Incidental Mutation 'R1401:Vmn2r84'
ID |
160148 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r84
|
Ensembl Gene |
ENSMUSG00000070601 |
Gene Name |
vomeronasal 2, receptor 84 |
Synonyms |
EG625068 |
MMRRC Submission |
039463-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.070)
|
Stock # |
R1401 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
10 |
Chromosomal Location |
130221669-130230110 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 130227859 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Cysteine
at position 126
(S126C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000092079
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094502]
|
AlphaFold |
D3YWE3 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000094502
AA Change: S126C
PolyPhen 2
Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000092079 Gene: ENSMUSG00000070601 AA Change: S126C
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
21 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
448 |
1.3e-27 |
PFAM |
Pfam:NCD3G
|
508 |
561 |
6.9e-21 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
4.6e-55 |
PFAM |
|
Meta Mutation Damage Score |
0.1795 |
Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.1%
- 10x: 95.8%
- 20x: 91.4%
|
Validation Efficiency |
98% (87/89) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 84 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930433I11Rik |
A |
T |
7: 40,642,480 (GRCm39) |
T141S |
probably benign |
Het |
Abcg1 |
T |
A |
17: 31,333,132 (GRCm39) |
I625N |
possibly damaging |
Het |
Adam33 |
C |
A |
2: 130,893,391 (GRCm39) |
|
probably benign |
Het |
Adgrl2 |
A |
T |
3: 148,528,617 (GRCm39) |
I1185N |
probably damaging |
Het |
Afp |
A |
T |
5: 90,649,486 (GRCm39) |
|
probably benign |
Het |
Aggf1 |
A |
G |
13: 95,501,356 (GRCm39) |
V342A |
probably benign |
Het |
Ankrd11 |
A |
T |
8: 123,619,789 (GRCm39) |
S1333R |
probably benign |
Het |
Arhgef11 |
C |
A |
3: 87,640,776 (GRCm39) |
S1311* |
probably null |
Het |
Atp6v1g1 |
T |
C |
4: 63,466,878 (GRCm39) |
Y47H |
probably benign |
Het |
Atp8b4 |
T |
C |
2: 126,165,013 (GRCm39) |
|
probably null |
Het |
Barx2 |
A |
G |
9: 31,770,327 (GRCm39) |
L67P |
probably damaging |
Het |
Bbs7 |
G |
A |
3: 36,627,706 (GRCm39) |
P694S |
probably benign |
Het |
Btbd10 |
A |
T |
7: 112,946,266 (GRCm39) |
V33E |
probably benign |
Het |
C2 |
T |
C |
17: 35,091,457 (GRCm39) |
T69A |
possibly damaging |
Het |
C8b |
T |
G |
4: 104,641,679 (GRCm39) |
L205R |
possibly damaging |
Het |
Cct4 |
T |
G |
11: 22,944,333 (GRCm39) |
N72K |
probably damaging |
Het |
Cd300lg |
C |
A |
11: 101,944,981 (GRCm39) |
P353H |
possibly damaging |
Het |
Cdh20 |
A |
T |
1: 104,875,222 (GRCm39) |
I335L |
possibly damaging |
Het |
Cfhr2 |
T |
A |
1: 139,738,757 (GRCm39) |
H268L |
probably benign |
Het |
Chia1 |
T |
A |
3: 106,036,255 (GRCm39) |
D278E |
probably benign |
Het |
Cntn6 |
A |
G |
6: 104,781,359 (GRCm39) |
T482A |
possibly damaging |
Het |
Cst13 |
T |
A |
2: 148,665,016 (GRCm39) |
F4I |
probably benign |
Het |
Ctsc |
T |
A |
7: 87,930,706 (GRCm39) |
V95E |
probably damaging |
Het |
Ddhd1 |
A |
T |
14: 45,842,508 (GRCm39) |
|
probably null |
Het |
Dmxl2 |
A |
T |
9: 54,322,712 (GRCm39) |
|
probably null |
Het |
Dnah5 |
A |
C |
15: 28,402,059 (GRCm39) |
T3407P |
probably damaging |
Het |
Dock1 |
T |
A |
7: 134,735,665 (GRCm39) |
Y1344* |
probably null |
Het |
Eif4g3 |
T |
C |
4: 137,933,395 (GRCm39) |
V1740A |
probably damaging |
Het |
Epb41l5 |
A |
G |
1: 119,506,634 (GRCm39) |
|
probably benign |
Het |
Flt4 |
C |
T |
11: 49,527,166 (GRCm39) |
|
probably benign |
Het |
Fnbp1l |
C |
T |
3: 122,339,955 (GRCm39) |
R499Q |
probably damaging |
Het |
Gm10033 |
T |
C |
8: 69,826,022 (GRCm39) |
|
noncoding transcript |
Het |
Gm12790 |
A |
G |
4: 101,825,396 (GRCm39) |
L6P |
probably benign |
Het |
Gramd4 |
A |
G |
15: 86,009,397 (GRCm39) |
D210G |
probably damaging |
Het |
Hectd3 |
T |
C |
4: 116,859,466 (GRCm39) |
S697P |
possibly damaging |
Het |
Hsf4 |
T |
C |
8: 106,002,235 (GRCm39) |
V399A |
probably benign |
Het |
Hyal6 |
T |
A |
6: 24,743,434 (GRCm39) |
C377S |
probably damaging |
Het |
Myb |
C |
T |
10: 21,028,844 (GRCm39) |
V85M |
probably damaging |
Het |
Mypn |
A |
G |
10: 62,988,636 (GRCm39) |
V463A |
probably damaging |
Het |
Nav1 |
T |
A |
1: 135,388,163 (GRCm39) |
I1144L |
probably benign |
Het |
Nckap5 |
A |
G |
1: 125,942,398 (GRCm39) |
|
probably benign |
Het |
Nipbl |
A |
T |
15: 8,401,657 (GRCm39) |
S30T |
probably damaging |
Het |
Nmt1 |
T |
C |
11: 102,948,307 (GRCm39) |
F277S |
probably damaging |
Het |
Nploc4 |
A |
C |
11: 120,274,115 (GRCm39) |
|
probably benign |
Het |
Nup54 |
C |
A |
5: 92,576,080 (GRCm39) |
R137I |
probably damaging |
Het |
Or52n2b |
T |
C |
7: 104,565,963 (GRCm39) |
Y180C |
probably damaging |
Het |
Oxtr |
C |
T |
6: 112,454,138 (GRCm39) |
R42Q |
probably benign |
Het |
Pkd1l1 |
G |
T |
11: 8,804,487 (GRCm39) |
Y1701* |
probably null |
Het |
Plekhg6 |
T |
C |
6: 125,340,072 (GRCm39) |
T763A |
probably damaging |
Het |
Pmepa1 |
C |
T |
2: 173,070,368 (GRCm39) |
|
probably null |
Het |
Ppfia2 |
A |
G |
10: 106,666,518 (GRCm39) |
E408G |
possibly damaging |
Het |
Pramel13 |
G |
A |
4: 144,121,658 (GRCm39) |
T122M |
probably benign |
Het |
Prl8a2 |
G |
A |
13: 27,537,979 (GRCm39) |
V218I |
possibly damaging |
Het |
Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
Rims4 |
C |
T |
2: 163,705,849 (GRCm39) |
V262M |
possibly damaging |
Het |
Shisal2b |
A |
T |
13: 105,000,113 (GRCm39) |
C37S |
probably damaging |
Het |
Slc13a1 |
A |
T |
6: 24,118,082 (GRCm39) |
|
probably null |
Het |
Slc17a8 |
T |
A |
10: 89,427,076 (GRCm39) |
T342S |
probably damaging |
Het |
Slc30a9 |
A |
G |
5: 67,510,005 (GRCm39) |
E519G |
probably benign |
Het |
Slc35e1 |
T |
C |
8: 73,246,415 (GRCm39) |
|
probably benign |
Het |
Slc39a5 |
G |
A |
10: 128,233,610 (GRCm39) |
L296F |
probably damaging |
Het |
Slco6b1 |
A |
C |
1: 96,857,610 (GRCm39) |
|
noncoding transcript |
Het |
Slco6d1 |
G |
A |
1: 98,418,341 (GRCm39) |
G509D |
probably damaging |
Het |
Spen |
A |
G |
4: 141,199,132 (GRCm39) |
V3142A |
probably damaging |
Het |
Spta1 |
T |
A |
1: 174,050,250 (GRCm39) |
H1763Q |
probably damaging |
Het |
Srcap |
T |
C |
7: 127,159,124 (GRCm39) |
|
probably benign |
Het |
Stard9 |
T |
C |
2: 120,543,328 (GRCm39) |
|
probably benign |
Het |
Stat4 |
A |
G |
1: 52,111,106 (GRCm39) |
|
probably benign |
Het |
Svbp |
T |
A |
4: 119,053,225 (GRCm39) |
|
probably benign |
Het |
Tm2d1 |
A |
T |
4: 98,258,833 (GRCm39) |
|
probably benign |
Het |
Trpv1 |
C |
A |
11: 73,130,952 (GRCm39) |
|
probably null |
Het |
Trrap |
A |
G |
5: 144,794,232 (GRCm39) |
D3713G |
possibly damaging |
Het |
Ubr1 |
T |
A |
2: 120,786,125 (GRCm39) |
D165V |
probably benign |
Het |
Utrn |
C |
A |
10: 12,524,897 (GRCm39) |
M2195I |
probably benign |
Het |
Vmn1r229 |
G |
A |
17: 21,034,904 (GRCm39) |
V50I |
possibly damaging |
Het |
Vmn1r44 |
A |
T |
6: 89,870,632 (GRCm39) |
H126L |
probably benign |
Het |
Vmn2r116 |
T |
C |
17: 23,605,570 (GRCm39) |
|
probably benign |
Het |
Vmn2r27 |
A |
C |
6: 124,168,591 (GRCm39) |
Y846* |
probably null |
Het |
Xylb |
T |
A |
9: 119,197,133 (GRCm39) |
|
probably benign |
Het |
Zfp282 |
A |
T |
6: 47,867,108 (GRCm39) |
K232* |
probably null |
Het |
Zfp39 |
C |
A |
11: 58,781,149 (GRCm39) |
V538L |
probably benign |
Het |
Zfp560 |
T |
C |
9: 20,263,149 (GRCm39) |
N76D |
possibly damaging |
Het |
Zmym4 |
C |
T |
4: 126,804,962 (GRCm39) |
V433I |
probably benign |
Het |
Zscan5b |
A |
G |
7: 6,233,425 (GRCm39) |
E83G |
probably damaging |
Het |
|
Other mutations in Vmn2r84 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01461:Vmn2r84
|
APN |
10 |
130,227,094 (GRCm39) |
missense |
possibly damaging |
0.65 |
IGL01590:Vmn2r84
|
APN |
10 |
130,221,964 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01639:Vmn2r84
|
APN |
10 |
130,225,141 (GRCm39) |
nonsense |
probably null |
|
IGL01843:Vmn2r84
|
APN |
10 |
130,222,148 (GRCm39) |
missense |
probably benign |
|
IGL01911:Vmn2r84
|
APN |
10 |
130,222,277 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01937:Vmn2r84
|
APN |
10 |
130,221,755 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01977:Vmn2r84
|
APN |
10 |
130,229,935 (GRCm39) |
missense |
probably benign |
0.11 |
IGL02177:Vmn2r84
|
APN |
10 |
130,227,881 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02291:Vmn2r84
|
APN |
10 |
130,226,617 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02590:Vmn2r84
|
APN |
10 |
130,227,356 (GRCm39) |
splice site |
probably benign |
|
IGL02727:Vmn2r84
|
APN |
10 |
130,229,995 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02900:Vmn2r84
|
APN |
10 |
130,223,861 (GRCm39) |
splice site |
probably benign |
|
IGL03383:Vmn2r84
|
APN |
10 |
130,222,556 (GRCm39) |
missense |
probably damaging |
1.00 |
PIT4378001:Vmn2r84
|
UTSW |
10 |
130,221,784 (GRCm39) |
missense |
probably damaging |
1.00 |
R0076:Vmn2r84
|
UTSW |
10 |
130,230,062 (GRCm39) |
missense |
probably damaging |
1.00 |
R0089:Vmn2r84
|
UTSW |
10 |
130,222,588 (GRCm39) |
splice site |
probably benign |
|
R0153:Vmn2r84
|
UTSW |
10 |
130,227,877 (GRCm39) |
missense |
probably benign |
0.06 |
R0611:Vmn2r84
|
UTSW |
10 |
130,221,991 (GRCm39) |
missense |
probably damaging |
1.00 |
R0883:Vmn2r84
|
UTSW |
10 |
130,226,984 (GRCm39) |
missense |
probably damaging |
0.99 |
R1237:Vmn2r84
|
UTSW |
10 |
130,223,725 (GRCm39) |
splice site |
probably null |
|
R1295:Vmn2r84
|
UTSW |
10 |
130,225,008 (GRCm39) |
missense |
probably benign |
0.12 |
R1521:Vmn2r84
|
UTSW |
10 |
130,225,137 (GRCm39) |
missense |
probably benign |
0.10 |
R1590:Vmn2r84
|
UTSW |
10 |
130,227,349 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1710:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
R1891:Vmn2r84
|
UTSW |
10 |
130,221,938 (GRCm39) |
missense |
possibly damaging |
0.78 |
R1956:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
R1957:Vmn2r84
|
UTSW |
10 |
130,226,677 (GRCm39) |
missense |
probably benign |
0.01 |
R1962:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
R1994:Vmn2r84
|
UTSW |
10 |
130,221,878 (GRCm39) |
missense |
probably damaging |
1.00 |
R2124:Vmn2r84
|
UTSW |
10 |
130,227,100 (GRCm39) |
missense |
probably damaging |
0.99 |
R2409:Vmn2r84
|
UTSW |
10 |
130,227,940 (GRCm39) |
missense |
probably damaging |
0.99 |
R2474:Vmn2r84
|
UTSW |
10 |
130,222,392 (GRCm39) |
missense |
possibly damaging |
0.50 |
R2851:Vmn2r84
|
UTSW |
10 |
130,230,036 (GRCm39) |
missense |
probably benign |
0.05 |
R3508:Vmn2r84
|
UTSW |
10 |
130,226,777 (GRCm39) |
missense |
probably damaging |
1.00 |
R3792:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
R4051:Vmn2r84
|
UTSW |
10 |
130,226,767 (GRCm39) |
missense |
probably damaging |
1.00 |
R4061:Vmn2r84
|
UTSW |
10 |
130,221,898 (GRCm39) |
missense |
probably damaging |
1.00 |
R4091:Vmn2r84
|
UTSW |
10 |
130,227,238 (GRCm39) |
missense |
probably damaging |
1.00 |
R4190:Vmn2r84
|
UTSW |
10 |
130,227,163 (GRCm39) |
nonsense |
probably null |
|
R4520:Vmn2r84
|
UTSW |
10 |
130,222,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R4584:Vmn2r84
|
UTSW |
10 |
130,226,582 (GRCm39) |
missense |
probably benign |
0.00 |
R4588:Vmn2r84
|
UTSW |
10 |
130,221,809 (GRCm39) |
missense |
probably damaging |
0.98 |
R4655:Vmn2r84
|
UTSW |
10 |
130,229,973 (GRCm39) |
nonsense |
probably null |
|
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
R4860:Vmn2r84
|
UTSW |
10 |
130,221,712 (GRCm39) |
missense |
probably damaging |
0.99 |
R5022:Vmn2r84
|
UTSW |
10 |
130,222,417 (GRCm39) |
missense |
probably damaging |
1.00 |
R5146:Vmn2r84
|
UTSW |
10 |
130,221,971 (GRCm39) |
missense |
probably damaging |
1.00 |
R5237:Vmn2r84
|
UTSW |
10 |
130,221,863 (GRCm39) |
missense |
probably damaging |
0.99 |
R5695:Vmn2r84
|
UTSW |
10 |
130,225,064 (GRCm39) |
missense |
probably benign |
0.12 |
R5793:Vmn2r84
|
UTSW |
10 |
130,221,754 (GRCm39) |
missense |
probably damaging |
0.99 |
R6210:Vmn2r84
|
UTSW |
10 |
130,222,114 (GRCm39) |
missense |
probably damaging |
1.00 |
R6286:Vmn2r84
|
UTSW |
10 |
130,226,737 (GRCm39) |
missense |
possibly damaging |
0.65 |
R6580:Vmn2r84
|
UTSW |
10 |
130,225,110 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6607:Vmn2r84
|
UTSW |
10 |
130,226,731 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6818:Vmn2r84
|
UTSW |
10 |
130,222,147 (GRCm39) |
missense |
probably benign |
0.09 |
R6956:Vmn2r84
|
UTSW |
10 |
130,225,136 (GRCm39) |
missense |
probably damaging |
0.98 |
R6994:Vmn2r84
|
UTSW |
10 |
130,226,876 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7075:Vmn2r84
|
UTSW |
10 |
130,226,941 (GRCm39) |
missense |
probably damaging |
0.99 |
R7225:Vmn2r84
|
UTSW |
10 |
130,222,552 (GRCm39) |
missense |
probably damaging |
0.99 |
R7252:Vmn2r84
|
UTSW |
10 |
130,222,279 (GRCm39) |
missense |
probably damaging |
1.00 |
R7263:Vmn2r84
|
UTSW |
10 |
130,225,077 (GRCm39) |
missense |
probably damaging |
1.00 |
R7297:Vmn2r84
|
UTSW |
10 |
130,227,119 (GRCm39) |
missense |
probably benign |
0.19 |
R7439:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7441:Vmn2r84
|
UTSW |
10 |
130,227,982 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7857:Vmn2r84
|
UTSW |
10 |
130,226,738 (GRCm39) |
missense |
probably benign |
0.00 |
R8263:Vmn2r84
|
UTSW |
10 |
130,227,037 (GRCm39) |
missense |
probably damaging |
1.00 |
R8555:Vmn2r84
|
UTSW |
10 |
130,230,100 (GRCm39) |
missense |
probably benign |
0.28 |
R8766:Vmn2r84
|
UTSW |
10 |
130,222,241 (GRCm39) |
missense |
probably damaging |
0.98 |
R8821:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
R8831:Vmn2r84
|
UTSW |
10 |
130,226,968 (GRCm39) |
missense |
probably benign |
0.02 |
R8970:Vmn2r84
|
UTSW |
10 |
130,222,244 (GRCm39) |
missense |
probably damaging |
0.98 |
R9164:Vmn2r84
|
UTSW |
10 |
130,221,669 (GRCm39) |
makesense |
probably null |
|
R9190:Vmn2r84
|
UTSW |
10 |
130,226,843 (GRCm39) |
missense |
probably benign |
0.03 |
R9261:Vmn2r84
|
UTSW |
10 |
130,229,976 (GRCm39) |
missense |
probably benign |
0.00 |
R9310:Vmn2r84
|
UTSW |
10 |
130,227,993 (GRCm39) |
missense |
possibly damaging |
0.81 |
R9434:Vmn2r84
|
UTSW |
10 |
130,221,745 (GRCm39) |
missense |
possibly damaging |
0.65 |
R9613:Vmn2r84
|
UTSW |
10 |
130,226,591 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1177:Vmn2r84
|
UTSW |
10 |
130,227,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- tgtgtgGCAGCACACTCATAAATTCA -3'
(R):5'- AGGACTGTAATCTAGTTCAAGGATGGCA -3'
Sequencing Primer
(F):5'- GCACACTCATAAATTCATGCTGTC -3'
(R):5'- TCTAGTTCAAGGATGGCATTGAGAG -3'
|
Posted On |
2014-03-14 |