|Institutional Source||Beutler Lab|
|Gene Name||tenascin C|
|Synonyms||TN, TN-C, hexabrachion, tenascin-C, C130033P17Rik, cytotactin, Hxb|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R1414 (G1)|
|Chromosomal Location||63959785-64047015 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 63965695 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000103000 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000030056] [ENSMUST00000107372] [ENSMUST00000107377]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||97% (36/37)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
PHENOTYPE: Mice homozygous for several different targeted mutations show variable behavioral and nervous system phenotypes such as abnormal circadian rhythm, anxiety behavior, novelty-induced activity, swimming, impaired synaptic plasticity, long term potentiation and serotonin and dopamine neurotransmission. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tnc||
(F):5'- TGTTGCTCACGACAGGAGGGTAAG -3'
(R):5'- GGCTAAGATCCAACGATGTCACCAG -3'
(F):5'- CGACAGGAGGGTAAGTGACC -3'
(R):5'- GCACTAAGAAGCGTTGTCCATTC -3'