Mutagenetix > Incidental Mutations

Incidental Mutation 'R1446:Zfp808'

158900

Institutional Source

Beutler Lab

Gene Symbol

Zfp808

Ensembl Gene

ENSMUSG00000074867

Gene Name

zinc finger protein 808

Synonyms

Gm7036

MMRRC Submission

039501-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R1446 (G1)

Quality Score

199

Status

Not validated

Chromosome

Chromosomal Location

62129886-62236144 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 62173007 bp

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 683 (H683Q)

Ref Sequence

ENSEMBL: ENSMUSP00000097048 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099449] [ENSMUST00000221772]

Predicted Effect

probably damaging
Transcript: ENSMUST00000099449
AA Change: H683Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000097048
Gene: ENSMUSG00000074867
AA Change: H683Q

Domain	Start	End	E-Value	Type
KRAB	4	66	2.1e-17	SMART
ZnF_C2H2	133	155	2.4e-3	SMART
ZnF_C2H2	161	183	8.34e-3	SMART
ZnF_C2H2	189	211	2.75e-3	SMART
ZnF_C2H2	217	239	1.98e-4	SMART
ZnF_C2H2	245	267	3.21e-4	SMART
ZnF_C2H2	273	295	2.43e-4	SMART
ZnF_C2H2	301	323	8.6e-5	SMART
ZnF_C2H2	329	351	4.54e-4	SMART
ZnF_C2H2	357	379	9.22e-5	SMART
ZnF_C2H2	385	407	8.22e-2	SMART
ZnF_C2H2	413	435	1.56e-2	SMART
ZnF_C2H2	441	463	5.99e-4	SMART
ZnF_C2H2	469	491	2.79e-4	SMART
ZnF_C2H2	497	519	4.54e-4	SMART
ZnF_C2H2	525	547	1.95e-3	SMART
ZnF_C2H2	553	575	4.24e-4	SMART
ZnF_C2H2	581	603	2.27e-4	SMART
ZnF_C2H2	609	631	2.27e-4	SMART
ZnF_C2H2	637	659	9.08e-4	SMART
ZnF_C2H2	665	687	1.4e-4	SMART
ZnF_C2H2	693	715	4.24e-4	SMART
ZnF_C2H2	721	743	1.26e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221542

Predicted Effect

probably benign
Transcript: ENSMUST00000221772

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222809

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222947

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223094

Coding Region Coverage

1x: 99.0%
3x: 98.0%
10x: 95.3%
20x: 89.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aasdh	C	T	5: 76,886,289	A472T	probably benign	Het
Adcy4	A	T	14: 55,770,023		probably null	Het
Ahcyl2	T	C	6: 29,891,240	S448P	probably damaging	Het
Anks1b	A	G	10: 90,511,073	Y745C	probably benign	Het
Anxa1	A	T	19: 20,373,739	L339Q	probably damaging	Het
Apoa4	A	G	9: 46,242,293	D64G	probably benign	Het
Arpc1a	A	G	5: 145,101,086		probably null	Het
Bank1	C	T	3: 136,064,143	G727R	probably damaging	Het
Best2	T	C	8: 85,007,964	Q375R	probably benign	Het
Cacna1b	T	A	2: 24,706,177	M501L	probably benign	Het
Col27a1	T	A	4: 63,224,803	Y243N	probably damaging	Het
Cyp11a1	A	T	9: 58,015,277	Q80L	possibly damaging	Het
Dnah10	T	A	5: 124,789,796	W2260R	probably damaging	Het
Dnajc19	T	C	3: 34,057,979	H139R	probably benign	Het
Dppa5a	T	A	9: 78,367,789	N77I	probably benign	Het
Edc4	T	C	8: 105,888,132	S125P	probably damaging	Het
Eid2	T	C	7: 28,268,589	I212T	possibly damaging	Het
Fam234b	T	A	6: 135,209,330		probably null	Het
Frem2	T	C	3: 53,654,596	E830G	probably benign	Het
Fyb	A	T	15: 6,652,466	I765L	probably benign	Het
Fyn	T	G	10: 39,522,779	S124A	probably benign	Het
Gal3st3	T	A	19: 5,306,911	F105I	probably damaging	Het
Gm13762	A	G	2: 88,973,765	I42T	probably benign	Het
Gpr146	A	G	5: 139,393,422	I326M	probably benign	Het
Grk2	G	A	19: 4,287,409	R617C	possibly damaging	Het
Gsn	A	G	2: 35,306,586	K669R	probably benign	Het
H2-T10	A	T	17: 36,119,374	I225N	possibly damaging	Het
Il12rb2	T	C	6: 67,309,143	H106R	probably benign	Het
Kat14	A	G	2: 144,373,718	E41G	probably damaging	Het
Kcnma1	G	T	14: 23,311,724	T1006K	probably damaging	Het
Kif18b	G	A	11: 102,914,699	T244I	probably damaging	Het
Klb	A	T	5: 65,348,995	H195L	probably damaging	Het
Lrriq4	T	C	3: 30,650,578	F252L	probably benign	Het
Lum	C	T	10: 97,568,390	T49I	possibly damaging	Het
Map3k4	T	A	17: 12,256,794	L84*	probably null	Het
Mindy2	A	G	9: 70,607,456		probably null	Het
Mpped2	G	T	2: 106,783,732	R137L	possibly damaging	Het
Myo18b	G	A	5: 112,757,559	R2058W	probably damaging	Het
Nol8	T	A	13: 49,655,227	L65Q	probably damaging	Het
Olfr1009	A	G	2: 85,721,573	H56R	probably damaging	Het
Olfr1269	A	T	2: 90,118,858	L247M	probably damaging	Het
Olfr1458	G	A	19: 13,103,016	A96V	possibly damaging	Het
Olfr147	T	G	9: 38,403,305	C144G	possibly damaging	Het
Olfr460	C	T	6: 40,571,899	S171L	probably benign	Het
Olfr743	T	C	14: 50,533,702	S97P	possibly damaging	Het
Parp12	G	T	6: 39,102,561	D338E	probably benign	Het
Pde6d	T	C	1: 86,546,692	E77G	probably damaging	Het
Phkg1	A	C	5: 129,873,214		probably null	Het
Pigw	A	C	11: 84,878,360	S48A	probably benign	Het
Pkm	T	A	9: 59,668,910		probably null	Het
Ppp1r3f	G	A	X: 7,560,363	T553M	probably damaging	Het
Retreg2	T	A	1: 75,143,459	F44L	possibly damaging	Het
Ryr2	A	T	13: 11,738,149	M1762K	probably benign	Het
Sec16a	A	G	2: 26,423,567	V1927A	probably benign	Het
Sec23a	G	T	12: 58,978,559	A492E	probably damaging	Het
Skint4	T	A	4: 112,118,114	H82Q	probably benign	Het
Srbd1	T	C	17: 86,139,152	K60E	probably benign	Het
Stk24	A	G	14: 121,308,044	Y101H	probably damaging	Het
Sult1e1	A	T	5: 87,578,537	N239K	probably damaging	Het
Tgs1	C	T	4: 3,604,848	P757S	probably damaging	Het
Tmc2	A	T	2: 130,248,730	E665D	probably damaging	Het
Tmprss15	C	A	16: 79,078,958	D163Y	probably benign	Het
Unc13a	C	A	8: 71,648,981	V1009L	possibly damaging	Het
Unc45b	G	T	11: 82,928,670	G490C	probably damaging	Het
Vmn1r177	T	A	7: 23,866,340	H37L	probably damaging	Het
Vwa5a	A	G	9: 38,733,968	M450V	possibly damaging	Het
Wars2	T	C	3: 99,187,527	I46T	probably benign	Het
Wdfy3	G	T	5: 101,851,310	T3098K	possibly damaging	Het
Zan	A	T	5: 137,389,360	I4863N	unknown	Het
Zfp616	A	G	11: 74,083,238		probably null	Het
Zfp770	A	T	2: 114,197,033	I185N	probably damaging	Het
Zmym4	A	T	4: 126,882,482	W1221R	probably damaging	Het

Other mutations in Zfp808

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01609:Zfp808	APN	13	62173209	missense	probably damaging	0.96
IGL02517:Zfp808	APN	13	62173218	makesense	probably null
IGL02809:Zfp808	APN	13	62173180	missense	probably benign	0.00
IGL02882:Zfp808	APN	13	62173180	missense	probably benign	0.00
IGL02941:Zfp808	APN	13	62173130	missense	possibly damaging	0.82
IGL03184:Zfp808	APN	13	62169567	missense	possibly damaging	0.90
LCD18:Zfp808	UTSW	13	62166651	intron	probably benign
R0387:Zfp808	UTSW	13	62169478	missense	probably damaging	1.00
R0472:Zfp808	UTSW	13	62172306	missense	probably damaging	1.00
R0544:Zfp808	UTSW	13	62169434	splice site	probably benign
R0635:Zfp808	UTSW	13	62172419	missense	probably damaging	1.00
R0981:Zfp808	UTSW	13	62171673	missense	possibly damaging	0.47
R1569:Zfp808	UTSW	13	62172900	nonsense	probably null
R1573:Zfp808	UTSW	13	62171497	missense	possibly damaging	0.52
R1761:Zfp808	UTSW	13	62171646	missense	possibly damaging	0.71
R1796:Zfp808	UTSW	13	62171856	missense	probably damaging	1.00
R1993:Zfp808	UTSW	13	62172907	missense	probably benign	0.10
R2656:Zfp808	UTSW	13	62172852	missense	possibly damaging	0.63
R2938:Zfp808	UTSW	13	62171218	missense	probably benign
R3027:Zfp808	UTSW	13	62171590	missense	probably benign	0.33
R3777:Zfp808	UTSW	13	62171903	missense	probably damaging	0.97
R3779:Zfp808	UTSW	13	62171903	missense	probably damaging	0.97
R3801:Zfp808	UTSW	13	62172083	missense	probably damaging	1.00
R3802:Zfp808	UTSW	13	62172083	missense	probably damaging	1.00
R3804:Zfp808	UTSW	13	62172083	missense	probably damaging	1.00
R4024:Zfp808	UTSW	13	62171730	missense	possibly damaging	0.71
R4741:Zfp808	UTSW	13	62171949	missense	probably damaging	1.00
R4791:Zfp808	UTSW	13	62171231	missense	probably damaging	0.97
R4809:Zfp808	UTSW	13	62171292	nonsense	probably null
R4907:Zfp808	UTSW	13	62171473	missense	possibly damaging	0.71
R5056:Zfp808	UTSW	13	62172630	missense	probably damaging	1.00
R5760:Zfp808	UTSW	13	62171926	missense	probably damaging	1.00
R5869:Zfp808	UTSW	13	62171255	missense	probably damaging	1.00
R6230:Zfp808	UTSW	13	62172322	missense	probably benign	0.19
R6372:Zfp808	UTSW	13	62172477	missense	probably damaging	1.00
R6545:Zfp808	UTSW	13	62171895	missense	probably benign	0.02
R6620:Zfp808	UTSW	13	62172824	missense	probably benign	0.08
R6622:Zfp808	UTSW	13	62171832	missense	possibly damaging	0.90
R6813:Zfp808	UTSW	13	62173035	missense	probably damaging	0.99
R6920:Zfp808	UTSW	13	62173168	missense	probably benign	0.05
R7511:Zfp808	UTSW	13	62172823	missense	probably benign
R7666:Zfp808	UTSW	13	62171411	missense	probably benign
R7747:Zfp808	UTSW	13	62171505	missense	probably benign	0.39
R7763:Zfp808	UTSW	13	62172664	missense	probably benign	0.28
R7779:Zfp808	UTSW	13	62172757	missense	possibly damaging	0.68
R8147:Zfp808	UTSW	13	62173120	missense	probably damaging	1.00
R8182:Zfp808	UTSW	13	62171707	missense	probably damaging	0.96
R8260:Zfp808	UTSW	13	62172738	missense	probably benign	0.01
R8434:Zfp808	UTSW	13	62172112	missense	probably damaging	1.00
R8822:Zfp808	UTSW	13	62173055	missense	probably damaging	1.00
RF005:Zfp808	UTSW	13	62171299	missense	probably benign	0.14
RF024:Zfp808	UTSW	13	62171299	missense	probably benign	0.14

Predicted Primers

Posted On

2014-03-14