Mutagenetix > Incidental Mutations

Incidental Mutation 'R1433:Oas1g'

159305

Institutional Source

Beutler Lab

Gene Symbol

Oas1g

Ensembl Gene

ENSMUSG00000066861

Gene Name

2'-5' oligoadenylate synthetase 1G

Synonyms

Mmu-L2, Mmu-L, L2, Oas1a, Oias1, Oias-1

MMRRC Submission

039488-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R1433 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

120876142-120887613 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 120881949 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 198 (F198S)

Ref Sequence

ENSEMBL: ENSMUSP00000124597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086368] [ENSMUST00000162096]

Predicted Effect

probably damaging
Transcript: ENSMUST00000086368
AA Change: F198S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000083555
Gene: ENSMUSG00000066861
AA Change: F198S

Domain	Start	End	E-Value	Type
Pfam:NTP_transf_2	38	139	1.6e-13	PFAM
Pfam:OAS1_C	164	349	6.9e-87	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161809

Predicted Effect

probably damaging
Transcript: ENSMUST00000162096
AA Change: F198S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124597
Gene: ENSMUSG00000066861
AA Change: F198S

Domain	Start	End	E-Value	Type
Pfam:NTP_transf_2	42	138	1.1e-9	PFAM
Pfam:OAS1_C	163	231	1.4e-24	PFAM

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 94.8%
20x: 87.9%

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a member of the oligoadenylate synthetase family of proteins. This gene and several other family members are present in a gene cluster on chromosome 5. These proteins are believed to function in antiviral immunity through binding to viral dsRNA and subsequent synthesis of 2'-5'-oligoadenylates. The expression of this gene has been shown to be induced by interferon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
8430408G22Rik	A	T	6: 116,652,262	S189C	possibly damaging	Het
Acp1	C	T	12: 30,895,935	E140K	possibly damaging	Het
Acsm4	T	A	7: 119,693,819	D57E	probably damaging	Het
Adamts9	A	G	6: 92,849,290		probably null	Het
Aen	T	A	7: 78,907,312	Y303N	probably damaging	Het
Alcam	T	C	16: 52,295,752		probably null	Het
Apol7b	A	G	15: 77,425,546	L17P	probably damaging	Het
Cacna1c	A	T	6: 118,652,793	Y1058*	probably null	Het
Camk2d	T	C	3: 126,808,224	V354A	probably benign	Het
Carf	T	G	1: 60,124,858	M43R	probably damaging	Het
Casp8	T	A	1: 58,824,124	F81Y	probably damaging	Het
Cd74	G	A	18: 60,803,992	R20H	probably benign	Het
Cers5	A	T	15: 99,745,931	Y16*	probably null	Het
Chuk	A	T	19: 44,078,958	M586K	probably null	Het
D130043K22Rik	C	A	13: 24,871,341	P496Q	probably damaging	Het
Dab2	A	G	15: 6,429,938	R311G	probably damaging	Het
Diaph1	A	T	18: 37,905,134	I48N	unknown	Het
Dnajc13	T	C	9: 104,180,121	D1560G	probably damaging	Het
Dsg2	T	C	18: 20,582,723	S241P	probably damaging	Het
Efcab5	T	C	11: 77,105,378	D1119G	probably benign	Het
Efr3a	G	T	15: 65,869,057		probably benign	Het
Evc2	A	G	5: 37,393,083	K814E	probably damaging	Het
Gm5724	A	G	6: 141,765,703	M94T	probably benign	Het
Hic2	A	G	16: 17,258,822	D505G	probably benign	Het
Ing1	T	A	8: 11,557,010	V34D	probably damaging	Het
Inpp5k	A	G	11: 75,637,491	M172V	probably benign	Het
Itgae	T	C	11: 73,115,592	V362A	probably damaging	Het
Lama2	T	A	10: 27,187,754	R1346S	probably damaging	Het
Lrrc7	T	C	3: 158,177,306	N450S	probably damaging	Het
Lrrn3	T	A	12: 41,452,584	Y578F	possibly damaging	Het
Maml2	A	T	9: 13,706,501	N381I	probably damaging	Het
Mettl15	T	G	2: 109,092,921	E385D	probably benign	Het
Mthfr	T	A	4: 148,055,443	I623N	possibly damaging	Het
Muc4	A	C	16: 32,753,020	N966T	probably benign	Het
Myoc	A	G	1: 162,648,996	Y423C	probably damaging	Het
Ncoa2	A	T	1: 13,148,378	M1409K	probably benign	Het
Ncor2	T	C	5: 125,109,975		probably benign	Het
Numb	T	C	12: 83,797,259	E395G	probably damaging	Het
Olfr1367	T	C	13: 21,347,024	V32A	probably benign	Het
Olfr181	A	G	16: 58,925,686	V295A	probably benign	Het
Prdm13	T	A	4: 21,678,909	Y527F	probably damaging	Het
Prr14l	A	G	5: 32,828,833	L1106P	probably damaging	Het
Ptbp1	T	A	10: 79,863,273	I555N	probably damaging	Het
Ptchd4	A	T	17: 42,503,715	T836S	possibly damaging	Het
Rlbp1	T	C	7: 79,383,938	D3G	probably benign	Het
Sdk2	T	C	11: 113,795,045	E1883G	probably damaging	Het
Serpinc1	A	T	1: 160,993,404	K140N	probably damaging	Het
Serpind1	A	T	16: 17,342,385	Y382F	probably damaging	Het
Slc28a3	T	C	13: 58,563,106	E534G	probably damaging	Het
Ttyh2	T	A	11: 114,710,179	I418N	probably benign	Het
Tubgcp4	C	T	2: 121,175,424	Q98*	probably null	Het
Ugt2a2	A	G	5: 87,464,106	L315P	probably damaging	Het
Vwa1	A	T	4: 155,772,901	S147T	probably damaging	Het
Xylt1	T	C	7: 117,591,952	V325A	possibly damaging	Het
Zfp335	T	C	2: 164,899,456	H685R	probably damaging	Het

Other mutations in Oas1g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00339:Oas1g	APN	5	120886046	nonsense	probably null
R0389:Oas1g	UTSW	5	120887529	missense	probably benign	0.01
R1468:Oas1g	UTSW	5	120882006	missense	probably benign	0.02
R1468:Oas1g	UTSW	5	120882006	missense	probably benign	0.02
R1926:Oas1g	UTSW	5	120879142	missense	probably benign	0.00
R2062:Oas1g	UTSW	5	120885883	missense	probably damaging	1.00
R2063:Oas1g	UTSW	5	120885883	missense	probably damaging	1.00
R2064:Oas1g	UTSW	5	120885883	missense	probably damaging	1.00
R2067:Oas1g	UTSW	5	120885883	missense	probably damaging	1.00
R2932:Oas1g	UTSW	5	120879143	missense	probably benign	0.00
R4296:Oas1g	UTSW	5	120879167	missense	probably damaging	1.00
R4808:Oas1g	UTSW	5	120879322	missense	possibly damaging	0.45
R5874:Oas1g	UTSW	5	120877018	missense	probably benign
R6842:Oas1g	UTSW	5	120887558	missense	probably benign	0.01
R7314:Oas1g	UTSW	5	120878463	missense	probably damaging	1.00
R7729:Oas1g	UTSW	5	120886000	missense	probably damaging	1.00
Z1177:Oas1g	UTSW	5	120878330	missense	probably damaging	1.00

Predicted Primers

Posted On

2014-03-14