Mutagenetix > Incidental Mutation

Incidental Mutation 'R1451:Vmn1r179'

161664

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r179

Ensembl Gene

ENSMUSG00000046924

Gene Name

vomeronasal 1 receptor 179

Synonyms

V1rd17

MMRRC Submission

039506-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R1451 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23627811-23628782 bp(+) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 23628275 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 155 (C155*)

Ref Sequence

ENSEMBL: ENSMUSP00000055372 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049819]

AlphaFold

Q8R2B4

Predicted Effect

probably null
Transcript: ENSMUST00000049819
AA Change: C155*

SMART Domains

Protein: ENSMUSP00000055372
Gene: ENSMUSG00000046924
AA Change: C155*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	23	313	3.8e-13	PFAM
Pfam:7tm_1	45	304	2e-8	PFAM
Pfam:V1R	57	312	4.2e-15	PFAM

Meta Mutation Damage Score

0.9644

Coding Region Coverage

1x: 98.8%
3x: 97.8%
10x: 94.4%
20x: 86.3%

Validation Efficiency

96% (55/57)

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700024G13Rik	T	C	14: 32,098,588 (GRCm39)	E83G	possibly damaging	Het
Abca9	A	G	11: 110,018,273 (GRCm39)	S1116P	probably damaging	Het
Abcc12	T	A	8: 87,284,322 (GRCm39)	T296S	probably damaging	Het
Adarb2	A	G	13: 8,389,657 (GRCm39)		probably benign	Het
Arhgef12	C	T	9: 42,903,874 (GRCm39)		probably benign	Het
Asah1	A	G	8: 41,807,049 (GRCm39)		probably null	Het
C1ra	A	T	6: 124,498,600 (GRCm39)	Q431L	probably benign	Het
C1s2	A	T	6: 124,602,453 (GRCm39)	I580N	probably benign	Het
Cacna2d4	C	T	6: 119,213,785 (GRCm39)	T68I	probably benign	Het
Car8	A	T	4: 8,189,327 (GRCm39)	H162Q	probably benign	Het
Ccdc106	A	G	7: 5,062,527 (GRCm39)	R116G	probably damaging	Het
Ccdc136	T	A	6: 29,419,376 (GRCm39)	N965K	probably benign	Het
Cd200r3	A	G	16: 44,771,910 (GRCm39)	E58G	possibly damaging	Het
Cnksr3	T	A	10: 7,076,830 (GRCm39)	S121C	probably null	Het
Cog6	T	C	3: 52,916,534 (GRCm39)	M212V	possibly damaging	Het
Ebna1bp2	C	A	4: 118,478,269 (GRCm39)		probably null	Het
Epha1	C	A	6: 42,338,385 (GRCm39)	M730I	probably damaging	Het
Fcgbpl1	T	C	7: 27,836,582 (GRCm39)	F167S	probably damaging	Het
Fscn2	A	T	11: 120,252,848 (GRCm39)	E105V	probably damaging	Het
Gars1	T	C	6: 55,030,108 (GRCm39)		probably benign	Het
Itgb4	G	T	11: 115,881,710 (GRCm39)	G753V	probably damaging	Het
Kif23	C	T	9: 61,832,084 (GRCm39)	V634M	probably damaging	Het
Krt8	T	C	15: 101,907,264 (GRCm39)	Y273C	possibly damaging	Het
Lgmn	A	G	12: 102,372,151 (GRCm39)		probably benign	Het
Lrig3	T	C	10: 125,845,926 (GRCm39)	I785T	possibly damaging	Het
Lrriq1	A	G	10: 103,038,376 (GRCm39)		probably benign	Het
Lta4h	A	G	10: 93,316,590 (GRCm39)	D491G	probably damaging	Het
Megf10	A	T	18: 57,385,931 (GRCm39)	S315C	probably damaging	Het
Mphosph8	C	T	14: 56,905,878 (GRCm39)	R24C	possibly damaging	Het
Neurog2	A	G	3: 127,427,490 (GRCm39)	D38G	possibly damaging	Het
Or1j11	G	T	2: 36,311,877 (GRCm39)	A156S	probably benign	Het
Or2w2	A	T	13: 21,758,457 (GRCm39)	Y56*	probably null	Het
Or2z2	C	T	11: 58,346,358 (GRCm39)	R139H	probably benign	Het
Or6b3	T	A	1: 92,439,517 (GRCm39)	I78F	possibly damaging	Het
Or8b50	A	T	9: 38,518,234 (GRCm39)	I158F	probably benign	Het
Or8g50	T	A	9: 39,648,612 (GRCm39)	V167D	probably benign	Het
Pcdhb17	A	T	18: 37,619,989 (GRCm39)	D593V	probably damaging	Het
Pde2a	G	T	7: 101,071,198 (GRCm39)	E23*	probably null	Het
Prex2	G	A	1: 11,226,483 (GRCm39)	V749I	probably benign	Het
Ptchd4	A	G	17: 42,813,809 (GRCm39)	Y570C	probably damaging	Het
Robo3	C	T	9: 37,329,007 (GRCm39)	R1237K	probably benign	Het
Slc6a1	C	A	6: 114,284,756 (GRCm39)	Y87*	probably null	Het
Snx13	G	A	12: 35,128,983 (GRCm39)	A34T	probably benign	Het
Sppl3	T	C	5: 115,226,424 (GRCm39)	L193P	probably damaging	Het
Tia1	A	T	6: 86,407,321 (GRCm39)	Y277F	probably benign	Het
Tns2	C	T	15: 102,017,369 (GRCm39)	R281C	probably damaging	Het
Trappc2l	T	C	8: 123,342,134 (GRCm39)	F127L	probably damaging	Het
Ushbp1	G	T	8: 71,838,663 (GRCm39)	Q588K	possibly damaging	Het
Usp43	T	A	11: 67,747,007 (GRCm39)	H895L	probably benign	Het
Vmn2r8	T	A	5: 108,945,933 (GRCm39)	D558V	probably damaging	Het
Vps13a	T	C	19: 16,688,228 (GRCm39)	T860A	probably benign	Het
Vps50	A	G	6: 3,565,628 (GRCm39)	N522S	possibly damaging	Het
Zfp180	T	C	7: 23,804,643 (GRCm39)	F354S	probably benign	Het
Zgpat	A	G	2: 181,021,984 (GRCm39)		probably benign	Het

Other mutations in Vmn1r179

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02211:Vmn1r179	APN	7	23,628,630 (GRCm39)	missense	probably benign	0.00
R0029:Vmn1r179	UTSW	7	23,628,630 (GRCm39)	missense	probably benign	0.00
R0029:Vmn1r179	UTSW	7	23,628,630 (GRCm39)	missense	probably benign	0.00
R0058:Vmn1r179	UTSW	7	23,628,592 (GRCm39)	missense	possibly damaging	0.88
R0470:Vmn1r179	UTSW	7	23,627,818 (GRCm39)	missense	probably benign	0.00
R4923:Vmn1r179	UTSW	7	23,628,491 (GRCm39)	missense	possibly damaging	0.79
R4953:Vmn1r179	UTSW	7	23,628,515 (GRCm39)	missense	probably damaging	0.99
R5248:Vmn1r179	UTSW	7	23,628,478 (GRCm39)	missense	probably damaging	0.99
R5304:Vmn1r179	UTSW	7	23,628,100 (GRCm39)	missense	probably benign	0.02
R5434:Vmn1r179	UTSW	7	23,628,387 (GRCm39)	missense	probably benign	0.21
R6341:Vmn1r179	UTSW	7	23,628,491 (GRCm39)	missense	possibly damaging	0.79
R6451:Vmn1r179	UTSW	7	23,628,076 (GRCm39)	missense	possibly damaging	0.94
R6501:Vmn1r179	UTSW	7	23,628,342 (GRCm39)	missense	probably benign	0.25
R7107:Vmn1r179	UTSW	7	23,627,819 (GRCm39)	nonsense	probably null
R7480:Vmn1r179	UTSW	7	23,628,558 (GRCm39)	nonsense	probably null
R8185:Vmn1r179	UTSW	7	23,628,163 (GRCm39)	missense	possibly damaging	0.89
R8245:Vmn1r179	UTSW	7	23,628,396 (GRCm39)	missense	possibly damaging	0.54
R8255:Vmn1r179	UTSW	7	23,628,436 (GRCm39)	missense	probably benign	0.21
R8413:Vmn1r179	UTSW	7	23,628,277 (GRCm39)	missense	probably benign	0.20
R9031:Vmn1r179	UTSW	7	23,628,234 (GRCm39)	missense	probably benign	0.01
R9522:Vmn1r179	UTSW	7	23,628,202 (GRCm39)	missense	probably damaging	0.97
X0061:Vmn1r179	UTSW	7	23,627,819 (GRCm39)	nonsense	probably null
Z1088:Vmn1r179	UTSW	7	23,627,907 (GRCm39)	missense	probably benign	0.10

Predicted Primers

PCR Primer
(F):5'- TGGTTCTCAACAGAGTCCCAGACAG -3'
(R):5'- TGTGGCATCATAGGCAATCCTCAAG -3'

Sequencing Primer
(F):5'- GTCCCAGACAGGTGATTTTAAGC -3'
(R):5'- TCCTCAAGAAGAAAATGACTCTACTG -3'

Posted On

2014-03-14