Incidental Mutation 'R1420:Ankrd35'
ID 160028
Institutional Source Beutler Lab
Gene Symbol Ankrd35
Ensembl Gene ENSMUSG00000038354
Gene Name ankyrin repeat domain 35
Synonyms 4732436F15Rik
MMRRC Submission 039476-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1420 (G1)
Quality Score 184
Status Not validated
Chromosome 3
Chromosomal Location 96577447-96598348 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 96592054 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 780 (E780G)
Ref Sequence ENSEMBL: ENSMUSP00000047244 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048427] [ENSMUST00000122960]
AlphaFold E9Q9D8
Predicted Effect probably benign
Transcript: ENSMUST00000048427
AA Change: E780G

PolyPhen 2 Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000047244
Gene: ENSMUSG00000038354
AA Change: E780G

DomainStartEndE-ValueType
ANK 53 82 4.03e-5 SMART
ANK 86 115 6.46e-4 SMART
ANK 119 148 4.36e-1 SMART
ANK 152 181 1.4e-4 SMART
ANK 185 214 2.25e-3 SMART
ANK 218 247 6.24e2 SMART
coiled coil region 294 339 N/A INTRINSIC
low complexity region 438 455 N/A INTRINSIC
low complexity region 487 498 N/A INTRINSIC
low complexity region 524 536 N/A INTRINSIC
coiled coil region 606 653 N/A INTRINSIC
coiled coil region 729 799 N/A INTRINSIC
low complexity region 815 829 N/A INTRINSIC
coiled coil region 847 956 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000122960
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130429
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.6%
  • 20x: 90.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 A G 10: 83,331,799 (GRCm39) Y669H probably damaging Het
Amotl2 A T 9: 102,601,982 (GRCm39) M409L possibly damaging Het
Brwd1 T C 16: 95,837,234 (GRCm39) Y866C probably damaging Het
Cul4b G C X: 37,653,918 (GRCm39) probably null Het
Daw1 A T 1: 83,137,548 (GRCm39) Y10F possibly damaging Het
Dgki A T 6: 37,027,204 (GRCm39) probably null Het
Dnah3 A T 7: 119,551,202 (GRCm39) V3039E probably damaging Het
Ercc4 C T 16: 12,948,073 (GRCm39) T340I probably benign Het
Fam83b T C 9: 76,399,894 (GRCm39) N403S possibly damaging Het
Fbh1 A G 2: 11,772,493 (GRCm39) F63L probably benign Het
Foxm1 G A 6: 128,349,884 (GRCm39) R395H possibly damaging Het
Gtpbp4 C T 13: 9,023,298 (GRCm39) A589T probably benign Het
Ifna7 C A 4: 88,734,906 (GRCm39) H148N probably damaging Het
Il23r T C 6: 67,463,181 (GRCm39) Y104C probably damaging Het
Il31ra A T 13: 112,668,286 (GRCm39) W347R probably damaging Het
Ints7 T G 1: 191,345,169 (GRCm39) F620V possibly damaging Het
Iqcd T C 5: 120,738,860 (GRCm39) L226P probably damaging Het
Jak3 G T 8: 72,134,182 (GRCm39) R428L possibly damaging Het
Kif28 C A 1: 179,529,962 (GRCm39) C733F probably damaging Het
Klkb1 C A 8: 45,729,183 (GRCm39) C347F probably damaging Het
Ksr2 A G 5: 117,552,904 (GRCm39) E4G probably benign Het
Lama1 T C 17: 68,097,942 (GRCm39) L1774P probably damaging Het
Lrriq3 A G 3: 154,893,349 (GRCm39) E350G probably benign Het
Nav3 G A 10: 109,659,115 (GRCm39) A834V probably benign Het
Ncoa6 G A 2: 155,263,073 (GRCm39) Q454* probably null Het
Nfatc2 C A 2: 168,346,585 (GRCm39) M836I probably benign Het
Nphp3 G T 9: 103,913,092 (GRCm39) probably null Het
Olfml2b C T 1: 170,496,596 (GRCm39) T409M probably benign Het
Oprk1 A G 1: 5,672,544 (GRCm39) K227R probably damaging Het
Or8g35 A T 9: 39,381,289 (GRCm39) H244Q probably damaging Het
Pate1 A T 9: 35,596,505 (GRCm39) W87R probably damaging Het
Pcnx4 T C 12: 72,602,760 (GRCm39) Y341H probably benign Het
Pde4c T A 8: 71,201,066 (GRCm39) H421Q probably damaging Het
Pglyrp4 T C 3: 90,636,021 (GRCm39) V82A probably damaging Het
Pnmt G T 11: 98,278,502 (GRCm39) R156L probably benign Het
Prdm9 C A 17: 15,764,638 (GRCm39) C714F probably damaging Het
Pwp1 T C 10: 85,712,402 (GRCm39) V80A probably damaging Het
Pxdn T C 12: 30,052,067 (GRCm39) L568P probably damaging Het
Rasgrp4 C A 7: 28,839,770 (GRCm39) Q161K probably damaging Het
Rnf138 A G 18: 21,159,159 (GRCm39) E193G probably damaging Het
Slc16a6 A G 11: 109,345,772 (GRCm39) V413A probably damaging Het
Slc7a15 T C 12: 8,584,442 (GRCm39) T363A probably benign Het
Sufu T C 19: 46,385,623 (GRCm39) S28P probably benign Het
Tex19.1 T C 11: 121,037,872 (GRCm39) S77P probably damaging Het
Tmc7 A T 7: 118,165,440 (GRCm39) Y91* probably null Het
Ttbk2 C G 2: 120,576,393 (GRCm39) R792S probably benign Het
Tyw1 T C 5: 130,303,586 (GRCm39) probably null Het
U2surp A G 9: 95,344,856 (GRCm39) S907P probably benign Het
Vmn2r115 ATCTTCT ATCT 17: 23,578,962 (GRCm39) probably benign Het
Vps50 T A 6: 3,588,007 (GRCm39) L660* probably null Het
Wdr55 A G 18: 36,893,392 (GRCm39) E18G probably benign Het
Wipi1 A G 11: 109,469,198 (GRCm39) V331A probably benign Het
Other mutations in Ankrd35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00819:Ankrd35 APN 3 96,590,350 (GRCm39) splice site probably null
IGL00896:Ankrd35 APN 3 96,591,592 (GRCm39) missense probably damaging 1.00
IGL01565:Ankrd35 APN 3 96,592,101 (GRCm39) missense probably damaging 0.99
IGL01837:Ankrd35 APN 3 96,587,982 (GRCm39) missense probably damaging 1.00
IGL02605:Ankrd35 APN 3 96,588,388 (GRCm39) splice site probably null
IGL02819:Ankrd35 APN 3 96,597,524 (GRCm39) missense possibly damaging 0.80
IGL02994:Ankrd35 APN 3 96,590,307 (GRCm39) splice site probably benign
IGL03083:Ankrd35 APN 3 96,592,117 (GRCm39) missense probably damaging 1.00
IGL03105:Ankrd35 APN 3 96,591,373 (GRCm39) missense probably benign
FR4304:Ankrd35 UTSW 3 96,591,163 (GRCm39) utr 3 prime probably benign
FR4342:Ankrd35 UTSW 3 96,590,831 (GRCm39) frame shift probably null
FR4737:Ankrd35 UTSW 3 96,591,165 (GRCm39) utr 3 prime probably benign
R0003:Ankrd35 UTSW 3 96,591,331 (GRCm39) missense probably damaging 1.00
R0047:Ankrd35 UTSW 3 96,591,379 (GRCm39) missense probably benign 0.00
R0551:Ankrd35 UTSW 3 96,591,276 (GRCm39) missense probably benign 0.08
R1455:Ankrd35 UTSW 3 96,585,471 (GRCm39) missense probably damaging 1.00
R2201:Ankrd35 UTSW 3 96,586,564 (GRCm39) missense possibly damaging 0.93
R3522:Ankrd35 UTSW 3 96,592,378 (GRCm39) missense probably damaging 1.00
R3605:Ankrd35 UTSW 3 96,589,497 (GRCm39) nonsense probably null
R4166:Ankrd35 UTSW 3 96,586,471 (GRCm39) splice site probably null
R4651:Ankrd35 UTSW 3 96,591,343 (GRCm39) missense probably benign 0.00
R4668:Ankrd35 UTSW 3 96,586,524 (GRCm39) missense probably damaging 1.00
R4916:Ankrd35 UTSW 3 96,591,438 (GRCm39) missense probably benign
R4921:Ankrd35 UTSW 3 96,592,140 (GRCm39) missense possibly damaging 0.61
R4953:Ankrd35 UTSW 3 96,590,989 (GRCm39) missense possibly damaging 0.56
R5180:Ankrd35 UTSW 3 96,587,789 (GRCm39) missense probably damaging 1.00
R5583:Ankrd35 UTSW 3 96,592,219 (GRCm39) missense probably damaging 1.00
R5604:Ankrd35 UTSW 3 96,592,215 (GRCm39) missense probably benign 0.02
R5613:Ankrd35 UTSW 3 96,590,334 (GRCm39) missense possibly damaging 0.76
R6165:Ankrd35 UTSW 3 96,590,623 (GRCm39) missense possibly damaging 0.93
R6413:Ankrd35 UTSW 3 96,592,129 (GRCm39) missense probably damaging 0.96
R6711:Ankrd35 UTSW 3 96,590,784 (GRCm39) nonsense probably null
R6834:Ankrd35 UTSW 3 96,590,599 (GRCm39) missense possibly damaging 0.68
R6841:Ankrd35 UTSW 3 96,577,742 (GRCm39) missense probably damaging 1.00
R7028:Ankrd35 UTSW 3 96,590,650 (GRCm39) missense possibly damaging 0.92
R7396:Ankrd35 UTSW 3 96,590,813 (GRCm39) missense probably damaging 1.00
R7425:Ankrd35 UTSW 3 96,592,104 (GRCm39) missense not run
R7815:Ankrd35 UTSW 3 96,592,117 (GRCm39) missense probably damaging 1.00
R7887:Ankrd35 UTSW 3 96,592,216 (GRCm39) missense probably damaging 1.00
R8103:Ankrd35 UTSW 3 96,586,997 (GRCm39) missense possibly damaging 0.93
R8318:Ankrd35 UTSW 3 96,592,038 (GRCm39) missense probably damaging 1.00
R8492:Ankrd35 UTSW 3 96,589,529 (GRCm39) critical splice donor site probably null
R8527:Ankrd35 UTSW 3 96,589,353 (GRCm39) missense probably damaging 1.00
R8542:Ankrd35 UTSW 3 96,589,353 (GRCm39) missense probably damaging 1.00
R8742:Ankrd35 UTSW 3 96,586,502 (GRCm39) missense probably damaging 1.00
R8963:Ankrd35 UTSW 3 96,587,003 (GRCm39) nonsense probably null
R9029:Ankrd35 UTSW 3 96,591,460 (GRCm39) missense probably benign 0.43
R9229:Ankrd35 UTSW 3 96,592,215 (GRCm39) missense probably benign 0.02
R9488:Ankrd35 UTSW 3 96,589,343 (GRCm39) missense probably damaging 1.00
R9669:Ankrd35 UTSW 3 96,587,797 (GRCm39) missense probably damaging 1.00
R9761:Ankrd35 UTSW 3 96,591,733 (GRCm39) missense possibly damaging 0.80
Z1177:Ankrd35 UTSW 3 96,591,086 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- AAGGACTGTGGAAATGCCTACCCC -3'
(R):5'- ACTTCTCCAGCACGACTTTGAGC -3'

Sequencing Primer
(F):5'- TGCAGAACCCCTGGAGGAG -3'
(R):5'- CCCCAAGCCTGTGCCTG -3'
Posted On 2014-03-14