Mutagenetix > Incidental Mutation

Incidental Mutation 'R1448:Ptpro'

159033

Institutional Source

Beutler Lab

Gene Symbol

Ptpro

Ensembl Gene

ENSMUSG00000030223

Gene Name

protein tyrosine phosphatase, receptor type, O

Synonyms

Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, D28, PTPROt

MMRRC Submission

039503-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1448 (G1)

Quality Score

207

Status

Not validated

Chromosome

Chromosomal Location

137252319-137463233 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 137441116 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 126 (K126E)

Ref Sequence

ENSEMBL: ENSMUSP00000144870 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077115] [ENSMUST00000167002] [ENSMUST00000167679] [ENSMUST00000203914]

AlphaFold

E9Q612

Predicted Effect

probably damaging
Transcript: ENSMUST00000077115
AA Change: K975E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000076364
Gene: ENSMUSG00000030223
AA Change: K975E

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
transmembrane domain	890	912	N/A	INTRINSIC
PTPc	947	1207	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000167002
AA Change: K154E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000131764
Gene: ENSMUSG00000030223
AA Change: K154E

Domain	Start	End	E-Value	Type
transmembrane domain	10	32	N/A	INTRINSIC
transmembrane domain	69	91	N/A	INTRINSIC
PTPc	126	386	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000167679
AA Change: K947E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000127112
Gene: ENSMUSG00000030223
AA Change: K947E

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
PTPc	919	1179	1.43e-127	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000203914
AA Change: K126E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000144870
Gene: ENSMUSG00000030223
AA Change: K126E

Domain	Start	End	E-Value	Type
signal peptide	1	33	N/A	INTRINSIC
PTPc	98	358	6.1e-130	SMART

Coding Region Coverage

1x: 98.8%
3x: 97.8%
10x: 94.6%
20x: 87.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 85 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417H12Rik	T	A	7: 107,624,745 (GRCm38)		probably benign	Het
A1cf	A	T	19: 31,908,796 (GRCm38)	N35I	possibly damaging	Het
Abca2	T	C	2: 25,440,530 (GRCm38)	I1106T	possibly damaging	Het
Abca4	G	A	3: 122,162,928 (GRCm38)		probably null	Het
Adgrv1	T	C	13: 81,433,513 (GRCm38)	D4804G	probably benign	Het
Adk	T	A	14: 21,052,640 (GRCm38)	M1K	probably null	Het
Aff3	T	C	1: 38,191,283 (GRCm38)	N1006D	probably damaging	Het
Akap12	A	G	10: 4,355,475 (GRCm38)	T762A	probably benign	Het
Atosa	C	G	9: 75,010,174 (GRCm38)	S685*	probably null	Het
Atp12a	T	A	14: 56,385,839 (GRCm38)	M843K	probably damaging	Het
Bbx	T	A	16: 50,266,270 (GRCm38)	K169*	probably null	Het
Bicra	A	T	7: 15,988,359 (GRCm38)	V411E	possibly damaging	Het
Camk1d	A	T	2: 5,362,025 (GRCm38)	Y126*	probably null	Het
Cel	T	C	2: 28,556,326 (GRCm38)	Y511C	probably damaging	Het
Celf4	G	T	18: 25,503,083 (GRCm38)		probably null	Het
Clasp1	A	G	1: 118,508,916 (GRCm38)	N310S	probably benign	Het
Col6a3	T	C	1: 90,781,855 (GRCm38)	K1873R	unknown	Het
Cstf1	A	G	2: 172,375,875 (GRCm38)	D136G	probably damaging	Het
Cwc22	T	A	2: 77,911,555 (GRCm38)	E470D	probably damaging	Het
Cxcr2	A	T	1: 74,158,368 (GRCm38)	D7V	probably benign	Het
Cytip	A	G	2: 58,145,180 (GRCm38)	I168T	probably damaging	Het
D5Ertd579e	A	G	5: 36,602,739 (GRCm38)	L1359P	probably benign	Het
Ddx25	A	C	9: 35,557,738 (GRCm38)	V26G	probably benign	Het
Dennd4a	T	A	9: 64,906,045 (GRCm38)	S1429T	possibly damaging	Het
Dmd	A	G	X: 84,848,700 (GRCm38)	D2990G	probably damaging	Het
Dop1a	C	A	9: 86,542,732 (GRCm38)		probably null	Het
Eps8	T	C	6: 137,522,854 (GRCm38)	Q209R	possibly damaging	Het
Fabp6	T	A	11: 43,596,165 (GRCm38)	I112F	probably benign	Het
Fbxw10	T	C	11: 62,847,592 (GRCm38)	V104A	possibly damaging	Het
Gp1ba	C	T	11: 70,641,427 (GRCm38)	P673L	probably damaging	Het
Grin3a	T	C	4: 49,702,804 (GRCm38)	Y894C	probably damaging	Het
Hydin	C	T	8: 110,446,585 (GRCm38)	H967Y	probably benign	Het
Ip6k3	T	C	17: 27,145,268 (GRCm38)	K269E	possibly damaging	Het
Jup	T	C	11: 100,383,200 (GRCm38)	K172E	probably damaging	Het
Katnal1	T	C	5: 148,904,676 (GRCm38)	D126G	probably benign	Het
Knl1	A	T	2: 119,068,307 (GRCm38)	K163M	probably damaging	Het
Krt17	C	T	11: 100,257,539 (GRCm38)	E359K	possibly damaging	Het
Lct	T	A	1: 128,307,822 (GRCm38)	I483F	probably damaging	Het
Loxl2	G	A	14: 69,693,040 (GRCm38)	G751D	probably damaging	Het
Ltbp4	G	A	7: 27,306,577 (GRCm38)	R1559C	possibly damaging	Het
Man2c1	T	A	9: 57,135,219 (GRCm38)	D183E	probably benign	Het
Med17	T	C	9: 15,275,843 (GRCm38)		probably null	Het
Mrgpra9	A	C	7: 47,235,813 (GRCm38)	S34R	probably benign	Het
Mrpl44	T	A	1: 79,777,960 (GRCm38)	N94K	probably damaging	Het
Nat8f1	A	G	6: 85,910,942 (GRCm38)	V12A	probably benign	Het
Nr2e3	C	A	9: 59,943,514 (GRCm38)	G354V	probably damaging	Het
Nrbp1	T	A	5: 31,245,813 (GRCm38)	I210N	probably damaging	Het
Nup155	T	C	15: 8,112,406 (GRCm38)	V94A	probably benign	Het
Or14a256	A	T	7: 86,616,361 (GRCm38)	C95S	probably damaging	Het
Or52h2	C	T	7: 104,189,875 (GRCm38)	V111I	possibly damaging	Het
Or5p76	T	C	7: 108,523,318 (GRCm38)	I211V	probably benign	Het
Or9q2	A	T	19: 13,794,776 (GRCm38)	Y278*	probably null	Het
Pcdhb10	A	T	18: 37,412,503 (GRCm38)	I211F	possibly damaging	Het
Phip	A	C	9: 82,915,423 (GRCm38)	I509S	possibly damaging	Het
Pkhd1	C	T	1: 20,585,157 (GRCm38)		probably null	Het
Psme4	T	G	11: 30,852,744 (GRCm38)	L1487R	probably damaging	Het
Ptgdr2	A	G	19: 10,940,493 (GRCm38)	S125G	probably damaging	Het
Rdh16f2	T	A	10: 127,876,925 (GRCm38)	V264E	probably benign	Het
Ric8b	C	T	10: 84,947,671 (GRCm38)	A131V	possibly damaging	Het
Rock1	A	T	18: 10,070,233 (GRCm38)	I1280N	probably damaging	Het
Rprd2	A	G	3: 95,818,576 (GRCm38)	V59A	possibly damaging	Het
Ruvbl1	T	A	6: 88,467,569 (GRCm38)	C49S	probably benign	Het
Scn2a	A	G	2: 65,683,845 (GRCm38)	N291S	probably benign	Het
Serbp1	T	A	6: 67,277,920 (GRCm38)	H325Q	probably damaging	Het
Shf	G	A	2: 122,368,682 (GRCm38)	P51S	probably damaging	Het
Shisal2b	T	C	13: 104,845,962 (GRCm38)	I151V	probably benign	Het
Slitrk3	G	A	3: 73,050,341 (GRCm38)	T366I	probably damaging	Het
Spryd3	A	T	15: 102,118,392 (GRCm38)	H307Q	possibly damaging	Het
Spx	A	T	6: 142,418,513 (GRCm38)	D100V	probably benign	Het
Surf4	A	G	2: 26,924,464 (GRCm38)	F142L	probably damaging	Het
Syne2	T	A	12: 76,020,325 (GRCm38)		probably null	Het
Syne2	T	C	12: 76,052,178 (GRCm38)	M5278T	possibly damaging	Het
Thap12	T	C	7: 98,716,023 (GRCm38)	V466A	probably benign	Het
Thap3	T	C	4: 151,983,216 (GRCm38)	K135R	possibly damaging	Het
Tmem131	G	T	1: 36,827,358 (GRCm38)	D448E	probably benign	Het
Tmem63b	C	G	17: 45,678,978 (GRCm38)	R88P	possibly damaging	Het
Trim43a	G	T	9: 88,582,093 (GRCm38)	C19F	probably damaging	Het
Trp63	C	T	16: 25,889,120 (GRCm38)	P526L	possibly damaging	Het
Ubqln3	T	C	7: 104,142,790 (GRCm38)	D31G	probably damaging	Het
Utp14b	C	A	1: 78,665,445 (GRCm38)	N353K	probably damaging	Het
Vmn1r40	A	G	6: 89,714,576 (GRCm38)	K125R	probably damaging	Het
Vmn2r1	A	G	3: 64,101,313 (GRCm38)	Y471C	probably damaging	Het
Vmn2r13	A	G	5: 109,174,135 (GRCm38)	I232T	probably damaging	Het
Zfp263	A	C	16: 3,746,459 (GRCm38)	E204D	probably benign	Het
Zfp865	A	T	7: 5,029,279 (GRCm38)	K88*	probably null	Het

Other mutations in Ptpro

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Ptpro	APN	6	137,394,909 (GRCm38)	critical splice donor site	probably null
IGL00844:Ptpro	APN	6	137,414,239 (GRCm38)	missense	probably damaging	1.00
IGL00983:Ptpro	APN	6	137,418,248 (GRCm38)	missense	probably benign	0.01
IGL01073:Ptpro	APN	6	137,377,088 (GRCm38)	missense	probably damaging	1.00
IGL01832:Ptpro	APN	6	137,393,668 (GRCm38)	missense	possibly damaging	0.93
IGL02308:Ptpro	APN	6	137,454,700 (GRCm38)	missense	probably benign	0.37
IGL02387:Ptpro	APN	6	137,410,980 (GRCm38)	missense	probably damaging	0.96
IGL02605:Ptpro	APN	6	137,380,318 (GRCm38)	missense	probably benign	0.02
IGL02666:Ptpro	APN	6	137,378,059 (GRCm38)	missense	probably damaging	0.96
IGL03275:Ptpro	APN	6	137,450,006 (GRCm38)	missense	probably damaging	1.00
Brau	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
court	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
Hoff	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
Jester	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
mann	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0020:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0022:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0023:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0024:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0103:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0106:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0316:Ptpro	UTSW	6	137,376,989 (GRCm38)	missense	possibly damaging	0.81
R0427:Ptpro	UTSW	6	137,368,296 (GRCm38)	missense	possibly damaging	0.81
R0456:Ptpro	UTSW	6	137,414,230 (GRCm38)	missense	probably benign	0.04
R0536:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0537:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0552:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0555:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0664:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0708:Ptpro	UTSW	6	137,386,253 (GRCm38)	missense	probably benign	0.26
R0730:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0735:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0738:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0786:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0811:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0812:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0881:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0973:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1259:Ptpro	UTSW	6	137,392,741 (GRCm38)	missense	probably damaging	0.98
R1340:Ptpro	UTSW	6	137,441,081 (GRCm38)	missense	possibly damaging	0.95
R1381:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1382:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1385:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1396:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1401:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1416:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1422:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1513:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1518:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1526:Ptpro	UTSW	6	137,461,726 (GRCm38)	missense	probably damaging	1.00
R1540:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1571:Ptpro	UTSW	6	137,378,130 (GRCm38)	missense	probably benign
R1573:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1587:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1588:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1649:Ptpro	UTSW	6	137,444,017 (GRCm38)	nonsense	probably null
R1700:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1701:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1745:Ptpro	UTSW	6	137,400,645 (GRCm38)	missense	probably benign	0.03
R1772:Ptpro	UTSW	6	137,430,743 (GRCm38)	missense	probably damaging	1.00
R1911:Ptpro	UTSW	6	137,400,619 (GRCm38)	splice site	probably benign
R1958:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1967:Ptpro	UTSW	6	137,416,865 (GRCm38)	missense	probably benign	0.38
R2025:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2026:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2040:Ptpro	UTSW	6	137,386,164 (GRCm38)	splice site	probably benign
R2115:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2117:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2130:Ptpro	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R2161:Ptpro	UTSW	6	137,449,887 (GRCm38)	missense	probably benign	0.01
R2431:Ptpro	UTSW	6	137,443,585 (GRCm38)	nonsense	probably null
R2915:Ptpro	UTSW	6	137,414,241 (GRCm38)	start gained	probably benign
R2988:Ptpro	UTSW	6	137,443,599 (GRCm38)	nonsense	probably null
R3772:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3773:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3795:Ptpro	UTSW	6	137,380,309 (GRCm38)	missense	probably benign
R3885:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3886:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3887:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3888:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3893:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4032:Ptpro	UTSW	6	137,461,742 (GRCm38)	missense	probably damaging	1.00
R4133:Ptpro	UTSW	6	137,420,372 (GRCm38)	missense	probably damaging	1.00
R4377:Ptpro	UTSW	6	137,380,266 (GRCm38)	missense	probably benign	0.26
R4455:Ptpro	UTSW	6	137,393,659 (GRCm38)	missense	probably damaging	1.00
R4613:Ptpro	UTSW	6	137,416,836 (GRCm38)	nonsense	probably null
R4827:Ptpro	UTSW	6	137,442,710 (GRCm38)	missense	probably damaging	1.00
R4863:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4870:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R4910:Ptpro	UTSW	6	137,368,338 (GRCm38)	missense	probably damaging	0.99
R4932:Ptpro	UTSW	6	137,411,105 (GRCm38)	nonsense	probably null
R4941:Ptpro	UTSW	6	137,392,765 (GRCm38)	missense	probably damaging	1.00
R4989:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5009:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R5032:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5033:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5162:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5393:Ptpro	UTSW	6	137,380,224 (GRCm38)	missense	probably benign	0.04
R5423:Ptpro	UTSW	6	137,442,707 (GRCm38)	missense	probably damaging	1.00
R5782:Ptpro	UTSW	6	137,399,498 (GRCm38)	missense	possibly damaging	0.80
R6103:Ptpro	UTSW	6	137,400,706 (GRCm38)	missense	possibly damaging	0.76
R6239:Ptpro	UTSW	6	137,380,608 (GRCm38)	missense	probably benign	0.28
R6488:Ptpro	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
R6494:Ptpro	UTSW	6	137,382,642 (GRCm38)	missense	probably benign	0.20
R6746:Ptpro	UTSW	6	137,394,823 (GRCm38)	missense	probably damaging	1.00
R6763:Ptpro	UTSW	6	137,418,281 (GRCm38)	splice site	probably null
R6888:Ptpro	UTSW	6	137,380,200 (GRCm38)	missense	probably benign	0.30
R6983:Ptpro	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
R7019:Ptpro	UTSW	6	137,380,478 (GRCm38)	missense	probably benign
R7218:Ptpro	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
R7236:Ptpro	UTSW	6	137,368,337 (GRCm38)	missense	probably damaging	1.00
R7299:Ptpro	UTSW	6	137,441,144 (GRCm38)	critical splice donor site	probably null
R7381:Ptpro	UTSW	6	137,399,561 (GRCm38)	missense	possibly damaging	0.93
R7493:Ptpro	UTSW	6	137,382,649 (GRCm38)	missense	probably benign	0.01
R7733:Ptpro	UTSW	6	137,414,286 (GRCm38)	nonsense	probably null
R7793:Ptpro	UTSW	6	137,416,820 (GRCm38)	missense	probably damaging	0.99
R7804:Ptpro	UTSW	6	137,399,601 (GRCm38)	splice site	probably null
R7833:Ptpro	UTSW	6	137,416,863 (GRCm38)	nonsense	probably null
R7859:Ptpro	UTSW	6	137,392,807 (GRCm38)	critical splice donor site	probably null
R7873:Ptpro	UTSW	6	137,430,739 (GRCm38)	missense	probably benign	0.44
R8042:Ptpro	UTSW	6	137,416,883 (GRCm38)	missense	possibly damaging	0.71
R8859:Ptpro	UTSW	6	137,426,784 (GRCm38)	nonsense	probably null
R8979:Ptpro	UTSW	6	137,368,142 (GRCm38)	missense	probably benign
R9138:Ptpro	UTSW	6	137,411,115 (GRCm38)	critical splice donor site	probably null
R9309:Ptpro	UTSW	6	137,454,658 (GRCm38)	missense	probably damaging	1.00
R9420:Ptpro	UTSW	6	137,443,935 (GRCm38)	missense	probably benign	0.08
R9612:Ptpro	UTSW	6	137,414,320 (GRCm38)	missense	probably benign	0.31
R9625:Ptpro	UTSW	6	137,394,875 (GRCm38)	missense	probably damaging	1.00
R9697:Ptpro	UTSW	6	137,386,290 (GRCm38)	missense	probably damaging	1.00
R9715:Ptpro	UTSW	6	137,368,110 (GRCm38)	missense	probably damaging	0.96
Z1177:Ptpro	UTSW	6	137,378,140 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CACTCTGCCCTTAGAAGGAATCGC -3'
(R):5'- AGGGAGAGTCCAATGCTCAGATGC -3'

Sequencing Primer
(F):5'- GAAGGAATCGCTATGTTATCAGC -3'
(R):5'- TCCACTGAGTAAGACCAGTGC -3'

Posted On

2014-03-14