Incidental Mutation 'R0046:Taok3'
ID 16090
Institutional Source Beutler Lab
Gene Symbol Taok3
Ensembl Gene ENSMUSG00000061288
Gene Name TAO kinase 3
Synonyms 2900006A08Rik, A430105I05Rik
MMRRC Submission 038340-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0046 (G1)
Quality Score
Status Validated
Chromosome 5
Chromosomal Location 117258194-117413284 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 117410294 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 829 (Q829*)
Ref Sequence ENSEMBL: ENSMUSP00000136750 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092889] [ENSMUST00000111975] [ENSMUST00000111978] [ENSMUST00000179276]
AlphaFold Q8BYC6
Predicted Effect probably null
Transcript: ENSMUST00000092889
AA Change: Q829*
SMART Domains Protein: ENSMUSP00000090565
Gene: ENSMUSG00000061288
AA Change: Q829*

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000111975
AA Change: Q369*
SMART Domains Protein: ENSMUSP00000107606
Gene: ENSMUSG00000061288
AA Change: Q369*

DomainStartEndE-ValueType
coiled coil region 1 35 N/A INTRINSIC
low complexity region 60 72 N/A INTRINSIC
low complexity region 92 106 N/A INTRINSIC
coiled coil region 158 189 N/A INTRINSIC
coiled coil region 329 409 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000111978
AA Change: Q829*
SMART Domains Protein: ENSMUSP00000107609
Gene: ENSMUSG00000061288
AA Change: Q829*

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000179276
AA Change: Q829*
SMART Domains Protein: ENSMUSP00000136750
Gene: ENSMUSG00000061288
AA Change: Q829*

DomainStartEndE-ValueType
S_TKc 24 277 4.4e-84 SMART
low complexity region 321 337 N/A INTRINSIC
low complexity region 349 366 N/A INTRINSIC
coiled coil region 452 495 N/A INTRINSIC
low complexity region 520 532 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
coiled coil region 618 649 N/A INTRINSIC
coiled coil region 789 869 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 89.2%
  • 3x: 86.2%
  • 10x: 78.3%
  • 20x: 64.0%
Validation Efficiency 98% (86/88)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl7a A T 4: 56,743,877 (GRCm39) K135* probably null Het
Adamts16 A G 13: 70,911,579 (GRCm39) S871P probably benign Het
Adcy10 A T 1: 165,367,403 (GRCm39) I558F probably damaging Het
Adsl T G 15: 80,846,989 (GRCm39) probably null Het
Aldob T C 4: 49,543,842 (GRCm39) I47V possibly damaging Het
Alkbh8 A G 9: 3,343,247 (GRCm39) E46G probably damaging Het
Atp1a4 A T 1: 172,067,664 (GRCm39) L533Q probably benign Het
Auts2 T C 5: 131,799,624 (GRCm39) noncoding transcript Het
B3gnt3 T C 8: 72,145,567 (GRCm39) Y267C probably damaging Het
Ccdc39 A G 3: 33,898,301 (GRCm39) F15L possibly damaging Het
Cntnap5c T G 17: 58,666,295 (GRCm39) D1108E probably benign Het
Col14a1 G A 15: 55,272,359 (GRCm39) probably benign Het
Col9a3 G A 2: 180,251,280 (GRCm39) A317T possibly damaging Het
Cpt1c A T 7: 44,609,256 (GRCm39) probably benign Het
Cpt2 A G 4: 107,761,559 (GRCm39) probably null Het
Crebrf T A 17: 26,982,308 (GRCm39) L565M probably damaging Het
Dmxl1 T A 18: 50,011,149 (GRCm39) V1102E probably benign Het
Dock4 G A 12: 40,787,359 (GRCm39) probably benign Het
Dpp3 G T 19: 4,964,671 (GRCm39) N545K probably damaging Het
Elmo2 T A 2: 165,140,646 (GRCm39) N275I probably damaging Het
Farp1 A G 14: 121,492,925 (GRCm39) K509R probably benign Het
Flg T A 3: 93,185,028 (GRCm39) probably benign Het
Gas2l2 A T 11: 83,312,736 (GRCm39) W859R probably damaging Het
Gatm T C 2: 122,431,225 (GRCm39) D254G probably damaging Het
Gjd4 T A 18: 9,280,998 (GRCm39) I27F probably damaging Het
Gm19410 A G 8: 36,269,799 (GRCm39) E1148G probably benign Het
Haus5 C T 7: 30,353,605 (GRCm39) V591I probably benign Het
Kcnab3 G A 11: 69,221,053 (GRCm39) probably null Het
Limk1 T C 5: 134,701,615 (GRCm39) Y96C probably damaging Het
Lrp2bp T A 8: 46,466,192 (GRCm39) Y100* probably null Het
Ly75 A T 2: 60,169,801 (GRCm39) probably benign Het
Mamstr T G 7: 45,291,194 (GRCm39) probably benign Het
Man1a A G 10: 53,795,283 (GRCm39) Y657H probably damaging Het
Marf1 G A 16: 13,929,591 (GRCm39) P1672S possibly damaging Het
Mboat7 T C 7: 3,686,817 (GRCm39) Y341C probably damaging Het
Nhsl1 A T 10: 18,401,417 (GRCm39) N881I probably damaging Het
Nox3 T C 17: 3,733,236 (GRCm39) Y225C probably benign Het
Or4c109 C T 2: 88,817,693 (GRCm39) M284I probably benign Het
Or4c35 C T 2: 89,808,851 (GRCm39) T243I probably damaging Het
Pclo C T 5: 14,590,493 (GRCm39) T931M unknown Het
Pfas G T 11: 68,881,293 (GRCm39) R1025S probably benign Het
Prg4 T C 1: 150,331,837 (GRCm39) T279A possibly damaging Het
Psma1 A T 7: 113,866,440 (GRCm39) probably benign Het
Rab11fip1 A G 8: 27,643,149 (GRCm39) L550P probably damaging Het
Rgs12 T A 5: 35,122,664 (GRCm39) I149N probably damaging Het
Rmnd5a T C 6: 71,376,215 (GRCm39) H195R probably damaging Het
Rnf17 T C 14: 56,708,830 (GRCm39) L750P probably damaging Het
Rtcb T C 10: 85,793,520 (GRCm39) N18D probably benign Het
Seh1l T C 18: 67,925,086 (GRCm39) probably null Het
Sptbn2 T C 19: 4,795,405 (GRCm39) probably benign Het
Stag3 C T 5: 138,281,285 (GRCm39) probably benign Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Tsbp1 T C 17: 34,679,095 (GRCm39) probably null Het
Ttn A G 2: 76,781,886 (GRCm39) probably benign Het
Unc79 A G 12: 103,091,940 (GRCm39) E1756G probably damaging Het
Usp35 A T 7: 96,962,804 (GRCm39) probably null Het
Zbtb40 A G 4: 136,714,589 (GRCm39) C1067R probably damaging Het
Other mutations in Taok3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Taok3 APN 5 117,410,262 (GRCm39) missense probably benign 0.20
IGL01632:Taok3 APN 5 117,403,993 (GRCm39) missense possibly damaging 0.95
IGL02894:Taok3 APN 5 117,401,678 (GRCm39) missense probably benign 0.19
bonze UTSW 5 117,410,294 (GRCm39) nonsense probably null
daoist UTSW 5 117,347,636 (GRCm39) missense probably damaging 0.99
haller UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
Perseveration UTSW 5 117,393,928 (GRCm39) missense probably benign 0.25
taoist UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
Three_treasures UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
PIT4366001:Taok3 UTSW 5 117,366,050 (GRCm39) missense probably benign 0.21
R0046:Taok3 UTSW 5 117,410,294 (GRCm39) nonsense probably null
R0158:Taok3 UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
R0245:Taok3 UTSW 5 117,390,744 (GRCm39) splice site probably benign
R0371:Taok3 UTSW 5 117,344,752 (GRCm39) nonsense probably null
R1140:Taok3 UTSW 5 117,366,118 (GRCm39) missense possibly damaging 0.94
R1302:Taok3 UTSW 5 117,337,108 (GRCm39) missense possibly damaging 0.46
R1376:Taok3 UTSW 5 117,404,026 (GRCm39) missense probably damaging 1.00
R1376:Taok3 UTSW 5 117,404,026 (GRCm39) missense probably damaging 1.00
R1387:Taok3 UTSW 5 117,344,720 (GRCm39) missense probably damaging 1.00
R1711:Taok3 UTSW 5 117,393,991 (GRCm39) missense possibly damaging 0.68
R1977:Taok3 UTSW 5 117,403,989 (GRCm39) missense probably damaging 0.98
R2898:Taok3 UTSW 5 117,338,134 (GRCm39) critical splice acceptor site probably null
R3824:Taok3 UTSW 5 117,394,002 (GRCm39) missense probably benign 0.01
R4378:Taok3 UTSW 5 117,347,636 (GRCm39) missense probably damaging 0.99
R4695:Taok3 UTSW 5 117,366,131 (GRCm39) missense probably benign 0.11
R4882:Taok3 UTSW 5 117,390,695 (GRCm39) missense probably damaging 0.99
R5286:Taok3 UTSW 5 117,404,140 (GRCm39) missense probably damaging 1.00
R5522:Taok3 UTSW 5 117,411,822 (GRCm39) missense probably benign 0.00
R5562:Taok3 UTSW 5 117,389,029 (GRCm39) missense probably damaging 1.00
R5643:Taok3 UTSW 5 117,344,785 (GRCm39) missense probably benign
R6241:Taok3 UTSW 5 117,410,262 (GRCm39) missense probably benign 0.33
R6290:Taok3 UTSW 5 117,342,433 (GRCm39) missense probably damaging 1.00
R6310:Taok3 UTSW 5 117,394,003 (GRCm39) missense possibly damaging 0.48
R6339:Taok3 UTSW 5 117,366,095 (GRCm39) missense probably benign
R6717:Taok3 UTSW 5 117,379,015 (GRCm39) intron probably benign
R6721:Taok3 UTSW 5 117,393,928 (GRCm39) missense probably benign 0.25
R6755:Taok3 UTSW 5 117,344,732 (GRCm39) missense probably damaging 1.00
R7046:Taok3 UTSW 5 117,411,771 (GRCm39) missense probably damaging 1.00
R7053:Taok3 UTSW 5 117,390,627 (GRCm39) missense probably benign 0.00
R7259:Taok3 UTSW 5 117,390,608 (GRCm39) missense probably benign 0.00
R7308:Taok3 UTSW 5 117,338,216 (GRCm39) nonsense probably null
R7439:Taok3 UTSW 5 117,388,974 (GRCm39) missense probably damaging 0.99
R7732:Taok3 UTSW 5 117,331,813 (GRCm39) missense possibly damaging 0.53
R7758:Taok3 UTSW 5 117,388,972 (GRCm39) missense probably damaging 1.00
R7939:Taok3 UTSW 5 117,331,902 (GRCm39) missense probably benign 0.01
R8412:Taok3 UTSW 5 117,404,102 (GRCm39) missense possibly damaging 0.59
R8485:Taok3 UTSW 5 117,389,142 (GRCm39) missense possibly damaging 0.54
R8989:Taok3 UTSW 5 117,379,227 (GRCm39) missense probably benign
R9135:Taok3 UTSW 5 117,379,245 (GRCm39) missense possibly damaging 0.70
R9135:Taok3 UTSW 5 117,379,168 (GRCm39) missense probably benign
R9135:Taok3 UTSW 5 117,344,744 (GRCm39) missense probably damaging 1.00
R9182:Taok3 UTSW 5 117,355,307 (GRCm39) critical splice donor site probably null
Posted On 2013-01-08