Incidental Mutation 'R1462:Naip6'
ID 158978
Institutional Source Beutler Lab
Gene Symbol Naip6
Ensembl Gene ENSMUSG00000078942
Gene Name NLR family, apoptosis inhibitory protein 6
Synonyms Naip-rs4, Birc1f, Naip-rs4A
MMRRC Submission 039516-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # R1462 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 100417629-100453124 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 100436748 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 592 (Y592H)
Ref Sequence ENSEMBL: ENSMUSP00000112867 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042220] [ENSMUST00000118574]
AlphaFold Q9JIB6
Predicted Effect possibly damaging
Transcript: ENSMUST00000042220
AA Change: Y592H

PolyPhen 2 Score 0.645 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000041766
Gene: ENSMUSG00000078942
AA Change: Y592H

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 7.6e-37 PFAM
low complexity region 851 862 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000118574
AA Change: Y592H

PolyPhen 2 Score 0.645 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000112867
Gene: ENSMUSG00000078942
AA Change: Y592H

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 2.5e-35 PFAM
low complexity region 851 862 N/A INTRINSIC
Meta Mutation Damage Score 0.4252 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.4%
  • 10x: 92.6%
  • 20x: 79.9%
Validation Efficiency
MGI Phenotype FUNCTION: Closest sequence match is AF381772. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik C A 7: 40,642,370 (GRCm39) S104* probably null Het
Abca9 T C 11: 110,051,342 (GRCm39) D118G probably benign Het
Adamts16 A G 13: 70,984,253 (GRCm39) F137L probably benign Het
Adamts3 T C 5: 90,009,208 (GRCm39) I152V probably benign Het
Adcy4 T A 14: 56,015,765 (GRCm39) E441D possibly damaging Het
Adgra1 T A 7: 139,455,745 (GRCm39) Y458N probably damaging Het
Bhlhe22 C G 3: 18,109,946 (GRCm39) S332C probably damaging Het
Card19 T A 13: 49,358,760 (GRCm39) Q71L probably benign Het
Ccdc12 T C 9: 110,485,662 (GRCm39) L11P probably damaging Het
Cdadc1 A G 14: 59,813,307 (GRCm39) Y367H probably damaging Het
Cdc5l G T 17: 45,719,288 (GRCm39) Q542K possibly damaging Het
Cep170 T C 1: 176,584,211 (GRCm39) K723E possibly damaging Het
Cep70 A G 9: 99,145,773 (GRCm39) I147V probably benign Het
Cfap58 A T 19: 47,950,869 (GRCm39) H410L probably damaging Het
Chat T C 14: 32,142,735 (GRCm39) K418R probably damaging Het
Cic T G 7: 24,971,032 (GRCm39) D254E probably damaging Het
Ckap4 T C 10: 84,363,431 (GRCm39) E544G probably damaging Het
Crnkl1 C T 2: 145,763,739 (GRCm39) A500T probably damaging Het
Cyp2c38 T C 19: 39,380,632 (GRCm39) N418D probably damaging Het
Daam1 A T 12: 71,990,916 (GRCm39) I177L unknown Het
Ercc5 A G 1: 44,219,784 (GRCm39) T1019A probably damaging Het
F13b T A 1: 139,435,374 (GRCm39) V173E probably damaging Het
Fam20a A C 11: 109,568,143 (GRCm39) F316V probably damaging Het
Flrt2 T C 12: 95,746,112 (GRCm39) V150A probably damaging Het
Fnta A C 8: 26,489,599 (GRCm39) probably null Het
Ghsr A G 3: 27,426,025 (GRCm39) D27G probably benign Het
Gtpbp1 A G 15: 79,592,086 (GRCm39) N96D probably damaging Het
H1f7 A T 15: 98,154,454 (GRCm39) W232R unknown Het
Ibtk A T 9: 85,606,198 (GRCm39) I443N probably damaging Het
Ifi207 T C 1: 173,552,513 (GRCm39) H968R probably damaging Het
Ifit2 A G 19: 34,550,586 (GRCm39) D42G probably null Het
Il17rc A T 6: 113,455,950 (GRCm39) D265V probably damaging Het
Itfg2 T C 6: 128,401,691 (GRCm39) D29G probably damaging Het
Itprid1 A G 6: 55,952,649 (GRCm39) H864R probably damaging Het
Lrrc1 A G 9: 77,349,547 (GRCm39) F295L probably benign Het
Mrps28 T A 3: 8,965,184 (GRCm39) H85L possibly damaging Het
Mtpn T A 6: 35,499,693 (GRCm39) K37M possibly damaging Het
Mug1 C T 6: 121,859,588 (GRCm39) H1196Y probably benign Het
Mup4 T C 4: 59,960,084 (GRCm39) H60R possibly damaging Het
Mybl2 T C 2: 162,914,628 (GRCm39) S249P probably benign Het
Nrp1 A G 8: 129,229,279 (GRCm39) N919S probably benign Het
Nudt9 C T 5: 104,212,904 (GRCm39) Q326* probably null Het
Or5w13 A T 2: 87,523,720 (GRCm39) C169S probably damaging Het
Or6c76b A G 10: 129,693,100 (GRCm39) T238A probably damaging Het
Or7g17 T A 9: 18,768,407 (GRCm39) M162K probably benign Het
Or9k7 T A 10: 130,046,592 (GRCm39) I136F probably benign Het
Pcsk4 T C 10: 80,161,815 (GRCm39) E142G probably damaging Het
Pde3a C A 6: 141,405,560 (GRCm39) P471T probably benign Het
Pign A T 1: 105,512,727 (GRCm39) V652E possibly damaging Het
Prkcb T A 7: 122,181,672 (GRCm39) M420K probably damaging Het
Prr14 T A 7: 127,073,160 (GRCm39) probably null Het
Rchy1 T A 5: 92,105,741 (GRCm39) Q69L probably damaging Het
Sec23ip T G 7: 128,367,862 (GRCm39) S625A probably benign Het
Smpdl3b A G 4: 132,473,925 (GRCm39) S47P probably damaging Het
Speer4a3 T A 5: 26,156,623 (GRCm39) I119F possibly damaging Het
Stil G A 4: 114,881,161 (GRCm39) M568I probably benign Het
Syt3 T A 7: 44,045,434 (GRCm39) V558E probably damaging Het
Szt2 A G 4: 118,231,164 (GRCm39) V2533A unknown Het
Tenm4 A G 7: 96,353,360 (GRCm39) Y384C probably damaging Het
Tfam T C 10: 71,071,380 (GRCm39) E94G probably damaging Het
Tmbim7 A G 5: 3,714,304 (GRCm39) T14A probably damaging Het
Tmtc2 A T 10: 105,409,566 (GRCm39) Y15* probably null Het
Uhrf1 C T 17: 56,625,035 (GRCm39) A526V probably damaging Het
Vmn2r67 T C 7: 84,805,046 (GRCm39) D22G probably benign Het
Vmn2r96 A G 17: 18,817,660 (GRCm39) I412M possibly damaging Het
Wdr17 A T 8: 55,123,363 (GRCm39) I479K probably damaging Het
Wt1 T C 2: 104,997,176 (GRCm39) V371A probably damaging Het
Zfp536 G T 7: 37,178,735 (GRCm39) S226Y probably damaging Het
Zfp827 T C 8: 79,803,108 (GRCm39) V560A probably benign Het
Other mutations in Naip6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Naip6 APN 13 100,452,525 (GRCm39) missense probably benign 0.03
IGL01123:Naip6 APN 13 100,440,946 (GRCm39) missense probably benign 0.02
IGL01151:Naip6 APN 13 100,435,601 (GRCm39) missense probably benign 0.00
IGL01382:Naip6 APN 13 100,436,364 (GRCm39) missense possibly damaging 0.95
IGL01415:Naip6 APN 13 100,439,798 (GRCm39) missense probably benign 0.17
IGL01654:Naip6 APN 13 100,435,853 (GRCm39) missense probably benign 0.00
IGL01662:Naip6 APN 13 100,436,862 (GRCm39) missense probably damaging 1.00
IGL01726:Naip6 APN 13 100,439,760 (GRCm39) missense probably benign 0.02
IGL01810:Naip6 APN 13 100,424,603 (GRCm39) splice site probably benign
IGL01867:Naip6 APN 13 100,436,820 (GRCm39) missense probably benign 0.40
IGL01926:Naip6 APN 13 100,436,704 (GRCm39) missense probably damaging 1.00
IGL01964:Naip6 APN 13 100,435,238 (GRCm39) splice site probably benign
IGL02145:Naip6 APN 13 100,433,486 (GRCm39) missense possibly damaging 0.77
IGL02160:Naip6 APN 13 100,435,933 (GRCm39) missense probably benign 0.01
IGL02214:Naip6 APN 13 100,452,567 (GRCm39) missense probably damaging 1.00
IGL02342:Naip6 APN 13 100,439,748 (GRCm39) missense possibly damaging 0.69
IGL02568:Naip6 APN 13 100,452,780 (GRCm39) missense probably damaging 1.00
IGL02573:Naip6 APN 13 100,435,979 (GRCm39) nonsense probably null
IGL02680:Naip6 APN 13 100,420,256 (GRCm39) missense probably benign
IGL02829:Naip6 APN 13 100,437,273 (GRCm39) missense probably benign 0.11
IGL02833:Naip6 APN 13 100,436,121 (GRCm39) missense probably damaging 1.00
IGL02851:Naip6 APN 13 100,437,168 (GRCm39) missense probably benign 0.01
IGL02860:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL02886:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL03155:Naip6 APN 13 100,452,932 (GRCm39) missense possibly damaging 0.62
R0032:Naip6 UTSW 13 100,439,745 (GRCm39) missense probably benign 0.00
R0310:Naip6 UTSW 13 100,444,721 (GRCm39) missense possibly damaging 0.72
R0437:Naip6 UTSW 13 100,433,432 (GRCm39) missense possibly damaging 0.75
R0472:Naip6 UTSW 13 100,438,768 (GRCm39) missense probably benign 0.02
R0560:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R0638:Naip6 UTSW 13 100,437,036 (GRCm39) missense probably benign 0.00
R0792:Naip6 UTSW 13 100,420,274 (GRCm39) missense possibly damaging 0.78
R0963:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign 0.11
R1102:Naip6 UTSW 13 100,440,923 (GRCm39) missense possibly damaging 0.62
R1278:Naip6 UTSW 13 100,436,870 (GRCm39) missense probably damaging 1.00
R1462:Naip6 UTSW 13 100,436,748 (GRCm39) missense possibly damaging 0.64
R1544:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign
R1595:Naip6 UTSW 13 100,435,602 (GRCm39) missense probably damaging 0.96
R1749:Naip6 UTSW 13 100,444,763 (GRCm39) missense probably benign 0.03
R1838:Naip6 UTSW 13 100,452,644 (GRCm39) missense probably damaging 0.99
R1863:Naip6 UTSW 13 100,437,067 (GRCm39) missense probably benign 0.03
R1914:Naip6 UTSW 13 100,435,936 (GRCm39) missense probably benign 0.13
R2001:Naip6 UTSW 13 100,437,237 (GRCm39) missense probably benign 0.44
R2082:Naip6 UTSW 13 100,440,852 (GRCm39) splice site probably null
R2143:Naip6 UTSW 13 100,436,367 (GRCm39) missense probably damaging 1.00
R2174:Naip6 UTSW 13 100,435,495 (GRCm39) missense probably benign
R2266:Naip6 UTSW 13 100,420,067 (GRCm39) missense possibly damaging 0.46
R2284:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2285:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2286:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2351:Naip6 UTSW 13 100,420,169 (GRCm39) missense probably damaging 1.00
R2363:Naip6 UTSW 13 100,452,928 (GRCm39) missense possibly damaging 0.90
R2445:Naip6 UTSW 13 100,437,176 (GRCm39) missense probably damaging 0.99
R2971:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2975:Naip6 UTSW 13 100,424,695 (GRCm39) missense probably damaging 1.00
R3081:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R3082:Naip6 UTSW 13 100,452,925 (GRCm39) missense probably benign 0.00
R3122:Naip6 UTSW 13 100,453,031 (GRCm39) missense probably benign 0.00
R3417:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R3943:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R3944:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R4080:Naip6 UTSW 13 100,435,815 (GRCm39) missense probably damaging 1.00
R4166:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R4396:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4397:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4418:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4512:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4670:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4671:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4722:Naip6 UTSW 13 100,443,580 (GRCm39) missense possibly damaging 0.72
R4811:Naip6 UTSW 13 100,422,299 (GRCm39) missense probably damaging 1.00
R4900:Naip6 UTSW 13 100,433,477 (GRCm39) missense probably damaging 0.99
R5162:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R5316:Naip6 UTSW 13 100,420,290 (GRCm39) missense probably benign 0.00
R5403:Naip6 UTSW 13 100,436,585 (GRCm39) missense probably benign 0.12
R5437:Naip6 UTSW 13 100,439,812 (GRCm39) nonsense probably null
R5507:Naip6 UTSW 13 100,435,423 (GRCm39) missense probably benign 0.01
R5631:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R5657:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R5684:Naip6 UTSW 13 100,436,888 (GRCm39) missense probably damaging 1.00
R5786:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5787:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5788:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5878:Naip6 UTSW 13 100,436,181 (GRCm39) missense probably damaging 1.00
R5895:Naip6 UTSW 13 100,452,500 (GRCm39) missense possibly damaging 0.90
R5898:Naip6 UTSW 13 100,435,829 (GRCm39) missense possibly damaging 0.93
R6113:Naip6 UTSW 13 100,435,794 (GRCm39) missense possibly damaging 0.96
R6141:Naip6 UTSW 13 100,444,741 (GRCm39) missense possibly damaging 0.91
R6199:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R6321:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6402:Naip6 UTSW 13 100,437,226 (GRCm39) missense probably benign 0.30
R6435:Naip6 UTSW 13 100,431,249 (GRCm39) missense probably benign 0.04
R6477:Naip6 UTSW 13 100,452,516 (GRCm39) missense probably damaging 1.00
R6601:Naip6 UTSW 13 100,420,266 (GRCm39) missense probably benign
R6638:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6639:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6804:Naip6 UTSW 13 100,435,675 (GRCm39) missense probably benign
R6922:Naip6 UTSW 13 100,438,706 (GRCm39) missense possibly damaging 0.88
R6975:Naip6 UTSW 13 100,452,773 (GRCm39) missense probably damaging 1.00
R7050:Naip6 UTSW 13 100,452,007 (GRCm39) missense probably damaging 1.00
R7135:Naip6 UTSW 13 100,436,927 (GRCm39) missense probably damaging 1.00
R7140:Naip6 UTSW 13 100,436,708 (GRCm39) missense possibly damaging 0.95
R7182:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R7196:Naip6 UTSW 13 100,436,666 (GRCm39) missense probably benign 0.10
R7234:Naip6 UTSW 13 100,452,011 (GRCm39) nonsense probably null
R7259:Naip6 UTSW 13 100,440,863 (GRCm39) missense probably damaging 1.00
R7322:Naip6 UTSW 13 100,435,896 (GRCm39) missense possibly damaging 0.94
R7332:Naip6 UTSW 13 100,437,209 (GRCm39) missense possibly damaging 0.62
R7339:Naip6 UTSW 13 100,452,527 (GRCm39) missense probably damaging 1.00
R7353:Naip6 UTSW 13 100,436,259 (GRCm39) missense probably benign 0.00
R7485:Naip6 UTSW 13 100,420,359 (GRCm39) missense probably benign 0.07
R7597:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R7835:Naip6 UTSW 13 100,452,512 (GRCm39) missense probably benign 0.19
R7840:Naip6 UTSW 13 100,451,979 (GRCm39) missense probably damaging 1.00
R8082:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R8082:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R8103:Naip6 UTSW 13 100,437,851 (GRCm39) missense probably benign 0.00
R8164:Naip6 UTSW 13 100,452,797 (GRCm39) missense probably benign 0.00
R8206:Naip6 UTSW 13 100,431,344 (GRCm39) nonsense probably null
R8258:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8259:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8348:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8405:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8406:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8441:Naip6 UTSW 13 100,422,265 (GRCm39) missense possibly damaging 0.77
R8448:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8465:Naip6 UTSW 13 100,433,423 (GRCm39) missense possibly damaging 0.95
R8501:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8502:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8687:Naip6 UTSW 13 100,435,636 (GRCm39) missense probably benign 0.10
R8806:Naip6 UTSW 13 100,437,161 (GRCm39) missense possibly damaging 0.93
R9186:Naip6 UTSW 13 100,436,390 (GRCm39) missense possibly damaging 0.89
R9340:Naip6 UTSW 13 100,452,494 (GRCm39) missense probably damaging 1.00
R9352:Naip6 UTSW 13 100,437,893 (GRCm39) missense possibly damaging 0.85
R9585:Naip6 UTSW 13 100,436,577 (GRCm39) missense probably damaging 0.96
R9597:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R9601:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
X0066:Naip6 UTSW 13 100,451,970 (GRCm39) nonsense probably null
Z1177:Naip6 UTSW 13 100,437,308 (GRCm39) missense probably damaging 1.00
Z1177:Naip6 UTSW 13 100,435,925 (GRCm39) missense probably benign 0.20
Z1177:Naip6 UTSW 13 100,452,638 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCACGATGAGAAAAGCCCTGTCAAG -3'
(R):5'- AGCAGCAGCATCCAGCAGTTAC -3'

Sequencing Primer
(F):5'- ACATCTTGAAAGTCATCCTGGGC -3'
(R):5'- GTTACAACACCAGGTGCTGTTC -3'
Posted On 2014-03-14