Incidental Mutation 'R1442:Zmym2'
ID 161562
Institutional Source Beutler Lab
Gene Symbol Zmym2
Ensembl Gene ENSMUSG00000021945
Gene Name zinc finger, MYM-type 2
Synonyms SCLL, RAMP, Zfp198, FIM, MYM
MMRRC Submission 039497-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.569) question?
Stock # R1442 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 57123986-57199815 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 57180784 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 899 (Y899H)
Ref Sequence ENSEMBL: ENSMUSP00000022511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022511]
AlphaFold Q9CU65
Predicted Effect probably damaging
Transcript: ENSMUST00000022511
AA Change: Y899H

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000022511
Gene: ENSMUSG00000021945
AA Change: Y899H

DomainStartEndE-ValueType
TRASH 330 366 1.55e-5 SMART
TRASH 372 412 7.69e-1 SMART
TRASH 424 459 7.5e1 SMART
TRASH 466 505 6.53e-4 SMART
Pfam:zf-FCS 527 569 1.8e-9 PFAM
TRASH 583 619 4.79e1 SMART
TRASH 638 674 8.49e-3 SMART
TRASH 680 715 7.28e-2 SMART
TRASH 726 761 1.95e-2 SMART
TRASH 767 802 3.89e1 SMART
low complexity region 881 895 N/A INTRINSIC
low complexity region 904 917 N/A INTRINSIC
low complexity region 1087 1111 N/A INTRINSIC
Pfam:DUF3504 1191 1359 7.3e-66 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224922
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225282
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225393
Meta Mutation Damage Score 0.2126 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.0%
  • 20x: 88.4%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: This gene encodes a protein that contains nine MYM-type zinc finger motifs. Expression of this gene may mediate the inhibition of hematopoietic cell development during ontogeny, and the encoded protein may also play a role in transforming growth factor-beta signaling as a Smad binding protein. [provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit prenatal lethality. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5031439G07Rik A T 15: 84,839,833 (GRCm39) probably benign Het
Adamts7 T A 9: 90,070,823 (GRCm39) I648N probably damaging Het
Akap13 T A 7: 75,385,526 (GRCm39) F2252I probably damaging Het
Akr1c6 A T 13: 4,507,159 (GRCm39) H314L probably damaging Het
Anxa3 T A 5: 96,976,549 (GRCm39) probably null Het
Apob T G 12: 8,036,165 (GRCm39) F298V probably benign Het
Atp8a2 A C 14: 60,097,772 (GRCm39) probably benign Het
Atp8b5 A T 4: 43,334,313 (GRCm39) T360S probably damaging Het
BC051665 A T 13: 60,932,555 (GRCm39) N43K probably benign Het
Bicral T A 17: 47,112,650 (GRCm39) H850L probably benign Het
C1qtnf1 A G 11: 118,339,011 (GRCm39) D227G probably damaging Het
C8a T A 4: 104,685,275 (GRCm39) T323S possibly damaging Het
Cep89 T C 7: 35,117,636 (GRCm39) probably benign Het
Cercam G T 2: 29,770,652 (GRCm39) V408L probably benign Het
CN725425 G A 15: 91,123,158 (GRCm39) V76M possibly damaging Het
Cops7b T A 1: 86,532,835 (GRCm39) M231K probably benign Het
Cpa2 T A 6: 30,544,865 (GRCm39) probably null Het
Dab2ip A T 2: 35,600,268 (GRCm39) I287F probably damaging Het
Defb10 A T 8: 22,348,944 (GRCm39) M1L probably benign Het
Dscam C A 16: 96,409,274 (GRCm39) R1883L possibly damaging Het
Dsg4 T A 18: 20,595,717 (GRCm39) I640N possibly damaging Het
Duox2 G C 2: 122,112,232 (GRCm39) P1318R probably benign Het
Dzip3 T C 16: 48,765,985 (GRCm39) D466G probably benign Het
E230025N22Rik T A 18: 36,824,462 (GRCm39) probably null Het
E2f3 A G 13: 30,102,652 (GRCm39) L80P probably damaging Het
Eif2b2 T C 12: 85,266,360 (GRCm39) S9P probably benign Het
Etaa1 A T 11: 17,897,201 (GRCm39) D305E probably benign Het
Fads6 C A 11: 115,188,235 (GRCm39) R23L probably benign Het
Flrt2 T C 12: 95,746,979 (GRCm39) V439A probably damaging Het
Galm A C 17: 80,452,614 (GRCm39) Q184P probably damaging Het
Gtse1 C T 15: 85,744,303 (GRCm39) probably benign Het
Irf7 T C 7: 140,843,935 (GRCm39) T246A probably damaging Het
Kif28 A G 1: 179,532,697 (GRCm39) V639A possibly damaging Het
Klhdc8a G A 1: 132,230,385 (GRCm39) A167T possibly damaging Het
Lrfn3 T C 7: 30,059,469 (GRCm39) H252R probably benign Het
Lzts1 G T 8: 69,591,638 (GRCm39) A170E probably damaging Het
Mphosph9 T A 5: 124,403,461 (GRCm39) I856F possibly damaging Het
Mroh2a C T 1: 88,160,075 (GRCm39) probably benign Het
Mroh2a C A 1: 88,170,142 (GRCm39) A685D possibly damaging Het
Myh3 A G 11: 66,978,103 (GRCm39) N392D possibly damaging Het
Naalad2 T C 9: 18,262,328 (GRCm39) probably benign Het
Npc1 T A 18: 12,328,106 (GRCm39) M1068L probably benign Het
Nup58 T A 14: 60,469,992 (GRCm39) probably benign Het
Or10c1 T C 17: 37,522,595 (GRCm39) T50A probably benign Het
Or4k40 A T 2: 111,250,438 (GRCm39) I286N probably damaging Het
Or8b1 A T 9: 38,399,939 (GRCm39) I205F probably benign Het
Or8s16 T C 15: 98,211,068 (GRCm39) Y121C probably damaging Het
Parp2 T G 14: 51,056,732 (GRCm39) probably null Het
Ppp4r4 T C 12: 103,564,504 (GRCm39) V9A probably damaging Het
Ptprc T A 1: 138,000,050 (GRCm39) D856V probably damaging Het
Ptpru T A 4: 131,535,580 (GRCm39) T466S probably benign Het
Rhob A G 12: 8,549,325 (GRCm39) V103A possibly damaging Het
Sec23ip A C 7: 128,378,510 (GRCm39) S775R probably benign Het
Slit2 T G 5: 48,395,725 (GRCm39) D709E probably damaging Het
Smok2b C G 17: 13,454,390 (GRCm39) I183M probably damaging Het
Smtnl1 T A 2: 84,648,780 (GRCm39) D158V probably damaging Het
Syne2 T C 12: 75,993,489 (GRCm39) I2087T probably damaging Het
Tada1 G A 1: 166,214,319 (GRCm39) R106H possibly damaging Het
Tecta T A 9: 42,243,778 (GRCm39) I2025F probably damaging Het
Themis T C 10: 28,658,131 (GRCm39) V386A probably damaging Het
Ubr5 G A 15: 38,015,168 (GRCm39) probably benign Het
Vcl T A 14: 21,033,446 (GRCm39) I134N probably damaging Het
Vegfa G A 17: 46,336,418 (GRCm39) T56I possibly damaging Het
Vmn2r108 T A 17: 20,692,623 (GRCm39) K78* probably null Het
Vmn2r82 A T 10: 79,215,201 (GRCm39) T395S probably benign Het
Wbp2nl T C 15: 82,198,407 (GRCm39) S315P probably benign Het
Zfp566 T C 7: 29,777,344 (GRCm39) Y279C probably damaging Het
Other mutations in Zmym2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00516:Zmym2 APN 14 57,185,394 (GRCm39) splice site probably benign
IGL00587:Zmym2 APN 14 57,140,817 (GRCm39) missense possibly damaging 0.86
IGL00736:Zmym2 APN 14 57,140,668 (GRCm39) missense probably benign 0.01
IGL00753:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL01608:Zmym2 APN 14 57,185,472 (GRCm39) missense possibly damaging 0.57
IGL01744:Zmym2 APN 14 57,184,029 (GRCm39) missense probably benign 0.24
IGL02150:Zmym2 APN 14 57,148,526 (GRCm39) splice site probably benign
IGL02186:Zmym2 APN 14 57,180,808 (GRCm39) missense probably benign 0.09
IGL02654:Zmym2 APN 14 57,148,772 (GRCm39) missense probably damaging 1.00
IGL02960:Zmym2 APN 14 57,175,870 (GRCm39) missense probably benign 0.09
IGL03104:Zmym2 APN 14 57,187,784 (GRCm39) missense possibly damaging 0.88
IGL03162:Zmym2 APN 14 57,151,500 (GRCm39) missense probably benign 0.24
IGL03356:Zmym2 APN 14 57,194,517 (GRCm39) nonsense probably null
IGL03412:Zmym2 APN 14 57,197,176 (GRCm39) nonsense probably null
R5038_Zmym2_756 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0131:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0132:Zmym2 UTSW 14 57,180,715 (GRCm39) missense probably benign
R0270:Zmym2 UTSW 14 57,187,141 (GRCm39) splice site probably null
R0834:Zmym2 UTSW 14 57,194,420 (GRCm39) missense probably damaging 1.00
R1071:Zmym2 UTSW 14 57,197,278 (GRCm39) missense possibly damaging 0.93
R1386:Zmym2 UTSW 14 57,150,548 (GRCm39) missense probably damaging 1.00
R1472:Zmym2 UTSW 14 57,148,640 (GRCm39) missense probably benign 0.20
R1595:Zmym2 UTSW 14 57,158,187 (GRCm39) missense probably benign 0.25
R1598:Zmym2 UTSW 14 57,151,524 (GRCm39) missense probably damaging 1.00
R1598:Zmym2 UTSW 14 57,140,226 (GRCm39) missense possibly damaging 0.94
R1916:Zmym2 UTSW 14 57,197,299 (GRCm39) missense probably damaging 1.00
R2261:Zmym2 UTSW 14 57,165,719 (GRCm39) missense probably damaging 1.00
R2393:Zmym2 UTSW 14 57,158,180 (GRCm39) missense probably benign 0.17
R2866:Zmym2 UTSW 14 57,165,705 (GRCm39) missense probably damaging 1.00
R3727:Zmym2 UTSW 14 57,156,806 (GRCm39) splice site probably benign
R3847:Zmym2 UTSW 14 57,158,956 (GRCm39) splice site probably benign
R4043:Zmym2 UTSW 14 57,195,765 (GRCm39) splice site probably benign
R4074:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 0.99
R4343:Zmym2 UTSW 14 57,159,019 (GRCm39) missense probably damaging 0.99
R4420:Zmym2 UTSW 14 57,194,335 (GRCm39) missense probably damaging 0.98
R4645:Zmym2 UTSW 14 57,165,764 (GRCm39) missense probably damaging 1.00
R5015:Zmym2 UTSW 14 57,159,051 (GRCm39) missense probably damaging 1.00
R5038:Zmym2 UTSW 14 57,193,637 (GRCm39) missense possibly damaging 0.86
R5223:Zmym2 UTSW 14 57,183,971 (GRCm39) missense probably benign
R5364:Zmym2 UTSW 14 57,158,102 (GRCm39) missense possibly damaging 0.58
R5488:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5489:Zmym2 UTSW 14 57,193,712 (GRCm39) missense possibly damaging 0.56
R5818:Zmym2 UTSW 14 57,183,986 (GRCm39) missense probably benign
R6160:Zmym2 UTSW 14 57,187,766 (GRCm39) missense probably damaging 1.00
R6437:Zmym2 UTSW 14 57,140,461 (GRCm39) missense probably damaging 1.00
R7107:Zmym2 UTSW 14 57,140,169 (GRCm39) missense probably benign 0.01
R7153:Zmym2 UTSW 14 57,187,659 (GRCm39) missense probably benign 0.16
R7337:Zmym2 UTSW 14 57,181,557 (GRCm39) missense probably benign 0.04
R7535:Zmym2 UTSW 14 57,194,536 (GRCm39) missense probably damaging 1.00
R7730:Zmym2 UTSW 14 57,193,638 (GRCm39) missense possibly damaging 0.95
R7779:Zmym2 UTSW 14 57,165,740 (GRCm39) missense probably damaging 1.00
R7849:Zmym2 UTSW 14 57,184,020 (GRCm39) missense probably benign 0.03
R8219:Zmym2 UTSW 14 57,163,316 (GRCm39) missense probably benign 0.07
R8493:Zmym2 UTSW 14 57,151,606 (GRCm39) missense probably damaging 1.00
R8885:Zmym2 UTSW 14 57,185,329 (GRCm39) intron probably benign
R9162:Zmym2 UTSW 14 57,163,361 (GRCm39) missense probably benign 0.02
R9165:Zmym2 UTSW 14 57,185,464 (GRCm39) missense probably damaging 0.98
R9250:Zmym2 UTSW 14 57,148,732 (GRCm39) missense probably damaging 1.00
R9453:Zmym2 UTSW 14 57,180,770 (GRCm39) missense probably damaging 1.00
R9677:Zmym2 UTSW 14 57,187,115 (GRCm39) missense probably benign 0.01
Z1176:Zmym2 UTSW 14 57,150,456 (GRCm39) missense possibly damaging 0.94
Z1177:Zmym2 UTSW 14 57,151,419 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTGGACTATTGTGCAGCTCAATGTTT -3'
(R):5'- GCATTAAATCCACTTTGTCACAGCAACT -3'

Sequencing Primer
(F):5'- agacagaagcagaggcatc -3'
(R):5'- GCAACTATAATTAGTACAGCTTTGCC -3'
Posted On 2014-03-14