Incidental Mutation 'R1403:Prl7d1'
ID 160459
Institutional Source Beutler Lab
Gene Symbol Prl7d1
Ensembl Gene ENSMUSG00000021348
Gene Name prolactin family 7, subfamily d, member 1
Synonyms Plfr, PLF-RP, PRP
MMRRC Submission 039465-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1403 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 27892981-27900720 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 27893180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 243 (F243I)
Ref Sequence ENSEMBL: ENSMUSP00000021776 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021776] [ENSMUST00000224026]
AlphaFold P04769
Predicted Effect possibly damaging
Transcript: ENSMUST00000021776
AA Change: F243I

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000021776
Gene: ENSMUSG00000021348
AA Change: F243I

DomainStartEndE-ValueType
Pfam:Hormone_1 17 240 1.1e-78 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000224026
AA Change: F244I

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 97.5%
  • 10x: 88.5%
  • 20x: 65.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsf2 G T 11: 94,453,700 (GRCm39) N420K probably benign Het
Adam26a A T 8: 44,022,229 (GRCm39) C420* probably null Het
Afap1l1 T C 18: 61,874,909 (GRCm39) Y424C probably damaging Het
Agl A G 3: 116,576,246 (GRCm39) V553A probably benign Het
Akr7a5 T A 4: 139,045,434 (GRCm39) M325K probably damaging Het
Aldh7a1 C A 18: 56,692,341 (GRCm39) E87* probably null Het
Arhgap29 A G 3: 121,767,578 (GRCm39) K7E probably damaging Het
Brca2 T A 5: 150,466,114 (GRCm39) D1959E probably benign Het
Cdh20 G A 1: 109,988,862 (GRCm39) V255I probably benign Het
Chil5 G T 3: 105,925,409 (GRCm39) Q171K probably benign Het
Cul9 C G 17: 46,833,101 (GRCm39) A1326P probably damaging Het
Dhrs7c A T 11: 67,702,476 (GRCm39) I155F probably damaging Het
Dip2c A G 13: 9,603,300 (GRCm39) probably null Het
Fam124b T C 1: 80,191,056 (GRCm39) Y109C possibly damaging Het
Gak T A 5: 108,739,011 (GRCm39) K156M probably damaging Het
Gm17535 A G 9: 3,035,804 (GRCm39) Y224C probably null Het
Got1l1 C G 8: 27,690,745 (GRCm39) probably null Het
Grm1 T C 10: 10,955,879 (GRCm39) D135G probably benign Het
Hrh3 T G 2: 179,744,547 (GRCm39) D131A probably damaging Het
Hspg2 C T 4: 137,267,411 (GRCm39) L2042F possibly damaging Het
Itpr1 A T 6: 108,366,514 (GRCm39) Q979L probably null Het
Klb G C 5: 65,506,089 (GRCm39) R112P possibly damaging Het
Lingo2 A T 4: 35,709,420 (GRCm39) C187S possibly damaging Het
Lrp1 T A 10: 127,417,760 (GRCm39) probably null Het
Ltbp4 T C 7: 27,028,464 (GRCm39) N266S unknown Het
Mgam G A 6: 40,643,815 (GRCm39) S581N possibly damaging Het
Mrgpra9 T A 7: 46,885,386 (GRCm39) I94L probably benign Het
Msantd4 A T 9: 4,384,023 (GRCm39) I115F probably benign Het
Nrxn1 A C 17: 90,950,481 (GRCm39) L566R probably benign Het
Or5p59 T A 7: 107,702,822 (GRCm39) I102N probably benign Het
Rbm27 T C 18: 42,450,746 (GRCm39) S509P probably damaging Het
Rnf44 C T 13: 54,829,821 (GRCm39) E306K probably damaging Het
Rp1 T C 1: 4,416,520 (GRCm39) R1531G possibly damaging Het
Sf3b4 A G 3: 96,080,953 (GRCm39) probably null Het
Sfi1 TCGC TC 11: 3,096,254 (GRCm39) probably null Het
Sfi1 CCTCTC CCTCTCTC 11: 3,127,419 (GRCm39) probably benign Het
Sp110 T G 1: 85,506,800 (GRCm39) E421A probably benign Het
Stk4 C T 2: 163,942,448 (GRCm39) T360M probably benign Het
Vcan T A 13: 89,836,603 (GRCm39) E2980D probably benign Het
Vwa2 C T 19: 56,869,570 (GRCm39) P2S unknown Het
Wdr77 G A 3: 105,874,573 (GRCm39) V322I possibly damaging Het
Zfp12 C A 5: 143,230,535 (GRCm39) Y287* probably null Het
Zfp937 T A 2: 150,080,868 (GRCm39) Y299* probably null Het
Other mutations in Prl7d1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01390:Prl7d1 APN 13 27,894,149 (GRCm39) missense possibly damaging 0.91
IGL01735:Prl7d1 APN 13 27,898,372 (GRCm39) missense possibly damaging 0.83
IGL02139:Prl7d1 APN 13 27,896,066 (GRCm39) missense probably damaging 1.00
PIT4305001:Prl7d1 UTSW 13 27,898,320 (GRCm39) missense possibly damaging 0.90
PIT4531001:Prl7d1 UTSW 13 27,894,161 (GRCm39) missense probably damaging 1.00
R0555:Prl7d1 UTSW 13 27,896,038 (GRCm39) missense probably benign 0.13
R0625:Prl7d1 UTSW 13 27,894,123 (GRCm39) missense probably benign 0.10
R0631:Prl7d1 UTSW 13 27,894,165 (GRCm39) missense probably benign 0.32
R0837:Prl7d1 UTSW 13 27,898,321 (GRCm39) missense probably benign 0.06
R1403:Prl7d1 UTSW 13 27,893,180 (GRCm39) missense possibly damaging 0.89
R1459:Prl7d1 UTSW 13 27,893,240 (GRCm39) missense possibly damaging 0.81
R1643:Prl7d1 UTSW 13 27,896,114 (GRCm39) missense possibly damaging 0.53
R1691:Prl7d1 UTSW 13 27,893,365 (GRCm39) missense probably damaging 0.97
R2016:Prl7d1 UTSW 13 27,894,156 (GRCm39) missense probably damaging 1.00
R3873:Prl7d1 UTSW 13 27,900,651 (GRCm39) start codon destroyed probably null 0.92
R3874:Prl7d1 UTSW 13 27,900,651 (GRCm39) start codon destroyed probably null 0.92
R5251:Prl7d1 UTSW 13 27,893,227 (GRCm39) missense probably benign 0.33
R5275:Prl7d1 UTSW 13 27,893,230 (GRCm39) missense probably damaging 0.99
R5295:Prl7d1 UTSW 13 27,893,230 (GRCm39) missense probably damaging 0.99
R5398:Prl7d1 UTSW 13 27,894,057 (GRCm39) missense probably damaging 1.00
R6798:Prl7d1 UTSW 13 27,893,380 (GRCm39) critical splice acceptor site probably null
R6818:Prl7d1 UTSW 13 27,898,454 (GRCm39) missense probably benign 0.07
R6825:Prl7d1 UTSW 13 27,894,125 (GRCm39) missense probably benign 0.01
R7478:Prl7d1 UTSW 13 27,894,168 (GRCm39) nonsense probably null
R7795:Prl7d1 UTSW 13 27,893,263 (GRCm39) missense probably damaging 1.00
R7995:Prl7d1 UTSW 13 27,894,054 (GRCm39) missense probably benign
R8193:Prl7d1 UTSW 13 27,893,230 (GRCm39) missense
R9313:Prl7d1 UTSW 13 27,893,182 (GRCm39) missense probably benign
R9424:Prl7d1 UTSW 13 27,894,185 (GRCm39) missense probably benign 0.00
R9430:Prl7d1 UTSW 13 27,898,360 (GRCm39) missense possibly damaging 0.80
R9733:Prl7d1 UTSW 13 27,898,339 (GRCm39) missense probably benign 0.00
R9758:Prl7d1 UTSW 13 27,893,260 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- CCTTGCCTGGAATGTGACTTAAGCC -3'
(R):5'- AGAAGCAGAAATCCATGCCTGTGAC -3'

Sequencing Primer
(F):5'- CTTAAGCCACAGAAGAATGCTG -3'
(R):5'- TCAGCCTTTAGAAGGCATAGGTC -3'
Posted On 2014-03-14