Incidental Mutation 'R1424:Vmn2r23'
ID 161222
Institutional Source Beutler Lab
Gene Symbol Vmn2r23
Ensembl Gene ENSMUSG00000091620
Gene Name vomeronasal 2, receptor 23
Synonyms EG435916
MMRRC Submission 039480-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R1424 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 123702821-123742291 bp(+) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 123713270 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 368 (Y368*)
Ref Sequence ENSEMBL: ENSMUSP00000126682 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172391]
AlphaFold E9PXI5
Predicted Effect probably null
Transcript: ENSMUST00000172391
AA Change: Y368*
SMART Domains Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: Y368*

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 79 461 1.7e-31 PFAM
Pfam:NCD3G 513 566 1.2e-23 PFAM
Pfam:7tm_3 596 834 1.5e-55 PFAM
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.1%
  • 20x: 88.6%
Validation Efficiency 97% (57/59)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447C04Rik C A 12: 72,892,895 (GRCm38) E415* probably null Het
8430408G22Rik A G 6: 116,652,005 (GRCm38) N103S possibly damaging Het
Abcb10 C T 8: 123,962,052 (GRCm38) G495D probably damaging Het
Acad12 C T 5: 121,604,322 (GRCm38) A408T probably benign Het
Acox2 T A 14: 8,230,247 (GRCm38) H632L probably benign Het
Anxa5 A T 3: 36,452,292 (GRCm38) probably null Het
Ap1m2 A T 9: 21,298,204 (GRCm38) I392N possibly damaging Het
Casp2 T C 6: 42,276,791 (GRCm38) probably benign Het
Cel C T 2: 28,559,624 (GRCm38) A243T probably damaging Het
Dgka A T 10: 128,733,333 (GRCm38) S177T possibly damaging Het
Dnajc6 A G 4: 101,639,347 (GRCm38) T836A possibly damaging Het
Dock3 T C 9: 106,913,193 (GRCm38) S1444G probably damaging Het
Dtl T C 1: 191,561,537 (GRCm38) D176G probably benign Het
Eif4g1 T C 16: 20,678,942 (GRCm38) I230T probably benign Het
Fam227a T A 15: 79,634,108 (GRCm38) I328F probably benign Het
Fam98a A G 17: 75,540,178 (GRCm38) L179S probably damaging Het
Fgb A T 3: 83,046,763 (GRCm38) I56N probably damaging Het
Fmo1 C T 1: 162,830,066 (GRCm38) R502Q probably damaging Het
Fndc3a C T 14: 72,574,371 (GRCm38) A340T probably damaging Het
Gli3 C A 13: 15,726,314 (GRCm38) Q1429K probably benign Het
Gm3443 A T 19: 21,557,595 (GRCm38) I75F possibly damaging Het
Gtpbp6 C T 5: 110,104,289 (GRCm38) probably null Het
Gtsf1 A T 15: 103,409,643 (GRCm38) Y156* probably null Het
Hmcn1 T C 1: 150,646,794 (GRCm38) T3452A probably benign Het
Kcnj10 T A 1: 172,369,255 (GRCm38) V112E probably damaging Het
Lama3 C A 18: 12,519,991 (GRCm38) T256K probably benign Het
Lrrc8d G A 5: 105,826,916 (GRCm38) V63M unknown Het
Matn3 G T 12: 8,961,132 (GRCm38) A348S possibly damaging Het
Mmp16 A G 4: 18,112,121 (GRCm38) probably null Het
Nsd3 A G 8: 25,700,566 (GRCm38) N175S probably damaging Het
Olfr1260 C T 2: 89,978,071 (GRCm38) Q98* probably null Het
Olfr412 C A 11: 74,364,954 (GRCm38) P95Q probably benign Het
Olfr729 C A 14: 50,148,465 (GRCm38) M136I possibly damaging Het
Olfr749 A T 14: 50,737,064 (GRCm38) F33I probably benign Het
Pcdhb12 T A 18: 37,438,079 (GRCm38) N759K probably benign Het
Pcsk2 T C 2: 143,573,428 (GRCm38) probably benign Het
Polq G A 16: 37,086,528 (GRCm38) D2284N probably damaging Het
Prdm12 C T 2: 31,643,811 (GRCm38) R147C probably damaging Het
Ptprz1 A G 6: 23,000,383 (GRCm38) D824G probably benign Het
Rere C T 4: 150,617,038 (GRCm38) R1292C probably damaging Het
Rptor T A 11: 119,780,593 (GRCm38) L294* probably null Het
Sbf2 A T 7: 110,315,026 (GRCm38) C1650S probably damaging Het
Sdk1 C T 5: 142,161,866 (GRCm38) T1751I probably damaging Het
Sh3bp1 T C 15: 78,903,699 (GRCm38) probably null Het
Shank2 T A 7: 144,052,372 (GRCm38) D97E probably damaging Het
Tab2 A C 10: 7,920,048 (GRCm38) S149R possibly damaging Het
Taok1 G T 11: 77,549,364 (GRCm38) R606S probably benign Het
Tas2r121 A G 6: 132,700,682 (GRCm38) L109P probably damaging Het
Tmem117 A G 15: 94,931,808 (GRCm38) M175V probably benign Het
Tmprss11b T C 5: 86,664,973 (GRCm38) K155E probably benign Het
Tmtc2 G T 10: 105,413,368 (GRCm38) T168N probably benign Het
Top2b G A 14: 16,383,177 (GRCm38) R55H probably damaging Het
Tsga10ip C T 19: 5,390,914 (GRCm38) probably null Het
Tuba8 A G 6: 121,220,511 (GRCm38) N44S probably benign Het
Ube2o A G 11: 116,543,732 (GRCm38) V590A probably benign Het
Ush2a T G 1: 188,542,878 (GRCm38) probably null Het
Other mutations in Vmn2r23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00324:Vmn2r23 APN 6 123,729,725 (GRCm38) missense possibly damaging 0.89
IGL01012:Vmn2r23 APN 6 123,729,596 (GRCm38) missense probably benign
IGL01073:Vmn2r23 APN 6 123,712,800 (GRCm38) missense possibly damaging 0.82
IGL01547:Vmn2r23 APN 6 123,704,424 (GRCm38) missense possibly damaging 0.88
IGL01571:Vmn2r23 APN 6 123,704,407 (GRCm38) missense probably damaging 1.00
IGL01950:Vmn2r23 APN 6 123,741,886 (GRCm38) missense possibly damaging 0.80
IGL02028:Vmn2r23 APN 6 123,741,860 (GRCm38) missense probably damaging 1.00
IGL02248:Vmn2r23 APN 6 123,741,744 (GRCm38) missense probably damaging 0.96
IGL02318:Vmn2r23 APN 6 123,741,836 (GRCm38) missense probably benign 0.10
IGL02649:Vmn2r23 APN 6 123,704,478 (GRCm38) missense probably benign
IGL02831:Vmn2r23 APN 6 123,704,385 (GRCm38) missense probably benign 0.22
IGL02832:Vmn2r23 APN 6 123,704,396 (GRCm38) missense probably benign 0.00
IGL02865:Vmn2r23 APN 6 123,741,619 (GRCm38) missense probably damaging 1.00
IGL02964:Vmn2r23 APN 6 123,741,782 (GRCm38) missense possibly damaging 0.93
IGL03347:Vmn2r23 APN 6 123,704,374 (GRCm38) missense probably benign 0.01
IGL03396:Vmn2r23 APN 6 123,729,626 (GRCm38) missense probably damaging 1.00
PIT4472001:Vmn2r23 UTSW 6 123,712,977 (GRCm38) missense possibly damaging 0.62
R0597:Vmn2r23 UTSW 6 123,729,721 (GRCm38) missense probably benign 0.08
R0677:Vmn2r23 UTSW 6 123,713,451 (GRCm38) missense probably benign 0.00
R0904:Vmn2r23 UTSW 6 123,742,135 (GRCm38) missense probably damaging 1.00
R1330:Vmn2r23 UTSW 6 123,742,004 (GRCm38) missense probably damaging 1.00
R1629:Vmn2r23 UTSW 6 123,713,427 (GRCm38) missense probably benign 0.05
R1842:Vmn2r23 UTSW 6 123,729,690 (GRCm38) missense possibly damaging 0.77
R1867:Vmn2r23 UTSW 6 123,702,915 (GRCm38) missense probably damaging 1.00
R1919:Vmn2r23 UTSW 6 123,713,010 (GRCm38) missense possibly damaging 0.94
R2087:Vmn2r23 UTSW 6 123,741,499 (GRCm38) missense probably benign 0.00
R2338:Vmn2r23 UTSW 6 123,704,425 (GRCm38) missense possibly damaging 0.88
R2568:Vmn2r23 UTSW 6 123,742,188 (GRCm38) nonsense probably null
R2867:Vmn2r23 UTSW 6 123,713,164 (GRCm38) missense possibly damaging 0.94
R2867:Vmn2r23 UTSW 6 123,713,164 (GRCm38) missense possibly damaging 0.94
R3500:Vmn2r23 UTSW 6 123,713,170 (GRCm38) missense possibly damaging 0.81
R3789:Vmn2r23 UTSW 6 123,741,389 (GRCm38) missense probably damaging 1.00
R4164:Vmn2r23 UTSW 6 123,729,738 (GRCm38) missense probably benign
R4506:Vmn2r23 UTSW 6 123,702,925 (GRCm38) missense probably damaging 1.00
R4652:Vmn2r23 UTSW 6 123,741,730 (GRCm38) missense probably damaging 1.00
R4697:Vmn2r23 UTSW 6 123,741,826 (GRCm38) missense probably damaging 1.00
R4840:Vmn2r23 UTSW 6 123,713,074 (GRCm38) missense probably damaging 1.00
R4983:Vmn2r23 UTSW 6 123,733,349 (GRCm38) missense probably damaging 1.00
R5276:Vmn2r23 UTSW 6 123,712,977 (GRCm38) missense possibly damaging 0.62
R5392:Vmn2r23 UTSW 6 123,704,364 (GRCm38) missense probably benign 0.36
R5528:Vmn2r23 UTSW 6 123,713,002 (GRCm38) missense probably damaging 1.00
R5529:Vmn2r23 UTSW 6 123,713,451 (GRCm38) missense probably benign 0.00
R5664:Vmn2r23 UTSW 6 123,713,074 (GRCm38) missense probably damaging 1.00
R5749:Vmn2r23 UTSW 6 123,733,273 (GRCm38) missense probably benign
R5761:Vmn2r23 UTSW 6 123,712,759 (GRCm38) missense probably benign 0.39
R5762:Vmn2r23 UTSW 6 123,733,393 (GRCm38) missense probably damaging 1.00
R5868:Vmn2r23 UTSW 6 123,712,942 (GRCm38) missense probably benign 0.12
R5935:Vmn2r23 UTSW 6 123,741,895 (GRCm38) missense possibly damaging 0.94
R6242:Vmn2r23 UTSW 6 123,704,400 (GRCm38) missense possibly damaging 0.82
R6416:Vmn2r23 UTSW 6 123,712,902 (GRCm38) missense probably damaging 1.00
R6524:Vmn2r23 UTSW 6 123,713,425 (GRCm38) missense probably damaging 1.00
R6576:Vmn2r23 UTSW 6 123,733,273 (GRCm38) missense probably benign
R6925:Vmn2r23 UTSW 6 123,704,553 (GRCm38) missense probably damaging 1.00
R7148:Vmn2r23 UTSW 6 123,713,022 (GRCm38) missense probably benign
R7215:Vmn2r23 UTSW 6 123,704,364 (GRCm38) missense probably benign 0.36
R7252:Vmn2r23 UTSW 6 123,741,581 (GRCm38) missense probably damaging 0.97
R7403:Vmn2r23 UTSW 6 123,704,579 (GRCm38) missense probably benign 0.01
R8015:Vmn2r23 UTSW 6 123,704,541 (GRCm38) missense probably benign 0.00
R8143:Vmn2r23 UTSW 6 123,741,353 (GRCm38) missense probably damaging 0.99
R8474:Vmn2r23 UTSW 6 123,704,640 (GRCm38) missense probably benign 0.36
R8520:Vmn2r23 UTSW 6 123,741,656 (GRCm38) missense probably damaging 0.99
R8679:Vmn2r23 UTSW 6 123,713,472 (GRCm38) missense probably damaging 0.99
R8713:Vmn2r23 UTSW 6 123,703,032 (GRCm38) missense
R8966:Vmn2r23 UTSW 6 123,742,120 (GRCm38) missense possibly damaging 0.94
R9124:Vmn2r23 UTSW 6 123,742,079 (GRCm38) missense possibly damaging 0.57
R9163:Vmn2r23 UTSW 6 123,741,823 (GRCm38) missense probably damaging 1.00
R9189:Vmn2r23 UTSW 6 123,704,364 (GRCm38) missense probably benign 0.36
R9451:Vmn2r23 UTSW 6 123,733,393 (GRCm38) missense probably damaging 1.00
R9495:Vmn2r23 UTSW 6 123,712,713 (GRCm38) missense probably benign 0.30
R9514:Vmn2r23 UTSW 6 123,712,713 (GRCm38) missense probably benign 0.30
RF018:Vmn2r23 UTSW 6 123,713,116 (GRCm38) missense probably benign 0.00
T0975:Vmn2r23 UTSW 6 123,713,161 (GRCm38) missense probably benign 0.00
Z1088:Vmn2r23 UTSW 6 123,742,108 (GRCm38) missense probably damaging 0.98
Z1177:Vmn2r23 UTSW 6 123,729,725 (GRCm38) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TCCCAGATGATATGCGGGGAGAAC -3'
(R):5'- TGAGCCTCCTTCTACTCTGAGTGAC -3'

Sequencing Primer
(F):5'- CTGGATCACAACGTCTGATTG -3'
(R):5'- TGACAGCTCCTCATGGAGTG -3'
Posted On 2014-03-14