Incidental Mutation 'R1416:Vmn2r63'
| ID |
159587 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r63
|
| Ensembl Gene |
ENSMUSG00000090751 |
| Gene Name |
vomeronasal 2, receptor 63 |
| Synonyms |
EG435975 |
| MMRRC Submission |
039472-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.074)
|
| Stock # |
R1416 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
42552675-42583213 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 42577339 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 400
(I400L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000163803]
|
| AlphaFold |
E9Q0K5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163803
AA Change: I400L
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000129089
Gene: ENSMUSG00000090751
AA Change: I400L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
3.5e-43 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
5.1e-23 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
3.5e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 92.1%
|
| Validation Efficiency |
94% (63/67) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad11 |
T |
C |
9: 103,950,822 (GRCm39) |
S49P |
probably damaging |
Het |
| Afm |
T |
C |
5: 90,674,238 (GRCm39) |
I250T |
possibly damaging |
Het |
| Alox5 |
G |
A |
6: 116,400,106 (GRCm39) |
Q278* |
probably null |
Het |
| Anxa7 |
G |
A |
14: 20,512,775 (GRCm39) |
R253C |
probably damaging |
Het |
| Arfgef1 |
T |
A |
1: 10,243,164 (GRCm39) |
T1059S |
probably damaging |
Het |
| Arpp21 |
T |
C |
9: 112,008,197 (GRCm39) |
E101G |
probably damaging |
Het |
| Bcr |
A |
T |
10: 74,897,338 (GRCm39) |
I161F |
possibly damaging |
Het |
| Ccdc141 |
T |
C |
2: 76,845,140 (GRCm39) |
E1309G |
probably damaging |
Het |
| Ccdc39 |
T |
C |
3: 33,880,629 (GRCm39) |
K446R |
probably damaging |
Het |
| Cep41 |
C |
T |
6: 30,657,356 (GRCm39) |
S233N |
probably damaging |
Het |
| Col5a1 |
T |
G |
2: 27,812,076 (GRCm39) |
S53A |
unknown |
Het |
| Cplane1 |
C |
T |
15: 8,276,422 (GRCm39) |
Q2689* |
probably null |
Het |
| Efnb2 |
A |
G |
8: 8,672,329 (GRCm39) |
|
probably null |
Het |
| Epb41l5 |
T |
C |
1: 119,477,606 (GRCm39) |
|
probably benign |
Het |
| Eri2 |
A |
G |
7: 119,390,397 (GRCm39) |
F77S |
probably damaging |
Het |
| Ern1 |
C |
T |
11: 106,312,806 (GRCm39) |
|
probably benign |
Het |
| Eya3 |
T |
C |
4: 132,434,440 (GRCm39) |
|
probably benign |
Het |
| Icos |
T |
C |
1: 61,033,802 (GRCm39) |
L144P |
probably damaging |
Het |
| Ipo8 |
A |
G |
6: 148,690,591 (GRCm39) |
V717A |
probably benign |
Het |
| Lrp12 |
T |
C |
15: 39,742,019 (GRCm39) |
E232G |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 40,888,228 (GRCm39) |
I2344T |
probably damaging |
Het |
| Mettl5 |
A |
T |
2: 69,701,633 (GRCm39) |
F207I |
possibly damaging |
Het |
| Mtor |
G |
T |
4: 148,575,871 (GRCm39) |
E1342* |
probably null |
Het |
| Nrap |
A |
G |
19: 56,315,725 (GRCm39) |
Y1360H |
possibly damaging |
Het |
| Nsun7 |
T |
C |
5: 66,418,423 (GRCm39) |
V51A |
probably damaging |
Het |
| Or5an11 |
C |
A |
19: 12,246,258 (GRCm39) |
F221L |
probably benign |
Het |
| Or5p5 |
T |
C |
7: 107,414,469 (GRCm39) |
L228P |
probably damaging |
Het |
| Or8g18 |
G |
C |
9: 39,149,547 (GRCm39) |
P58A |
probably benign |
Het |
| Or8k27 |
T |
C |
2: 86,275,664 (GRCm39) |
I221V |
probably benign |
Het |
| Or9m1b |
T |
A |
2: 87,836,915 (GRCm39) |
Y60F |
probably damaging |
Het |
| Otud6b |
A |
C |
4: 14,818,473 (GRCm39) |
L143V |
probably damaging |
Het |
| Pabir2 |
T |
C |
X: 52,335,023 (GRCm39) |
*256W |
probably null |
Het |
| Pp2d1 |
T |
C |
17: 53,822,835 (GRCm39) |
N77S |
probably benign |
Het |
| Ppp4r3c2 |
A |
T |
X: 88,797,283 (GRCm39) |
M372L |
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Pwwp4a |
G |
T |
X: 72,171,261 (GRCm39) |
G218C |
probably damaging |
Het |
| Raly |
G |
T |
2: 154,699,273 (GRCm39) |
G26* |
probably null |
Het |
| Rarb |
T |
C |
14: 16,435,177 (GRCm38) |
M290V |
possibly damaging |
Het |
| Rusc2 |
A |
G |
4: 43,421,617 (GRCm39) |
E679G |
possibly damaging |
Het |
| Scap |
T |
C |
9: 110,213,841 (GRCm39) |
V1268A |
probably damaging |
Het |
| Setd1b |
C |
T |
5: 123,298,748 (GRCm39) |
|
probably benign |
Het |
| Shisa3 |
C |
G |
5: 67,768,777 (GRCm39) |
P226A |
probably benign |
Het |
| Smox |
C |
T |
2: 131,364,051 (GRCm39) |
S481F |
probably damaging |
Het |
| Stard9 |
T |
C |
2: 120,531,453 (GRCm39) |
V2570A |
probably benign |
Het |
| Sucla2 |
C |
T |
14: 73,798,074 (GRCm39) |
|
probably benign |
Het |
| Sult4a1 |
C |
T |
15: 83,970,847 (GRCm39) |
R186Q |
probably benign |
Het |
| Taf2 |
G |
T |
15: 54,901,806 (GRCm39) |
A796E |
possibly damaging |
Het |
| Taf4b |
T |
C |
18: 14,954,484 (GRCm39) |
|
probably benign |
Het |
| Thbs4 |
G |
T |
13: 92,898,041 (GRCm39) |
Q593K |
probably benign |
Het |
| Tigd3 |
T |
C |
19: 5,941,753 (GRCm39) |
D459G |
probably benign |
Het |
| Tmem168 |
A |
T |
6: 13,591,400 (GRCm39) |
L472Q |
probably damaging |
Het |
| Tmem169 |
G |
T |
1: 72,339,875 (GRCm39) |
V102F |
probably damaging |
Het |
| Tmem241 |
T |
C |
18: 12,126,631 (GRCm39) |
T274A |
probably benign |
Het |
| Trip10 |
A |
G |
17: 57,557,800 (GRCm39) |
Y28C |
probably damaging |
Het |
| Ubp1 |
T |
C |
9: 113,799,239 (GRCm39) |
V398A |
probably benign |
Het |
| Ubr3 |
A |
G |
2: 69,775,415 (GRCm39) |
Y567C |
probably damaging |
Het |
| Uckl1 |
A |
T |
2: 181,211,362 (GRCm39) |
M489K |
possibly damaging |
Het |
| Ush2a |
C |
T |
1: 188,169,080 (GRCm39) |
P1074S |
probably damaging |
Het |
| Vmn1r62 |
T |
C |
7: 5,678,904 (GRCm39) |
V195A |
probably damaging |
Het |
| Vmn2r67 |
T |
A |
7: 84,800,824 (GRCm39) |
I371F |
probably benign |
Het |
| Wdr64 |
A |
G |
1: 175,633,568 (GRCm39) |
T940A |
probably benign |
Het |
| Zfp105 |
A |
T |
9: 122,759,742 (GRCm39) |
Y471F |
probably damaging |
Het |
| Zfp287 |
A |
T |
11: 62,605,166 (GRCm39) |
H580Q |
probably damaging |
Het |
|
| Other mutations in Vmn2r63 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01399:Vmn2r63
|
APN |
7 |
42,553,543 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01765:Vmn2r63
|
APN |
7 |
42,552,788 (GRCm39) |
missense |
probably benign |
|
|
IGL02203:Vmn2r63
|
APN |
7 |
42,553,432 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02825:Vmn2r63
|
APN |
7 |
42,576,274 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03155:Vmn2r63
|
APN |
7 |
42,552,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03260:Vmn2r63
|
APN |
7 |
42,578,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03411:Vmn2r63
|
APN |
7 |
42,577,368 (GRCm39) |
missense |
probably benign |
0.42 |
|
PIT4280001:Vmn2r63
|
UTSW |
7 |
42,553,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0066:Vmn2r63
|
UTSW |
7 |
42,576,514 (GRCm39) |
splice site |
probably benign |
|
|
R0328:Vmn2r63
|
UTSW |
7 |
42,552,699 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0344:Vmn2r63
|
UTSW |
7 |
42,553,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0554:Vmn2r63
|
UTSW |
7 |
42,583,129 (GRCm39) |
nonsense |
probably null |
|
|
R0555:Vmn2r63
|
UTSW |
7 |
42,577,952 (GRCm39) |
nonsense |
probably null |
|
|
R0685:Vmn2r63
|
UTSW |
7 |
42,577,434 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0751:Vmn2r63
|
UTSW |
7 |
42,577,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1372:Vmn2r63
|
UTSW |
7 |
42,578,642 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1502:Vmn2r63
|
UTSW |
7 |
42,578,015 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1563:Vmn2r63
|
UTSW |
7 |
42,553,550 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1652:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1693:Vmn2r63
|
UTSW |
7 |
42,577,743 (GRCm39) |
missense |
probably benign |
|
|
R1698:Vmn2r63
|
UTSW |
7 |
42,583,038 (GRCm39) |
missense |
probably benign |
|
|
R1753:Vmn2r63
|
UTSW |
7 |
42,577,669 (GRCm39) |
nonsense |
probably null |
|
|
R2136:Vmn2r63
|
UTSW |
7 |
42,576,297 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2175:Vmn2r63
|
UTSW |
7 |
42,583,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2261:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2262:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2263:Vmn2r63
|
UTSW |
7 |
42,578,031 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3413:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3426:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3427:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3802:Vmn2r63
|
UTSW |
7 |
42,552,829 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4319:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4321:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4323:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4346:Vmn2r63
|
UTSW |
7 |
42,577,537 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4568:Vmn2r63
|
UTSW |
7 |
42,583,250 (GRCm39) |
splice site |
probably null |
|
|
R4649:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4653:Vmn2r63
|
UTSW |
7 |
42,553,114 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4679:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4741:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4748:Vmn2r63
|
UTSW |
7 |
42,577,544 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4806:Vmn2r63
|
UTSW |
7 |
42,576,314 (GRCm39) |
missense |
probably benign |
0.34 |
|
R4933:Vmn2r63
|
UTSW |
7 |
42,553,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5198:Vmn2r63
|
UTSW |
7 |
42,553,169 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5399:Vmn2r63
|
UTSW |
7 |
42,577,701 (GRCm39) |
missense |
probably benign |
|
|
R5400:Vmn2r63
|
UTSW |
7 |
42,577,635 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6158:Vmn2r63
|
UTSW |
7 |
42,583,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6185:Vmn2r63
|
UTSW |
7 |
42,578,435 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6267:Vmn2r63
|
UTSW |
7 |
42,578,059 (GRCm39) |
splice site |
probably null |
|
|
R6362:Vmn2r63
|
UTSW |
7 |
42,552,721 (GRCm39) |
missense |
probably benign |
|
|
R6706:Vmn2r63
|
UTSW |
7 |
42,578,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6764:Vmn2r63
|
UTSW |
7 |
42,552,695 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7104:Vmn2r63
|
UTSW |
7 |
42,577,959 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7503:Vmn2r63
|
UTSW |
7 |
42,583,014 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7506:Vmn2r63
|
UTSW |
7 |
42,576,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Vmn2r63
|
UTSW |
7 |
42,576,406 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7658:Vmn2r63
|
UTSW |
7 |
42,574,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Vmn2r63
|
UTSW |
7 |
42,576,466 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7702:Vmn2r63
|
UTSW |
7 |
42,577,553 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7918:Vmn2r63
|
UTSW |
7 |
42,552,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8826:Vmn2r63
|
UTSW |
7 |
42,576,441 (GRCm39) |
missense |
probably benign |
0.38 |
|
R8973:Vmn2r63
|
UTSW |
7 |
42,577,919 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9024:Vmn2r63
|
UTSW |
7 |
42,577,874 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9154:Vmn2r63
|
UTSW |
7 |
42,576,413 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9731:Vmn2r63
|
UTSW |
7 |
42,553,361 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1088:Vmn2r63
|
UTSW |
7 |
42,577,983 (GRCm39) |
missense |
probably benign |
0.09 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGCGTCTGCTCTGAGGAATATACAC -3'
(R):5'- TGACATGGAAAGTCTGGGTCTTGAAC -3'
Sequencing Primer
(F):5'- TGTAAAAGCCTGTGAAGCAACTTG -3'
(R):5'- AAGTCTGGGTCTTGAACTCTCAATG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation