Incidental Mutation 'R1440:Lgr6'
| ID |
160897 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lgr6
|
| Ensembl Gene |
ENSMUSG00000042793 |
| Gene Name |
leucine-rich repeat-containing G protein-coupled receptor 6 |
| Synonyms |
A530037C04Rik |
| MMRRC Submission |
039495-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R1440 (G1)
|
| Quality Score |
136 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
134911039-135033014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 134915210 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Serine
at position 513
(A513S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122334
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044828]
[ENSMUST00000137968]
|
| AlphaFold |
Q3UVD5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044828
AA Change: A790S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000035444
Gene: ENSMUSG00000042793
AA Change: A790S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
LRRNT
|
34 |
70 |
5.19e-3 |
SMART |
|
LRR
|
64 |
88 |
1.03e1 |
SMART |
|
LRR_TYP
|
89 |
112 |
6.52e-5 |
SMART |
|
LRR_TYP
|
113 |
136 |
2.71e-2 |
SMART |
|
LRR_TYP
|
137 |
160 |
4.79e-3 |
SMART |
|
LRR_TYP
|
161 |
184 |
1.58e-3 |
SMART |
|
LRR_TYP
|
185 |
208 |
2.36e-2 |
SMART |
|
LRR_TYP
|
209 |
232 |
3.39e-3 |
SMART |
|
LRR
|
233 |
255 |
8.97e0 |
SMART |
|
LRR_TYP
|
256 |
279 |
1.36e-2 |
SMART |
|
Blast:LRR
|
281 |
303 |
6e-7 |
BLAST |
|
LRR
|
327 |
350 |
9.24e1 |
SMART |
|
LRR
|
351 |
373 |
1.41e0 |
SMART |
|
LRR
|
374 |
396 |
4.84e1 |
SMART |
|
LRR_TYP
|
397 |
420 |
4.54e-4 |
SMART |
|
LRR_TYP
|
421 |
444 |
7.15e-2 |
SMART |
|
transmembrane domain
|
568 |
590 |
N/A |
INTRINSIC |
|
transmembrane domain
|
599 |
621 |
N/A |
INTRINSIC |
|
transmembrane domain
|
643 |
665 |
N/A |
INTRINSIC |
|
transmembrane domain
|
686 |
708 |
N/A |
INTRINSIC |
|
transmembrane domain
|
728 |
750 |
N/A |
INTRINSIC |
|
transmembrane domain
|
776 |
798 |
N/A |
INTRINSIC |
|
transmembrane domain
|
808 |
830 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000137968
AA Change: A513S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000122334
Gene: ENSMUSG00000042793
AA Change: A513S
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:LRR
|
4 |
26 |
2e-7 |
BLAST |
|
LRR
|
50 |
73 |
9.24e1 |
SMART |
|
LRR
|
74 |
96 |
1.41e0 |
SMART |
|
LRR
|
97 |
119 |
4.84e1 |
SMART |
|
LRR_TYP
|
120 |
143 |
4.54e-4 |
SMART |
|
LRR_TYP
|
144 |
167 |
7.15e-2 |
SMART |
|
Pfam:7tm_1
|
301 |
550 |
3.6e-9 |
PFAM |
|
| Meta Mutation Damage Score |
0.3999 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 94.0%
- 20x: 84.7%
|
| Validation Efficiency |
95% (94/99) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a reporter/null allele are viable and fertile with no apparent abnormal phenotype. Similarly, mice homozygous for a knock-in allele are healthy and fertile. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 91 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930447C04Rik |
T |
G |
12: 72,928,195 (GRCm39) |
N512T |
possibly damaging |
Het |
| Aadacl2 |
A |
T |
3: 59,932,313 (GRCm39) |
H276L |
probably damaging |
Het |
| Adam12 |
G |
A |
7: 133,533,543 (GRCm39) |
T445M |
probably benign |
Het |
| Ash2l |
A |
T |
8: 26,317,406 (GRCm39) |
F290L |
probably benign |
Het |
| Asxl3 |
C |
T |
18: 22,658,281 (GRCm39) |
P2097L |
probably benign |
Het |
| Atmin |
A |
G |
8: 117,684,115 (GRCm39) |
I592V |
probably damaging |
Het |
| Atxn2 |
T |
C |
5: 121,941,145 (GRCm39) |
|
probably null |
Het |
| BC004004 |
T |
C |
17: 29,515,665 (GRCm39) |
|
probably null |
Het |
| Cacna1e |
T |
C |
1: 154,437,552 (GRCm39) |
N328S |
possibly damaging |
Het |
| Cacna2d1 |
A |
T |
5: 16,560,493 (GRCm39) |
K765I |
probably damaging |
Het |
| Cc2d1a |
A |
G |
8: 84,860,604 (GRCm39) |
|
probably null |
Het |
| Ccdc28b |
A |
G |
4: 129,514,408 (GRCm39) |
V198A |
probably benign |
Het |
| Ces1b |
G |
T |
8: 93,794,736 (GRCm39) |
R288S |
probably damaging |
Het |
| Cfap100 |
T |
G |
6: 90,389,166 (GRCm39) |
T198P |
probably benign |
Het |
| Clint1 |
T |
C |
11: 45,781,610 (GRCm39) |
S227P |
probably damaging |
Het |
| Cntn5 |
C |
A |
9: 10,145,344 (GRCm39) |
C122F |
probably damaging |
Het |
| Col3a1 |
A |
G |
1: 45,382,472 (GRCm39) |
|
probably null |
Het |
| Cyp4a10 |
A |
C |
4: 115,386,646 (GRCm39) |
D431A |
probably damaging |
Het |
| Cyp4f16 |
CTATG |
CTATGTATG |
17: 32,769,708 (GRCm39) |
|
probably null |
Het |
| Dlc1 |
A |
T |
8: 37,060,617 (GRCm39) |
|
probably benign |
Het |
| Dlgap2 |
T |
C |
8: 14,777,060 (GRCm39) |
S102P |
probably benign |
Het |
| Dnah7b |
G |
A |
1: 46,117,753 (GRCm39) |
|
probably benign |
Het |
| Dock10 |
A |
C |
1: 80,526,853 (GRCm39) |
S1124A |
probably benign |
Het |
| Dscam |
C |
T |
16: 96,621,151 (GRCm39) |
R519H |
probably damaging |
Het |
| Efcab3 |
A |
T |
11: 104,999,581 (GRCm39) |
|
probably benign |
Het |
| Evi2a |
G |
T |
11: 79,418,096 (GRCm39) |
N171K |
probably damaging |
Het |
| Fbxl15 |
T |
C |
19: 46,318,684 (GRCm39) |
L286P |
probably damaging |
Het |
| Fpr1 |
T |
A |
17: 18,097,525 (GRCm39) |
I155F |
probably benign |
Het |
| Gcat |
C |
T |
15: 78,918,194 (GRCm39) |
A84V |
probably null |
Het |
| Gls |
A |
G |
1: 52,230,293 (GRCm39) |
F473L |
possibly damaging |
Het |
| Gnat1 |
T |
C |
9: 107,554,164 (GRCm39) |
D169G |
probably damaging |
Het |
| Grm3 |
A |
C |
5: 9,639,958 (GRCm39) |
M29R |
probably benign |
Het |
| Herc1 |
A |
T |
9: 66,375,085 (GRCm39) |
D3303V |
probably damaging |
Het |
| Ibsp |
G |
A |
5: 104,458,405 (GRCm39) |
G314D |
unknown |
Het |
| Irag2 |
C |
T |
6: 145,120,237 (GRCm39) |
T484M |
possibly damaging |
Het |
| Lrriq4 |
T |
A |
3: 30,704,910 (GRCm39) |
C313S |
probably damaging |
Het |
| Marchf10 |
G |
T |
11: 105,281,409 (GRCm39) |
T292K |
probably damaging |
Het |
| Mcoln2 |
C |
A |
3: 145,896,137 (GRCm39) |
Y6* |
probably null |
Het |
| Mup4 |
A |
G |
4: 59,958,076 (GRCm39) |
I164T |
probably damaging |
Het |
| Myo1b |
T |
C |
1: 51,817,717 (GRCm39) |
|
probably benign |
Het |
| Ncam1 |
A |
G |
9: 49,456,100 (GRCm39) |
I506T |
probably damaging |
Het |
| Notch1 |
A |
T |
2: 26,370,976 (GRCm39) |
|
probably benign |
Het |
| Nr4a3 |
A |
T |
4: 48,051,777 (GRCm39) |
Q177L |
probably benign |
Het |
| Nsun4 |
A |
G |
4: 115,910,147 (GRCm39) |
S138P |
possibly damaging |
Het |
| Or1a1 |
A |
G |
11: 74,086,505 (GRCm39) |
M59V |
probably damaging |
Het |
| Or2b6 |
G |
T |
13: 21,823,560 (GRCm39) |
N44K |
probably benign |
Het |
| Or2d36 |
A |
T |
7: 106,747,405 (GRCm39) |
N294I |
probably damaging |
Het |
| Or4k5 |
T |
C |
14: 50,385,815 (GRCm39) |
N172S |
probably damaging |
Het |
| Pagr1a |
A |
T |
7: 126,615,469 (GRCm39) |
|
probably benign |
Het |
| Pcdhb2 |
A |
T |
18: 37,429,343 (GRCm39) |
I82L |
probably benign |
Het |
| Pds5b |
A |
T |
5: 150,677,882 (GRCm39) |
N500I |
probably damaging |
Het |
| Pik3r6 |
A |
T |
11: 68,422,271 (GRCm39) |
E223D |
possibly damaging |
Het |
| Pkhd1l1 |
A |
T |
15: 44,404,384 (GRCm39) |
|
probably benign |
Het |
| Prex1 |
T |
C |
2: 166,422,383 (GRCm39) |
D1204G |
probably damaging |
Het |
| Prickle1 |
C |
T |
15: 93,402,955 (GRCm39) |
E244K |
possibly damaging |
Het |
| Ptprd |
A |
T |
4: 76,002,789 (GRCm39) |
V211E |
probably damaging |
Het |
| Rad51d |
G |
A |
11: 82,781,179 (GRCm39) |
R23* |
probably null |
Het |
| Rapgef6 |
G |
A |
11: 54,517,534 (GRCm39) |
G262R |
probably damaging |
Het |
| Reln |
A |
G |
5: 22,333,600 (GRCm39) |
|
probably benign |
Het |
| Rev1 |
T |
C |
1: 38,127,286 (GRCm39) |
T325A |
probably damaging |
Het |
| Rnd3 |
T |
A |
2: 51,022,518 (GRCm39) |
I175L |
probably benign |
Het |
| Rp1 |
C |
A |
1: 4,417,619 (GRCm39) |
L1164F |
probably damaging |
Het |
| S100a7a |
T |
C |
3: 90,562,942 (GRCm39) |
V43A |
probably benign |
Het |
| Scaper |
A |
C |
9: 55,510,202 (GRCm39) |
Y1104* |
probably null |
Het |
| Scn2a |
T |
A |
2: 65,594,938 (GRCm39) |
V1929D |
probably benign |
Het |
| Scn3a |
T |
C |
2: 65,359,785 (GRCm39) |
N141S |
possibly damaging |
Het |
| Slc12a7 |
T |
G |
13: 73,949,127 (GRCm39) |
L718R |
probably damaging |
Het |
| Slc15a2 |
T |
C |
16: 36,605,005 (GRCm39) |
|
probably benign |
Het |
| Slc35b3 |
G |
A |
13: 39,138,110 (GRCm39) |
Q100* |
probably null |
Het |
| Slc9a5 |
T |
A |
8: 106,081,785 (GRCm39) |
V170E |
possibly damaging |
Het |
| Snx5 |
T |
G |
2: 144,096,731 (GRCm39) |
K278T |
possibly damaging |
Het |
| Sorbs2 |
T |
C |
8: 46,243,000 (GRCm39) |
|
probably benign |
Het |
| Stab1 |
C |
T |
14: 30,873,647 (GRCm39) |
W1008* |
probably null |
Het |
| Stab2 |
C |
T |
10: 86,697,231 (GRCm39) |
|
probably null |
Het |
| Tacc3 |
A |
G |
5: 33,825,321 (GRCm39) |
E377G |
probably benign |
Het |
| Tango6 |
T |
C |
8: 107,415,671 (GRCm39) |
L164P |
probably damaging |
Het |
| Tbc1d12 |
T |
A |
19: 38,902,796 (GRCm39) |
S570T |
possibly damaging |
Het |
| Thbs1 |
T |
C |
2: 117,944,836 (GRCm39) |
F217L |
probably damaging |
Het |
| Tmbim6 |
T |
A |
15: 99,300,004 (GRCm39) |
V40E |
probably damaging |
Het |
| Tmigd1 |
A |
T |
11: 76,800,986 (GRCm39) |
N158Y |
probably damaging |
Het |
| Top3b |
C |
T |
16: 16,710,641 (GRCm39) |
R824* |
probably null |
Het |
| Tram1l1 |
A |
T |
3: 124,115,580 (GRCm39) |
K247* |
probably null |
Het |
| Tsc2 |
T |
C |
17: 24,833,366 (GRCm39) |
Y686C |
probably damaging |
Het |
| Tsga10 |
T |
C |
1: 37,858,680 (GRCm39) |
Q218R |
probably damaging |
Het |
| Uba6 |
G |
T |
5: 86,288,282 (GRCm39) |
A439D |
probably damaging |
Het |
| Ubn1 |
C |
A |
16: 4,895,158 (GRCm39) |
P735T |
probably damaging |
Het |
| Usp40 |
A |
G |
1: 87,909,808 (GRCm39) |
S549P |
probably benign |
Het |
| Utp20 |
T |
C |
10: 88,655,201 (GRCm39) |
T176A |
probably benign |
Het |
| Utp4 |
T |
G |
8: 107,624,685 (GRCm39) |
|
probably benign |
Het |
| Xpo5 |
C |
T |
17: 46,518,853 (GRCm39) |
|
probably benign |
Het |
| Zfp979 |
A |
T |
4: 147,698,493 (GRCm39) |
I72K |
possibly damaging |
Het |
|
| Other mutations in Lgr6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02481:Lgr6
|
APN |
1 |
134,929,429 (GRCm39) |
splice site |
probably benign |
|
|
IGL02483:Lgr6
|
APN |
1 |
134,929,429 (GRCm39) |
splice site |
probably benign |
|
|
IGL03270:Lgr6
|
APN |
1 |
134,925,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0002:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0294:Lgr6
|
UTSW |
1 |
135,032,799 (GRCm39) |
missense |
unknown |
|
|
R0294:Lgr6
|
UTSW |
1 |
134,915,629 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0361:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0390:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0731:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0734:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0742:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0765:Lgr6
|
UTSW |
1 |
134,921,624 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0903:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0904:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0905:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0906:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0907:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0908:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0967:Lgr6
|
UTSW |
1 |
134,921,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1078:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1079:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1131:Lgr6
|
UTSW |
1 |
134,915,042 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1533:Lgr6
|
UTSW |
1 |
135,032,670 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1728:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1728:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1728:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1729:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1729:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1730:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1730:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1730:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1739:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1739:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1739:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1762:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1762:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1762:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1782:Lgr6
|
UTSW |
1 |
134,915,717 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1783:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1783:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1783:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1783:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1784:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1784:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1785:Lgr6
|
UTSW |
1 |
134,915,747 (GRCm39) |
missense |
probably benign |
|
|
R1785:Lgr6
|
UTSW |
1 |
134,914,826 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Lgr6
|
UTSW |
1 |
134,931,214 (GRCm39) |
missense |
probably benign |
|
|
R1785:Lgr6
|
UTSW |
1 |
134,918,373 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2020:Lgr6
|
UTSW |
1 |
135,003,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3104:Lgr6
|
UTSW |
1 |
134,928,210 (GRCm39) |
splice site |
probably null |
|
|
R4629:Lgr6
|
UTSW |
1 |
135,032,670 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4792:Lgr6
|
UTSW |
1 |
134,949,544 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5001:Lgr6
|
UTSW |
1 |
134,918,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5191:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5194:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5196:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5197:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5228:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5230:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5243:Lgr6
|
UTSW |
1 |
135,037,010 (GRCm39) |
unclassified |
probably benign |
|
|
R5299:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5300:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5417:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5419:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5601:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5603:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5636:Lgr6
|
UTSW |
1 |
134,914,816 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5699:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5748:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5767:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5825:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5971:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6078:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6079:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6138:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6258:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6259:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6260:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6740:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6871:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6984:Lgr6
|
UTSW |
1 |
134,915,740 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R6986:Lgr6
|
UTSW |
1 |
134,921,694 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7233:Lgr6
|
UTSW |
1 |
134,928,214 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7699:Lgr6
|
UTSW |
1 |
134,923,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7700:Lgr6
|
UTSW |
1 |
134,923,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7734:Lgr6
|
UTSW |
1 |
134,930,981 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7849:Lgr6
|
UTSW |
1 |
134,915,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7970:Lgr6
|
UTSW |
1 |
134,921,723 (GRCm39) |
missense |
probably benign |
|
|
R8068:Lgr6
|
UTSW |
1 |
134,991,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8252:Lgr6
|
UTSW |
1 |
134,931,215 (GRCm39) |
missense |
probably null |
0.78 |
|
R8516:Lgr6
|
UTSW |
1 |
135,003,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8771:Lgr6
|
UTSW |
1 |
134,933,429 (GRCm39) |
nonsense |
probably null |
|
|
R8858:Lgr6
|
UTSW |
1 |
134,923,849 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8885:Lgr6
|
UTSW |
1 |
134,915,342 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9014:Lgr6
|
UTSW |
1 |
134,931,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9277:Lgr6
|
UTSW |
1 |
134,915,217 (GRCm39) |
nonsense |
probably null |
|
|
R9660:Lgr6
|
UTSW |
1 |
134,915,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9728:Lgr6
|
UTSW |
1 |
134,915,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Lgr6
|
UTSW |
1 |
134,915,809 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1191:Lgr6
|
UTSW |
1 |
134,921,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAAAATGGTTTCCCTCCAGCCTG -3'
(R):5'- ATGATGAACTCGCTCTGCTTCCTG -3'
Sequencing Primer
(F):5'- GGAAGCCATAGGTCTCTAGC -3'
(R):5'- CTCTGCTTCCTGGTGGTG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation