Mutagenetix > Incidental Mutation

Incidental Mutation 'R0049:Fras1'

16100

Institutional Source

Beutler Lab

Gene Symbol

Fras1

Ensembl Gene

ENSMUSG00000034687

Gene Name

Fraser extracellular matrix complex subunit 1

Synonyms

bl, E130113P14Rik

MMRRC Submission

038343-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R0049 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

96373955-96784728 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 96776622 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 3641 (F3641I)

Ref Sequence

ENSEMBL: ENSMUSP00000043250 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000036019]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000036019
AA Change: F3641I

PolyPhen 2 Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000043250
Gene: ENSMUSG00000034687
AA Change: F3641I

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
VWC	27	86	9.23e-9	SMART
VWC	94	151	9.37e-10	SMART
VWC	158	215	8.61e-9	SMART
VWC	220	277	7.1e-10	SMART
VWC	284	341	7.8e-7	SMART
VWC	365	415	1.93e-1	SMART
FU	408	459	3.33e-1	SMART
FU	461	504	9.12e-8	SMART
EGF_like	466	495	6.67e1	SMART
FU	506	552	6.01e-8	SMART
FU	554	598	2.21e-6	SMART
FU	601	646	1.28e-11	SMART
FU	648	704	4.19e-7	SMART
FU	707	752	9.12e-8	SMART
FU	754	799	1.11e-6	SMART
EGF_like	759	790	7.23e1	SMART
FU	802	851	5.44e-6	SMART
EGF_like	807	842	4.55e1	SMART
FU	853	899	7.4e-8	SMART
FU	902	947	4.78e-2	SMART
FU	951	996	4.52e-12	SMART
EGF_like	956	987	2.75e1	SMART
FU	998	1041	1.38e-7	SMART
FU	1045	1088	9.7e-3	SMART
EGF_like	1057	1096	3.16e1	SMART
Pfam:Cadherin_3	1098	1198	5.2e-12	PFAM
Pfam:Cadherin_3	1167	1309	6.5e-27	PFAM
Pfam:Cadherin_3	1278	1442	7e-24	PFAM
Pfam:Cadherin_3	1411	1560	1.3e-23	PFAM
Pfam:Cadherin_3	1561	1693	6.4e-15	PFAM
Pfam:Cadherin_3	1695	1814	1.1e-10	PFAM
Pfam:Cadherin_3	1780	1940	1.6e-18	PFAM
Pfam:Cadherin_3	1906	2061	2.8e-22	PFAM
Pfam:Cadherin_3	2063	2181	3.3e-18	PFAM
Pfam:Cadherin_3	2172	2295	1.4e-26	PFAM
Pfam:Cadherin_3	2296	2408	2.3e-31	PFAM
Pfam:Cadherin_3	2413	2540	7.9e-23	PFAM
Calx_beta	2544	2648	1.23e-10	SMART
Calx_beta	2661	2772	3.3e-11	SMART
Calx_beta	2787	2892	1.21e-9	SMART
Calx_beta	2907	3009	4.45e-3	SMART
Calx_beta	3027	3131	1.5e-14	SMART
Blast:Calx_beta	3162	3187	1e-5	BLAST
transmembrane domain	3902	3924	N/A	INTRINSIC
low complexity region	3927	3935	N/A	INTRINSIC

Meta Mutation Damage Score

0.1315

Coding Region Coverage

1x: 90.0%
3x: 87.7%
10x: 82.4%
20x: 74.6%

Validation Efficiency

89% (108/122)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
PHENOTYPE: Mice homozygous for mutations at this locus display a significant amount of embryonic lethality due to hemorrhaging of embryonic blisters. Survival is variable on genetic backgrounds. Kidney development is severely affected and syndactyly is common. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 79 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	T	6: 121,638,308	H9L	possibly damaging	Het
Aars	T	A	8: 111,052,451	I739K	possibly damaging	Het
Acod1	T	A	14: 103,055,207	I389K	possibly damaging	Het
Akap1	C	A	11: 88,839,624		probably null	Het
Anxa7	T	C	14: 20,462,610	D285G	probably damaging	Het
Arhgap1	T	C	2: 91,670,169	Y308H	probably damaging	Het
Arhgef11	T	A	3: 87,729,193		probably null	Het
Atp6v0a4	G	A	6: 38,082,081	R256C	probably damaging	Het
Camsap3	C	A	8: 3,598,772	S163R	probably benign	Het
Ccdc110	A	T	8: 45,942,626	E518V	probably damaging	Het
Ccdc180	G	A	4: 45,930,119		probably null	Het
Ccnt1	T	C	15: 98,565,079	M71V	probably benign	Het
Celsr2	T	A	3: 108,397,254	Y2263F	probably benign	Het
Cfap69	T	C	5: 5,613,734	T498A	probably benign	Het
Clstn3	T	A	6: 124,459,853	I132F	possibly damaging	Het
Cnot4	A	G	6: 35,051,277	V468A	probably benign	Het
Crmp1	T	G	5: 37,265,273	D141E	possibly damaging	Het
Cryz	C	A	3: 154,611,552	A136D	probably damaging	Het
Dcst2	T	C	3: 89,371,606	V550A	probably benign	Het
Dph6	A	G	2: 114,523,044	V221A	probably benign	Het
Ecm2	A	T	13: 49,524,446	K403*	probably null	Het
Eif3d	T	C	15: 77,959,724	N474S	probably benign	Het
F12	T	C	13: 55,426,317	D34G	probably benign	Het
Fam214b	A	T	4: 43,036,441	S97T	probably benign	Het
Fam228b	A	T	12: 4,748,117	F200Y	probably damaging	Het
Fgl2	T	A	5: 21,375,663	D334E	possibly damaging	Het
Gabrb2	T	G	11: 42,593,847	Y244D	probably damaging	Het
Gcc1	A	T	6: 28,421,269	D16E	probably benign	Het
Gm10648	T	C	7: 28,861,777		probably benign	Het
Gm6614	T	C	6: 141,990,421	T313A	probably benign	Het
Gorasp2	T	C	2: 70,690,723	S346P	possibly damaging	Het
Htt	A	C	5: 34,908,662	K3060N	probably damaging	Het
Ibsp	C	T	5: 104,302,158	L8F	probably damaging	Het
Kif27	A	T	13: 58,303,564	D983E	probably damaging	Het
Kif3a	T	A	11: 53,590,733		probably benign	Het
Kif3c	A	C	12: 3,367,090	K370N	possibly damaging	Het
Loxhd1	T	C	18: 77,380,560		probably benign	Het
Maz	A	T	7: 127,024,586	D74E	probably damaging	Het
Med21	T	C	6: 146,650,234	S128P	probably damaging	Het
Mms19	A	C	19: 41,955,168	M374R	probably damaging	Het
Mrpl3	T	C	9: 105,055,673	V111A	probably benign	Het
Mtfr2	T	A	10: 20,348,412	Y31N	probably damaging	Het
Neb	A	C	2: 52,170,467	M2286R	possibly damaging	Het
Ngf	A	T	3: 102,520,345	R137*	probably null	Het
Nr1i3	T	A	1: 171,214,413	V22E	probably damaging	Het
Nxpe5	T	C	5: 138,251,304	V452A	probably damaging	Het
Olfr743	A	T	14: 50,533,694	K94M	probably damaging	Het
Pax3	A	G	1: 78,103,504	L415P	probably damaging	Het
Pcnt	G	T	10: 76,369,821		probably benign	Het
Peg3	G	T	7: 6,711,673	D183E	possibly damaging	Het
Pglyrp1	G	T	7: 18,889,388	G120V	probably damaging	Het
Pomt1	T	A	2: 32,252,011	H584Q	possibly damaging	Het
Prkcq	G	A	2: 11,283,832	G532E	probably benign	Het
Pwp1	A	G	10: 85,885,616	T361A	possibly damaging	Het
Rab4a	A	T	8: 123,827,342	H5L	probably damaging	Het
Ramp1	T	C	1: 91,196,870	I51T	possibly damaging	Het
Raph1	G	T	1: 60,525,899	T143K	probably benign	Het
Rhpn1	A	G	15: 75,709,239	E110G	possibly damaging	Het
Rnf168	A	T	16: 32,298,469	T283S	possibly damaging	Het
Ros1	T	A	10: 52,101,761	Y1463F	possibly damaging	Het
Rtn4ip1	A	G	10: 43,921,434	Q223R	probably null	Het
Rtp4	G	T	16: 23,612,929	M70I	probably benign	Het
Sag	C	A	1: 87,834,618	T335K	probably damaging	Het
Sgo1	C	T	17: 53,679,663	D167N	probably damaging	Het
St6gal1	G	T	16: 23,321,141	A21S	probably damaging	Het
Stard9	C	A	2: 120,699,819	L2186I	probably damaging	Het
Sun2	T	A	15: 79,727,609		probably benign	Het
Taf4	G	A	2: 179,924,091	T849M	probably damaging	Het
Taok2	G	A	7: 126,866,411	H404Y	possibly damaging	Het
Tdrd7	A	G	4: 45,987,582	I72V	probably damaging	Het
Trav1	T	A	14: 52,428,698	S52T	probably damaging	Het
Trim30a	C	T	7: 104,429,352		probably null	Het
Tro	T	C	X: 150,654,569	N364S	possibly damaging	Het
Tshz3	A	G	7: 36,770,109	T508A	probably damaging	Het
Ttc21b	A	G	2: 66,223,564	L757P	probably damaging	Het
Vmn1r218	C	T	13: 23,137,055	Q111*	probably null	Het
Vmn2r75	G	A	7: 86,148,101	Q835*	probably null	Het
Xcr1	T	A	9: 123,855,875	D274V	possibly damaging	Het
Ypel5	C	T	17: 72,846,337	T12I	probably benign	Het

Other mutations in Fras1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00332:Fras1	APN	5	96739358	missense	possibly damaging	0.55
IGL00507:Fras1	APN	5	96778189	missense	probably damaging	1.00
IGL00672:Fras1	APN	5	96759450	splice site	probably benign
IGL00772:Fras1	APN	5	96636112	missense	probably benign	0.42
IGL00844:Fras1	APN	5	96534853	splice site	probably benign
IGL00913:Fras1	APN	5	96695076	missense	probably damaging	0.99
IGL00959:Fras1	APN	5	96781281	missense	probably damaging	0.96
IGL00966:Fras1	APN	5	96555221	missense	probably benign	0.00
IGL01296:Fras1	APN	5	96673698	missense	probably null	0.58
IGL01307:Fras1	APN	5	96781692	missense	probably benign
IGL01481:Fras1	APN	5	96657241	missense	probably damaging	1.00
IGL01525:Fras1	APN	5	96739336	missense	probably damaging	0.99
IGL01599:Fras1	APN	5	96709891	missense	possibly damaging	0.94
IGL01646:Fras1	APN	5	96758148	missense	probably benign	0.29
IGL01795:Fras1	APN	5	96778045	missense	probably damaging	1.00
IGL01867:Fras1	APN	5	96588131	missense	probably benign
IGL01869:Fras1	APN	5	96708783	splice site	probably benign
IGL01923:Fras1	APN	5	96735280	missense	probably damaging	1.00
IGL01982:Fras1	APN	5	96739248	missense	possibly damaging	0.46
IGL02109:Fras1	APN	5	96700523	missense	probably benign
IGL02132:Fras1	APN	5	96781637	nonsense	probably null
IGL02171:Fras1	APN	5	96735181	missense	probably benign	0.15
IGL02213:Fras1	APN	5	96645871	nonsense	probably null
IGL02277:Fras1	APN	5	96588118	missense	probably benign	0.00
IGL02507:Fras1	APN	5	96657408	missense	possibly damaging	0.95
IGL02589:Fras1	APN	5	96769513	missense	probably damaging	1.00
IGL02671:Fras1	APN	5	96728616	missense	possibly damaging	0.91
IGL02677:Fras1	APN	5	96545024	missense	probably damaging	1.00
IGL02691:Fras1	APN	5	96744705	missense	possibly damaging	0.68
IGL02741:Fras1	APN	5	96691371	missense	probably benign	0.35
IGL02836:Fras1	APN	5	96534866	missense	possibly damaging	0.67
IGL02850:Fras1	APN	5	96778175	missense	probably damaging	1.00
IGL02998:Fras1	APN	5	96702181	missense	possibly damaging	0.82
IGL03040:Fras1	APN	5	96710101	missense	probably benign
IGL03078:Fras1	APN	5	96636135	missense	probably damaging	1.00
IGL03096:Fras1	APN	5	96764901	missense	probably damaging	1.00
IGL03102:Fras1	APN	5	96726535	missense	probably benign	0.11
IGL03183:Fras1	APN	5	96733781	splice site	probably benign
IGL03189:Fras1	APN	5	96743071	missense	probably benign	0.00
IGL03193:Fras1	APN	5	96778106	missense	probably damaging	0.99
IGL03292:Fras1	APN	5	96707491	missense	probably damaging	1.00
IGL03328:Fras1	APN	5	96781760	missense	probably damaging	0.96
IGL03335:Fras1	APN	5	96733944	splice site	probably benign
IGL03394:Fras1	APN	5	96667477	missense	probably damaging	0.98
IGL03404:Fras1	APN	5	96728581	missense	probably damaging	0.99
baby_ruth	UTSW	5	96708758	missense	probably benign	0.01
BB002:Fras1	UTSW	5	96781584	missense	probably damaging	0.96
BB012:Fras1	UTSW	5	96781584	missense	probably damaging	0.96
G1patch:Fras1	UTSW	5	96781340	missense	possibly damaging	0.91
I0000:Fras1	UTSW	5	96740829	missense	probably damaging	0.99
PIT4581001:Fras1	UTSW	5	96555301	missense	probably benign	0.01
R0028:Fras1	UTSW	5	96677316	missense	probably benign	0.07
R0049:Fras1	UTSW	5	96776622	missense	probably benign	0.07
R0099:Fras1	UTSW	5	96614917	critical splice donor site	probably null
R0109:Fras1	UTSW	5	96710077	missense	probably benign	0.01
R0158:Fras1	UTSW	5	96776634	missense	possibly damaging	0.83
R0268:Fras1	UTSW	5	96737009	missense	probably damaging	0.99
R0305:Fras1	UTSW	5	96596888	missense	probably benign
R0352:Fras1	UTSW	5	96726540	missense	probably damaging	0.97
R0359:Fras1	UTSW	5	96762590	missense	probably damaging	0.98
R0371:Fras1	UTSW	5	96555331	missense	possibly damaging	0.90
R0379:Fras1	UTSW	5	96755509	nonsense	probably null
R0395:Fras1	UTSW	5	96769653	missense	possibly damaging	0.50
R0417:Fras1	UTSW	5	96691372	missense	probably benign	0.18
R0454:Fras1	UTSW	5	96762665	missense	probably damaging	0.96
R0456:Fras1	UTSW	5	96554788	missense	probably damaging	1.00
R0456:Fras1	UTSW	5	96714343	splice site	probably null
R0464:Fras1	UTSW	5	96636803	missense	probably damaging	0.98
R0613:Fras1	UTSW	5	96700488	splice site	probably benign
R0652:Fras1	UTSW	5	96781340	missense	possibly damaging	0.91
R0675:Fras1	UTSW	5	96667387	splice site	probably benign
R0765:Fras1	UTSW	5	96552796	missense	probably benign	0.00
R0783:Fras1	UTSW	5	96768430	missense	probably damaging	1.00
R0811:Fras1	UTSW	5	96752998	missense	probably benign	0.35
R0812:Fras1	UTSW	5	96752998	missense	probably benign	0.35
R0943:Fras1	UTSW	5	96726543	missense	probably benign	0.00
R1037:Fras1	UTSW	5	96714463	missense	probably damaging	0.97
R1104:Fras1	UTSW	5	96708671	missense	probably benign	0.00
R1108:Fras1	UTSW	5	96642629	missense	probably damaging	0.99
R1332:Fras1	UTSW	5	96707308	missense	probably benign	0.00
R1336:Fras1	UTSW	5	96707308	missense	probably benign	0.00
R1458:Fras1	UTSW	5	96600733	missense	probably benign	0.00
R1495:Fras1	UTSW	5	96528586	missense	possibly damaging	0.49
R1499:Fras1	UTSW	5	96743187	missense	probably benign	0.31
R1528:Fras1	UTSW	5	96636819	missense	probably damaging	0.99
R1532:Fras1	UTSW	5	96713996	missense	probably damaging	1.00
R1556:Fras1	UTSW	5	96743062	missense	possibly damaging	0.88
R1625:Fras1	UTSW	5	96709978	missense	possibly damaging	0.94
R1625:Fras1	UTSW	5	96713990	missense	probably damaging	1.00
R1645:Fras1	UTSW	5	96700586	missense	possibly damaging	0.90
R1647:Fras1	UTSW	5	96726613	critical splice donor site	probably null
R1648:Fras1	UTSW	5	96726613	critical splice donor site	probably null
R1661:Fras1	UTSW	5	96598909	missense	probably damaging	1.00
R1665:Fras1	UTSW	5	96598909	missense	probably damaging	1.00
R1682:Fras1	UTSW	5	96645873	missense	probably benign	0.00
R1701:Fras1	UTSW	5	96600784	missense	probably benign	0.00
R1716:Fras1	UTSW	5	96552725	missense	probably benign	0.10
R1718:Fras1	UTSW	5	96554889	splice site	probably null
R1800:Fras1	UTSW	5	96709882	missense	probably benign
R1806:Fras1	UTSW	5	96713970	splice site	probably benign
R1806:Fras1	UTSW	5	96764976	missense	possibly damaging	0.88
R1822:Fras1	UTSW	5	96770688	missense	probably damaging	1.00
R1823:Fras1	UTSW	5	96770688	missense	probably damaging	1.00
R1824:Fras1	UTSW	5	96770688	missense	probably damaging	1.00
R1847:Fras1	UTSW	5	96749423	splice site	probably null
R1929:Fras1	UTSW	5	96667437	missense	probably benign	0.24
R1951:Fras1	UTSW	5	96712383	missense	probably benign	0.38
R2093:Fras1	UTSW	5	96781203	missense	probably damaging	1.00
R2283:Fras1	UTSW	5	96654305	missense	probably benign	0.10
R2884:Fras1	UTSW	5	96700268	missense	probably benign	0.07
R2913:Fras1	UTSW	5	96733915	missense	probably benign
R2914:Fras1	UTSW	5	96733915	missense	probably benign
R3054:Fras1	UTSW	5	96764943	missense	probably damaging	0.99
R3117:Fras1	UTSW	5	96771712	missense	probably damaging	1.00
R3118:Fras1	UTSW	5	96771712	missense	probably damaging	1.00
R3691:Fras1	UTSW	5	96781512	missense	probably benign	0.02
R3714:Fras1	UTSW	5	96645970	critical splice donor site	probably null
R3715:Fras1	UTSW	5	96645970	critical splice donor site	probably null
R3801:Fras1	UTSW	5	96733932	missense	probably benign	0.26
R3961:Fras1	UTSW	5	96677385	critical splice donor site	probably null
R4065:Fras1	UTSW	5	96770683	missense	possibly damaging	0.64
R4066:Fras1	UTSW	5	96770683	missense	possibly damaging	0.64
R4076:Fras1	UTSW	5	96743158	missense	probably damaging	1.00
R4124:Fras1	UTSW	5	96770653	missense	probably benign	0.05
R4127:Fras1	UTSW	5	96770653	missense	probably benign	0.05
R4153:Fras1	UTSW	5	96776735	missense	probably benign	0.17
R4233:Fras1	UTSW	5	96714376	missense	possibly damaging	0.91
R4273:Fras1	UTSW	5	96614904	missense	probably benign	0.00
R4355:Fras1	UTSW	5	96700242	missense	probably benign
R4401:Fras1	UTSW	5	96642620	missense	probably damaging	0.97
R4402:Fras1	UTSW	5	96642620	missense	probably damaging	0.97
R4403:Fras1	UTSW	5	96642620	missense	probably damaging	0.97
R4505:Fras1	UTSW	5	96781348	missense	probably damaging	1.00
R4548:Fras1	UTSW	5	96709895	missense	probably benign	0.00
R4559:Fras1	UTSW	5	96781289	missense	probably damaging	1.00
R4629:Fras1	UTSW	5	96776734	missense	probably benign	0.00
R4637:Fras1	UTSW	5	96778088	missense	probably damaging	1.00
R4678:Fras1	UTSW	5	96700568	missense	probably benign	0.13
R4707:Fras1	UTSW	5	96735238	missense	probably damaging	0.96
R4735:Fras1	UTSW	5	96588163	missense	probably benign	0.00
R4756:Fras1	UTSW	5	96781659	missense	probably benign	0.00
R4762:Fras1	UTSW	5	96731618	missense	probably benign
R4820:Fras1	UTSW	5	96728653	missense	probably benign	0.00
R4847:Fras1	UTSW	5	96544992	missense	possibly damaging	0.94
R4857:Fras1	UTSW	5	96778159	missense	probably benign	0.00
R4909:Fras1	UTSW	5	96708758	missense	probably benign	0.01
R4931:Fras1	UTSW	5	96636840	missense	probably benign	0.02
R4938:Fras1	UTSW	5	96776724	missense	probably damaging	0.99
R4952:Fras1	UTSW	5	96647498	missense	probably benign	0.01
R4965:Fras1	UTSW	5	96726580	missense	possibly damaging	0.95
R4989:Fras1	UTSW	5	96650682	missense	possibly damaging	0.75
R5151:Fras1	UTSW	5	96645110	missense	probably damaging	1.00
R5168:Fras1	UTSW	5	96708757	missense	probably benign	0.00
R5182:Fras1	UTSW	5	96636173	nonsense	probably null
R5214:Fras1	UTSW	5	96769593	missense	probably damaging	1.00
R5220:Fras1	UTSW	5	96768363	missense	probably damaging	1.00
R5235:Fras1	UTSW	5	96600750	missense	probably benign	0.02
R5242:Fras1	UTSW	5	96657250	missense	probably benign	0.11
R5253:Fras1	UTSW	5	96741025	missense	probably damaging	0.99
R5260:Fras1	UTSW	5	96735187	missense	possibly damaging	0.79
R5301:Fras1	UTSW	5	96657266	missense	possibly damaging	0.88
R5411:Fras1	UTSW	5	96645160	missense	probably benign	0.00
R5467:Fras1	UTSW	5	96780053	missense	probably benign	0.04
R5543:Fras1	UTSW	5	96528535	missense	probably benign	0.01
R5555:Fras1	UTSW	5	96677377	missense	probably benign	0.34
R5602:Fras1	UTSW	5	96737021	missense	probably damaging	1.00
R5664:Fras1	UTSW	5	96728535	missense	possibly damaging	0.91
R5695:Fras1	UTSW	5	96781344	missense	probably damaging	1.00
R5717:Fras1	UTSW	5	96781737	missense	possibly damaging	0.93
R5742:Fras1	UTSW	5	96768381	missense	possibly damaging	0.50
R5759:Fras1	UTSW	5	96709916	missense	probably benign	0.02
R5766:Fras1	UTSW	5	96731689	missense	possibly damaging	0.91
R5890:Fras1	UTSW	5	96645948	missense	probably benign
R6052:Fras1	UTSW	5	96764866	missense	probably damaging	1.00
R6058:Fras1	UTSW	5	96709985	missense	probably benign
R6256:Fras1	UTSW	5	96733843	missense	possibly damaging	0.84
R6306:Fras1	UTSW	5	96764946	missense	probably damaging	1.00
R6494:Fras1	UTSW	5	96759564	missense	possibly damaging	0.59
R6638:Fras1	UTSW	5	96758094	missense	possibly damaging	0.94
R6647:Fras1	UTSW	5	96735202	missense	probably damaging	1.00
R6725:Fras1	UTSW	5	96781340	missense	possibly damaging	0.91
R6769:Fras1	UTSW	5	96598941	missense	possibly damaging	0.60
R6771:Fras1	UTSW	5	96598941	missense	possibly damaging	0.60
R6837:Fras1	UTSW	5	96726973	missense	probably damaging	0.99
R6841:Fras1	UTSW	5	96728551	missense	probably damaging	0.99
R6863:Fras1	UTSW	5	96543306	missense	probably benign	0.19
R6868:Fras1	UTSW	5	96682378	missense	probably benign	0.38
R6936:Fras1	UTSW	5	96768352	missense	possibly damaging	0.92
R6997:Fras1	UTSW	5	96614873	nonsense	probably null
R7023:Fras1	UTSW	5	96710084	missense	probably benign	0.00
R7091:Fras1	UTSW	5	96708676	missense	probably benign
R7102:Fras1	UTSW	5	96571041	missense	probably benign
R7120:Fras1	UTSW	5	96752960	nonsense	probably null
R7124:Fras1	UTSW	5	96714401	missense	probably damaging	1.00
R7129:Fras1	UTSW	5	96781284	missense	probably benign	0.00
R7173:Fras1	UTSW	5	96778078	missense	probably damaging	1.00
R7174:Fras1	UTSW	5	96755577	critical splice donor site	probably null
R7185:Fras1	UTSW	5	96636776	missense	probably damaging	1.00
R7191:Fras1	UTSW	5	96614912	missense	probably benign	0.05
R7216:Fras1	UTSW	5	96739314	missense	probably damaging	1.00
R7222:Fras1	UTSW	5	96636186	missense	probably damaging	1.00
R7222:Fras1	UTSW	5	96636809	missense	probably benign	0.00
R7320:Fras1	UTSW	5	96709886	missense	probably benign	0.03
R7335:Fras1	UTSW	5	96736970	missense	possibly damaging	0.82
R7378:Fras1	UTSW	5	96596785	missense	probably damaging	0.98
R7394:Fras1	UTSW	5	96712450	nonsense	probably null
R7412:Fras1	UTSW	5	96614889	missense	probably benign	0.06
R7422:Fras1	UTSW	5	96673599	missense	probably benign	0.21
R7552:Fras1	UTSW	5	96768438	missense	probably damaging	1.00
R7559:Fras1	UTSW	5	96740854	missense	possibly damaging	0.82
R7575:Fras1	UTSW	5	96543314	missense	probably benign	0.02
R7578:Fras1	UTSW	5	96684437	missense	probably damaging	1.00
R7600:Fras1	UTSW	5	96684436	missense	probably damaging	1.00
R7669:Fras1	UTSW	5	96692624	missense	probably benign	0.01
R7710:Fras1	UTSW	5	96645103	nonsense	probably null
R7722:Fras1	UTSW	5	96769554	missense	probably damaging	1.00
R7726:Fras1	UTSW	5	96712451	missense	probably benign	0.41
R7745:Fras1	UTSW	5	96726895	missense	probably benign	0.11
R7777:Fras1	UTSW	5	96752904	missense	probably damaging	1.00
R7923:Fras1	UTSW	5	96739318	missense	probably damaging	1.00
R7925:Fras1	UTSW	5	96781584	missense	probably damaging	0.96
R8000:Fras1	UTSW	5	96762677	missense	probably damaging	0.96
R8056:Fras1	UTSW	5	96744774	missense	probably damaging	1.00
R8058:Fras1	UTSW	5	96694919	missense	probably benign
R8117:Fras1	UTSW	5	96707386	missense	probably damaging	1.00
R8157:Fras1	UTSW	5	96554855	missense	probably benign	0.00
R8312:Fras1	UTSW	5	96588191	missense	probably benign
R8315:Fras1	UTSW	5	96743182	missense	probably damaging	0.97
R8412:Fras1	UTSW	5	96596852	missense	probably benign	0.00
R8546:Fras1	UTSW	5	96709966	missense	probably benign	0.00
R8705:Fras1	UTSW	5	96691401	missense	probably benign	0.01
R8790:Fras1	UTSW	5	96755377	missense	probably damaging	1.00
R8848:Fras1	UTSW	5	96781348	missense	probably damaging	1.00
R8855:Fras1	UTSW	5	96769606	missense
R8871:Fras1	UTSW	5	96707398	missense	probably benign	0.34
R8894:Fras1	UTSW	5	96759543	missense	probably damaging	1.00
R8904:Fras1	UTSW	5	96781279	missense	probably benign	0.16
R8910:Fras1	UTSW	5	96567996	missense	probably benign	0.01
R8916:Fras1	UTSW	5	96752915	missense	probably damaging	1.00
R8929:Fras1	UTSW	5	96769507	missense	probably damaging	0.98
R8995:Fras1	UTSW	5	96712556	missense	possibly damaging	0.83
R9016:Fras1	UTSW	5	96636064	missense	probably damaging	0.96
R9021:Fras1	UTSW	5	96740750	missense	probably damaging	1.00
R9038:Fras1	UTSW	5	96726883	missense	probably benign	0.25
R9204:Fras1	UTSW	5	96735163	missense	probably damaging	1.00
R9222:Fras1	UTSW	5	96657228	missense	probably benign	0.15
R9231:Fras1	UTSW	5	96545045	missense	probably damaging	1.00
R9238:Fras1	UTSW	5	96684361	missense	possibly damaging	0.90
R9257:Fras1	UTSW	5	96762500	missense	probably damaging	1.00
R9302:Fras1	UTSW	5	96534892	missense	probably damaging	1.00
R9329:Fras1	UTSW	5	96736954	missense	probably damaging	1.00
R9361:Fras1	UTSW	5	96776698	missense	probably damaging	1.00
R9430:Fras1	UTSW	5	96781392	missense	probably benign	0.00
R9431:Fras1	UTSW	5	96753014	missense	possibly damaging	0.71
R9474:Fras1	UTSW	5	96739265	missense	probably benign	0.00
R9475:Fras1	UTSW	5	96780070	missense	probably damaging	0.96
R9497:Fras1	UTSW	5	96737036	missense	probably damaging	1.00
R9597:Fras1	UTSW	5	96740692	missense	probably damaging	1.00
R9650:Fras1	UTSW	5	96762528	missense	probably damaging	1.00
R9694:Fras1	UTSW	5	96781686	missense	probably benign	0.03
R9779:Fras1	UTSW	5	96569494	missense	probably damaging	0.99
Z1088:Fras1	UTSW	5	96743211	missense	probably damaging	0.97
Z1088:Fras1	UTSW	5	96758142	missense	probably benign
Z1176:Fras1	UTSW	5	96758142	missense	probably benign
Z1177:Fras1	UTSW	5	96691457	missense	probably damaging	1.00
Z1177:Fras1	UTSW	5	96700251	missense	possibly damaging	0.71
Z1177:Fras1	UTSW	5	96740811	missense	probably benign	0.18
Z1177:Fras1	UTSW	5	96740983	missense	possibly damaging	0.95
Z1177:Fras1	UTSW	5	96758142	missense	probably benign

Posted On

2013-01-08