Incidental Mutation 'R0046:Or4c35'
ID 16176
Institutional Source Beutler Lab
Gene Symbol Or4c35
Ensembl Gene ENSMUSG00000042894
Gene Name olfactory receptor family 4 subfamily C member 35
Synonyms GA_x6K02T2Q125-51409740-51410672, Olfr1260, MOR232-2
MMRRC Submission 038340-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R0046 (G1)
Quality Score
Status Validated
Chromosome 2
Chromosomal Location 89808124-89809056 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 89808851 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 243 (T243I)
Ref Sequence ENSEMBL: ENSMUSP00000107137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061830] [ENSMUST00000111512] [ENSMUST00000144710] [ENSMUST00000214630] [ENSMUST00000216678]
AlphaFold Q8VGN9
Predicted Effect probably damaging
Transcript: ENSMUST00000061830
AA Change: T243I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000053523
Gene: ENSMUSG00000042894
AA Change: T243I

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.7e-45 PFAM
Pfam:7tm_1 39 285 1.7e-15 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111512
AA Change: T243I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000107137
Gene: ENSMUSG00000042894
AA Change: T243I

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 7.4e-27 PFAM
Pfam:7tm_4 137 278 2.4e-38 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141685
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144613
Predicted Effect probably benign
Transcript: ENSMUST00000144710
SMART Domains Protein: ENSMUSP00000119512
Gene: ENSMUSG00000042894

DomainStartEndE-ValueType
Pfam:7tm_1 39 121 4.2e-14 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213162
Predicted Effect probably benign
Transcript: ENSMUST00000214630
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216744
Predicted Effect probably benign
Transcript: ENSMUST00000216678
Meta Mutation Damage Score 0.3387 question?
Coding Region Coverage
  • 1x: 89.2%
  • 3x: 86.2%
  • 10x: 78.3%
  • 20x: 64.0%
Validation Efficiency 98% (86/88)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl7a A T 4: 56,743,877 (GRCm39) K135* probably null Het
Adamts16 A G 13: 70,911,579 (GRCm39) S871P probably benign Het
Adcy10 A T 1: 165,367,403 (GRCm39) I558F probably damaging Het
Adsl T G 15: 80,846,989 (GRCm39) probably null Het
Aldob T C 4: 49,543,842 (GRCm39) I47V possibly damaging Het
Alkbh8 A G 9: 3,343,247 (GRCm39) E46G probably damaging Het
Atp1a4 A T 1: 172,067,664 (GRCm39) L533Q probably benign Het
Auts2 T C 5: 131,799,624 (GRCm39) noncoding transcript Het
B3gnt3 T C 8: 72,145,567 (GRCm39) Y267C probably damaging Het
Ccdc39 A G 3: 33,898,301 (GRCm39) F15L possibly damaging Het
Cntnap5c T G 17: 58,666,295 (GRCm39) D1108E probably benign Het
Col14a1 G A 15: 55,272,359 (GRCm39) probably benign Het
Col9a3 G A 2: 180,251,280 (GRCm39) A317T possibly damaging Het
Cpt1c A T 7: 44,609,256 (GRCm39) probably benign Het
Cpt2 A G 4: 107,761,559 (GRCm39) probably null Het
Crebrf T A 17: 26,982,308 (GRCm39) L565M probably damaging Het
Dmxl1 T A 18: 50,011,149 (GRCm39) V1102E probably benign Het
Dock4 G A 12: 40,787,359 (GRCm39) probably benign Het
Dpp3 G T 19: 4,964,671 (GRCm39) N545K probably damaging Het
Elmo2 T A 2: 165,140,646 (GRCm39) N275I probably damaging Het
Farp1 A G 14: 121,492,925 (GRCm39) K509R probably benign Het
Flg T A 3: 93,185,028 (GRCm39) probably benign Het
Gas2l2 A T 11: 83,312,736 (GRCm39) W859R probably damaging Het
Gatm T C 2: 122,431,225 (GRCm39) D254G probably damaging Het
Gjd4 T A 18: 9,280,998 (GRCm39) I27F probably damaging Het
Gm19410 A G 8: 36,269,799 (GRCm39) E1148G probably benign Het
Haus5 C T 7: 30,353,605 (GRCm39) V591I probably benign Het
Kcnab3 G A 11: 69,221,053 (GRCm39) probably null Het
Limk1 T C 5: 134,701,615 (GRCm39) Y96C probably damaging Het
Lrp2bp T A 8: 46,466,192 (GRCm39) Y100* probably null Het
Ly75 A T 2: 60,169,801 (GRCm39) probably benign Het
Mamstr T G 7: 45,291,194 (GRCm39) probably benign Het
Man1a A G 10: 53,795,283 (GRCm39) Y657H probably damaging Het
Marf1 G A 16: 13,929,591 (GRCm39) P1672S possibly damaging Het
Mboat7 T C 7: 3,686,817 (GRCm39) Y341C probably damaging Het
Nhsl1 A T 10: 18,401,417 (GRCm39) N881I probably damaging Het
Nox3 T C 17: 3,733,236 (GRCm39) Y225C probably benign Het
Or4c109 C T 2: 88,817,693 (GRCm39) M284I probably benign Het
Pclo C T 5: 14,590,493 (GRCm39) T931M unknown Het
Pfas G T 11: 68,881,293 (GRCm39) R1025S probably benign Het
Prg4 T C 1: 150,331,837 (GRCm39) T279A possibly damaging Het
Psma1 A T 7: 113,866,440 (GRCm39) probably benign Het
Rab11fip1 A G 8: 27,643,149 (GRCm39) L550P probably damaging Het
Rgs12 T A 5: 35,122,664 (GRCm39) I149N probably damaging Het
Rmnd5a T C 6: 71,376,215 (GRCm39) H195R probably damaging Het
Rnf17 T C 14: 56,708,830 (GRCm39) L750P probably damaging Het
Rtcb T C 10: 85,793,520 (GRCm39) N18D probably benign Het
Seh1l T C 18: 67,925,086 (GRCm39) probably null Het
Sptbn2 T C 19: 4,795,405 (GRCm39) probably benign Het
Stag3 C T 5: 138,281,285 (GRCm39) probably benign Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Taok3 C T 5: 117,410,294 (GRCm39) Q829* probably null Het
Tsbp1 T C 17: 34,679,095 (GRCm39) probably null Het
Ttn A G 2: 76,781,886 (GRCm39) probably benign Het
Unc79 A G 12: 103,091,940 (GRCm39) E1756G probably damaging Het
Usp35 A T 7: 96,962,804 (GRCm39) probably null Het
Zbtb40 A G 4: 136,714,589 (GRCm39) C1067R probably damaging Het
Other mutations in Or4c35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Or4c35 APN 2 89,808,883 (GRCm39) missense possibly damaging 0.69
IGL01657:Or4c35 APN 2 89,808,221 (GRCm39) missense probably damaging 1.00
IGL01942:Or4c35 APN 2 89,808,322 (GRCm39) missense probably benign 0.03
IGL02139:Or4c35 APN 2 89,808,773 (GRCm39) missense possibly damaging 0.80
IGL02926:Or4c35 APN 2 89,808,506 (GRCm39) missense probably damaging 1.00
IGL03110:Or4c35 APN 2 89,808,493 (GRCm39) missense probably damaging 1.00
IGL03368:Or4c35 APN 2 89,808,133 (GRCm39) missense probably benign
R0046:Or4c35 UTSW 2 89,808,851 (GRCm39) missense probably damaging 1.00
R0087:Or4c35 UTSW 2 89,808,475 (GRCm39) missense probably damaging 1.00
R0599:Or4c35 UTSW 2 89,808,545 (GRCm39) missense probably benign 0.01
R1208:Or4c35 UTSW 2 89,808,836 (GRCm39) missense probably damaging 0.99
R1208:Or4c35 UTSW 2 89,808,836 (GRCm39) missense probably damaging 0.99
R1424:Or4c35 UTSW 2 89,808,415 (GRCm39) nonsense probably null
R1503:Or4c35 UTSW 2 89,808,872 (GRCm39) missense probably damaging 0.99
R1708:Or4c35 UTSW 2 89,808,382 (GRCm39) missense probably benign 0.00
R1863:Or4c35 UTSW 2 89,808,754 (GRCm39) missense probably benign 0.02
R1866:Or4c35 UTSW 2 89,808,671 (GRCm39) missense probably damaging 1.00
R2072:Or4c35 UTSW 2 89,808,557 (GRCm39) missense probably benign 0.04
R2219:Or4c35 UTSW 2 89,808,256 (GRCm39) missense possibly damaging 0.62
R4606:Or4c35 UTSW 2 89,808,350 (GRCm39) missense possibly damaging 0.79
R4674:Or4c35 UTSW 2 89,808,250 (GRCm39) missense possibly damaging 0.52
R4825:Or4c35 UTSW 2 89,808,497 (GRCm39) missense probably damaging 1.00
R5822:Or4c35 UTSW 2 89,808,787 (GRCm39) missense probably damaging 1.00
R6487:Or4c35 UTSW 2 89,808,182 (GRCm39) missense probably benign 0.31
R6706:Or4c35 UTSW 2 89,808,929 (GRCm39) missense probably damaging 0.96
R7961:Or4c35 UTSW 2 89,808,131 (GRCm39) missense probably benign
R8812:Or4c35 UTSW 2 89,808,715 (GRCm39) missense possibly damaging 0.94
R9504:Or4c35 UTSW 2 89,808,497 (GRCm39) missense probably damaging 1.00
R9618:Or4c35 UTSW 2 89,808,343 (GRCm39) missense probably benign 0.00
X0050:Or4c35 UTSW 2 89,808,360 (GRCm39) missense possibly damaging 0.94
Posted On 2013-01-08