Mutagenetix > Incidental Mutation

Incidental Mutation 'R1419:Nlrp4g'

159999

Institutional Source

Beutler Lab

Gene Symbol

Nlrp4g

Ensembl Gene

ENSMUSG00000079741

Gene Name

NLR family, pyrin domain containing 4G

Synonyms

nalp4g

MMRRC Submission

039475-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

R1419 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

124348831-124354028 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to A at 124349434 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000067621

SMART Domains

Protein: ENSMUSP00000065508
Gene: ENSMUSG00000079741

Domain	Start	End	E-Value	Type
Pfam:NACHT	69	238	1.5e-39	PFAM
Blast:LRR	555	582	9e-10	BLAST
Blast:LRR	610	637	7e-10	BLAST

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214229

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215276

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215602

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000216416

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217178

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000217183

Coding Region Coverage

1x: 98.9%
3x: 98.0%
10x: 95.5%
20x: 90.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca15	T	A	7: 120,374,902	M894K	probably benign	Het
Ablim1	C	A	19: 57,134,633	C173F	probably damaging	Het
Abtb2	G	T	2: 103,709,420	R710L	probably benign	Het
AI481877	T	C	4: 59,064,457	T826A	possibly damaging	Het
Arap3	T	C	18: 37,978,432	T1144A	possibly damaging	Het
Arhgef12	A	T	9: 43,027,220	V92D	probably damaging	Het
Ash1l	T	G	3: 88,984,897	M1361R	probably damaging	Het
Atm	A	C	9: 53,457,489	N2337K	probably benign	Het
Cog7	T	C	7: 121,955,992	E316G	probably damaging	Het
Dsp	A	G	13: 38,186,695	Y858C	probably damaging	Het
Enc1	G	T	13: 97,246,184	G401C	probably damaging	Het
Gata6	T	C	18: 11,064,706	V506A	probably benign	Het
Gm16380	C	T	9: 53,884,187		noncoding transcript	Het
H2-Ke6	G	A	17: 34,027,643	R89C	probably benign	Het
Hsh2d	G	A	8: 72,200,460	D229N	probably benign	Het
Ift80	T	A	3: 68,940,198	N322Y	probably damaging	Het
Igsf9	T	A	1: 172,498,011	V1082E	probably damaging	Het
Katnal2	A	T	18: 76,977,432	L481Q	possibly damaging	Het
Kcnma1	T	C	14: 23,367,642	T713A	probably damaging	Het
Kif13a	T	C	13: 46,825,235	T230A	probably damaging	Het
Klhl14	C	A	18: 21,652,193	R59L	probably damaging	Het
Mecom	A	G	3: 29,980,889	C213R	probably damaging	Het
Mrpl13	T	A	15: 55,534,321	M178L	probably benign	Het
Myof	T	C	19: 37,901,911	E1971G	probably damaging	Het
Naa10	A	G	X: 73,917,916	V133A	probably damaging	Het
Ofcc1	C	T	13: 40,208,829	G206R	probably benign	Het
Olfr1042	A	G	2: 86,159,429	*314Q	probably null	Het
Olfr1234	T	C	2: 89,363,322	T36A	probably damaging	Het
Olfr1297	A	T	2: 111,621,295	F260I	probably benign	Het
Oplah	T	C	15: 76,297,920	I1047V	probably benign	Het
Paip1	A	G	13: 119,457,017	D189G	probably damaging	Het
Pkn1	A	G	8: 83,673,522	F624L	probably damaging	Het
Plxnb1	C	A	9: 109,114,386	P1899H	probably damaging	Het
Rpa3	T	A	6: 8,257,720	E47D	probably benign	Het
Snai2	C	T	16: 14,708,180	H232Y	possibly damaging	Het
Spint5	T	C	2: 164,715,411	S23P	possibly damaging	Het
St8sia2	G	A	7: 73,966,994	Q78*	probably null	Het
Tktl2	A	G	8: 66,513,038	N416S	probably damaging	Het
Tm7sf3	T	A	6: 146,603,977	I494F	possibly damaging	Het
Trf	C	T	9: 103,226,108	V119M	probably damaging	Het

Other mutations in Nlrp4g

Allele	Source	Chr	Coord	Type	Predicted Effect
IGL01066:Nlrp4g	APN	9	124349526	unclassified	noncoding transcript
IGL01087:Nlrp4g	APN	9	124353858	critical splice acceptor site	noncoding transcript
IGL01106:Nlrp4g	APN	9	124350452	unclassified	noncoding transcript
IGL01938:Nlrp4g	APN	9	124349068	unclassified	noncoding transcript
IGL02088:Nlrp4g	APN	9	124350453	unclassified	noncoding transcript
IGL02170:Nlrp4g	APN	9	124348980	unclassified	noncoding transcript
IGL02582:Nlrp4g	APN	9	124349764	unclassified	noncoding transcript
IGL02588:Nlrp4g	APN	9	124348843	unclassified	noncoding transcript
IGL02931:Nlrp4g	APN	9	124348940	unclassified	noncoding transcript
IGL03111:Nlrp4g	APN	9	124353978	exon	noncoding transcript
IGL03373:Nlrp4g	APN	9	124349853	unclassified	noncoding transcript
R0617:Nlrp4g	UTSW	9	124349540	unclassified	noncoding transcript
R2060:Nlrp4g	UTSW	9	124349693	unclassified	noncoding transcript
R2152:Nlrp4g	UTSW	9	124353339	exon	noncoding transcript
R2356:Nlrp4g	UTSW	9	124349306	unclassified	noncoding transcript
R2384:Nlrp4g	UTSW	9	124349707	unclassified	noncoding transcript
R2698:Nlrp4g	UTSW	9	124349630	unclassified	noncoding transcript
R3878:Nlrp4g	UTSW	9	124349362	unclassified	noncoding transcript
R4640:Nlrp4g	UTSW	9	124349153	unclassified	noncoding transcript
R4745:Nlrp4g	UTSW	9	124349515	unclassified	noncoding transcript
R4754:Nlrp4g	UTSW	9	124349788	unclassified	noncoding transcript
R4937:Nlrp4g	UTSW	9	124354005	exon	noncoding transcript
R5024:Nlrp4g	UTSW	9	124350155	unclassified	noncoding transcript
R5162:Nlrp4g	UTSW	9	124350394	unclassified	noncoding transcript
R5407:Nlrp4g	UTSW	9	124349930	unclassified	noncoding transcript
R5521:Nlrp4g	UTSW	9	124350020	unclassified	noncoding transcript
R8224:Nlrp4g	UTSW	9	124353374	missense	noncoding transcript
R8259:Nlrp4g	UTSW	9	124353392	missense	noncoding transcript
Z1088:Nlrp4g	UTSW	9	124349201	unclassified	noncoding transcript

Predicted Primers

PCR Primer
(F):5'- AAGCAGTTGAAGACAGCCAGCC -3'
(R):5'- GCCCTCAGCAGCTAGAGAACATAAG -3'

Sequencing Primer
(F):5'- CTGAACTTATCTCCAGAGAGTGGC -3'
(R):5'- AGACAGAGACTGGGTCTCCTC -3'

Posted On

2014-03-14