Incidental Mutation 'R1415:Lrp1b'
ID 159764
Institutional Source Beutler Lab
Gene Symbol Lrp1b
Ensembl Gene ENSMUSG00000049252
Gene Name low density lipoprotein-related protein 1B (deleted in tumors)
Synonyms 9630004P12Rik
MMRRC Submission 039471-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1415 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 40595246-42653624 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40629664 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 137 (Y137C)
Ref Sequence ENSEMBL: ENSMUSP00000145066 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052550] [ENSMUST00000185258] [ENSMUST00000203015]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000052550
AA Change: Y4397C
SMART Domains Protein: ENSMUSP00000054275
Gene: ENSMUSG00000049252
AA Change: Y4397C

DomainStartEndE-ValueType
low complexity region 3 19 N/A INTRINSIC
low complexity region 35 46 N/A INTRINSIC
LDLa 62 102 2.97e-12 SMART
LDLa 107 146 1.31e-8 SMART
EGF 150 185 1.95e1 SMART
EGF_CA 186 225 8.37e-8 SMART
LY 256 300 4.06e1 SMART
LY 304 348 1.15e-5 SMART
LY 349 392 1.17e-11 SMART
LY 393 435 1.12e-8 SMART
LY 436 478 2.21e1 SMART
EGF 505 548 2.45e0 SMART
LY 579 621 1.32e-5 SMART
LY 622 665 1.88e-10 SMART
LY 668 717 1.47e-12 SMART
LY 718 760 5.78e-11 SMART
LY 761 802 1.45e0 SMART
EGF_like 828 865 4.55e1 SMART
LDLa 875 914 7.15e-15 SMART
LDLa 916 955 5.26e-13 SMART
LDLa 957 995 6.13e-14 SMART
LDLa 997 1035 6.47e-13 SMART
LDLa 1036 1075 1.76e-14 SMART
LDLa 1083 1121 2.29e-13 SMART
LDLa 1125 1164 3.36e-11 SMART
LDLa 1166 1206 2.57e-7 SMART
EGF 1206 1244 1.58e-3 SMART
EGF 1248 1284 4.56e0 SMART
LY 1311 1353 4.85e-4 SMART
LY 1358 1400 6.49e-14 SMART
LY 1401 1445 8.18e-11 SMART
LY 1446 1490 4.25e-9 SMART
LY 1492 1534 5.4e-2 SMART
EGF 1561 1601 9.41e-2 SMART
LY 1629 1671 3.03e-5 SMART
LY 1672 1716 1.22e-9 SMART
LY 1718 1756 1.02e-2 SMART
LY 1757 1798 8.25e-7 SMART
EGF 1868 1906 4.03e-1 SMART
LY 1933 1975 1.01e-1 SMART
LY 1976 2018 3.03e-14 SMART
LY 2019 2062 2.16e-10 SMART
LY 2063 2105 4.09e-11 SMART
LY 2107 2149 9.96e0 SMART
EGF 2177 2214 2.13e0 SMART
LY 2292 2334 6.96e-5 SMART
LY 2340 2385 1.07e-5 SMART
LY 2386 2428 1.1e-11 SMART
LY 2429 2470 4.78e-3 SMART
EGF 2498 2535 2.03e1 SMART
LDLa 2540 2580 1.1e-6 SMART
LDLa 2582 2619 1.72e-8 SMART
LDLa 2621 2658 2.45e-13 SMART
LDLa 2669 2707 6.53e-9 SMART
LDLa 2712 2749 7.97e-13 SMART
LDLa 2750 2789 1.22e-8 SMART
LDLa 2791 2832 3.07e-14 SMART
LDLa 2835 2873 7.32e-12 SMART
LDLa 2875 2917 1.85e-8 SMART
LDLa 2921 2958 4.76e-11 SMART
EGF_CA 2957 2998 1.79e-7 SMART
EGF_CA 2999 3039 1.85e-9 SMART
LY 3066 3111 2.58e-8 SMART
LY 3112 3152 1.22e-9 SMART
LY 3153 3196 8.84e-7 SMART
LY 3197 3237 3.22e-9 SMART
LY 3238 3279 1.04e-3 SMART
EGF 3307 3345 7.13e-2 SMART
LDLa 3347 3385 9.29e-14 SMART
LDLa 3387 3424 2.25e-12 SMART
LDLa 3426 3464 5.63e-13 SMART
LDLa 3466 3504 1.07e-13 SMART
LDLa 3506 3543 1.35e-15 SMART
EGF_like 3545 3581 2.8e1 SMART
LDLa 3545 3582 1.49e-12 SMART
LDLa 3583 3620 4.21e-12 SMART
LDLa 3624 3661 4.9e-13 SMART
LDLa 3662 3700 9.58e-16 SMART
LDLa 3704 3743 5.38e-10 SMART
LDLa 3745 3784 1.42e-9 SMART
LDLa 3792 3829 3.66e-12 SMART
EGF 3835 3874 3.71e0 SMART
EGF_CA 3875 3912 6.8e-8 SMART
LY 3987 4033 4.24e0 SMART
LY 4050 4093 4.46e-3 SMART
LY 4094 4136 1.73e-9 SMART
EGF 4206 4239 2.45e0 SMART
EGF 4247 4280 2.48e-1 SMART
EGF 4283 4316 1.49e-4 SMART
EGF 4319 4352 1.69e-3 SMART
EGF 4355 4388 1.18e1 SMART
EGF_like 4391 4423 6.67e1 SMART
EGF 4424 4458 1.61e0 SMART
transmembrane domain 4476 4498 N/A INTRINSIC
low complexity region 4499 4509 N/A INTRINSIC
low complexity region 4512 4523 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000142546
AA Change: Y628C
SMART Domains Protein: ENSMUSP00000117212
Gene: ENSMUSG00000049252
AA Change: Y628C

DomainStartEndE-ValueType
LDLa 2 30 1.76e-2 SMART
EGF 36 75 3.71e0 SMART
EGF_CA 76 113 6.8e-8 SMART
LY 188 234 4.24e0 SMART
LY 251 294 4.46e-3 SMART
LY 295 337 1.73e-9 SMART
EGF 407 440 2.45e0 SMART
EGF 448 481 2.48e-1 SMART
EGF 484 517 1.49e-4 SMART
EGF 520 553 1.69e-3 SMART
EGF 556 589 1.18e1 SMART
EGF_like 592 624 6.67e1 SMART
EGF 625 659 1.61e0 SMART
transmembrane domain 677 699 N/A INTRINSIC
low complexity region 700 710 N/A INTRINSIC
low complexity region 713 724 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000185258
SMART Domains Protein: ENSMUSP00000139874
Gene: ENSMUSG00000049252

DomainStartEndE-ValueType
transmembrane domain 35 57 N/A INTRINSIC
low complexity region 59 69 N/A INTRINSIC
low complexity region 72 83 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000203015
AA Change: Y137C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000145066
Gene: ENSMUSG00000049252
AA Change: Y137C

DomainStartEndE-ValueType
Pfam:hEGF 12 24 1.6e-3 PFAM
EGF 28 61 8.3e-6 SMART
EGF 64 97 5.8e-2 SMART
EGF_like 100 132 3.3e-1 SMART
EGF 133 167 6.4e-3 SMART
EGF 172 205 1.9e-4 SMART
transmembrane domain 223 245 N/A INTRINSIC
low complexity region 246 256 N/A INTRINSIC
low complexity region 259 270 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.3%
  • 20x: 89.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
PHENOTYPE: Homozygous null mice appear normal, are fertile, have normal brain histology and function, normal plasma cholesterol and fasting triglycerides, and do not develop tumors. [provided by MGI curators]
Allele List at MGI

All alleles(9) : Targeted, knock-out(3) Targeted, other(2) Gene trapped(4)

Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb T C 5: 114,165,921 (GRCm38) V135A probably benign Het
Adam21 C T 12: 81,559,547 (GRCm38) W480* probably null Het
Ccdc71 T A 9: 108,463,208 (GRCm38) Y73* probably null Het
Cfap44 T A 16: 44,481,389 (GRCm38) I1830N probably damaging Het
Dnajb11 T C 16: 22,870,621 (GRCm38) V264A probably benign Het
Fam135b T C 15: 71,456,928 (GRCm38) E1174G probably damaging Het
Fam83e G A 7: 45,726,711 (GRCm38) E283K probably damaging Het
Gigyf1 A G 5: 137,519,216 (GRCm38) probably null Het
Gm38394 C T 1: 133,657,818 (GRCm38) V594M possibly damaging Het
Letm1 A T 5: 33,769,562 (GRCm38) N130K probably benign Het
Map3k2 A G 18: 32,228,277 (GRCm38) I597V possibly damaging Het
Nek1 A G 8: 61,089,686 (GRCm38) E770G probably benign Het
Olfr462 A C 11: 87,889,647 (GRCm38) V83G possibly damaging Het
Olfr667 A G 7: 104,916,336 (GRCm38) I320T probably benign Het
Pank2 T A 2: 131,282,718 (GRCm38) Y68* probably null Het
Prl2c2 G C 13: 13,002,201 (GRCm38) T47R probably damaging Het
Secisbp2l C A 2: 125,740,365 (GRCm38) G1057V probably benign Het
Slc30a2 C T 4: 134,349,349 (GRCm38) T265M probably damaging Het
Smarca2 A G 19: 26,710,684 (GRCm38) E1239G probably null Het
Snx30 C T 4: 59,879,261 (GRCm38) R167C probably damaging Het
Tmem26 T C 10: 68,778,661 (GRCm38) F302S possibly damaging Het
Tpgs2 A G 18: 25,168,553 (GRCm38) L19S probably damaging Het
Trp53bp1 T G 2: 121,236,184 (GRCm38) E687A probably damaging Het
Ttc27 C T 17: 74,739,672 (GRCm38) H243Y probably benign Het
Wdfy4 A T 14: 33,041,180 (GRCm38) V2318D possibly damaging Het
Wdr59 G A 8: 111,498,596 (GRCm38) P141S probably damaging Het
Zfp787 C A 7: 6,132,695 (GRCm38) G186C probably damaging Het
Other mutations in Lrp1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00484:Lrp1b APN 2 41,110,861 (GRCm38) missense probably damaging 1.00
IGL00543:Lrp1b APN 2 41,468,948 (GRCm38) missense possibly damaging 0.69
IGL00578:Lrp1b APN 2 40,679,173 (GRCm38) missense unknown
IGL01020:Lrp1b APN 2 40,998,247 (GRCm38) missense probably damaging 1.00
IGL01092:Lrp1b APN 2 40,750,947 (GRCm38) missense probably damaging 0.97
IGL01155:Lrp1b APN 2 41,770,935 (GRCm38) missense probably benign 0.17
IGL01361:Lrp1b APN 2 41,110,751 (GRCm38) splice site probably benign
IGL01377:Lrp1b APN 2 40,601,538 (GRCm38) missense probably damaging 1.00
IGL01459:Lrp1b APN 2 40,860,714 (GRCm38) missense probably damaging 0.97
IGL01473:Lrp1b APN 2 40,611,486 (GRCm38) missense probably damaging 0.97
IGL01528:Lrp1b APN 2 40,919,182 (GRCm38) missense probably damaging 0.99
IGL01536:Lrp1b APN 2 41,110,883 (GRCm38) missense probably benign 0.01
IGL01564:Lrp1b APN 2 40,677,486 (GRCm38) splice site probably benign
IGL01747:Lrp1b APN 2 40,860,685 (GRCm38) missense probably damaging 1.00
IGL01764:Lrp1b APN 2 40,697,442 (GRCm38) missense unknown
IGL01783:Lrp1b APN 2 41,312,572 (GRCm38) missense probably damaging 1.00
IGL01802:Lrp1b APN 2 41,511,482 (GRCm38) missense probably benign 0.07
IGL01826:Lrp1b APN 2 41,449,234 (GRCm38) missense probably damaging 1.00
IGL01884:Lrp1b APN 2 41,284,213 (GRCm38) nonsense probably null
IGL01908:Lrp1b APN 2 40,702,804 (GRCm38) missense probably benign
IGL01935:Lrp1b APN 2 41,268,355 (GRCm38) missense probably damaging 1.00
IGL01959:Lrp1b APN 2 41,312,527 (GRCm38) missense probably damaging 0.99
IGL02010:Lrp1b APN 2 41,468,942 (GRCm38) missense probably damaging 1.00
IGL02022:Lrp1b APN 2 41,282,160 (GRCm38) missense probably damaging 1.00
IGL02028:Lrp1b APN 2 41,511,452 (GRCm38) missense probably damaging 1.00
IGL02034:Lrp1b APN 2 41,268,370 (GRCm38) nonsense probably null
IGL02043:Lrp1b APN 2 40,697,525 (GRCm38) missense probably null 0.44
IGL02066:Lrp1b APN 2 41,111,079 (GRCm38) nonsense probably null
IGL02085:Lrp1b APN 2 40,889,309 (GRCm38) missense probably benign
IGL02137:Lrp1b APN 2 40,730,688 (GRCm38) splice site probably benign
IGL02218:Lrp1b APN 2 41,295,672 (GRCm38) missense probably benign 0.11
IGL02409:Lrp1b APN 2 41,445,196 (GRCm38) missense possibly damaging 0.93
IGL02513:Lrp1b APN 2 41,110,753 (GRCm38) critical splice donor site probably null
IGL02543:Lrp1b APN 2 40,870,401 (GRCm38) missense possibly damaging 0.89
IGL02701:Lrp1b APN 2 41,246,017 (GRCm38) missense possibly damaging 0.50
IGL02728:Lrp1b APN 2 40,801,398 (GRCm38) missense probably benign 0.03
IGL02739:Lrp1b APN 2 41,498,215 (GRCm38) missense probably damaging 1.00
IGL02748:Lrp1b APN 2 40,702,749 (GRCm38) missense probably damaging 0.99
IGL02754:Lrp1b APN 2 40,702,794 (GRCm38) missense probably benign 0.02
IGL02797:Lrp1b APN 2 41,671,057 (GRCm38) missense
IGL02813:Lrp1b APN 2 40,679,217 (GRCm38) critical splice acceptor site probably null
IGL02831:Lrp1b APN 2 41,193,591 (GRCm38) missense probably damaging 1.00
IGL02869:Lrp1b APN 2 40,701,830 (GRCm38) missense unknown
IGL02946:Lrp1b APN 2 41,312,559 (GRCm38) missense probably damaging 1.00
IGL02952:Lrp1b APN 2 41,506,703 (GRCm38) missense probably benign 0.33
IGL02958:Lrp1b APN 2 41,302,916 (GRCm38) missense probably damaging 1.00
IGL02977:Lrp1b APN 2 40,730,735 (GRCm38) missense probably damaging 1.00
IGL03001:Lrp1b APN 2 40,927,889 (GRCm38) missense probably damaging 1.00
IGL03010:Lrp1b APN 2 42,323,606 (GRCm38) missense possibly damaging 0.94
IGL03060:Lrp1b APN 2 40,637,753 (GRCm38) missense probably benign 0.04
IGL03129:Lrp1b APN 2 41,312,466 (GRCm38) splice site probably benign
IGL03166:Lrp1b APN 2 41,111,038 (GRCm38) missense probably damaging 1.00
IGL03170:Lrp1b APN 2 40,697,444 (GRCm38) missense unknown
IGL03195:Lrp1b APN 2 41,471,122 (GRCm38) missense possibly damaging 0.95
IGL03224:Lrp1b APN 2 41,471,031 (GRCm38) missense possibly damaging 0.92
IGL03251:Lrp1b APN 2 40,600,267 (GRCm38) missense probably benign 0.20
IGL03281:Lrp1b APN 2 40,725,514 (GRCm38) missense probably benign 0.01
IGL03295:Lrp1b APN 2 40,678,987 (GRCm38) splice site probably null
IGL03340:Lrp1b APN 2 41,468,969 (GRCm38) missense probably damaging 0.97
IGL03391:Lrp1b APN 2 41,295,641 (GRCm38) missense possibly damaging 0.95
IGL03401:Lrp1b APN 2 41,110,778 (GRCm38) missense probably benign 0.18
IGL03403:Lrp1b APN 2 40,702,824 (GRCm38) missense probably benign 0.16
IGL03408:Lrp1b APN 2 40,858,582 (GRCm38) missense probably damaging 0.97
Fetching UTSW 2 40,879,555 (GRCm38) missense probably benign 0.00
Heiden UTSW 2 40,637,775 (GRCm38) missense probably benign 0.00
hither UTSW 2 40,702,848 (GRCm38) missense probably benign 0.00
Roeslein UTSW 2 40,725,907 (GRCm38) missense probably damaging 1.00
I2288:Lrp1b UTSW 2 41,122,932 (GRCm38) missense probably damaging 0.99
I2289:Lrp1b UTSW 2 41,122,932 (GRCm38) missense probably damaging 0.99
LCD18:Lrp1b UTSW 2 42,237,562 (GRCm38) intron probably benign
PIT4431001:Lrp1b UTSW 2 41,004,755 (GRCm38) missense
PIT4585001:Lrp1b UTSW 2 41,269,204 (GRCm38) missense
R0022:Lrp1b UTSW 2 40,998,038 (GRCm38) splice site probably benign
R0022:Lrp1b UTSW 2 40,998,038 (GRCm38) splice site probably benign
R0054:Lrp1b UTSW 2 40,742,817 (GRCm38) missense probably benign 0.11
R0054:Lrp1b UTSW 2 40,742,817 (GRCm38) missense probably benign 0.11
R0094:Lrp1b UTSW 2 41,282,030 (GRCm38) unclassified probably benign
R0102:Lrp1b UTSW 2 41,408,985 (GRCm38) splice site probably benign
R0123:Lrp1b UTSW 2 40,596,983 (GRCm38) missense probably damaging 1.00
R0128:Lrp1b UTSW 2 41,511,508 (GRCm38) missense probably damaging 1.00
R0130:Lrp1b UTSW 2 41,511,508 (GRCm38) missense probably damaging 1.00
R0134:Lrp1b UTSW 2 40,596,983 (GRCm38) missense probably damaging 1.00
R0135:Lrp1b UTSW 2 41,269,239 (GRCm38) missense probably damaging 0.99
R0153:Lrp1b UTSW 2 41,123,019 (GRCm38) missense possibly damaging 0.92
R0178:Lrp1b UTSW 2 40,725,907 (GRCm38) missense probably damaging 1.00
R0225:Lrp1b UTSW 2 40,596,983 (GRCm38) missense probably damaging 1.00
R0242:Lrp1b UTSW 2 40,998,183 (GRCm38) missense probably benign 0.01
R0242:Lrp1b UTSW 2 40,998,183 (GRCm38) missense probably benign 0.01
R0312:Lrp1b UTSW 2 41,282,171 (GRCm38) missense probably damaging 1.00
R0325:Lrp1b UTSW 2 40,851,711 (GRCm38) missense probably damaging 1.00
R0330:Lrp1b UTSW 2 40,701,761 (GRCm38) nonsense probably null
R0372:Lrp1b UTSW 2 40,730,798 (GRCm38) missense probably benign 0.30
R0400:Lrp1b UTSW 2 40,750,914 (GRCm38) missense probably benign 0.40
R0408:Lrp1b UTSW 2 40,677,591 (GRCm38) missense probably damaging 1.00
R0498:Lrp1b UTSW 2 41,458,405 (GRCm38) missense probably benign 0.19
R0563:Lrp1b UTSW 2 40,750,914 (GRCm38) missense probably benign 0.40
R0569:Lrp1b UTSW 2 40,889,239 (GRCm38) missense probably benign 0.11
R0622:Lrp1b UTSW 2 41,728,551 (GRCm38) critical splice donor site probably null
R0682:Lrp1b UTSW 2 41,295,641 (GRCm38) missense probably benign 0.01
R0727:Lrp1b UTSW 2 40,750,944 (GRCm38) missense probably benign 0.40
R0747:Lrp1b UTSW 2 40,870,341 (GRCm38) missense probably damaging 1.00
R0761:Lrp1b UTSW 2 41,185,935 (GRCm38) missense probably damaging 0.99
R0905:Lrp1b UTSW 2 41,284,185 (GRCm38) missense probably damaging 1.00
R0959:Lrp1b UTSW 2 41,268,354 (GRCm38) missense possibly damaging 0.83
R1124:Lrp1b UTSW 2 40,875,051 (GRCm38) missense probably damaging 1.00
R1158:Lrp1b UTSW 2 40,677,494 (GRCm38) missense unknown
R1265:Lrp1b UTSW 2 41,476,654 (GRCm38) missense probably damaging 1.00
R1276:Lrp1b UTSW 2 41,728,576 (GRCm38) missense probably benign 0.35
R1277:Lrp1b UTSW 2 40,725,945 (GRCm38) missense probably benign
R1282:Lrp1b UTSW 2 40,860,761 (GRCm38) missense probably damaging 1.00
R1291:Lrp1b UTSW 2 41,341,895 (GRCm38) missense probably benign 0.05
R1316:Lrp1b UTSW 2 40,702,804 (GRCm38) missense probably benign
R1340:Lrp1b UTSW 2 40,702,794 (GRCm38) missense probably benign 0.02
R1371:Lrp1b UTSW 2 40,647,153 (GRCm38) missense probably damaging 1.00
R1416:Lrp1b UTSW 2 40,998,216 (GRCm38) missense probably damaging 1.00
R1417:Lrp1b UTSW 2 41,004,641 (GRCm38) missense probably benign 0.14
R1465:Lrp1b UTSW 2 41,111,059 (GRCm38) missense probably benign 0.00
R1465:Lrp1b UTSW 2 41,111,059 (GRCm38) missense probably benign 0.00
R1467:Lrp1b UTSW 2 40,657,356 (GRCm38) splice site probably benign
R1468:Lrp1b UTSW 2 40,927,829 (GRCm38) critical splice donor site probably null
R1468:Lrp1b UTSW 2 40,927,829 (GRCm38) critical splice donor site probably null
R1480:Lrp1b UTSW 2 40,903,389 (GRCm38) missense probably damaging 1.00
R1488:Lrp1b UTSW 2 41,502,024 (GRCm38) missense probably benign 0.01
R1496:Lrp1b UTSW 2 42,323,662 (GRCm38) missense probably damaging 0.98
R1542:Lrp1b UTSW 2 41,123,712 (GRCm38) missense probably damaging 1.00
R1571:Lrp1b UTSW 2 41,476,646 (GRCm38) missense probably damaging 1.00
R1598:Lrp1b UTSW 2 41,511,478 (GRCm38) missense probably damaging 1.00
R1619:Lrp1b UTSW 2 40,697,589 (GRCm38) missense unknown
R1697:Lrp1b UTSW 2 40,822,683 (GRCm38) missense probably damaging 0.99
R1698:Lrp1b UTSW 2 40,851,806 (GRCm38) nonsense probably null
R1699:Lrp1b UTSW 2 41,185,962 (GRCm38) missense possibly damaging 0.91
R1715:Lrp1b UTSW 2 41,185,981 (GRCm38) missense probably damaging 1.00
R1748:Lrp1b UTSW 2 41,728,706 (GRCm38) missense possibly damaging 0.56
R1756:Lrp1b UTSW 2 41,110,825 (GRCm38) missense probably damaging 1.00
R1889:Lrp1b UTSW 2 40,919,167 (GRCm38) nonsense probably null
R1895:Lrp1b UTSW 2 40,665,147 (GRCm38) missense unknown
R1902:Lrp1b UTSW 2 40,860,661 (GRCm38) missense probably damaging 1.00
R1919:Lrp1b UTSW 2 41,728,729 (GRCm38) missense probably benign 0.00
R1939:Lrp1b UTSW 2 40,697,589 (GRCm38) missense unknown
R1946:Lrp1b UTSW 2 40,665,147 (GRCm38) missense unknown
R1954:Lrp1b UTSW 2 40,858,441 (GRCm38) missense probably damaging 1.00
R1970:Lrp1b UTSW 2 40,875,069 (GRCm38) missense probably damaging 1.00
R1983:Lrp1b UTSW 2 41,511,404 (GRCm38) critical splice donor site probably null
R2029:Lrp1b UTSW 2 41,341,849 (GRCm38) missense probably benign 0.02
R2054:Lrp1b UTSW 2 40,697,482 (GRCm38) missense unknown
R2108:Lrp1b UTSW 2 41,110,757 (GRCm38) missense probably damaging 1.00
R2158:Lrp1b UTSW 2 40,879,555 (GRCm38) missense probably benign 0.00
R2168:Lrp1b UTSW 2 41,375,846 (GRCm38) missense probably damaging 1.00
R2184:Lrp1b UTSW 2 40,730,702 (GRCm38) missense probably benign
R2188:Lrp1b UTSW 2 41,408,959 (GRCm38) missense probably benign 0.25
R2200:Lrp1b UTSW 2 41,284,165 (GRCm38) missense probably benign 0.43
R2342:Lrp1b UTSW 2 40,919,196 (GRCm38) missense possibly damaging 0.89
R2421:Lrp1b UTSW 2 40,882,133 (GRCm38) splice site probably benign
R2656:Lrp1b UTSW 2 41,511,581 (GRCm38) missense probably damaging 0.99
R2864:Lrp1b UTSW 2 40,874,995 (GRCm38) missense possibly damaging 0.92
R2874:Lrp1b UTSW 2 40,851,693 (GRCm38) missense probably damaging 1.00
R2911:Lrp1b UTSW 2 41,506,692 (GRCm38) missense probably benign 0.00
R2919:Lrp1b UTSW 2 41,770,899 (GRCm38) missense probably damaging 1.00
R3027:Lrp1b UTSW 2 40,870,271 (GRCm38) missense probably benign 0.33
R3083:Lrp1b UTSW 2 40,600,324 (GRCm38) missense probably damaging 0.99
R3545:Lrp1b UTSW 2 40,600,288 (GRCm38) missense probably damaging 1.00
R3546:Lrp1b UTSW 2 40,600,288 (GRCm38) missense probably damaging 1.00
R3547:Lrp1b UTSW 2 40,600,288 (GRCm38) missense probably damaging 1.00
R3709:Lrp1b UTSW 2 40,697,442 (GRCm38) missense unknown
R3817:Lrp1b UTSW 2 40,876,658 (GRCm38) missense probably damaging 1.00
R3876:Lrp1b UTSW 2 41,445,194 (GRCm38) missense probably damaging 1.00
R3877:Lrp1b UTSW 2 41,445,194 (GRCm38) missense probably damaging 1.00
R3896:Lrp1b UTSW 2 40,922,428 (GRCm38) splice site probably null
R3901:Lrp1b UTSW 2 40,822,695 (GRCm38) missense probably damaging 1.00
R3915:Lrp1b UTSW 2 41,449,236 (GRCm38) missense probably damaging 1.00
R3922:Lrp1b UTSW 2 40,677,581 (GRCm38) missense unknown
R3964:Lrp1b UTSW 2 41,312,470 (GRCm38) splice site probably benign
R4013:Lrp1b UTSW 2 40,802,984 (GRCm38) missense possibly damaging 0.66
R4014:Lrp1b UTSW 2 40,802,984 (GRCm38) missense possibly damaging 0.66
R4015:Lrp1b UTSW 2 40,802,984 (GRCm38) missense possibly damaging 0.66
R4017:Lrp1b UTSW 2 40,802,984 (GRCm38) missense possibly damaging 0.66
R4031:Lrp1b UTSW 2 40,702,848 (GRCm38) missense probably benign 0.00
R4095:Lrp1b UTSW 2 41,449,191 (GRCm38) missense probably benign 0.03
R4108:Lrp1b UTSW 2 40,665,087 (GRCm38) missense unknown
R4176:Lrp1b UTSW 2 41,408,393 (GRCm38) missense probably damaging 1.00
R4181:Lrp1b UTSW 2 40,611,434 (GRCm38) missense probably damaging 1.00
R4359:Lrp1b UTSW 2 40,903,065 (GRCm38) missense probably damaging 1.00
R4410:Lrp1b UTSW 2 40,665,082 (GRCm38) missense possibly damaging 0.96
R4416:Lrp1b UTSW 2 40,663,667 (GRCm38) missense unknown
R4489:Lrp1b UTSW 2 40,661,489 (GRCm38) unclassified probably benign
R4577:Lrp1b UTSW 2 40,821,719 (GRCm38) missense probably damaging 1.00
R4623:Lrp1b UTSW 2 41,246,021 (GRCm38) missense probably damaging 1.00
R4677:Lrp1b UTSW 2 40,801,484 (GRCm38) missense probably damaging 1.00
R4684:Lrp1b UTSW 2 40,922,304 (GRCm38) missense probably benign 0.44
R4714:Lrp1b UTSW 2 41,110,759 (GRCm38) missense possibly damaging 0.90
R4721:Lrp1b UTSW 2 40,715,369 (GRCm38) splice site probably null
R4755:Lrp1b UTSW 2 41,471,016 (GRCm38) missense probably benign
R4755:Lrp1b UTSW 2 41,269,273 (GRCm38) missense probably benign 0.07
R4774:Lrp1b UTSW 2 40,661,532 (GRCm38) missense probably null 1.00
R4854:Lrp1b UTSW 2 41,111,077 (GRCm38) missense probably damaging 1.00
R4880:Lrp1b UTSW 2 41,770,919 (GRCm38) missense probably benign 0.07
R4885:Lrp1b UTSW 2 41,468,893 (GRCm38) missense probably benign
R4901:Lrp1b UTSW 2 40,821,645 (GRCm38) missense probably damaging 1.00
R4919:Lrp1b UTSW 2 40,647,234 (GRCm38) missense probably benign 0.25
R4935:Lrp1b UTSW 2 41,498,393 (GRCm38) missense probably benign 0.01
R4937:Lrp1b UTSW 2 40,802,885 (GRCm38) splice site probably null
R4967:Lrp1b UTSW 2 41,788,974 (GRCm38) missense probably damaging 1.00
R4968:Lrp1b UTSW 2 41,789,062 (GRCm38) missense probably damaging 1.00
R4968:Lrp1b UTSW 2 40,702,707 (GRCm38) splice site probably null
R5155:Lrp1b UTSW 2 41,728,622 (GRCm38) splice site probably null
R5221:Lrp1b UTSW 2 41,112,982 (GRCm38) missense possibly damaging 0.79
R5224:Lrp1b UTSW 2 41,110,840 (GRCm38) missense possibly damaging 0.61
R5227:Lrp1b UTSW 2 40,851,793 (GRCm38) missense possibly damaging 0.95
R5246:Lrp1b UTSW 2 41,470,940 (GRCm38) critical splice donor site probably null
R5263:Lrp1b UTSW 2 41,960,679 (GRCm38) missense probably damaging 1.00
R5274:Lrp1b UTSW 2 41,344,444 (GRCm38) missense probably null 1.00
R5291:Lrp1b UTSW 2 40,903,003 (GRCm38) missense probably damaging 1.00
R5362:Lrp1b UTSW 2 41,375,902 (GRCm38) missense probably damaging 1.00
R5365:Lrp1b UTSW 2 40,647,125 (GRCm38) missense possibly damaging 0.55
R5369:Lrp1b UTSW 2 41,004,613 (GRCm38) nonsense probably null
R5419:Lrp1b UTSW 2 40,730,704 (GRCm38) nonsense probably null
R5434:Lrp1b UTSW 2 41,770,868 (GRCm38) missense probably damaging 0.96
R5452:Lrp1b UTSW 2 40,922,316 (GRCm38) missense probably damaging 1.00
R5453:Lrp1b UTSW 2 41,282,237 (GRCm38) missense probably damaging 1.00
R5496:Lrp1b UTSW 2 40,927,973 (GRCm38) missense probably benign 0.02
R5524:Lrp1b UTSW 2 41,110,888 (GRCm38) missense probably damaging 1.00
R5538:Lrp1b UTSW 2 40,697,474 (GRCm38) missense unknown
R5571:Lrp1b UTSW 2 41,408,342 (GRCm38) missense probably damaging 0.97
R5577:Lrp1b UTSW 2 40,875,123 (GRCm38) missense possibly damaging 0.70
R5609:Lrp1b UTSW 2 41,341,795 (GRCm38) missense probably damaging 1.00
R5635:Lrp1b UTSW 2 42,652,822 (GRCm38) utr 5 prime probably benign
R5669:Lrp1b UTSW 2 41,111,038 (GRCm38) missense probably damaging 1.00
R5672:Lrp1b UTSW 2 41,341,759 (GRCm38) missense probably benign 0.01
R5690:Lrp1b UTSW 2 40,750,894 (GRCm38) splice site probably null
R5752:Lrp1b UTSW 2 41,295,612 (GRCm38) missense probably damaging 1.00
R5853:Lrp1b UTSW 2 40,663,726 (GRCm38) missense unknown
R5869:Lrp1b UTSW 2 41,004,603 (GRCm38) missense probably damaging 0.98
R5880:Lrp1b UTSW 2 41,341,814 (GRCm38) missense probably benign 0.23
R5887:Lrp1b UTSW 2 40,821,707 (GRCm38) missense possibly damaging 0.91
R5893:Lrp1b UTSW 2 40,601,587 (GRCm38) missense probably damaging 1.00
R5894:Lrp1b UTSW 2 41,498,221 (GRCm38) missense probably benign 0.11
R6019:Lrp1b UTSW 2 41,302,970 (GRCm38) missense probably damaging 1.00
R6019:Lrp1b UTSW 2 41,476,809 (GRCm38) missense probably damaging 1.00
R6021:Lrp1b UTSW 2 41,344,427 (GRCm38) missense probably benign 0.02
R6045:Lrp1b UTSW 2 40,701,813 (GRCm38) missense unknown
R6047:Lrp1b UTSW 2 40,637,775 (GRCm38) missense probably benign 0.00
R6060:Lrp1b UTSW 2 40,750,934 (GRCm38) missense
R6063:Lrp1b UTSW 2 41,284,144 (GRCm38) nonsense probably null
R6090:Lrp1b UTSW 2 41,185,868 (GRCm38) critical splice donor site probably null
R6112:Lrp1b UTSW 2 41,341,882 (GRCm38) missense probably benign 0.14
R6128:Lrp1b UTSW 2 40,860,655 (GRCm38) missense probably benign
R6149:Lrp1b UTSW 2 40,875,153 (GRCm38) splice site probably null
R6174:Lrp1b UTSW 2 41,449,263 (GRCm38) missense probably benign
R6177:Lrp1b UTSW 2 41,123,736 (GRCm38) splice site probably null
R6257:Lrp1b UTSW 2 40,596,969 (GRCm38) splice site probably null
R6267:Lrp1b UTSW 2 40,657,525 (GRCm38) missense probably benign 0.00
R6268:Lrp1b UTSW 2 40,821,717 (GRCm38) missense probably benign 0.01
R6331:Lrp1b UTSW 2 40,803,209 (GRCm38) missense probably damaging 1.00
R6334:Lrp1b UTSW 2 41,789,033 (GRCm38) missense probably benign
R6359:Lrp1b UTSW 2 41,295,596 (GRCm38) missense probably damaging 1.00
R6371:Lrp1b UTSW 2 40,851,654 (GRCm38) missense possibly damaging 0.61
R6421:Lrp1b UTSW 2 40,889,270 (GRCm38) missense probably damaging 1.00
R6524:Lrp1b UTSW 2 40,851,804 (GRCm38) missense possibly damaging 0.95
R6616:Lrp1b UTSW 2 40,699,631 (GRCm38) missense unknown
R6632:Lrp1b UTSW 2 40,725,442 (GRCm38) missense probably benign 0.23
R6656:Lrp1b UTSW 2 40,637,864 (GRCm38) nonsense probably null
R6698:Lrp1b UTSW 2 41,302,946 (GRCm38) missense probably damaging 1.00
R6741:Lrp1b UTSW 2 41,245,989 (GRCm38) missense possibly damaging 0.82
R6742:Lrp1b UTSW 2 41,471,120 (GRCm38) missense probably benign 0.31
R6811:Lrp1b UTSW 2 41,449,194 (GRCm38) missense probably benign 0.01
R6811:Lrp1b UTSW 2 40,715,500 (GRCm38) splice site probably null
R6855:Lrp1b UTSW 2 40,628,696 (GRCm38) missense possibly damaging 0.66
R6888:Lrp1b UTSW 2 41,471,126 (GRCm38) missense probably benign 0.18
R6946:Lrp1b UTSW 2 40,697,439 (GRCm38) missense probably benign
R6984:Lrp1b UTSW 2 40,822,628 (GRCm38) missense probably damaging 0.97
R7026:Lrp1b UTSW 2 41,269,222 (GRCm38) missense probably damaging 1.00
R7028:Lrp1b UTSW 2 41,246,011 (GRCm38) missense probably benign 0.45
R7036:Lrp1b UTSW 2 41,112,342 (GRCm38) missense possibly damaging 0.89
R7043:Lrp1b UTSW 2 40,922,414 (GRCm38) missense possibly damaging 0.84
R7071:Lrp1b UTSW 2 41,408,264 (GRCm38) missense
R7077:Lrp1b UTSW 2 41,770,846 (GRCm38) missense
R7115:Lrp1b UTSW 2 40,998,235 (GRCm38) missense
R7143:Lrp1b UTSW 2 41,312,643 (GRCm38) missense
R7146:Lrp1b UTSW 2 41,375,994 (GRCm38) nonsense probably null
R7149:Lrp1b UTSW 2 40,637,860 (GRCm38) missense
R7185:Lrp1b UTSW 2 40,801,512 (GRCm38) critical splice acceptor site probably null
R7239:Lrp1b UTSW 2 41,004,713 (GRCm38) missense
R7247:Lrp1b UTSW 2 41,269,212 (GRCm38) missense
R7331:Lrp1b UTSW 2 40,663,610 (GRCm38) splice site probably null
R7369:Lrp1b UTSW 2 41,282,039 (GRCm38) missense
R7378:Lrp1b UTSW 2 41,295,669 (GRCm38) missense
R7381:Lrp1b UTSW 2 40,802,917 (GRCm38) missense
R7406:Lrp1b UTSW 2 41,376,018 (GRCm38) critical splice acceptor site probably null
R7437:Lrp1b UTSW 2 40,822,646 (GRCm38) missense
R7437:Lrp1b UTSW 2 40,822,645 (GRCm38) missense
R7446:Lrp1b UTSW 2 41,671,057 (GRCm38) missense
R7460:Lrp1b UTSW 2 40,598,466 (GRCm38) missense
R7462:Lrp1b UTSW 2 41,113,029 (GRCm38) missense
R7475:Lrp1b UTSW 2 41,344,576 (GRCm38) missense
R7479:Lrp1b UTSW 2 40,801,505 (GRCm38) missense
R7523:Lrp1b UTSW 2 41,511,461 (GRCm38) missense
R7525:Lrp1b UTSW 2 40,657,416 (GRCm38) missense
R7549:Lrp1b UTSW 2 40,875,122 (GRCm38) missense
R7552:Lrp1b UTSW 2 40,677,570 (GRCm38) missense
R7558:Lrp1b UTSW 2 41,341,936 (GRCm38) missense
R7587:Lrp1b UTSW 2 40,730,717 (GRCm38) missense
R7599:Lrp1b UTSW 2 40,661,549 (GRCm38) missense
R7635:Lrp1b UTSW 2 41,123,597 (GRCm38) critical splice donor site probably null
R7663:Lrp1b UTSW 2 42,653,035 (GRCm38) unclassified probably benign
R7674:Lrp1b UTSW 2 42,652,909 (GRCm38) start gained probably benign
R7681:Lrp1b UTSW 2 40,874,999 (GRCm38) nonsense probably null
R7703:Lrp1b UTSW 2 41,110,786 (GRCm38) missense
R7742:Lrp1b UTSW 2 40,822,629 (GRCm38) missense
R7767:Lrp1b UTSW 2 40,801,505 (GRCm38) missense
R7829:Lrp1b UTSW 2 40,903,448 (GRCm38) nonsense probably null
R7861:Lrp1b UTSW 2 40,697,558 (GRCm38) missense
R7868:Lrp1b UTSW 2 41,449,234 (GRCm38) missense
R7883:Lrp1b UTSW 2 40,665,129 (GRCm38) missense
R7956:Lrp1b UTSW 2 41,282,149 (GRCm38) splice site probably null
R7963:Lrp1b UTSW 2 40,927,935 (GRCm38) missense
R7964:Lrp1b UTSW 2 40,598,511 (GRCm38) missense
R8035:Lrp1b UTSW 2 40,860,655 (GRCm38) missense
R8046:Lrp1b UTSW 2 41,269,187 (GRCm38) missense
R8128:Lrp1b UTSW 2 41,269,236 (GRCm38) missense probably null
R8234:Lrp1b UTSW 2 41,312,656 (GRCm38) missense
R8237:Lrp1b UTSW 2 40,851,774 (GRCm38) missense
R8244:Lrp1b UTSW 2 41,506,782 (GRCm38) missense
R8370:Lrp1b UTSW 2 40,998,105 (GRCm38) missense
R8395:Lrp1b UTSW 2 40,657,399 (GRCm38) missense
R8398:Lrp1b UTSW 2 40,701,807 (GRCm38) missense
R8421:Lrp1b UTSW 2 40,725,423 (GRCm38) missense
R8426:Lrp1b UTSW 2 41,498,306 (GRCm38) missense
R8443:Lrp1b UTSW 2 41,375,855 (GRCm38) nonsense probably null
R8444:Lrp1b UTSW 2 40,870,260 (GRCm38) missense
R8486:Lrp1b UTSW 2 41,728,690 (GRCm38) missense probably damaging 1.00
R8500:Lrp1b UTSW 2 41,506,779 (GRCm38) missense probably benign 0.12
R8507:Lrp1b UTSW 2 41,408,375 (GRCm38) missense
R8552:Lrp1b UTSW 2 41,408,981 (GRCm38) missense probably benign 0.00
R8554:Lrp1b UTSW 2 41,344,483 (GRCm38) missense probably benign 0.28
R8669:Lrp1b UTSW 2 41,282,035 (GRCm38) critical splice donor site probably null
R8699:Lrp1b UTSW 2 41,282,195 (GRCm38) missense
R8796:Lrp1b UTSW 2 40,903,414 (GRCm38) missense
R8815:Lrp1b UTSW 2 40,665,159 (GRCm38) missense
R8842:Lrp1b UTSW 2 41,268,405 (GRCm38) missense
R8858:Lrp1b UTSW 2 41,670,815 (GRCm38) intron probably benign
R8864:Lrp1b UTSW 2 41,112,706 (GRCm38) missense
R8918:Lrp1b UTSW 2 40,725,881 (GRCm38) missense
R8920:Lrp1b UTSW 2 42,323,598 (GRCm38) missense
R8963:Lrp1b UTSW 2 40,998,184 (GRCm38) missense probably benign 0.28
R8971:Lrp1b UTSW 2 41,435,628 (GRCm38) missense
R9007:Lrp1b UTSW 2 40,697,552 (GRCm38) missense
R9042:Lrp1b UTSW 2 41,502,017 (GRCm38) missense
R9053:Lrp1b UTSW 2 40,858,489 (GRCm38) missense
R9063:Lrp1b UTSW 2 41,341,826 (GRCm38) missense
R9072:Lrp1b UTSW 2 40,725,445 (GRCm38) nonsense probably null
R9105:Lrp1b UTSW 2 41,506,791 (GRCm38) missense
R9131:Lrp1b UTSW 2 40,699,578 (GRCm38) nonsense probably null
R9226:Lrp1b UTSW 2 41,511,448 (GRCm38) missense
R9245:Lrp1b UTSW 2 40,598,444 (GRCm38) missense
R9275:Lrp1b UTSW 2 40,597,064 (GRCm38) missense
R9278:Lrp1b UTSW 2 40,597,064 (GRCm38) missense
R9303:Lrp1b UTSW 2 41,728,562 (GRCm38) missense
R9305:Lrp1b UTSW 2 41,728,562 (GRCm38) missense
R9306:Lrp1b UTSW 2 40,628,750 (GRCm38) missense possibly damaging 0.66
R9320:Lrp1b UTSW 2 41,445,099 (GRCm38) critical splice donor site probably null
R9330:Lrp1b UTSW 2 41,122,981 (GRCm38) missense
R9352:Lrp1b UTSW 2 40,858,426 (GRCm38) missense
R9386:Lrp1b UTSW 2 41,123,628 (GRCm38) missense
R9397:Lrp1b UTSW 2 40,750,910 (GRCm38) missense
R9444:Lrp1b UTSW 2 41,123,718 (GRCm38) missense
R9452:Lrp1b UTSW 2 41,960,714 (GRCm38) nonsense probably null
R9474:Lrp1b UTSW 2 40,601,587 (GRCm38) missense probably damaging 1.00
R9501:Lrp1b UTSW 2 41,282,235 (GRCm38) missense
R9523:Lrp1b UTSW 2 41,770,966 (GRCm38) missense
R9541:Lrp1b UTSW 2 41,344,588 (GRCm38) missense
R9555:Lrp1b UTSW 2 40,858,426 (GRCm38) missense
R9555:Lrp1b UTSW 2 40,851,681 (GRCm38) missense
R9563:Lrp1b UTSW 2 41,295,699 (GRCm38) missense
R9568:Lrp1b UTSW 2 40,679,215 (GRCm38) missense
R9622:Lrp1b UTSW 2 40,889,342 (GRCm38) nonsense probably null
R9623:Lrp1b UTSW 2 41,476,636 (GRCm38) missense
R9634:Lrp1b UTSW 2 41,245,939 (GRCm38) critical splice donor site probably null
R9640:Lrp1b UTSW 2 41,188,917 (GRCm38) missense
R9664:Lrp1b UTSW 2 40,874,992 (GRCm38) missense
R9668:Lrp1b UTSW 2 41,185,970 (GRCm38) missense
R9672:Lrp1b UTSW 2 40,889,279 (GRCm38) missense
R9717:Lrp1b UTSW 2 41,268,383 (GRCm38) missense
R9741:Lrp1b UTSW 2 41,112,288 (GRCm38) missense
RF018:Lrp1b UTSW 2 41,110,907 (GRCm38) missense
RF020:Lrp1b UTSW 2 41,770,846 (GRCm38) missense
V1662:Lrp1b UTSW 2 41,122,932 (GRCm38) missense probably damaging 0.99
X0028:Lrp1b UTSW 2 41,471,145 (GRCm38) missense probably damaging 1.00
X0064:Lrp1b UTSW 2 41,502,043 (GRCm38) missense probably damaging 1.00
Z1176:Lrp1b UTSW 2 40,922,383 (GRCm38) missense
Z1176:Lrp1b UTSW 2 40,697,582 (GRCm38) missense
Z1176:Lrp1b UTSW 2 40,677,506 (GRCm38) missense
Z1176:Lrp1b UTSW 2 41,728,710 (GRCm38) missense
Z1177:Lrp1b UTSW 2 41,188,848 (GRCm38) missense
Z1177:Lrp1b UTSW 2 40,637,749 (GRCm38) missense
Z1187:Lrp1b UTSW 2 40,750,934 (GRCm38) missense
Z1188:Lrp1b UTSW 2 40,750,934 (GRCm38) missense
Predicted Primers PCR Primer
(F):5'- ACACACTCACTTAGGAGTATTGCCCC -3'
(R):5'- TTGTCCTGTGGCTTATAACTCACACTG -3'

Sequencing Primer
(F):5'- TTAGGAGTATTGCCCCTCCAAAAG -3'
(R):5'- CCTCCTAGCATGTAGGTGATAGAC -3'
Posted On 2014-03-14