Incidental Mutation 'R1398:Wdr70'
ID 160258
Institutional Source Beutler Lab
Gene Symbol Wdr70
Ensembl Gene ENSMUSG00000039828
Gene Name WD repeat domain 70
Synonyms 4833422F06Rik
MMRRC Submission 039460-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.965) question?
Stock # R1398 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 7902536-8128693 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 8065325 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 246 (M246L)
Ref Sequence ENSEMBL: ENSMUSP00000037340 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045766]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000045766
AA Change: M246L

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000037340
Gene: ENSMUSG00000039828
AA Change: M246L

DomainStartEndE-ValueType
coiled coil region 51 81 N/A INTRINSIC
low complexity region 137 167 N/A INTRINSIC
WD40 174 213 1.61e-3 SMART
WD40 220 260 3.2e0 SMART
WD40 272 315 1.03e0 SMART
WD40 324 363 1.7e-2 SMART
WD40 367 409 1.38e-2 SMART
Blast:WD40 413 460 5e-16 BLAST
WD40 463 502 3.44e0 SMART
low complexity region 570 586 N/A INTRINSIC
Meta Mutation Damage Score 0.0679 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.7%
Validation Efficiency 96% (75/78)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 T C 17: 24,547,511 (GRCm39) K288E probably damaging Het
Aldh3a2 T C 11: 61,147,562 (GRCm39) probably null Het
Anks1b A G 10: 89,885,891 (GRCm39) T196A probably damaging Het
Anks6 T A 4: 47,044,926 (GRCm39) T327S possibly damaging Het
Bdh2 T C 3: 135,001,057 (GRCm39) probably benign Het
C4b T A 17: 34,949,693 (GRCm39) probably benign Het
Cacna2d1 G A 5: 16,562,764 (GRCm39) V847I possibly damaging Het
Cadps G T 14: 12,449,822 (GRCm38) T1129K probably damaging Het
Cdc45 A G 16: 18,600,721 (GRCm39) probably benign Het
Cep63 A T 9: 102,480,285 (GRCm39) probably benign Het
Chil4 T A 3: 106,126,825 (GRCm39) probably null Het
Cnot11 A G 1: 39,584,261 (GRCm39) R478G probably damaging Het
Cyp2c67 A G 19: 39,627,069 (GRCm39) S254P probably damaging Het
Dnah11 T A 12: 118,020,841 (GRCm39) K87* probably null Het
Dpy19l2 T A 9: 24,492,559 (GRCm39) probably benign Het
Dsc1 A T 18: 20,221,393 (GRCm39) I694N probably damaging Het
Ehd4 A T 2: 119,958,081 (GRCm39) I168K probably benign Het
Eif4e A T 3: 138,252,136 (GRCm39) N25Y probably damaging Het
Elapor2 A G 5: 9,430,297 (GRCm39) Y69C probably damaging Het
Eme2 G A 17: 25,111,892 (GRCm39) S263F probably damaging Het
Fgfrl1 T A 5: 108,854,147 (GRCm39) probably benign Het
Fhip2a T A 19: 57,361,358 (GRCm39) probably benign Het
Gm3159 T A 14: 4,398,586 (GRCm38) Y92* probably null Het
Gm4922 T A 10: 18,659,496 (GRCm39) S409C possibly damaging Het
Gmcl1 G A 6: 86,691,244 (GRCm39) probably benign Het
Grsf1 A G 5: 88,813,706 (GRCm39) Y231H probably benign Het
Heatr4 T A 12: 84,014,395 (GRCm39) H614L possibly damaging Het
Hoxa13 C G 6: 52,260,647 (GRCm38) probably benign Het
Hoxa13 G C 6: 52,260,648 (GRCm38) probably benign Het
Isg20l2 C A 3: 87,846,061 (GRCm39) L325I probably benign Het
Kalrn A G 16: 34,033,190 (GRCm39) Y879H probably damaging Het
Kcnk10 C A 12: 98,402,485 (GRCm39) W318L probably damaging Het
Kctd1 T C 18: 15,195,654 (GRCm39) E323G possibly damaging Het
Kif4 G T X: 99,732,703 (GRCm39) A492S probably benign Het
Krtap4-1 T C 11: 99,518,558 (GRCm39) T151A unknown Het
Ldlr A T 9: 21,650,838 (GRCm39) Q449L probably benign Het
Lepr T A 4: 101,649,216 (GRCm39) D872E probably damaging Het
Lgals12 C T 19: 7,581,322 (GRCm39) probably benign Het
Lrig3 C T 10: 125,838,957 (GRCm39) P488L probably benign Het
Lrrc4b A C 7: 44,111,876 (GRCm39) I583L probably benign Het
Lyst T C 13: 13,915,121 (GRCm39) S3272P possibly damaging Het
Marchf2 T C 17: 33,915,096 (GRCm39) H166R probably damaging Het
Mtbp C A 15: 55,440,933 (GRCm39) Y373* probably null Het
Myh2 C T 11: 67,076,113 (GRCm39) H767Y probably benign Het
Ncam1 G A 9: 49,428,889 (GRCm39) probably benign Het
Neb T A 2: 52,179,658 (GRCm39) N1282Y probably damaging Het
Nectin3 A G 16: 46,269,119 (GRCm39) Y428H possibly damaging Het
Nrros A T 16: 31,961,962 (GRCm39) I649N probably damaging Het
Nvl A T 1: 180,924,691 (GRCm39) probably benign Het
Or5p70 T A 7: 107,994,708 (GRCm39) V127E probably damaging Het
Pms1 A T 1: 53,246,435 (GRCm39) V368E possibly damaging Het
Polq T A 16: 36,882,857 (GRCm39) S1674T possibly damaging Het
Ppp1r21 T C 17: 88,850,307 (GRCm39) V31A probably damaging Het
Rev3l T A 10: 39,697,579 (GRCm39) V692E probably benign Het
Robo4 T C 9: 37,319,372 (GRCm39) probably null Het
Rps6kc1 T C 1: 190,532,212 (GRCm39) I597V probably damaging Het
Rtel1 T A 2: 180,977,658 (GRCm39) probably null Het
Scn9a A G 2: 66,314,930 (GRCm39) M1587T probably benign Het
Sec31b T A 19: 44,512,104 (GRCm39) I597F probably benign Het
Skint5 T C 4: 113,636,268 (GRCm39) N650S unknown Het
Slc22a28 G T 19: 8,107,566 (GRCm39) S167* probably null Het
Slfn1 T A 11: 83,011,968 (GRCm39) M28K probably damaging Het
Smc6 T C 12: 11,321,880 (GRCm39) probably benign Het
Sox8 T C 17: 25,786,857 (GRCm39) H282R probably benign Het
Spata31e2 G T 1: 26,724,422 (GRCm39) Q253K possibly damaging Het
Syngr3 C A 17: 24,905,414 (GRCm39) V161L probably benign Het
Trak1 C T 9: 121,283,425 (GRCm39) S397F probably damaging Het
Uso1 C T 5: 92,329,327 (GRCm39) A405V probably benign Het
Uvrag G T 7: 98,715,027 (GRCm39) Y190* probably null Het
Vps13d A T 4: 144,826,553 (GRCm39) L1726Q probably null Het
Vwf A T 6: 125,580,420 (GRCm39) Q556L probably benign Het
Yipf3 T C 17: 46,562,372 (GRCm39) F285S probably damaging Het
Zdhhc13 G A 7: 48,476,621 (GRCm39) G579R probably damaging Het
Zdhhc18 G C 4: 133,354,608 (GRCm39) F125L probably benign Het
Other mutations in Wdr70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00777:Wdr70 APN 15 8,049,088 (GRCm39) missense probably benign 0.07
IGL01121:Wdr70 APN 15 7,902,655 (GRCm39) missense possibly damaging 0.53
IGL01508:Wdr70 APN 15 8,108,747 (GRCm39) missense probably benign 0.33
IGL01801:Wdr70 APN 15 7,916,805 (GRCm39) splice site probably null
IGL01815:Wdr70 APN 15 7,916,805 (GRCm39) splice site probably null
IGL01929:Wdr70 APN 15 7,950,115 (GRCm39) splice site probably null
IGL02150:Wdr70 APN 15 8,112,030 (GRCm39) missense possibly damaging 0.72
IGL02245:Wdr70 APN 15 8,075,965 (GRCm39) missense possibly damaging 0.86
IGL02541:Wdr70 APN 15 7,913,783 (GRCm39) nonsense probably null
IGL02800:Wdr70 APN 15 8,111,980 (GRCm39) missense probably benign 0.25
IGL02829:Wdr70 APN 15 8,006,463 (GRCm39) missense possibly damaging 0.92
IGL02831:Wdr70 APN 15 7,913,787 (GRCm39) missense possibly damaging 0.86
IGL03169:Wdr70 APN 15 7,913,821 (GRCm39) missense possibly damaging 0.73
IGL03405:Wdr70 APN 15 8,065,352 (GRCm39) missense possibly damaging 0.73
R0106:Wdr70 UTSW 15 8,049,068 (GRCm39) critical splice donor site probably null
R0106:Wdr70 UTSW 15 8,049,068 (GRCm39) critical splice donor site probably null
R0462:Wdr70 UTSW 15 8,108,645 (GRCm39) missense probably benign 0.00
R0539:Wdr70 UTSW 15 7,915,118 (GRCm39) missense possibly damaging 0.96
R1812:Wdr70 UTSW 15 8,108,663 (GRCm39) missense probably benign 0.00
R1863:Wdr70 UTSW 15 7,950,054 (GRCm39) missense probably benign 0.25
R1913:Wdr70 UTSW 15 7,913,891 (GRCm39) missense possibly damaging 0.72
R2425:Wdr70 UTSW 15 7,916,840 (GRCm39) nonsense probably null
R4013:Wdr70 UTSW 15 8,108,698 (GRCm39) nonsense probably null
R4015:Wdr70 UTSW 15 8,108,698 (GRCm39) nonsense probably null
R4017:Wdr70 UTSW 15 8,108,698 (GRCm39) nonsense probably null
R4111:Wdr70 UTSW 15 8,006,472 (GRCm39) missense probably benign 0.32
R5241:Wdr70 UTSW 15 8,108,700 (GRCm39) missense probably benign
R5277:Wdr70 UTSW 15 8,006,465 (GRCm39) nonsense probably null
R5306:Wdr70 UTSW 15 7,953,754 (GRCm39) missense probably benign 0.04
R5426:Wdr70 UTSW 15 7,951,586 (GRCm39) missense possibly damaging 0.59
R5586:Wdr70 UTSW 15 7,913,769 (GRCm39) missense possibly damaging 0.86
R6010:Wdr70 UTSW 15 7,916,900 (GRCm39) splice site probably null
R6035:Wdr70 UTSW 15 7,916,830 (GRCm39) missense possibly damaging 0.86
R6035:Wdr70 UTSW 15 7,916,830 (GRCm39) missense possibly damaging 0.86
R6109:Wdr70 UTSW 15 8,108,638 (GRCm39) splice site probably null
R6139:Wdr70 UTSW 15 8,108,735 (GRCm39) missense probably benign 0.04
R6400:Wdr70 UTSW 15 8,072,322 (GRCm39) missense probably benign 0.32
R6456:Wdr70 UTSW 15 7,915,118 (GRCm39) missense possibly damaging 0.96
R6518:Wdr70 UTSW 15 8,108,821 (GRCm39) missense unknown
R7036:Wdr70 UTSW 15 7,913,855 (GRCm39) missense possibly damaging 0.85
R7056:Wdr70 UTSW 15 7,913,877 (GRCm39) missense possibly damaging 0.53
R7341:Wdr70 UTSW 15 7,953,725 (GRCm39) missense possibly damaging 0.71
R7484:Wdr70 UTSW 15 7,951,562 (GRCm39) missense probably benign 0.23
R7572:Wdr70 UTSW 15 8,065,327 (GRCm39) missense possibly damaging 0.85
R7652:Wdr70 UTSW 15 8,108,700 (GRCm39) missense probably benign
R7886:Wdr70 UTSW 15 8,108,733 (GRCm39) missense probably benign 0.02
R8103:Wdr70 UTSW 15 8,006,612 (GRCm39) missense possibly damaging 0.70
R8214:Wdr70 UTSW 15 7,916,851 (GRCm39) missense probably benign 0.03
R8252:Wdr70 UTSW 15 8,072,337 (GRCm39) splice site probably benign
R8869:Wdr70 UTSW 15 8,123,210 (GRCm39) missense probably benign 0.02
R9203:Wdr70 UTSW 15 7,902,684 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GAAAAGGAGCCCTGAACTCAAATCCAT -3'
(R):5'- TGGTTGTCACCTCTTCTCAGGACAT -3'

Sequencing Primer
(F):5'- ATTAAACACCGTCCATACTTACCTTG -3'
(R):5'- tgcccacacattccatgac -3'
Posted On 2014-03-14