Mutagenetix > Incidental Mutation

Incidental Mutation 'R1449:Or11g7'

159168

Institutional Source

Beutler Lab

Gene Symbol

Or11g7

Ensembl Gene

ENSMUSG00000095917

Gene Name

olfactory receptor family 11 subfamily G member 7

Synonyms

MOR106-4, Olfr740, GA_x6K02T2PMLR-6167145-6168080

MMRRC Submission

039504-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

R1449 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

50690511-50693135 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 50691378 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 290 (N290D)

Ref Sequence

ENSEMBL: ENSMUSP00000148916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089838] [ENSMUST00000214792]

AlphaFold

E9PV79

Predicted Effect

probably damaging
Transcript: ENSMUST00000089838
AA Change: N290D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000087276
Gene: ENSMUSG00000095917
AA Change: N290D

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	2.3e-56	PFAM
Pfam:7tm_1	45	294	1.6e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214792
AA Change: N290D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 98.8%
3x: 97.9%
10x: 94.7%
20x: 87.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700013G24Rik	A	G	4: 137,182,666 (GRCm39)	N274D	possibly damaging	Het
6430571L13Rik	T	A	9: 107,219,689 (GRCm39)	N47K	probably damaging	Het
Aasdh	C	T	5: 77,034,136 (GRCm39)	A472T	probably benign	Het
Abca13	A	G	11: 9,248,580 (GRCm39)	T2776A	probably damaging	Het
Adamts10	T	A	17: 33,764,613 (GRCm39)	V711D	probably damaging	Het
Adrb3	G	A	8: 27,717,415 (GRCm39)	R345C	probably damaging	Het
Ak7	T	C	12: 105,708,520 (GRCm39)	V325A	possibly damaging	Het
Armc6	G	A	8: 70,677,943 (GRCm39)	L129F	probably benign	Het
Bend6	T	C	1: 33,917,424 (GRCm39)	N10S	probably benign	Het
Bmpr1b	T	C	3: 141,577,134 (GRCm39)	E59G	possibly damaging	Het
Brd3	A	G	2: 27,340,263 (GRCm39)		probably null	Het
Brd3	A	G	2: 27,347,028 (GRCm39)	Y369H	probably damaging	Het
Cacna1e	C	T	1: 154,361,408 (GRCm39)		probably null	Het
Camk4	A	G	18: 33,072,528 (GRCm39)	D27G	probably damaging	Het
Camkk1	T	G	11: 72,924,710 (GRCm39)	S308A	probably damaging	Het
Catsperb	A	G	12: 101,554,456 (GRCm39)	T717A	probably benign	Het
Cdh23	A	T	10: 60,212,730 (GRCm39)	S1563R	probably damaging	Het
Cep44	A	T	8: 56,993,985 (GRCm39)	S197R	probably benign	Het
Col3a1	T	A	1: 45,360,771 (GRCm39)	I67N	unknown	Het
Dcaf12l1	T	C	X: 43,878,304 (GRCm39)	T165A	probably benign	Het
Dicer1	T	C	12: 104,695,502 (GRCm39)	Y143C	possibly damaging	Het
Dlg5	A	G	14: 24,185,711 (GRCm39)	I1898T	possibly damaging	Het
Dnah1	T	C	14: 30,985,908 (GRCm39)	N3762D	probably damaging	Het
Dscaml1	A	T	9: 45,653,521 (GRCm39)	T1382S	possibly damaging	Het
Entpd3	A	T	9: 120,395,555 (GRCm39)	R513W	probably damaging	Het
Foxred1	A	G	9: 35,120,738 (GRCm39)	S132P	probably damaging	Het
Ftsj3	T	C	11: 106,143,826 (GRCm39)	I273V	probably benign	Het
Hsd17b7	C	T	1: 169,787,251 (GRCm39)		probably null	Het
Iars1	T	A	13: 49,887,186 (GRCm39)	V1253D	probably damaging	Het
Iqsec1	T	A	6: 90,667,790 (GRCm39)	K216*	probably null	Het
Itga7	A	G	10: 128,789,370 (GRCm39)	D971G	probably benign	Het
Kcnk2	G	A	1: 189,072,223 (GRCm39)	S35L	probably benign	Het
Kif13a	T	C	13: 46,966,212 (GRCm39)	Y402C	probably damaging	Het
Lamc1	A	G	1: 153,126,241 (GRCm39)	S484P	probably benign	Het
Lap3	T	C	5: 45,666,861 (GRCm39)		probably null	Het
Lhx8	G	T	3: 154,033,742 (GRCm39)	S46*	probably null	Het
Lin7a	T	C	10: 107,159,813 (GRCm39)	S42P	probably damaging	Het
Lrba	G	A	3: 86,261,585 (GRCm39)	R1513Q	probably damaging	Het
Maml2	C	A	9: 13,531,980 (GRCm39)	P398Q	possibly damaging	Het
Mast2	T	C	4: 116,166,210 (GRCm39)	I1201V	probably damaging	Het
Mmp20	A	T	9: 7,642,769 (GRCm39)	D201V	probably damaging	Het
Morn5	T	A	2: 35,947,092 (GRCm39)	C123*	probably null	Het
Mrpl4	A	G	9: 20,918,807 (GRCm39)	K175E	possibly damaging	Het
Nav3	A	T	10: 109,689,372 (GRCm39)	S302T	probably benign	Het
Ndrg2	T	C	14: 52,145,591 (GRCm39)	Y217C	probably damaging	Het
Nfx1	A	G	4: 40,976,803 (GRCm39)	D159G	probably damaging	Het
Nlrp9b	A	T	7: 19,757,089 (GRCm39)	T109S	possibly damaging	Het
Npepps	A	G	11: 97,097,980 (GRCm39)	Y909H	probably benign	Het
Or10g1	A	G	14: 52,648,024 (GRCm39)	C102R	probably damaging	Het
Or51a25	A	T	7: 102,373,397 (GRCm39)	F100Y	probably damaging	Het
Or6c211	T	A	10: 129,506,238 (GRCm39)	D50V	probably damaging	Het
Or6c69b	A	C	10: 129,626,723 (GRCm39)	V245G	probably damaging	Het
Pcdh1	T	C	18: 38,322,929 (GRCm39)	H968R	probably damaging	Het
Pde1b	T	A	15: 103,433,470 (GRCm39)	I296N	probably damaging	Het
Phldb1	T	A	9: 44,627,930 (GRCm39)	T172S	probably benign	Het
Plxdc2	T	C	2: 16,665,592 (GRCm39)	V215A	possibly damaging	Het
Poln	A	G	5: 34,171,682 (GRCm39)	I695T	probably damaging	Het
Pou6f2	G	T	13: 18,347,000 (GRCm39)	Q31K	probably damaging	Het
Psd	T	A	19: 46,313,250 (GRCm39)	Y40F	probably damaging	Het
Rnf126	T	C	10: 79,597,448 (GRCm39)	N155D	probably benign	Het
Rpl36-ps3	C	A	12: 12,962,032 (GRCm39)		noncoding transcript	Het
Rrp15	C	A	1: 186,468,465 (GRCm39)	V184F	possibly damaging	Het
Rslcan18	G	T	13: 67,250,164 (GRCm39)	L24M	possibly damaging	Het
Sall1	A	G	8: 89,759,111 (GRCm39)	I331T	probably benign	Het
Slamf7	A	T	1: 171,468,606 (GRCm39)	N95K	possibly damaging	Het
Slc1a6	T	C	10: 78,635,951 (GRCm39)	Y339H	probably damaging	Het
Slc39a8	A	G	3: 135,532,446 (GRCm39)	N72D	probably benign	Het
Slf1	A	G	13: 77,231,568 (GRCm39)	S604P	probably damaging	Het
Slfn4	C	T	11: 83,079,819 (GRCm39)	T110M	probably benign	Het
Tnpo1	T	C	13: 99,015,220 (GRCm39)	T116A	probably damaging	Het
Tor1b	T	C	2: 30,845,893 (GRCm39)	I190T	probably damaging	Het
Ttn	C	A	2: 76,800,138 (GRCm39)	E357*	probably null	Het
Tubg2	G	T	11: 101,047,699 (GRCm39)	E95*	probably null	Het
Ubap2	A	G	4: 41,209,351 (GRCm39)		probably null	Het
Ube2i	T	C	17: 25,487,538 (GRCm39)	D67G	possibly damaging	Het
Ubxn11	A	G	4: 133,852,203 (GRCm39)	E50G	probably damaging	Het
Wnk1	A	G	6: 119,929,779 (GRCm39)	V1246A	probably damaging	Het
Zcchc7	A	G	4: 44,929,124 (GRCm39)	T38A	possibly damaging	Het
Zfp236	A	G	18: 82,664,130 (GRCm39)	S552P	probably damaging	Het

Other mutations in Or11g7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01663:Or11g7	APN	14	50,690,607 (GRCm39)	missense	probably benign	0.04
IGL02117:Or11g7	APN	14	50,691,399 (GRCm39)	missense	possibly damaging	0.91
IGL02663:Or11g7	APN	14	50,691,309 (GRCm39)	missense	probably benign	0.02
IGL02858:Or11g7	APN	14	50,690,507 (GRCm39)	utr 5 prime	probably benign
IGL02955:Or11g7	APN	14	50,691,442 (GRCm39)	missense	probably damaging	0.99
IGL03210:Or11g7	APN	14	50,691,440 (GRCm39)	missense	probably benign	0.10
IGL03249:Or11g7	APN	14	50,690,668 (GRCm39)	missense	probably damaging	0.98
G1Funyon:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
R0946:Or11g7	UTSW	14	50,691,130 (GRCm39)	missense	probably benign	0.13
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1465:Or11g7	UTSW	14	50,690,634 (GRCm39)	missense	possibly damaging	0.91
R1513:Or11g7	UTSW	14	50,691,138 (GRCm39)	missense	probably benign	0.00
R1908:Or11g7	UTSW	14	50,691,295 (GRCm39)	missense	probably damaging	0.99
R2422:Or11g7	UTSW	14	50,690,893 (GRCm39)	missense	probably damaging	1.00
R3406:Or11g7	UTSW	14	50,690,653 (GRCm39)	missense	probably benign	0.14
R4184:Or11g7	UTSW	14	50,690,827 (GRCm39)	missense	probably damaging	1.00
R4795:Or11g7	UTSW	14	50,690,874 (GRCm39)	missense	probably damaging	0.96
R5028:Or11g7	UTSW	14	50,691,196 (GRCm39)	missense	probably damaging	1.00
R5436:Or11g7	UTSW	14	50,691,184 (GRCm39)	missense	probably damaging	1.00
R6057:Or11g7	UTSW	14	50,691,201 (GRCm39)	nonsense	probably null
R6455:Or11g7	UTSW	14	50,691,042 (GRCm39)	missense	possibly damaging	0.92
R6903:Or11g7	UTSW	14	50,691,412 (GRCm39)	missense	possibly damaging	0.93
R6998:Or11g7	UTSW	14	50,690,890 (GRCm39)	missense	probably benign	0.29
R7671:Or11g7	UTSW	14	50,691,342 (GRCm39)	missense	probably benign	0.04
R8048:Or11g7	UTSW	14	50,691,373 (GRCm39)	missense	possibly damaging	0.52
R8301:Or11g7	UTSW	14	50,691,021 (GRCm39)	missense	probably benign	0.08
X0066:Or11g7	UTSW	14	50,691,115 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- AGGCTTTCTCCACTTGCGGATCTCAT -3'
(R):5'- CCTAGTCTCTGGGAAACATCCTATCCCT -3'

Sequencing Primer
(F):5'- GCGGATCTCATCTCACAGTAG -3'
(R):5'- gctcctgtcagtaagcacttc -3'

Posted On

2014-03-14