Incidental Mutation 'R1422:Or51f23'
ID 161122
Institutional Source Beutler Lab
Gene Symbol Or51f23
Ensembl Gene ENSMUSG00000048469
Gene Name olfactory receptor family 51 subfamily F member 23
Synonyms GA_x6K02T2PBJ9-5513635-5514627, MOR14-10, Olfr564
MMRRC Submission 039478-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R1422 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 102452687-102453637 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 102453057 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 124 (R124H)
Ref Sequence ENSEMBL: ENSMUSP00000129376 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061096]
AlphaFold E9PWA8
Predicted Effect probably benign
Transcript: ENSMUST00000061096
AA Change: R124H

PolyPhen 2 Score 0.078 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000129376
Gene: ENSMUSG00000048469
AA Change: R124H

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 3.6e-117 PFAM
Pfam:7TM_GPCR_Srsx 38 256 4.7e-8 PFAM
Pfam:7tm_1 43 294 2.5e-20 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.2%
  • 20x: 89.6%
Validation Efficiency 100% (51/51)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700062C07Rik A G 18: 24,610,333 (GRCm39) T170A probably benign Het
Arhgap5 T A 12: 52,566,297 (GRCm39) D1089E probably damaging Het
Atrn T C 2: 130,799,834 (GRCm39) Y404H probably damaging Het
Becn1 T C 11: 101,185,952 (GRCm39) D98G possibly damaging Het
Coro2b A G 9: 62,336,229 (GRCm39) probably null Het
Cpne4 T C 9: 104,777,484 (GRCm39) I143T probably damaging Het
Cr2 A G 1: 194,853,433 (GRCm39) I35T probably benign Het
Ctns T C 11: 73,076,072 (GRCm39) Y321C probably damaging Het
Cyp4f16 A T 17: 32,761,973 (GRCm39) M174L probably damaging Het
Dpy19l4 T C 4: 11,317,168 (GRCm39) E10G possibly damaging Het
Dtx3 T A 10: 127,027,158 (GRCm39) I339F possibly damaging Het
Fam184a A T 10: 53,551,304 (GRCm39) M625K probably benign Het
Fgd6 A G 10: 93,881,234 (GRCm39) E696G probably damaging Het
Gm17535 A G 9: 3,035,804 (GRCm39) Y224C probably null Het
Gria1 T A 11: 57,080,614 (GRCm39) L199Q probably benign Het
Hk1 T C 10: 62,131,873 (GRCm39) D184G probably null Het
Ift88 T C 14: 57,675,758 (GRCm39) probably benign Het
Ift88 G A 14: 57,710,436 (GRCm39) V403M probably damaging Het
Igsf1 C A X: 48,871,813 (GRCm39) G737* probably null Het
Kif19a A G 11: 114,676,635 (GRCm39) D488G probably benign Het
Lpcat2 T C 8: 93,606,045 (GRCm39) L232P probably damaging Het
Ly9 A G 1: 171,428,780 (GRCm39) V280A probably damaging Het
Macrod2 T A 2: 140,261,861 (GRCm39) probably null Het
Mmp1a A G 9: 7,464,298 (GRCm39) probably null Het
Mmrn2 A G 14: 34,118,196 (GRCm39) H80R probably damaging Het
Or2b4 T C 17: 38,116,254 (GRCm39) Y73H probably damaging Het
Or5l13 G A 2: 87,780,439 (GRCm39) T46I probably benign Het
Pkd1l3 C A 8: 110,348,340 (GRCm39) P194H unknown Het
Plk2 A G 13: 110,536,023 (GRCm39) M576V probably damaging Het
Pms2 T A 5: 143,850,523 (GRCm39) S113T probably damaging Het
Ptprk A G 10: 28,351,276 (GRCm39) I590V possibly damaging Het
Ptpro T A 6: 137,420,592 (GRCm39) V1007D probably damaging Het
Pwwp4a G T X: 72,171,261 (GRCm39) G218C probably damaging Het
Rad17 A G 13: 100,781,590 (GRCm39) L69P probably benign Het
Rmc1 G A 18: 12,314,680 (GRCm39) D87N probably damaging Het
Robo2 G A 16: 73,775,336 (GRCm39) T466M probably damaging Het
Sema6a A G 18: 47,439,498 (GRCm39) C9R probably benign Het
Slc6a19 A G 13: 73,833,988 (GRCm39) S357P probably benign Het
Spata31e2 C G 1: 26,721,547 (GRCm39) S1211T possibly damaging Het
Spock3 T C 8: 63,597,023 (GRCm39) I109T possibly damaging Het
Svs6 T C 2: 164,159,580 (GRCm39) probably null Het
Tenm4 A T 7: 96,199,258 (GRCm39) D17V probably damaging Het
Trp53bp2 T A 1: 182,274,029 (GRCm39) M558K probably benign Het
Ttn T C 2: 76,572,014 (GRCm39) E26293G probably damaging Het
Vmn1r29 A G 6: 58,284,871 (GRCm39) Y197C probably damaging Het
Wdfy3 A T 5: 102,032,080 (GRCm39) probably benign Het
Zfp366 A G 13: 99,365,804 (GRCm39) K322E probably damaging Het
Other mutations in Or51f23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Or51f23 APN 7 102,453,061 (GRCm39) nonsense probably null
IGL03248:Or51f23 APN 7 102,452,846 (GRCm39) nonsense probably null
R1108:Or51f23 UTSW 7 102,453,057 (GRCm39) missense probably benign 0.08
R1395:Or51f23 UTSW 7 102,453,414 (GRCm39) missense possibly damaging 0.90
R4032:Or51f23 UTSW 7 102,453,396 (GRCm39) missense probably benign 0.00
R5168:Or51f23 UTSW 7 102,453,528 (GRCm39) missense probably benign
R5269:Or51f23 UTSW 7 102,453,327 (GRCm39) missense probably benign
R5639:Or51f23 UTSW 7 102,453,200 (GRCm39) missense probably benign
R5930:Or51f23 UTSW 7 102,453,481 (GRCm39) missense probably damaging 1.00
R6019:Or51f23 UTSW 7 102,453,491 (GRCm39) nonsense probably null
R7206:Or51f23 UTSW 7 102,452,891 (GRCm39) missense probably damaging 1.00
R7254:Or51f23 UTSW 7 102,452,765 (GRCm39) missense probably benign
R7845:Or51f23 UTSW 7 102,453,492 (GRCm39) missense not run
R8036:Or51f23 UTSW 7 102,452,763 (GRCm39) missense possibly damaging 0.87
R8730:Or51f23 UTSW 7 102,453,348 (GRCm39) missense probably benign 0.00
R9156:Or51f23 UTSW 7 102,453,339 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TATGCAACTGCCCTGTCAGGGAAC -3'
(R):5'- AGTGATGAAGCACATGGCTGCTAC -3'

Sequencing Primer
(F):5'- TGTCAGGGAACAGCCTGATTC -3'
(R):5'- CATGGCTGCTACAGTAGGATAATC -3'
Posted On 2014-03-14