Incidental Mutation 'R1428:Cyp2j11'
ID 161386
Institutional Source Beutler Lab
Gene Symbol Cyp2j11
Ensembl Gene ENSMUSG00000066097
Gene Name cytochrome P450, family 2, subfamily j, polypeptide 11
Synonyms Cyp2j11-ps
MMRRC Submission 039484-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R1428 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 96182745-96236899 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 96183117 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 484 (K484E)
Ref Sequence ENSEMBL: ENSMUSP00000132180 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000015368]
AlphaFold Q3UNV2
Predicted Effect probably benign
Transcript: ENSMUST00000015368
AA Change: K484E

PolyPhen 2 Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
SMART Domains Protein: ENSMUSP00000132180
Gene: ENSMUSG00000066097
AA Change: K484E

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:p450 44 500 4.3e-133 PFAM
Meta Mutation Damage Score 0.0653 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.0%
  • 10x: 95.5%
  • 20x: 90.2%
Validation Efficiency 98% (56/57)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T C 6: 146,853,909 (GRCm39) I249M possibly damaging Het
Abl1 G T 2: 31,691,822 (GRCm39) A1114S probably damaging Het
Acbd5 T C 2: 22,989,733 (GRCm39) V452A probably damaging Het
Armc12 A G 17: 28,756,910 (GRCm39) D225G probably damaging Het
Atad3a T A 4: 155,840,139 (GRCm39) Q121H probably damaging Het
Atosa A T 9: 74,913,603 (GRCm39) T79S probably benign Het
Bptf T A 11: 106,963,873 (GRCm39) I1711F probably damaging Het
C2cd4c A T 10: 79,448,064 (GRCm39) I361N probably damaging Het
Canx A G 11: 50,199,221 (GRCm39) probably benign Het
Ccdc127 C T 13: 74,505,034 (GRCm39) T194I probably benign Het
Cdc42ep3 T C 17: 79,642,465 (GRCm39) K152E probably benign Het
Cdh15 G C 8: 123,584,234 (GRCm39) E112Q probably damaging Het
Cnbd2 T C 2: 156,181,204 (GRCm39) probably null Het
Cplane1 T A 15: 8,248,853 (GRCm39) Y1801N possibly damaging Het
Crybg1 T C 10: 43,851,074 (GRCm39) N1599S probably benign Het
Cyc1 T C 15: 76,228,548 (GRCm39) V59A probably benign Het
Ddx60 T C 8: 62,411,193 (GRCm39) probably benign Het
Epg5 T C 18: 78,005,642 (GRCm39) S711P probably damaging Het
Espl1 A T 15: 102,214,120 (GRCm39) Q649L probably benign Het
Eya1 G A 1: 14,374,638 (GRCm39) probably benign Het
Fat2 T A 11: 55,186,913 (GRCm39) Y1311F probably damaging Het
Garin5b T A 7: 4,760,687 (GRCm39) H675L possibly damaging Het
Gins4 T C 8: 23,717,144 (GRCm39) Y208C probably damaging Het
Gsk3b T C 16: 37,910,937 (GRCm39) V17A probably benign Het
Gykl1 A T 18: 52,827,833 (GRCm39) K347I probably benign Het
Helz T A 11: 107,483,666 (GRCm39) probably benign Het
Hivep3 C T 4: 119,953,772 (GRCm39) T696I possibly damaging Het
Ifi27l2a G T 12: 103,409,093 (GRCm39) probably benign Het
Kif13a A G 13: 46,944,987 (GRCm39) probably benign Het
Kpna3 C T 14: 61,620,669 (GRCm39) probably benign Het
Mmp15 C G 8: 96,096,190 (GRCm39) P327R probably benign Het
Mrc1 A T 2: 14,320,074 (GRCm39) T1003S probably benign Het
Mtss1 T C 15: 58,819,239 (GRCm39) D393G probably benign Het
Olfm4 T A 14: 80,258,843 (GRCm39) Y331N probably damaging Het
Or10a49 T A 7: 108,468,167 (GRCm39) N65Y probably damaging Het
Or4c12b G C 2: 89,646,725 (GRCm39) L12F probably damaging Het
P2rx3 G C 2: 84,855,294 (GRCm39) T54R possibly damaging Het
Pacsin1 C T 17: 27,924,937 (GRCm39) T217I probably damaging Het
Phlpp1 A G 1: 106,308,155 (GRCm39) probably null Het
Pknox1 T C 17: 31,811,066 (GRCm39) probably benign Het
Plb1 A G 5: 32,422,256 (GRCm39) R70G possibly damaging Het
Rab3gap2 G A 1: 184,980,101 (GRCm39) A340T probably damaging Het
Rnf103 T A 6: 71,485,983 (GRCm39) W205R probably damaging Het
Rps6kc1 G A 1: 190,530,923 (GRCm39) T936M probably damaging Het
Spef2 T C 15: 9,596,793 (GRCm39) probably benign Het
Sstr4 A G 2: 148,238,279 (GRCm39) S297G probably benign Het
Timm8a1 C T X: 133,438,872 (GRCm39) E93K probably benign Het
Uck1 A C 2: 32,148,367 (GRCm39) Y150D probably damaging Het
Yipf4 A G 17: 74,805,300 (GRCm39) probably benign Het
Other mutations in Cyp2j11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01101:Cyp2j11 APN 4 96,227,332 (GRCm39) missense probably benign
IGL01816:Cyp2j11 APN 4 96,183,161 (GRCm39) missense probably damaging 1.00
IGL02406:Cyp2j11 APN 4 96,236,776 (GRCm39) missense possibly damaging 0.56
E7848:Cyp2j11 UTSW 4 96,207,602 (GRCm39) missense probably benign 0.09
R0020:Cyp2j11 UTSW 4 96,195,641 (GRCm39) missense probably benign 0.19
R0020:Cyp2j11 UTSW 4 96,195,641 (GRCm39) missense probably benign 0.19
R1298:Cyp2j11 UTSW 4 96,195,497 (GRCm39) critical splice donor site probably null
R1411:Cyp2j11 UTSW 4 96,233,453 (GRCm39) missense probably benign 0.03
R1740:Cyp2j11 UTSW 4 96,207,613 (GRCm39) missense probably benign 0.00
R1818:Cyp2j11 UTSW 4 96,185,976 (GRCm39) missense probably damaging 0.97
R1819:Cyp2j11 UTSW 4 96,185,976 (GRCm39) missense probably damaging 0.97
R1917:Cyp2j11 UTSW 4 96,228,211 (GRCm39) missense probably damaging 1.00
R2084:Cyp2j11 UTSW 4 96,227,438 (GRCm39) missense probably damaging 1.00
R2146:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R2148:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R2150:Cyp2j11 UTSW 4 96,204,595 (GRCm39) missense probably damaging 1.00
R4963:Cyp2j11 UTSW 4 96,204,619 (GRCm39) missense probably damaging 1.00
R5335:Cyp2j11 UTSW 4 96,195,589 (GRCm39) missense probably damaging 1.00
R5450:Cyp2j11 UTSW 4 96,228,113 (GRCm39) missense probably benign 0.44
R5688:Cyp2j11 UTSW 4 96,233,358 (GRCm39) missense probably damaging 1.00
R5978:Cyp2j11 UTSW 4 96,207,589 (GRCm39) missense probably damaging 1.00
R6061:Cyp2j11 UTSW 4 96,236,853 (GRCm39) start gained probably benign
R6075:Cyp2j11 UTSW 4 96,233,322 (GRCm39) missense probably benign 0.04
R6912:Cyp2j11 UTSW 4 96,183,108 (GRCm39) missense probably benign 0.00
R7338:Cyp2j11 UTSW 4 96,195,524 (GRCm39) missense possibly damaging 0.64
R7394:Cyp2j11 UTSW 4 96,204,677 (GRCm39) missense probably benign 0.00
R7464:Cyp2j11 UTSW 4 96,233,357 (GRCm39) missense probably damaging 1.00
R7972:Cyp2j11 UTSW 4 96,185,871 (GRCm39) missense probably damaging 1.00
R8152:Cyp2j11 UTSW 4 96,195,529 (GRCm39) missense probably damaging 1.00
R8328:Cyp2j11 UTSW 4 96,236,605 (GRCm39) missense probably benign 0.03
R8383:Cyp2j11 UTSW 4 96,236,695 (GRCm39) missense probably benign 0.00
R8519:Cyp2j11 UTSW 4 96,207,539 (GRCm39) missense probably benign 0.44
R8789:Cyp2j11 UTSW 4 96,227,405 (GRCm39) missense probably damaging 0.99
R9268:Cyp2j11 UTSW 4 96,207,781 (GRCm39) intron probably benign
R9323:Cyp2j11 UTSW 4 96,195,619 (GRCm39) missense probably benign 0.01
R9457:Cyp2j11 UTSW 4 96,195,596 (GRCm39) missense probably damaging 0.98
R9590:Cyp2j11 UTSW 4 96,195,614 (GRCm39) missense probably benign 0.11
Z1176:Cyp2j11 UTSW 4 96,195,673 (GRCm39) missense probably damaging 0.99
Z1176:Cyp2j11 UTSW 4 96,195,540 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TGCCAAATTTAGGCACCAGGAATCC -3'
(R):5'- GAGGTGACTGAGAACAATGGTTCCC -3'

Sequencing Primer
(F):5'- TCTTCAGTATTTCTTGAATCTCCTTC -3'
(R):5'- CCAACGGTCAGAAATATCAATGTGTC -3'
Posted On 2014-03-14