|Institutional Source||Beutler Lab|
|Gene Name||somatostatin receptor 4|
|Is this an essential gene?||Probably non essential (E-score: 0.159)|
|Stock #||R1428 (G1)|
|Chromosomal Location||148395344-148396767 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 148396359 bp|
|Amino Acid Change||Serine to Glycine at position 297 (S297G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000105588 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000109962]|
|Predicted Effect||probably benign
AA Change: S297G
PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
AA Change: S297G
|Meta Mutation Damage Score||0.2395|
|Coding Region Coverage||
|Validation Efficiency||98% (56/57)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygote null mice have increased susceptibility to inflammation, delayed type hypersensitivity, hyperalgesia and airway hypersensitivity. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Sstr4||
(F):5'- TGCTACCTGCTTATTGTGGGCAAG -3'
(R):5'- TGAAAGGGCCTGGCTTAGTGAAAAC -3'
(F):5'- CTTATTGTGGGCAAGATGCG -3'
(R):5'- AAGGGACTTGCTTGCAGC -3'