Incidental Mutation 'R1419:Rpa3'
ID 159986
Institutional Source Beutler Lab
Gene Symbol Rpa3
Ensembl Gene ENSMUSG00000012483
Gene Name replication protein A3
Synonyms C330026P08Rik, 14kDa
MMRRC Submission 039475-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.858) question?
Stock # R1419 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 8255936-8259141 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 8257720 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 47 (E47D)
Ref Sequence ENSEMBL: ENSMUSP00000012627 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012627] [ENSMUST00000159335] [ENSMUST00000159378] [ENSMUST00000159433] [ENSMUST00000160705] [ENSMUST00000162564] [ENSMUST00000162034]
AlphaFold Q9CQ71
Predicted Effect probably benign
Transcript: ENSMUST00000012627
AA Change: E47D

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000012627
Gene: ENSMUSG00000012483
AA Change: E47D

DomainStartEndE-ValueType
Pfam:Rep_fac-A_3 5 113 2.5e-36 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159335
Predicted Effect probably benign
Transcript: ENSMUST00000159378
Predicted Effect probably benign
Transcript: ENSMUST00000159433
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159594
Predicted Effect probably benign
Transcript: ENSMUST00000160705
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161400
Predicted Effect probably benign
Transcript: ENSMUST00000162564
Predicted Effect probably benign
Transcript: ENSMUST00000162034
SMART Domains Protein: ENSMUSP00000124306
Gene: ENSMUSG00000089862

DomainStartEndE-ValueType
low complexity region 40 51 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 T A 7: 119,974,125 (GRCm39) M894K probably benign Het
Ablim1 C A 19: 57,123,065 (GRCm39) C173F probably damaging Het
Abtb2 G T 2: 103,539,765 (GRCm39) R710L probably benign Het
Arap3 T C 18: 38,111,485 (GRCm39) T1144A possibly damaging Het
Arhgef12 A T 9: 42,938,516 (GRCm39) V92D probably damaging Het
Ash1l T G 3: 88,892,204 (GRCm39) M1361R probably damaging Het
Atm A C 9: 53,368,789 (GRCm39) N2337K probably benign Het
Cog7 T C 7: 121,555,215 (GRCm39) E316G probably damaging Het
Dsp A G 13: 38,370,671 (GRCm39) Y858C probably damaging Het
Enc1 G T 13: 97,382,692 (GRCm39) G401C probably damaging Het
Gata6 T C 18: 11,064,706 (GRCm39) V506A probably benign Het
Gm16380 C T 9: 53,791,471 (GRCm39) noncoding transcript Het
Hsd17b8 G A 17: 34,246,617 (GRCm39) R89C probably benign Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Ift80 T A 3: 68,847,531 (GRCm39) N322Y probably damaging Het
Igsf9 T A 1: 172,325,578 (GRCm39) V1082E probably damaging Het
Katnal2 A T 18: 77,065,128 (GRCm39) L481Q possibly damaging Het
Kcnma1 T C 14: 23,417,710 (GRCm39) T713A probably damaging Het
Kif13a T C 13: 46,978,711 (GRCm39) T230A probably damaging Het
Klhl14 C A 18: 21,785,250 (GRCm39) R59L probably damaging Het
Mecom A G 3: 30,035,038 (GRCm39) C213R probably damaging Het
Mrpl13 T A 15: 55,397,717 (GRCm39) M178L probably benign Het
Myof T C 19: 37,890,359 (GRCm39) E1971G probably damaging Het
Naa10 A G X: 72,961,522 (GRCm39) V133A probably damaging Het
Nlrp4g G A 9: 124,349,434 (GRCm38) noncoding transcript Het
Ofcc1 C T 13: 40,362,305 (GRCm39) G206R probably benign Het
Oplah T C 15: 76,182,120 (GRCm39) I1047V probably benign Het
Or4a15 T C 2: 89,193,666 (GRCm39) T36A probably damaging Het
Or4k47 A T 2: 111,451,640 (GRCm39) F260I probably benign Het
Or5al1 A G 2: 85,989,773 (GRCm39) *314Q probably null Het
Paip1 A G 13: 119,593,553 (GRCm39) D189G probably damaging Het
Pkn1 A G 8: 84,400,151 (GRCm39) F624L probably damaging Het
Plxnb1 C A 9: 108,943,454 (GRCm39) P1899H probably damaging Het
Shoc1 T C 4: 59,064,457 (GRCm39) T826A possibly damaging Het
Snai2 C T 16: 14,526,044 (GRCm39) H232Y possibly damaging Het
Spint5 T C 2: 164,557,331 (GRCm39) S23P possibly damaging Het
St8sia2 G A 7: 73,616,742 (GRCm39) Q78* probably null Het
Tktl2 A G 8: 66,965,690 (GRCm39) N416S probably damaging Het
Tm7sf3 T A 6: 146,505,475 (GRCm39) I494F possibly damaging Het
Trf C T 9: 103,103,307 (GRCm39) V119M probably damaging Het
Other mutations in Rpa3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5592:Rpa3 UTSW 6 8,257,694 (GRCm39) missense probably benign 0.30
R6297:Rpa3 UTSW 6 8,256,767 (GRCm39) nonsense probably null
R8132:Rpa3 UTSW 6 8,256,790 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACACTTTCAGAAATGTTGGAGCCCT -3'
(R):5'- TGGCAACCAGTTCTTTTAGATCATCGT -3'

Sequencing Primer
(F):5'- TGTTGGAGCCCTAAGAATCAC -3'
(R):5'- gccagggctatactgagaaac -3'
Posted On 2014-03-14