Incidental Mutation 'R1433:Slco1a7'
ID 159313
Institutional Source Beutler Lab
Gene Symbol Slco1a7
Ensembl Gene ENSMUSG00000084927
Gene Name solute carrier organic anion transporter family, member 1a7
Synonyms Gm5724
MMRRC Submission 039488-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R1433 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 141653844-141719536 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 141711429 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 94 (M94T)
Ref Sequence ENSEMBL: ENSMUSP00000117177 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000148411]
AlphaFold L7N264
Predicted Effect probably benign
Transcript: ENSMUST00000148411
AA Change: M94T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000117177
Gene: ENSMUSG00000084927
AA Change: M94T

DomainStartEndE-ValueType
Pfam:MFS_1 22 405 3.4e-26 PFAM
KAZAL 438 484 1.71e0 SMART
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.8%
  • 20x: 87.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp1 C T 12: 30,945,934 (GRCm39) E140K possibly damaging Het
Acsm4 T A 7: 119,293,042 (GRCm39) D57E probably damaging Het
Adamts9 A G 6: 92,826,271 (GRCm39) probably null Het
Aen T A 7: 78,557,060 (GRCm39) Y303N probably damaging Het
Alcam T C 16: 52,116,115 (GRCm39) probably null Het
Apol7b A G 15: 77,309,746 (GRCm39) L17P probably damaging Het
Cacna1c A T 6: 118,629,754 (GRCm39) Y1058* probably null Het
Camk2d T C 3: 126,601,873 (GRCm39) V354A probably benign Het
Carf T G 1: 60,164,017 (GRCm39) M43R probably damaging Het
Casp8 T A 1: 58,863,283 (GRCm39) F81Y probably damaging Het
Cd74 G A 18: 60,937,064 (GRCm39) R20H probably benign Het
Cers5 A T 15: 99,643,812 (GRCm39) Y16* probably null Het
Chuk A T 19: 44,067,397 (GRCm39) M586K probably null Het
D130043K22Rik C A 13: 25,055,324 (GRCm39) P496Q probably damaging Het
Dab2 A G 15: 6,459,419 (GRCm39) R311G probably damaging Het
Depp1 A T 6: 116,629,223 (GRCm39) S189C possibly damaging Het
Diaph1 A T 18: 38,038,187 (GRCm39) I48N unknown Het
Dnajc13 T C 9: 104,057,320 (GRCm39) D1560G probably damaging Het
Dsg2 T C 18: 20,715,780 (GRCm39) S241P probably damaging Het
Efcab5 T C 11: 76,996,204 (GRCm39) D1119G probably benign Het
Efr3a G T 15: 65,740,906 (GRCm39) probably benign Het
Evc2 A G 5: 37,550,427 (GRCm39) K814E probably damaging Het
Hic2 A G 16: 17,076,686 (GRCm39) D505G probably benign Het
Ing1 T A 8: 11,607,010 (GRCm39) V34D probably damaging Het
Inpp5k A G 11: 75,528,317 (GRCm39) M172V probably benign Het
Itgae T C 11: 73,006,418 (GRCm39) V362A probably damaging Het
Lama2 T A 10: 27,063,750 (GRCm39) R1346S probably damaging Het
Lrrc7 T C 3: 157,882,943 (GRCm39) N450S probably damaging Het
Lrrn3 T A 12: 41,502,583 (GRCm39) Y578F possibly damaging Het
Maml2 A T 9: 13,617,797 (GRCm39) N381I probably damaging Het
Mettl15 T G 2: 108,923,266 (GRCm39) E385D probably benign Het
Mthfr T A 4: 148,139,900 (GRCm39) I623N possibly damaging Het
Muc4 A C 16: 32,574,448 (GRCm39) N966T probably benign Het
Myoc A G 1: 162,476,565 (GRCm39) Y423C probably damaging Het
Ncoa2 A T 1: 13,218,602 (GRCm39) M1409K probably benign Het
Ncor2 T C 5: 125,187,039 (GRCm39) probably benign Het
Numb T C 12: 83,844,033 (GRCm39) E395G probably damaging Het
Oas1g A G 5: 121,020,012 (GRCm39) F198S probably damaging Het
Or2b28 T C 13: 21,531,194 (GRCm39) V32A probably benign Het
Or5k17 A G 16: 58,746,049 (GRCm39) V295A probably benign Het
Prdm13 T A 4: 21,678,909 (GRCm39) Y527F probably damaging Het
Prr14l A G 5: 32,986,177 (GRCm39) L1106P probably damaging Het
Ptbp1 T A 10: 79,699,107 (GRCm39) I555N probably damaging Het
Ptchd4 A T 17: 42,814,606 (GRCm39) T836S possibly damaging Het
Rlbp1 T C 7: 79,033,686 (GRCm39) D3G probably benign Het
Sdk2 T C 11: 113,685,871 (GRCm39) E1883G probably damaging Het
Serpinc1 A T 1: 160,820,974 (GRCm39) K140N probably damaging Het
Serpind1 A T 16: 17,160,249 (GRCm39) Y382F probably damaging Het
Slc28a3 T C 13: 58,710,920 (GRCm39) E534G probably damaging Het
Ttyh2 T A 11: 114,601,005 (GRCm39) I418N probably benign Het
Tubgcp4 C T 2: 121,005,905 (GRCm39) Q98* probably null Het
Ugt2a2 A G 5: 87,611,965 (GRCm39) L315P probably damaging Het
Vwa1 A T 4: 155,857,358 (GRCm39) S147T probably damaging Het
Xylt1 T C 7: 117,191,179 (GRCm39) V325A possibly damaging Het
Zfp335 T C 2: 164,741,376 (GRCm39) H685R probably damaging Het
Other mutations in Slco1a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01023:Slco1a7 APN 6 141,700,155 (GRCm39) missense probably benign 0.14
IGL01347:Slco1a7 APN 6 141,700,192 (GRCm39) nonsense probably null
IGL01539:Slco1a7 APN 6 141,673,333 (GRCm39) missense possibly damaging 0.88
IGL01613:Slco1a7 APN 6 141,658,940 (GRCm39) missense possibly damaging 0.67
IGL02060:Slco1a7 APN 6 141,700,134 (GRCm39) missense probably benign 0.00
IGL02063:Slco1a7 APN 6 141,684,615 (GRCm39) missense probably benign 0.01
IGL02126:Slco1a7 APN 6 141,684,739 (GRCm39) missense probably benign 0.29
IGL02214:Slco1a7 APN 6 141,668,911 (GRCm39) missense possibly damaging 0.50
IGL02630:Slco1a7 APN 6 141,668,836 (GRCm39) missense probably damaging 1.00
R0966:Slco1a7 UTSW 6 141,673,299 (GRCm39) missense probably benign 0.00
R1082:Slco1a7 UTSW 6 141,657,859 (GRCm39) missense probably damaging 1.00
R1571:Slco1a7 UTSW 6 141,700,135 (GRCm39) nonsense probably null
R1765:Slco1a7 UTSW 6 141,700,084 (GRCm39) splice site probably benign
R2055:Slco1a7 UTSW 6 141,671,181 (GRCm39) missense probably benign 0.33
R2174:Slco1a7 UTSW 6 141,673,319 (GRCm39) nonsense probably null
R2495:Slco1a7 UTSW 6 141,711,503 (GRCm39) missense probably benign 0.02
R2857:Slco1a7 UTSW 6 141,690,264 (GRCm39) missense probably benign 0.35
R3551:Slco1a7 UTSW 6 141,654,322 (GRCm39) missense probably benign 0.20
R3824:Slco1a7 UTSW 6 141,700,100 (GRCm39) missense possibly damaging 0.50
R3912:Slco1a7 UTSW 6 141,673,362 (GRCm39) missense probably damaging 0.97
R3942:Slco1a7 UTSW 6 141,673,440 (GRCm39) missense probably damaging 0.98
R4161:Slco1a7 UTSW 6 141,654,322 (GRCm39) missense probably benign 0.20
R4168:Slco1a7 UTSW 6 141,684,673 (GRCm39) missense probably benign 0.03
R4395:Slco1a7 UTSW 6 141,657,844 (GRCm39) missense probably benign 0.02
R4720:Slco1a7 UTSW 6 141,668,948 (GRCm39) missense probably damaging 1.00
R4732:Slco1a7 UTSW 6 141,668,905 (GRCm39) missense probably benign 0.01
R4733:Slco1a7 UTSW 6 141,668,905 (GRCm39) missense probably benign 0.01
R4794:Slco1a7 UTSW 6 141,713,288 (GRCm39) missense probably benign 0.11
R5062:Slco1a7 UTSW 6 141,713,180 (GRCm39) missense possibly damaging 0.46
R5389:Slco1a7 UTSW 6 141,686,193 (GRCm39) missense probably benign 0.12
R5419:Slco1a7 UTSW 6 141,681,826 (GRCm39) splice site probably null
R5423:Slco1a7 UTSW 6 141,690,188 (GRCm39) missense probably damaging 1.00
R5704:Slco1a7 UTSW 6 141,658,980 (GRCm39) missense probably benign 0.00
R5973:Slco1a7 UTSW 6 141,700,182 (GRCm39) missense probably benign 0.01
R6041:Slco1a7 UTSW 6 141,684,764 (GRCm39) missense probably benign 0.11
R6284:Slco1a7 UTSW 6 141,671,119 (GRCm39) missense probably damaging 1.00
R6395:Slco1a7 UTSW 6 141,668,818 (GRCm39) splice site probably null
R6993:Slco1a7 UTSW 6 141,711,468 (GRCm39) missense possibly damaging 0.94
R7149:Slco1a7 UTSW 6 141,690,178 (GRCm39) missense probably damaging 1.00
R7159:Slco1a7 UTSW 6 141,719,504 (GRCm39) start codon destroyed probably damaging 1.00
R7627:Slco1a7 UTSW 6 141,690,271 (GRCm39) missense probably damaging 1.00
R7784:Slco1a7 UTSW 6 141,658,919 (GRCm39) critical splice donor site probably null
R7873:Slco1a7 UTSW 6 141,673,448 (GRCm39) missense probably benign 0.44
R8670:Slco1a7 UTSW 6 141,711,468 (GRCm39) missense possibly damaging 0.94
R8720:Slco1a7 UTSW 6 141,668,852 (GRCm39) missense probably benign 0.01
R9124:Slco1a7 UTSW 6 141,668,830 (GRCm39) missense possibly damaging 0.81
R9238:Slco1a7 UTSW 6 141,686,153 (GRCm39) missense probably damaging 0.98
R9381:Slco1a7 UTSW 6 141,711,490 (GRCm39) missense probably benign 0.00
X0020:Slco1a7 UTSW 6 141,700,091 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATAGTCCTCATGAAGGAGGCAGCACC -3'
(R):5'- CCAAAGAGCTGGAGAGGATGTTGACTC -3'

Sequencing Primer
(F):5'- AGAGAATCAGTTCCTGTGTCTCAC -3'
(R):5'- ATGTTGACTCAGTGTTGCTAAGAC -3'
Posted On 2014-03-14