|Institutional Source||Beutler Lab|
|Gene Name||fibrinogen-like protein 1|
|Is this an essential gene?||Probably non essential (E-score: 0.092)|
|Stock #||R1413 (G1)|
|Chromosomal Location||41191434-41215156 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to A at 41191601 bp|
|Amino Acid Change||Threonine to Serine at position 289 (T289S)|
|Ref Sequence||ENSEMBL: ENSMUSP00000034003 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000034003]|
|Predicted Effect||possibly damaging
AA Change: T289S
PolyPhen 2 Score 0.820 (Sensitivity: 0.84; Specificity: 0.93)
AA Change: T289S
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased body weight, decreased circulating cholesterol and free fatty acid, hyperglycemia, impaired glucose tolerance, increased gluconeogenesis, increased white adipose tissue and decreased respiratory quotient. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Fgl1||
(F):5'- AAGAGCCTGGACTGCGCTTAAC -3'
(R):5'- AACATGAAAGTTTTGTGGGAAAATGGCA -3'
(F):5'- ccacctgtgtctgccttc -3'
(R):5'- TTTTGTGGGAAAATGGCAGAAGTC -3'