Incidental Mutation 'R1462:Ifi207'
ID 158922
Institutional Source Beutler Lab
Gene Symbol Ifi207
Ensembl Gene ENSMUSG00000073490
Gene Name interferon activated gene 207
Synonyms AI607873, Pyhin-A
MMRRC Submission 039516-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R1462 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 173550993-173569313 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 173552513 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 968 (H968R)
Ref Sequence ENSEMBL: ENSMUSP00000048129 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042610] [ENSMUST00000127730]
AlphaFold E9Q3L4
Predicted Effect probably damaging
Transcript: ENSMUST00000042610
AA Change: H968R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000048129
Gene: ENSMUSG00000073490
AA Change: H968R

DomainStartEndE-ValueType
PYRIN 6 84 3.2e-15 SMART
low complexity region 121 133 N/A INTRINSIC
low complexity region 136 162 N/A INTRINSIC
low complexity region 207 215 N/A INTRINSIC
internal_repeat_1 286 472 4.17e-7 PROSPERO
low complexity region 476 496 N/A INTRINSIC
internal_repeat_1 565 782 4.17e-7 PROSPERO
Pfam:HIN 788 954 4.9e-76 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000127730
AA Change: H961R

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000119350
Gene: ENSMUSG00000073490
AA Change: H961R

DomainStartEndE-ValueType
PYRIN 6 84 3.2e-15 SMART
low complexity region 121 133 N/A INTRINSIC
low complexity region 136 155 N/A INTRINSIC
low complexity region 200 208 N/A INTRINSIC
internal_repeat_1 279 465 6.41e-7 PROSPERO
low complexity region 469 489 N/A INTRINSIC
internal_repeat_1 558 775 6.41e-7 PROSPERO
Pfam:HIN 781 948 1.8e-78 PFAM
Meta Mutation Damage Score 0.3799 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.4%
  • 10x: 92.6%
  • 20x: 79.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik C A 7: 40,642,370 (GRCm39) S104* probably null Het
Abca9 T C 11: 110,051,342 (GRCm39) D118G probably benign Het
Adamts16 A G 13: 70,984,253 (GRCm39) F137L probably benign Het
Adamts3 T C 5: 90,009,208 (GRCm39) I152V probably benign Het
Adcy4 T A 14: 56,015,765 (GRCm39) E441D possibly damaging Het
Adgra1 T A 7: 139,455,745 (GRCm39) Y458N probably damaging Het
Bhlhe22 C G 3: 18,109,946 (GRCm39) S332C probably damaging Het
Card19 T A 13: 49,358,760 (GRCm39) Q71L probably benign Het
Ccdc12 T C 9: 110,485,662 (GRCm39) L11P probably damaging Het
Cdadc1 A G 14: 59,813,307 (GRCm39) Y367H probably damaging Het
Cdc5l G T 17: 45,719,288 (GRCm39) Q542K possibly damaging Het
Cep170 T C 1: 176,584,211 (GRCm39) K723E possibly damaging Het
Cep70 A G 9: 99,145,773 (GRCm39) I147V probably benign Het
Cfap58 A T 19: 47,950,869 (GRCm39) H410L probably damaging Het
Chat T C 14: 32,142,735 (GRCm39) K418R probably damaging Het
Cic T G 7: 24,971,032 (GRCm39) D254E probably damaging Het
Ckap4 T C 10: 84,363,431 (GRCm39) E544G probably damaging Het
Crnkl1 C T 2: 145,763,739 (GRCm39) A500T probably damaging Het
Cyp2c38 T C 19: 39,380,632 (GRCm39) N418D probably damaging Het
Daam1 A T 12: 71,990,916 (GRCm39) I177L unknown Het
Ercc5 A G 1: 44,219,784 (GRCm39) T1019A probably damaging Het
F13b T A 1: 139,435,374 (GRCm39) V173E probably damaging Het
Fam20a A C 11: 109,568,143 (GRCm39) F316V probably damaging Het
Flrt2 T C 12: 95,746,112 (GRCm39) V150A probably damaging Het
Fnta A C 8: 26,489,599 (GRCm39) probably null Het
Ghsr A G 3: 27,426,025 (GRCm39) D27G probably benign Het
Gtpbp1 A G 15: 79,592,086 (GRCm39) N96D probably damaging Het
H1f7 A T 15: 98,154,454 (GRCm39) W232R unknown Het
Ibtk A T 9: 85,606,198 (GRCm39) I443N probably damaging Het
Ifit2 A G 19: 34,550,586 (GRCm39) D42G probably null Het
Il17rc A T 6: 113,455,950 (GRCm39) D265V probably damaging Het
Itfg2 T C 6: 128,401,691 (GRCm39) D29G probably damaging Het
Itprid1 A G 6: 55,952,649 (GRCm39) H864R probably damaging Het
Lrrc1 A G 9: 77,349,547 (GRCm39) F295L probably benign Het
Mrps28 T A 3: 8,965,184 (GRCm39) H85L possibly damaging Het
Mtpn T A 6: 35,499,693 (GRCm39) K37M possibly damaging Het
Mug1 C T 6: 121,859,588 (GRCm39) H1196Y probably benign Het
Mup4 T C 4: 59,960,084 (GRCm39) H60R possibly damaging Het
Mybl2 T C 2: 162,914,628 (GRCm39) S249P probably benign Het
Naip6 A G 13: 100,436,748 (GRCm39) Y592H possibly damaging Het
Nrp1 A G 8: 129,229,279 (GRCm39) N919S probably benign Het
Nudt9 C T 5: 104,212,904 (GRCm39) Q326* probably null Het
Or5w13 A T 2: 87,523,720 (GRCm39) C169S probably damaging Het
Or6c76b A G 10: 129,693,100 (GRCm39) T238A probably damaging Het
Or7g17 T A 9: 18,768,407 (GRCm39) M162K probably benign Het
Or9k7 T A 10: 130,046,592 (GRCm39) I136F probably benign Het
Pcsk4 T C 10: 80,161,815 (GRCm39) E142G probably damaging Het
Pde3a C A 6: 141,405,560 (GRCm39) P471T probably benign Het
Pign A T 1: 105,512,727 (GRCm39) V652E possibly damaging Het
Prkcb T A 7: 122,181,672 (GRCm39) M420K probably damaging Het
Prr14 T A 7: 127,073,160 (GRCm39) probably null Het
Rchy1 T A 5: 92,105,741 (GRCm39) Q69L probably damaging Het
Sec23ip T G 7: 128,367,862 (GRCm39) S625A probably benign Het
Smpdl3b A G 4: 132,473,925 (GRCm39) S47P probably damaging Het
Speer4a3 T A 5: 26,156,623 (GRCm39) I119F possibly damaging Het
Stil G A 4: 114,881,161 (GRCm39) M568I probably benign Het
Syt3 T A 7: 44,045,434 (GRCm39) V558E probably damaging Het
Szt2 A G 4: 118,231,164 (GRCm39) V2533A unknown Het
Tenm4 A G 7: 96,353,360 (GRCm39) Y384C probably damaging Het
Tfam T C 10: 71,071,380 (GRCm39) E94G probably damaging Het
Tmbim7 A G 5: 3,714,304 (GRCm39) T14A probably damaging Het
Tmtc2 A T 10: 105,409,566 (GRCm39) Y15* probably null Het
Uhrf1 C T 17: 56,625,035 (GRCm39) A526V probably damaging Het
Vmn2r67 T C 7: 84,805,046 (GRCm39) D22G probably benign Het
Vmn2r96 A G 17: 18,817,660 (GRCm39) I412M possibly damaging Het
Wdr17 A T 8: 55,123,363 (GRCm39) I479K probably damaging Het
Wt1 T C 2: 104,997,176 (GRCm39) V371A probably damaging Het
Zfp536 G T 7: 37,178,735 (GRCm39) S226Y probably damaging Het
Zfp827 T C 8: 79,803,108 (GRCm39) V560A probably benign Het
Other mutations in Ifi207
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01776:Ifi207 APN 1 173,552,610 (GRCm39) missense probably damaging 1.00
IGL01864:Ifi207 APN 1 173,564,007 (GRCm39) missense possibly damaging 0.72
IGL02293:Ifi207 APN 1 173,551,314 (GRCm39) missense probably damaging 1.00
IGL02402:Ifi207 APN 1 173,555,159 (GRCm39) missense probably damaging 1.00
IGL03160:Ifi207 APN 1 173,562,670 (GRCm39) splice site probably benign
PIT4458001:Ifi207 UTSW 1 173,562,738 (GRCm39) missense unknown
R0043:Ifi207 UTSW 1 173,556,678 (GRCm39) missense possibly damaging 0.48
R0212:Ifi207 UTSW 1 173,563,964 (GRCm39) missense possibly damaging 0.85
R0395:Ifi207 UTSW 1 173,557,431 (GRCm39) missense possibly damaging 0.85
R0506:Ifi207 UTSW 1 173,563,878 (GRCm39) missense possibly damaging 0.52
R0843:Ifi207 UTSW 1 173,555,143 (GRCm39) missense probably damaging 1.00
R1302:Ifi207 UTSW 1 173,562,861 (GRCm39) missense possibly damaging 0.96
R1373:Ifi207 UTSW 1 173,557,913 (GRCm39) missense unknown
R1462:Ifi207 UTSW 1 173,552,513 (GRCm39) missense probably damaging 1.00
R1471:Ifi207 UTSW 1 173,557,629 (GRCm39) missense unknown
R1502:Ifi207 UTSW 1 173,556,872 (GRCm39) missense possibly damaging 0.56
R1533:Ifi207 UTSW 1 173,555,306 (GRCm39) missense probably benign 0.30
R1831:Ifi207 UTSW 1 173,559,992 (GRCm39) missense unknown
R1928:Ifi207 UTSW 1 173,557,211 (GRCm39) missense possibly damaging 0.68
R1982:Ifi207 UTSW 1 173,562,805 (GRCm39) missense probably benign 0.01
R2132:Ifi207 UTSW 1 173,557,337 (GRCm39) missense possibly damaging 0.84
R2248:Ifi207 UTSW 1 173,564,036 (GRCm39) splice site probably benign
R3703:Ifi207 UTSW 1 173,555,029 (GRCm39) nonsense probably null
R3741:Ifi207 UTSW 1 173,555,128 (GRCm39) missense probably damaging 1.00
R3846:Ifi207 UTSW 1 173,562,869 (GRCm39) missense probably benign 0.33
R4747:Ifi207 UTSW 1 173,556,633 (GRCm39) missense probably benign 0.00
R4772:Ifi207 UTSW 1 173,555,253 (GRCm39) missense probably damaging 1.00
R4776:Ifi207 UTSW 1 173,557,622 (GRCm39) missense unknown
R4855:Ifi207 UTSW 1 173,557,381 (GRCm39) missense probably damaging 0.96
R5170:Ifi207 UTSW 1 173,558,064 (GRCm39) missense unknown
R5244:Ifi207 UTSW 1 173,557,503 (GRCm39) missense probably benign 0.04
R5280:Ifi207 UTSW 1 173,557,870 (GRCm39) missense unknown
R5301:Ifi207 UTSW 1 173,556,977 (GRCm39) missense possibly damaging 0.83
R5334:Ifi207 UTSW 1 173,555,097 (GRCm39) missense probably benign 0.21
R5445:Ifi207 UTSW 1 173,555,363 (GRCm39) missense probably damaging 0.99
R5691:Ifi207 UTSW 1 173,559,992 (GRCm39) missense unknown
R5838:Ifi207 UTSW 1 173,559,953 (GRCm39) missense unknown
R6060:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
R6220:Ifi207 UTSW 1 173,557,112 (GRCm39) missense probably damaging 0.99
R6264:Ifi207 UTSW 1 173,555,111 (GRCm39) missense probably damaging 1.00
R6307:Ifi207 UTSW 1 173,552,619 (GRCm39) missense probably damaging 1.00
R6326:Ifi207 UTSW 1 173,557,532 (GRCm39) missense probably benign 0.01
R6394:Ifi207 UTSW 1 173,556,581 (GRCm39) missense probably benign 0.43
R6532:Ifi207 UTSW 1 173,557,211 (GRCm39) missense possibly damaging 0.68
R6660:Ifi207 UTSW 1 173,556,972 (GRCm39) missense probably benign 0.01
R6893:Ifi207 UTSW 1 173,555,208 (GRCm39) missense possibly damaging 0.95
R7190:Ifi207 UTSW 1 173,557,818 (GRCm39) missense unknown
R7192:Ifi207 UTSW 1 173,556,584 (GRCm39) missense not run
R7194:Ifi207 UTSW 1 173,557,490 (GRCm39) missense possibly damaging 0.84
R7327:Ifi207 UTSW 1 173,556,581 (GRCm39) missense probably benign 0.43
R7348:Ifi207 UTSW 1 173,556,762 (GRCm39) small deletion probably benign
R7404:Ifi207 UTSW 1 173,556,494 (GRCm39) missense possibly damaging 0.92
R7442:Ifi207 UTSW 1 173,554,997 (GRCm39) missense probably benign 0.03
R7784:Ifi207 UTSW 1 173,557,698 (GRCm39) missense unknown
R8041:Ifi207 UTSW 1 173,555,268 (GRCm39) missense possibly damaging 0.78
R8116:Ifi207 UTSW 1 173,557,746 (GRCm39) missense unknown
R8166:Ifi207 UTSW 1 173,557,504 (GRCm39) missense probably benign 0.10
R8166:Ifi207 UTSW 1 173,557,166 (GRCm39) missense possibly damaging 0.95
R8168:Ifi207 UTSW 1 173,557,504 (GRCm39) missense probably benign 0.10
R8383:Ifi207 UTSW 1 173,556,770 (GRCm39) small deletion probably benign
R8388:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8389:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8390:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R8399:Ifi207 UTSW 1 173,557,844 (GRCm39) missense unknown
R8431:Ifi207 UTSW 1 173,558,070 (GRCm39) missense unknown
R8474:Ifi207 UTSW 1 173,556,605 (GRCm39) missense possibly damaging 0.63
R8505:Ifi207 UTSW 1 173,557,016 (GRCm39) frame shift probably null
R9009:Ifi207 UTSW 1 173,555,382 (GRCm39) missense probably damaging 0.97
R9061:Ifi207 UTSW 1 173,564,153 (GRCm39) intron probably benign
R9071:Ifi207 UTSW 1 173,557,764 (GRCm39) missense unknown
R9090:Ifi207 UTSW 1 173,556,762 (GRCm39) small deletion probably benign
R9323:Ifi207 UTSW 1 173,555,143 (GRCm39) missense probably damaging 1.00
R9407:Ifi207 UTSW 1 173,555,234 (GRCm39) missense probably damaging 1.00
R9493:Ifi207 UTSW 1 173,556,522 (GRCm39) missense probably benign 0.00
R9629:Ifi207 UTSW 1 173,556,561 (GRCm39) small deletion probably benign
RF009:Ifi207 UTSW 1 173,556,558 (GRCm39) missense probably benign 0.00
RF011:Ifi207 UTSW 1 173,556,687 (GRCm39) missense not run
RF032:Ifi207 UTSW 1 173,562,723 (GRCm39) small deletion probably benign
X0003:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0004:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0005:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0009:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0010:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0011:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0012:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0013:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0014:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0017:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0018:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0019:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0020:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0021:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0022:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0023:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0024:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0025:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0026:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0027:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0028:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0033:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0034:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0035:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0036:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0037:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0038:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0039:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0040:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0050:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0052:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0053:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0054:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0057:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0058:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0060:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0061:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0062:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0063:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0064:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0065:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0066:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
X0067:Ifi207 UTSW 1 173,556,548 (GRCm39) missense probably damaging 0.98
Z1177:Ifi207 UTSW 1 173,557,145 (GRCm39) missense probably damaging 1.00
Z1187:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
Z1192:Ifi207 UTSW 1 173,558,093 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- CTTGCTCAGGACATCCTTGGGAAC -3'
(R):5'- GTTTGACCAAAAGCACCCTTGCC -3'

Sequencing Primer
(F):5'- CTCAGGACATCCTTGGGAACTTATG -3'
(R):5'- CTAAGAACCATAGTTGCCTGGTTG -3'
Posted On 2014-03-14