Mutagenetix > Incidental Mutations

Incidental Mutation 'R1424:Vmn2r23'

161222

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

039480-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R1424 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 123713270 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 368 (Y368*)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably null
Transcript: ENSMUST00000172391
AA Change: Y368*

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: Y368*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 98.9%
3x: 97.9%
10x: 95.1%
20x: 88.6%

Validation Efficiency

97% (57/59)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447C04Rik	C	A	12: 72,892,895	E415*	probably null	Het
8430408G22Rik	A	G	6: 116,652,005	N103S	possibly damaging	Het
Abcb10	C	T	8: 123,962,052	G495D	probably damaging	Het
Acad12	C	T	5: 121,604,322	A408T	probably benign	Het
Acox2	T	A	14: 8,230,247	H632L	probably benign	Het
Anxa5	A	T	3: 36,452,292		probably null	Het
Ap1m2	A	T	9: 21,298,204	I392N	possibly damaging	Het
Casp2	T	C	6: 42,276,791		probably benign	Het
Cel	C	T	2: 28,559,624	A243T	probably damaging	Het
Dgka	A	T	10: 128,733,333	S177T	possibly damaging	Het
Dnajc6	A	G	4: 101,639,347	T836A	possibly damaging	Het
Dock3	T	C	9: 106,913,193	S1444G	probably damaging	Het
Dtl	T	C	1: 191,561,537	D176G	probably benign	Het
Eif4g1	T	C	16: 20,678,942	I230T	probably benign	Het
Fam227a	T	A	15: 79,634,108	I328F	probably benign	Het
Fam98a	A	G	17: 75,540,178	L179S	probably damaging	Het
Fgb	A	T	3: 83,046,763	I56N	probably damaging	Het
Fmo1	C	T	1: 162,830,066	R502Q	probably damaging	Het
Fndc3a	C	T	14: 72,574,371	A340T	probably damaging	Het
Gli3	C	A	13: 15,726,314	Q1429K	probably benign	Het
Gm3443	A	T	19: 21,557,595	I75F	possibly damaging	Het
Gtpbp6	C	T	5: 110,104,289		probably null	Het
Gtsf1	A	T	15: 103,409,643	Y156*	probably null	Het
Hmcn1	T	C	1: 150,646,794	T3452A	probably benign	Het
Kcnj10	T	A	1: 172,369,255	V112E	probably damaging	Het
Lama3	C	A	18: 12,519,991	T256K	probably benign	Het
Lrrc8d	G	A	5: 105,826,916	V63M	unknown	Het
Matn3	G	T	12: 8,961,132	A348S	possibly damaging	Het
Mmp16	A	G	4: 18,112,121		probably null	Het
Nsd3	A	G	8: 25,700,566	N175S	probably damaging	Het
Olfr1260	C	T	2: 89,978,071	Q98*	probably null	Het
Olfr412	C	A	11: 74,364,954	P95Q	probably benign	Het
Olfr729	C	A	14: 50,148,465	M136I	possibly damaging	Het
Olfr749	A	T	14: 50,737,064	F33I	probably benign	Het
Pcdhb12	T	A	18: 37,438,079	N759K	probably benign	Het
Pcsk2	T	C	2: 143,573,428		probably benign	Het
Polq	G	A	16: 37,086,528	D2284N	probably damaging	Het
Prdm12	C	T	2: 31,643,811	R147C	probably damaging	Het
Ptprz1	A	G	6: 23,000,383	D824G	probably benign	Het
Rere	C	T	4: 150,617,038	R1292C	probably damaging	Het
Rptor	T	A	11: 119,780,593	L294*	probably null	Het
Sbf2	A	T	7: 110,315,026	C1650S	probably damaging	Het
Sdk1	C	T	5: 142,161,866	T1751I	probably damaging	Het
Sh3bp1	T	C	15: 78,903,699		probably null	Het
Shank2	T	A	7: 144,052,372	D97E	probably damaging	Het
Tab2	A	C	10: 7,920,048	S149R	possibly damaging	Het
Taok1	G	T	11: 77,549,364	R606S	probably benign	Het
Tas2r121	A	G	6: 132,700,682	L109P	probably damaging	Het
Tmem117	A	G	15: 94,931,808	M175V	probably benign	Het
Tmprss11b	T	C	5: 86,664,973	K155E	probably benign	Het
Tmtc2	G	T	10: 105,413,368	T168N	probably benign	Het
Top2b	G	A	14: 16,383,177	R55H	probably damaging	Het
Tsga10ip	C	T	19: 5,390,914		probably null	Het
Tuba8	A	G	6: 121,220,511	N44S	probably benign	Het
Ube2o	A	G	11: 116,543,732	V590A	probably benign	Het
Ush2a	T	G	1: 188,542,878		probably null	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123729725	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123729596	missense	probably benign
IGL01073:Vmn2r23	APN	6	123712800	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123704424	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123704407	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123741886	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123741860	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123741744	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123741836	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123704478	missense	probably benign
IGL02831:Vmn2r23	APN	6	123704385	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123704396	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123741619	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123741782	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123704374	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123729626	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123729721	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123742135	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123742004	missense	probably damaging	1.00
R1629:Vmn2r23	UTSW	6	123713427	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123729690	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123702915	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123713010	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123741499	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123704425	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123742188	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123713164	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123713170	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123741389	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123729738	missense	probably benign
R4506:Vmn2r23	UTSW	6	123702925	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123741730	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123741826	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123733349	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123712977	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123713002	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123713451	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123713074	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123733273	missense	probably benign
R5761:Vmn2r23	UTSW	6	123712759	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123712942	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123741895	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123704400	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123712902	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123713425	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123733273	missense	probably benign
R6925:Vmn2r23	UTSW	6	123704553	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123713022	missense	probably benign
R7215:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123741581	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123704579	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123704541	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123741353	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123704640	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123741656	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123713472	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123703032	missense
R8966:Vmn2r23	UTSW	6	123742120	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123742079	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123741823	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123704364	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123733393	missense	probably damaging	1.00
RF018:Vmn2r23	UTSW	6	123713116	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123713161	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123742108	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123729725	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- TCCCAGATGATATGCGGGGAGAAC -3'
(R):5'- TGAGCCTCCTTCTACTCTGAGTGAC -3'

Sequencing Primer
(F):5'- CTGGATCACAACGTCTGATTG -3'
(R):5'- TGACAGCTCCTCATGGAGTG -3'

Posted On

2014-03-14