Incidental Mutation 'R1452:Lgals8'
ID 161095
Institutional Source Beutler Lab
Gene Symbol Lgals8
Ensembl Gene ENSMUSG00000057554
Gene Name lectin, galactose binding, soluble 8
Synonyms D13Ertd524e, Lgals-8, 1200015E08Rik
MMRRC Submission 039507-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R1452 (G1)
Quality Score 185
Status Validated
Chromosome 13
Chromosomal Location 12454296-12479825 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 12468208 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 140 (Y140*)
Ref Sequence ENSEMBL: ENSMUSP00000114200 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099820] [ENSMUST00000099821] [ENSMUST00000124888] [ENSMUST00000135166] [ENSMUST00000144283] [ENSMUST00000143693]
AlphaFold Q9JL15
Predicted Effect probably null
Transcript: ENSMUST00000099820
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000097408
Gene: ENSMUSG00000057554
AA Change: Y140*

DomainStartEndE-ValueType
GLECT 16 151 3.05e-50 SMART
Gal-bind_lectin 22 150 7.41e-55 SMART
GLECT 184 316 1.38e-48 SMART
Gal-bind_lectin 190 315 1.28e-49 SMART
Predicted Effect probably null
Transcript: ENSMUST00000099821
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000097409
Gene: ENSMUSG00000057554
AA Change: Y140*

DomainStartEndE-ValueType
GLECT 16 151 3.05e-50 SMART
Gal-bind_lectin 22 150 7.41e-55 SMART
GLECT 184 316 1.38e-48 SMART
Gal-bind_lectin 190 315 1.28e-49 SMART
Predicted Effect probably null
Transcript: ENSMUST00000124888
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000115094
Gene: ENSMUSG00000057554
AA Change: Y140*

DomainStartEndE-ValueType
GLECT 16 151 3.05e-50 SMART
Gal-bind_lectin 22 150 7.41e-55 SMART
GLECT 184 316 1.38e-48 SMART
Gal-bind_lectin 190 315 1.28e-49 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133143
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135060
Predicted Effect probably null
Transcript: ENSMUST00000135166
AA Change: Y47*
SMART Domains Protein: ENSMUSP00000120210
Gene: ENSMUSG00000057554
AA Change: Y47*

DomainStartEndE-ValueType
Pfam:Gal-bind_lectin 1 57 4e-16 PFAM
GLECT 91 223 1.38e-48 SMART
Gal-bind_lectin 97 222 1.28e-49 SMART
Predicted Effect probably null
Transcript: ENSMUST00000144283
AA Change: Y140*
SMART Domains Protein: ENSMUSP00000114200
Gene: ENSMUSG00000057554
AA Change: Y140*

DomainStartEndE-ValueType
GLECT 16 151 3.05e-50 SMART
Gal-bind_lectin 22 150 7.41e-55 SMART
GLECT 193 325 1.38e-48 SMART
Gal-bind_lectin 199 324 1.28e-49 SMART
Predicted Effect probably null
Transcript: ENSMUST00000143693
AA Change: Y47*
SMART Domains Protein: ENSMUSP00000118925
Gene: ENSMUSG00000057554
AA Change: Y47*

DomainStartEndE-ValueType
Pfam:Gal-bind_lectin 1 57 4e-16 PFAM
GLECT 91 223 1.38e-48 SMART
Gal-bind_lectin 97 222 1.28e-49 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155871
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.8%
  • 20x: 87.5%
Validation Efficiency 99% (70/71)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced VEGF-C-induced lymphangiogenesis, and ameliorated corneal pathology and lymphangiogenesis in a model of herpes simplex virus keratitis. Mice homozygous for a gene trapped allele exhibit hyperactivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A G 6: 121,655,015 (GRCm39) I1446M probably benign Het
Acaca T A 11: 84,185,885 (GRCm39) probably benign Het
Adgre4 A T 17: 56,091,996 (GRCm39) E85D probably benign Het
Akt3 A T 1: 176,958,633 (GRCm39) Y26N possibly damaging Het
Arl15 T C 13: 114,104,319 (GRCm39) V132A probably benign Het
Atp6v1h A G 1: 5,168,360 (GRCm39) probably benign Het
Atrip T A 9: 108,901,727 (GRCm39) D110V probably damaging Het
Bahcc1 T G 11: 120,173,065 (GRCm39) probably benign Het
Cd53 C T 3: 106,676,275 (GRCm39) G31S probably damaging Het
Cdk14 T C 5: 4,938,927 (GRCm39) S404G possibly damaging Het
Cers3 A T 7: 66,433,152 (GRCm39) K156N probably damaging Het
Colgalt2 C A 1: 152,379,904 (GRCm39) L448M probably damaging Het
Cox15 G T 19: 43,735,344 (GRCm39) T141K probably damaging Het
Csnk2a2 C T 8: 96,184,003 (GRCm39) probably benign Het
Cyp2b10 A T 7: 25,624,813 (GRCm39) probably benign Het
Cyp2c55 A G 19: 38,999,534 (GRCm39) Y80C probably damaging Het
Depdc1a A G 3: 159,232,328 (GRCm39) Y693C possibly damaging Het
Des T C 1: 75,340,121 (GRCm39) S343P probably damaging Het
Dync1i2 T C 2: 71,080,207 (GRCm39) probably benign Het
Eif3m T A 2: 104,837,122 (GRCm39) Q199L probably damaging Het
Emsy G T 7: 98,249,881 (GRCm39) T802K probably damaging Het
Endov A G 11: 119,382,651 (GRCm39) T33A probably damaging Het
Epb41l5 G A 1: 119,476,896 (GRCm39) T728I probably damaging Het
Fbxo39 A G 11: 72,209,228 (GRCm39) I363V probably benign Het
Gm8674 C T 13: 50,054,553 (GRCm39) noncoding transcript Het
Il6st T A 13: 112,617,998 (GRCm39) N137K possibly damaging Het
Inf2 A G 12: 112,567,778 (GRCm39) N136S probably damaging Het
Iqub A T 6: 24,491,558 (GRCm39) I376N probably benign Het
Kansl3 A G 1: 36,393,874 (GRCm39) probably benign Het
Kbtbd2 A T 6: 56,758,909 (GRCm39) H71Q probably damaging Het
Mab21l4 T C 1: 93,080,661 (GRCm39) Y415C probably damaging Het
Macf1 T A 4: 123,387,791 (GRCm39) I924L probably benign Het
Mcoln2 A T 3: 145,887,569 (GRCm39) T329S possibly damaging Het
Mex3d A T 10: 80,217,354 (GRCm39) L621Q probably damaging Het
Mmut A G 17: 41,248,359 (GRCm39) probably benign Het
Ncor1 T C 11: 62,225,457 (GRCm39) H1038R probably damaging Het
Neb A G 2: 52,161,309 (GRCm39) probably null Het
Ngrn A G 7: 79,914,520 (GRCm39) T224A probably benign Het
Nin G A 12: 70,064,424 (GRCm39) R2019* probably null Het
Nphp4 C G 4: 152,631,475 (GRCm39) Q792E probably damaging Het
Or13e8 C T 4: 43,696,823 (GRCm39) V117M probably benign Het
Or2z9 C T 8: 72,854,020 (GRCm39) Q139* probably null Het
Or4c3d C T 2: 89,882,015 (GRCm39) V218I possibly damaging Het
Or5d38 C T 2: 87,954,655 (GRCm39) V225I probably benign Het
Or8k3 T A 2: 86,058,799 (GRCm39) N172I probably damaging Het
Pde4dip C A 3: 97,631,418 (GRCm39) V1164L probably damaging Het
Plppr1 A G 4: 49,301,067 (GRCm39) probably benign Het
Pole2 G A 12: 69,254,703 (GRCm39) L381F probably benign Het
Ppp2r5e A G 12: 75,516,310 (GRCm39) probably benign Het
Prim2 T A 1: 33,669,485 (GRCm39) E163D probably benign Het
Prrc2b A T 2: 32,084,997 (GRCm39) D296V probably damaging Het
Pter A G 2: 12,983,432 (GRCm39) probably benign Het
Resf1 A T 6: 149,228,130 (GRCm39) K392I probably damaging Het
Robo2 C A 16: 73,758,798 (GRCm39) V662L probably damaging Het
Sirpd G T 3: 15,397,212 (GRCm39) T24K unknown Het
Slco1b2 A T 6: 141,617,926 (GRCm39) I424F probably benign Het
Snx29 A T 16: 11,449,335 (GRCm39) H260L probably damaging Het
Stil A G 4: 114,896,392 (GRCm39) N959S probably benign Het
Taar8c A T 10: 23,977,508 (GRCm39) D101E probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trpc6 G A 9: 8,653,148 (GRCm39) M573I probably damaging Het
Tsr1 A T 11: 74,790,425 (GRCm39) D171V probably benign Het
Ube4b T C 4: 149,455,626 (GRCm39) T348A probably damaging Het
Vmn1r85 A T 7: 12,818,808 (GRCm39) I112N probably damaging Het
Vps36 A G 8: 22,708,226 (GRCm39) probably null Het
Wdfy3 G A 5: 102,085,604 (GRCm39) A630V possibly damaging Het
Wdsub1 A T 2: 59,707,144 (GRCm39) D14E probably null Het
Ylpm1 T C 12: 85,077,157 (GRCm39) I1294T possibly damaging Het
Zdhhc17 A G 10: 110,790,936 (GRCm39) F378L probably benign Het
Other mutations in Lgals8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01601:Lgals8 APN 13 12,471,219 (GRCm39) splice site probably benign
IGL02407:Lgals8 APN 13 12,469,699 (GRCm39) missense probably benign 0.01
R0015:Lgals8 UTSW 13 12,462,179 (GRCm39) missense probably damaging 1.00
R0015:Lgals8 UTSW 13 12,462,179 (GRCm39) missense probably damaging 1.00
R0973:Lgals8 UTSW 13 12,466,276 (GRCm39) splice site probably benign
R1748:Lgals8 UTSW 13 12,469,824 (GRCm39) missense probably damaging 1.00
R1939:Lgals8 UTSW 13 12,474,069 (GRCm39) missense probably benign 0.00
R2076:Lgals8 UTSW 13 12,469,750 (GRCm39) nonsense probably null
R2214:Lgals8 UTSW 13 12,469,713 (GRCm39) missense probably benign 0.02
R4568:Lgals8 UTSW 13 12,468,254 (GRCm39) missense probably damaging 1.00
R4791:Lgals8 UTSW 13 12,468,203 (GRCm39) missense possibly damaging 0.94
R5243:Lgals8 UTSW 13 12,469,645 (GRCm39) missense probably benign 0.27
R6947:Lgals8 UTSW 13 12,469,682 (GRCm39) start gained probably benign
R7476:Lgals8 UTSW 13 12,463,362 (GRCm39) missense probably damaging 0.97
R7515:Lgals8 UTSW 13 12,463,343 (GRCm39) nonsense probably null
R7942:Lgals8 UTSW 13 12,468,137 (GRCm39) critical splice donor site probably null
R8208:Lgals8 UTSW 13 12,468,255 (GRCm39) missense probably damaging 1.00
R8674:Lgals8 UTSW 13 12,462,117 (GRCm39) missense probably damaging 1.00
R9232:Lgals8 UTSW 13 12,469,777 (GRCm39) missense probably damaging 1.00
R9727:Lgals8 UTSW 13 12,462,038 (GRCm39) missense possibly damaging 0.67
R9785:Lgals8 UTSW 13 12,462,051 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CACATTAGCCATCTGGTAGGCTCAC -3'
(R):5'- TGAGGAGACATCCCATCCATCCATC -3'

Sequencing Primer
(F):5'- ACTTGAGATTTGAGGTCCCAC -3'
(R):5'- tgttctttccaccacagctc -3'
Posted On 2014-03-14