Incidental Mutation 'R1448:Fbxw10'
| ID |
159065 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fbxw10
|
| Ensembl Gene |
ENSMUSG00000090173 |
| Gene Name |
F-box and WD-40 domain protein 10 |
| Synonyms |
SM2SH2, SM25H2, Fbw10 |
| MMRRC Submission |
039503-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.060)
|
| Stock # |
R1448 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
62737895-62768291 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 62738418 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 104
(V104A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036085]
[ENSMUST00000055006]
[ENSMUST00000072639]
[ENSMUST00000108703]
[ENSMUST00000150989]
[ENSMUST00000176577]
[ENSMUST00000177336]
|
| AlphaFold |
Q5SUS0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000036085
AA Change: V104A
PolyPhen 2
Score 0.565 (Sensitivity: 0.88; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000046156
Gene: ENSMUSG00000090173
AA Change: V104A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
262 |
274 |
N/A |
INTRINSIC |
|
Blast:FBOX
|
286 |
326 |
6e-14 |
BLAST |
|
Blast:WD40
|
416 |
453 |
2e-8 |
BLAST |
|
WD40
|
457 |
496 |
1.78e-5 |
SMART |
|
WD40
|
499 |
536 |
5.55e-7 |
SMART |
|
WD40
|
539 |
575 |
2.84e-4 |
SMART |
|
WD40
|
578 |
615 |
3.81e-5 |
SMART |
|
WD40
|
620 |
656 |
6.9e-1 |
SMART |
|
low complexity region
|
709 |
724 |
N/A |
INTRINSIC |
|
coiled coil region
|
964 |
992 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055006
|
| SMART Domains |
Protein: ENSMUSP00000055542
Gene: ENSMUSG00000047821
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:BBOX
|
64 |
113 |
6e-24 |
BLAST |
|
BBOX
|
117 |
157 |
3.24e-4 |
SMART |
|
coiled coil region
|
171 |
196 |
N/A |
INTRINSIC |
|
coiled coil region
|
237 |
265 |
N/A |
INTRINSIC |
|
PRY
|
364 |
417 |
1.41e-22 |
SMART |
|
SPRY
|
418 |
543 |
6.4e-27 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072639
|
| SMART Domains |
Protein: ENSMUSP00000072432
Gene: ENSMUSG00000047821
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:BBOX
|
64 |
113 |
5e-24 |
BLAST |
|
BBOX
|
117 |
157 |
3.24e-4 |
SMART |
|
coiled coil region
|
171 |
196 |
N/A |
INTRINSIC |
|
coiled coil region
|
237 |
265 |
N/A |
INTRINSIC |
|
PRY
|
364 |
417 |
1.41e-22 |
SMART |
|
Pfam:SPRY
|
418 |
483 |
1.4e-6 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108703
|
| SMART Domains |
Protein: ENSMUSP00000104343
Gene: ENSMUSG00000047821
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:BBOX
|
1 |
26 |
9e-10 |
BLAST |
|
BBOX
|
30 |
70 |
3.24e-4 |
SMART |
|
coiled coil region
|
84 |
109 |
N/A |
INTRINSIC |
|
coiled coil region
|
150 |
178 |
N/A |
INTRINSIC |
|
PRY
|
277 |
330 |
1.41e-22 |
SMART |
|
SPRY
|
331 |
456 |
6.4e-27 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000150989
AA Change: V104A
PolyPhen 2
Score 0.735 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000117872
Gene: ENSMUSG00000090173
AA Change: V104A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
262 |
274 |
N/A |
INTRINSIC |
|
Blast:FBOX
|
286 |
326 |
1e-13 |
BLAST |
|
Blast:WD40
|
406 |
443 |
2e-8 |
BLAST |
|
WD40
|
447 |
486 |
1.78e-5 |
SMART |
|
WD40
|
489 |
526 |
5.55e-7 |
SMART |
|
WD40
|
529 |
565 |
2.84e-4 |
SMART |
|
WD40
|
568 |
605 |
3.81e-5 |
SMART |
|
WD40
|
610 |
646 |
6.9e-1 |
SMART |
|
low complexity region
|
699 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
954 |
982 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000175804
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176577
AA Change: V104A
PolyPhen 2
Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000135870
Gene: ENSMUSG00000090173
AA Change: V104A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
262 |
274 |
N/A |
INTRINSIC |
|
Blast:FBOX
|
286 |
326 |
6e-14 |
BLAST |
|
Blast:WD40
|
406 |
443 |
2e-8 |
BLAST |
|
WD40
|
447 |
486 |
1.78e-5 |
SMART |
|
WD40
|
489 |
526 |
5.55e-7 |
SMART |
|
WD40
|
529 |
565 |
2.84e-4 |
SMART |
|
WD40
|
568 |
605 |
3.81e-5 |
SMART |
|
WD40
|
610 |
646 |
6.9e-1 |
SMART |
|
low complexity region
|
704 |
719 |
N/A |
INTRINSIC |
|
coiled coil region
|
959 |
987 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177336
AA Change: V104A
PolyPhen 2
Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000135294
Gene: ENSMUSG00000090173
AA Change: V104A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
262 |
274 |
N/A |
INTRINSIC |
|
Blast:FBOX
|
286 |
326 |
5e-14 |
BLAST |
|
Blast:WD40
|
406 |
443 |
1e-8 |
BLAST |
|
WD40
|
447 |
486 |
1.78e-5 |
SMART |
|
WD40
|
489 |
526 |
5.55e-7 |
SMART |
|
WD40
|
529 |
565 |
2.84e-4 |
SMART |
|
WD40
|
568 |
605 |
3.81e-5 |
SMART |
|
WD40
|
610 |
646 |
6.9e-1 |
SMART |
|
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.8%
- 10x: 94.6%
- 20x: 87.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5330417H12Rik |
T |
A |
7: 107,223,952 (GRCm39) |
|
probably benign |
Het |
| A1cf |
A |
T |
19: 31,886,196 (GRCm39) |
N35I |
possibly damaging |
Het |
| Abca2 |
T |
C |
2: 25,330,542 (GRCm39) |
I1106T |
possibly damaging |
Het |
| Abca4 |
G |
A |
3: 121,956,577 (GRCm39) |
|
probably null |
Het |
| Adgrv1 |
T |
C |
13: 81,581,632 (GRCm39) |
D4804G |
probably benign |
Het |
| Adk |
T |
A |
14: 21,102,708 (GRCm39) |
M1K |
probably null |
Het |
| Aff3 |
T |
C |
1: 38,230,364 (GRCm39) |
N1006D |
probably damaging |
Het |
| Akap12 |
A |
G |
10: 4,305,475 (GRCm39) |
T762A |
probably benign |
Het |
| Atosa |
C |
G |
9: 74,917,456 (GRCm39) |
S685* |
probably null |
Het |
| Atp12a |
T |
A |
14: 56,623,296 (GRCm39) |
M843K |
probably damaging |
Het |
| Bbx |
T |
A |
16: 50,086,633 (GRCm39) |
K169* |
probably null |
Het |
| Bicra |
A |
T |
7: 15,722,284 (GRCm39) |
V411E |
possibly damaging |
Het |
| Camk1d |
A |
T |
2: 5,366,836 (GRCm39) |
Y126* |
probably null |
Het |
| Cel |
T |
C |
2: 28,446,338 (GRCm39) |
Y511C |
probably damaging |
Het |
| Celf4 |
G |
T |
18: 25,636,140 (GRCm39) |
|
probably null |
Het |
| Clasp1 |
A |
G |
1: 118,436,646 (GRCm39) |
N310S |
probably benign |
Het |
| Col6a3 |
T |
C |
1: 90,709,577 (GRCm39) |
K1873R |
unknown |
Het |
| Cstf1 |
A |
G |
2: 172,217,795 (GRCm39) |
D136G |
probably damaging |
Het |
| Cwc22 |
T |
A |
2: 77,741,899 (GRCm39) |
E470D |
probably damaging |
Het |
| Cxcr2 |
A |
T |
1: 74,197,527 (GRCm39) |
D7V |
probably benign |
Het |
| Cytip |
A |
G |
2: 58,035,192 (GRCm39) |
I168T |
probably damaging |
Het |
| D5Ertd579e |
A |
G |
5: 36,760,083 (GRCm39) |
L1359P |
probably benign |
Het |
| Ddx25 |
A |
C |
9: 35,469,034 (GRCm39) |
V26G |
probably benign |
Het |
| Dennd4a |
T |
A |
9: 64,813,327 (GRCm39) |
S1429T |
possibly damaging |
Het |
| Dmd |
A |
G |
X: 83,892,306 (GRCm39) |
D2990G |
probably damaging |
Het |
| Dop1a |
C |
A |
9: 86,424,785 (GRCm39) |
|
probably null |
Het |
| Eps8 |
T |
C |
6: 137,499,852 (GRCm39) |
Q209R |
possibly damaging |
Het |
| Fabp6 |
T |
A |
11: 43,486,992 (GRCm39) |
I112F |
probably benign |
Het |
| Gp1ba |
C |
T |
11: 70,532,253 (GRCm39) |
P673L |
probably damaging |
Het |
| Grin3a |
T |
C |
4: 49,702,804 (GRCm39) |
Y894C |
probably damaging |
Het |
| Hydin |
C |
T |
8: 111,173,217 (GRCm39) |
H967Y |
probably benign |
Het |
| Ip6k3 |
T |
C |
17: 27,364,242 (GRCm39) |
K269E |
possibly damaging |
Het |
| Jup |
T |
C |
11: 100,274,026 (GRCm39) |
K172E |
probably damaging |
Het |
| Katnal1 |
T |
C |
5: 148,841,486 (GRCm39) |
D126G |
probably benign |
Het |
| Knl1 |
A |
T |
2: 118,898,788 (GRCm39) |
K163M |
probably damaging |
Het |
| Krt17 |
C |
T |
11: 100,148,365 (GRCm39) |
E359K |
possibly damaging |
Het |
| Lct |
T |
A |
1: 128,235,559 (GRCm39) |
I483F |
probably damaging |
Het |
| Loxl2 |
G |
A |
14: 69,930,489 (GRCm39) |
G751D |
probably damaging |
Het |
| Ltbp4 |
G |
A |
7: 27,006,002 (GRCm39) |
R1559C |
possibly damaging |
Het |
| Man2c1 |
T |
A |
9: 57,042,503 (GRCm39) |
D183E |
probably benign |
Het |
| Med17 |
T |
C |
9: 15,187,139 (GRCm39) |
|
probably null |
Het |
| Mrgpra9 |
A |
C |
7: 46,885,561 (GRCm39) |
S34R |
probably benign |
Het |
| Mrpl44 |
T |
A |
1: 79,755,677 (GRCm39) |
N94K |
probably damaging |
Het |
| Nat8f1 |
A |
G |
6: 85,887,924 (GRCm39) |
V12A |
probably benign |
Het |
| Nr2e3 |
C |
A |
9: 59,850,797 (GRCm39) |
G354V |
probably damaging |
Het |
| Nrbp1 |
T |
A |
5: 31,403,157 (GRCm39) |
I210N |
probably damaging |
Het |
| Nup155 |
T |
C |
15: 8,141,890 (GRCm39) |
V94A |
probably benign |
Het |
| Or14a256 |
A |
T |
7: 86,265,569 (GRCm39) |
C95S |
probably damaging |
Het |
| Or52h2 |
C |
T |
7: 103,839,082 (GRCm39) |
V111I |
possibly damaging |
Het |
| Or5p76 |
T |
C |
7: 108,122,525 (GRCm39) |
I211V |
probably benign |
Het |
| Or9q2 |
A |
T |
19: 13,772,140 (GRCm39) |
Y278* |
probably null |
Het |
| Pcdhb10 |
A |
T |
18: 37,545,556 (GRCm39) |
I211F |
possibly damaging |
Het |
| Phip |
A |
C |
9: 82,797,476 (GRCm39) |
I509S |
possibly damaging |
Het |
| Pkhd1 |
C |
T |
1: 20,655,381 (GRCm39) |
|
probably null |
Het |
| Psme4 |
T |
G |
11: 30,802,744 (GRCm39) |
L1487R |
probably damaging |
Het |
| Ptgdr2 |
A |
G |
19: 10,917,857 (GRCm39) |
S125G |
probably damaging |
Het |
| Ptpro |
A |
G |
6: 137,418,114 (GRCm39) |
K126E |
probably damaging |
Het |
| Rdh16f2 |
T |
A |
10: 127,712,794 (GRCm39) |
V264E |
probably benign |
Het |
| Ric8b |
C |
T |
10: 84,783,535 (GRCm39) |
A131V |
possibly damaging |
Het |
| Rock1 |
A |
T |
18: 10,070,233 (GRCm39) |
I1280N |
probably damaging |
Het |
| Rprd2 |
A |
G |
3: 95,725,888 (GRCm39) |
V59A |
possibly damaging |
Het |
| Ruvbl1 |
T |
A |
6: 88,444,551 (GRCm39) |
C49S |
probably benign |
Het |
| Scn2a |
A |
G |
2: 65,514,189 (GRCm39) |
N291S |
probably benign |
Het |
| Serbp1 |
T |
A |
6: 67,254,904 (GRCm39) |
H325Q |
probably damaging |
Het |
| Shf |
G |
A |
2: 122,199,163 (GRCm39) |
P51S |
probably damaging |
Het |
| Shisal2b |
T |
C |
13: 104,982,470 (GRCm39) |
I151V |
probably benign |
Het |
| Slitrk3 |
G |
A |
3: 72,957,674 (GRCm39) |
T366I |
probably damaging |
Het |
| Spryd3 |
A |
T |
15: 102,026,827 (GRCm39) |
H307Q |
possibly damaging |
Het |
| Spx |
A |
T |
6: 142,364,239 (GRCm39) |
D100V |
probably benign |
Het |
| Surf4 |
A |
G |
2: 26,814,476 (GRCm39) |
F142L |
probably damaging |
Het |
| Syne2 |
T |
A |
12: 76,067,099 (GRCm39) |
|
probably null |
Het |
| Syne2 |
T |
C |
12: 76,098,952 (GRCm39) |
M5278T |
possibly damaging |
Het |
| Thap12 |
T |
C |
7: 98,365,230 (GRCm39) |
V466A |
probably benign |
Het |
| Thap3 |
T |
C |
4: 152,067,673 (GRCm39) |
K135R |
possibly damaging |
Het |
| Tmem131 |
G |
T |
1: 36,866,439 (GRCm39) |
D448E |
probably benign |
Het |
| Tmem63b |
C |
G |
17: 45,989,904 (GRCm39) |
R88P |
possibly damaging |
Het |
| Trim43a |
G |
T |
9: 88,464,146 (GRCm39) |
C19F |
probably damaging |
Het |
| Trp63 |
C |
T |
16: 25,707,870 (GRCm39) |
P526L |
possibly damaging |
Het |
| Ubqln3 |
T |
C |
7: 103,791,997 (GRCm39) |
D31G |
probably damaging |
Het |
| Utp14b |
C |
A |
1: 78,643,162 (GRCm39) |
N353K |
probably damaging |
Het |
| Vmn1r40 |
A |
G |
6: 89,691,558 (GRCm39) |
K125R |
probably damaging |
Het |
| Vmn2r1 |
A |
G |
3: 64,008,734 (GRCm39) |
Y471C |
probably damaging |
Het |
| Vmn2r13 |
A |
G |
5: 109,322,001 (GRCm39) |
I232T |
probably damaging |
Het |
| Zfp263 |
A |
C |
16: 3,564,323 (GRCm39) |
E204D |
probably benign |
Het |
| Zfp865 |
A |
T |
7: 5,032,278 (GRCm39) |
K88* |
probably null |
Het |
|
| Other mutations in Fbxw10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00941:Fbxw10
|
APN |
11 |
62,764,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01552:Fbxw10
|
APN |
11 |
62,748,510 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01625:Fbxw10
|
APN |
11 |
62,750,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01960:Fbxw10
|
APN |
11 |
62,767,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02457:Fbxw10
|
APN |
11 |
62,765,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02475:Fbxw10
|
APN |
11 |
62,748,561 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02864:Fbxw10
|
APN |
11 |
62,764,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0083:Fbxw10
|
UTSW |
11 |
62,767,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0108:Fbxw10
|
UTSW |
11 |
62,767,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0147:Fbxw10
|
UTSW |
11 |
62,738,307 (GRCm39) |
splice site |
probably null |
|
|
R0180:Fbxw10
|
UTSW |
11 |
62,743,922 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0196:Fbxw10
|
UTSW |
11 |
62,768,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0454:Fbxw10
|
UTSW |
11 |
62,767,564 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0529:Fbxw10
|
UTSW |
11 |
62,750,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0791:Fbxw10
|
UTSW |
11 |
62,738,282 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0927:Fbxw10
|
UTSW |
11 |
62,767,770 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1026:Fbxw10
|
UTSW |
11 |
62,765,997 (GRCm39) |
missense |
probably benign |
|
|
R1468:Fbxw10
|
UTSW |
11 |
62,753,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Fbxw10
|
UTSW |
11 |
62,753,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1689:Fbxw10
|
UTSW |
11 |
62,750,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1785:Fbxw10
|
UTSW |
11 |
62,750,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2130:Fbxw10
|
UTSW |
11 |
62,750,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2132:Fbxw10
|
UTSW |
11 |
62,750,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2211:Fbxw10
|
UTSW |
11 |
62,758,361 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3078:Fbxw10
|
UTSW |
11 |
62,758,339 (GRCm39) |
splice site |
probably benign |
|
|
R3700:Fbxw10
|
UTSW |
11 |
62,759,983 (GRCm39) |
splice site |
probably null |
|
|
R3932:Fbxw10
|
UTSW |
11 |
62,759,983 (GRCm39) |
splice site |
probably benign |
|
|
R4843:Fbxw10
|
UTSW |
11 |
62,738,151 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4869:Fbxw10
|
UTSW |
11 |
62,753,557 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4879:Fbxw10
|
UTSW |
11 |
62,738,573 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4980:Fbxw10
|
UTSW |
11 |
62,738,583 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5417:Fbxw10
|
UTSW |
11 |
62,767,990 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5531:Fbxw10
|
UTSW |
11 |
62,753,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5877:Fbxw10
|
UTSW |
11 |
62,748,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6028:Fbxw10
|
UTSW |
11 |
62,764,345 (GRCm39) |
nonsense |
probably null |
|
|
R6616:Fbxw10
|
UTSW |
11 |
62,743,850 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6870:Fbxw10
|
UTSW |
11 |
62,746,193 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6967:Fbxw10
|
UTSW |
11 |
62,738,429 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7409:Fbxw10
|
UTSW |
11 |
62,767,606 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7464:Fbxw10
|
UTSW |
11 |
62,744,124 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7542:Fbxw10
|
UTSW |
11 |
62,741,422 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7568:Fbxw10
|
UTSW |
11 |
62,765,994 (GRCm39) |
missense |
probably benign |
|
|
R7733:Fbxw10
|
UTSW |
11 |
62,764,223 (GRCm39) |
missense |
unknown |
|
|
R7793:Fbxw10
|
UTSW |
11 |
62,738,213 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7943:Fbxw10
|
UTSW |
11 |
62,741,487 (GRCm39) |
nonsense |
probably null |
|
|
R8003:Fbxw10
|
UTSW |
11 |
62,748,587 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8323:Fbxw10
|
UTSW |
11 |
62,767,506 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8899:Fbxw10
|
UTSW |
11 |
62,748,567 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8904:Fbxw10
|
UTSW |
11 |
62,765,831 (GRCm39) |
nonsense |
probably null |
|
|
R9035:Fbxw10
|
UTSW |
11 |
62,758,449 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9121:Fbxw10
|
UTSW |
11 |
62,738,153 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9300:Fbxw10
|
UTSW |
11 |
62,768,109 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9332:Fbxw10
|
UTSW |
11 |
62,748,585 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9334:Fbxw10
|
UTSW |
11 |
62,765,910 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9417:Fbxw10
|
UTSW |
11 |
62,753,522 (GRCm39) |
nonsense |
probably null |
|
|
R9476:Fbxw10
|
UTSW |
11 |
62,743,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9510:Fbxw10
|
UTSW |
11 |
62,743,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9520:Fbxw10
|
UTSW |
11 |
62,750,842 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9526:Fbxw10
|
UTSW |
11 |
62,765,945 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9547:Fbxw10
|
UTSW |
11 |
62,767,647 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9602:Fbxw10
|
UTSW |
11 |
62,750,782 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
Z1186:Fbxw10
|
UTSW |
11 |
62,767,671 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Fbxw10
|
UTSW |
11 |
62,738,118 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Fbxw10
|
UTSW |
11 |
62,767,671 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Fbxw10
|
UTSW |
11 |
62,738,118 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Fbxw10
|
UTSW |
11 |
62,767,671 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Fbxw10
|
UTSW |
11 |
62,738,118 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Fbxw10
|
UTSW |
11 |
62,767,671 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Fbxw10
|
UTSW |
11 |
62,738,118 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Fbxw10
|
UTSW |
11 |
62,767,671 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Fbxw10
|
UTSW |
11 |
62,738,118 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Fbxw10
|
UTSW |
11 |
62,767,671 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Fbxw10
|
UTSW |
11 |
62,738,118 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Fbxw10
|
UTSW |
11 |
62,767,671 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Fbxw10
|
UTSW |
11 |
62,738,118 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCAGAAGTGTGAAGCCTGTGTC -3'
(R):5'- CAAGCCTGTCTGTCTGCACCTATG -3'
Sequencing Primer
(F):5'- TTGCCACCAAAGAGTGGTTC -3'
(R):5'- CATGAACAGGACTCTGATCACATTG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation