117 (GRCm39) probably null Het
Ncor1 T A 11: 62,294,632 (GRCm39) I280F probably damaging Het
Obox2 A C 7: 15,130,957 (GRCm39) Q63P possibly damaging Het
Or2ad1 C T 13: 21,326,337 (GRCm39) V297I probably benign Het
Or4d2b T A 11: 87,780,585 (GRCm39) I46L probably benign Het
Phldb2 T A 16: 45,577,616 (GRCm39) probably benign Het
Pkd1l1 A G 11: 8,804,386 (GRCm39) F1735S probably damaging Het
Pramel11 G T 4: 143,623,461 (GRCm39) L238I probably benign Het
Prss30 T C 17: 24,192,712 (GRCm39) Y156C probably damaging Het
Rnf213 T C 11: 119,333,226 (GRCm39) S2812P probably damaging Het
Rttn A G 18: 89,060,991 (GRCm39) D1053G probably benign Het
Slc6a2 A G 8: 93,697,882 (GRCm39) N120S probably damaging Het
Snrnp200 T C 2: 127,070,158 (GRCm39) probably benign Het
Spindoc G T 19: 7,360,086 (GRCm39) D27E probably benign Het
Svep1 T C 4: 58,115,754 (GRCm39) T980A possibly damaging Het
Tgfbr1 A G 4: 47,393,259 (GRCm39) E46G probably benign Het
Tmem183a T C 1: 134,289,284 (GRCm39) I49V probably benign Het
Tmem212 C T 3: 27,939,244 (GRCm39) V81I possibly damaging Het
Toporsl T A 4: 52,610,254 (GRCm39) I49N probably benign Het
Trim67 A G 8: 125,549,932 (GRCm39) T521A probably benign Het
Vsnl1 T C 12: 11,382,219 (GRCm39) probably null Het
Wdr87-ps T C 7: 29,229,380 (GRCm39) noncoding transcript Het
Xrn2 C T 2: 146,903,408 (GRCm39) R803W probably damaging Het
Zfp131 A T 13: 120,251,784 (GRCm39) C9S probably damaging Het
Zfp750 C T 11: 121,402,873 (GRCm39) S625N probably damaging Het
Zfp871 G T 17: 32,993,900 (GRCm39) T406N possibly damaging Het
Other mutations in Il10rb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00337:Il10rb APN 16 91,203,227 (GRCm39) missense probably benign 0.11
R0393:Il10rb UTSW 16 91,208,898 (GRCm39) missense probably benign 0.13
R1013:Il10rb UTSW 16 91,211,581 (GRCm39) missense probably benign 0.00
R2449:Il10rb UTSW 16 91,208,791 (GRCm39) missense probably benign
R4425:Il10rb UTSW 16 91,204,603 (GRCm39) missense possibly damaging 0.93
R4779:Il10rb UTSW 16 91,211,545 (GRCm39) missense possibly damaging 0.54
R6051:Il10rb UTSW 16 91,218,752 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- AGGCTTCTGGCTGCTCTACAAAC -3'
(R):5'- TGGAACAAACCTTTGCTGCTTTGG -3'

Sequencing Primer
(F):5'- AGCAAACCGGATCTTGCTTATC -3'
(R):5'- ATGCTCTTGGAGATCATGTTGC -3'
Posted On 2014-03-14