Incidental Mutation 'R1458:Gria2'
| ID |
161855 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gria2
|
| Ensembl Gene |
ENSMUSG00000033981 |
| Gene Name |
glutamate receptor, ionotropic, AMPA2 (alpha 2) |
| Synonyms |
Glur-2, GluA2, GluR2, GluR-B, Glur2 |
| MMRRC Submission |
039513-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.259)
|
| Stock # |
R1458 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
80588757-80710142 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 80639352 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 220
(V220E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000141447
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075316]
[ENSMUST00000107745]
[ENSMUST00000192463]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000075316
AA Change: V220E
PolyPhen 2
Score 0.657 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000074787
Gene: ENSMUSG00000033981
AA Change: V220E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
49 |
379 |
2.7e-58 |
PFAM |
|
PBPe
|
415 |
790 |
3.75e-132 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000107745
AA Change: V220E
PolyPhen 2
Score 0.709 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000103374
Gene: ENSMUSG00000033981
AA Change: V220E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
47 |
379 |
4.8e-53 |
PFAM |
|
PBPe
|
415 |
790 |
8.16e-133 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.96e-31 |
SMART |
|
low complexity region
|
820 |
832 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
865 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000192463
AA Change: V220E
PolyPhen 2
Score 0.709 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000141447
Gene: ENSMUSG00000033981
AA Change: V220E
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
47 |
379 |
1.7e-51 |
PFAM |
|
PBPe
|
415 |
770 |
1.2e-105 |
SMART |
|
Lig_chan-Glu_bd
|
425 |
490 |
2.2e-35 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193645
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194383
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194523
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195062
|
| Meta Mutation Damage Score |
0.7053 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.8%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted null mutations exhibit epilepsy, deficient dendritic architecture, altered exploratory behavior, impaired motor and learning performance, and increased mortality. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700036A12Rik |
A |
G |
9: 60,677,043 (GRCm39) |
|
noncoding transcript |
Het |
| A430110L20Rik |
T |
A |
1: 181,055,423 (GRCm39) |
|
noncoding transcript |
Het |
| Abce1 |
T |
C |
8: 80,433,864 (GRCm39) |
K63R |
possibly damaging |
Het |
| Acp6 |
A |
G |
3: 97,081,104 (GRCm39) |
|
probably benign |
Het |
| Adamts13 |
T |
A |
2: 26,878,366 (GRCm39) |
L579Q |
probably damaging |
Het |
| Adamtsl3 |
T |
A |
7: 82,172,528 (GRCm39) |
M497K |
probably damaging |
Het |
| Adgrb2 |
T |
A |
4: 129,908,384 (GRCm39) |
M1042K |
possibly damaging |
Het |
| Akap12 |
A |
T |
10: 4,303,693 (GRCm39) |
S168C |
probably damaging |
Het |
| Akap3 |
A |
T |
6: 126,842,517 (GRCm39) |
M379L |
probably damaging |
Het |
| Aldh6a1 |
C |
T |
12: 84,486,437 (GRCm39) |
M135I |
probably null |
Het |
| Arhgef12 |
A |
G |
9: 42,900,294 (GRCm39) |
S860P |
probably damaging |
Het |
| Atp11b |
A |
C |
3: 35,843,707 (GRCm39) |
T185P |
probably damaging |
Het |
| Bcas1 |
T |
C |
2: 170,229,871 (GRCm39) |
D243G |
probably damaging |
Het |
| Cdhr2 |
T |
A |
13: 54,865,685 (GRCm39) |
S228T |
probably damaging |
Het |
| Cic |
T |
C |
7: 24,979,162 (GRCm39) |
|
probably benign |
Het |
| Cimap1d |
A |
T |
10: 79,481,392 (GRCm39) |
|
probably benign |
Het |
| Cmya5 |
T |
A |
13: 93,201,835 (GRCm39) |
I3376L |
probably benign |
Het |
| Ctrc |
C |
A |
4: 141,573,535 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
G |
T |
7: 105,404,451 (GRCm39) |
P2697Q |
probably damaging |
Het |
| Dmbt1 |
A |
G |
7: 130,646,217 (GRCm39) |
|
probably benign |
Het |
| Drd2 |
G |
A |
9: 49,313,512 (GRCm39) |
R227H |
probably damaging |
Het |
| Dscc1 |
C |
A |
15: 54,950,160 (GRCm39) |
C195F |
probably damaging |
Het |
| Dzip1 |
T |
A |
14: 119,160,125 (GRCm39) |
M28L |
probably benign |
Het |
| Edar |
A |
T |
10: 58,443,188 (GRCm39) |
S313T |
probably benign |
Het |
| Eef1e1 |
C |
A |
13: 38,840,099 (GRCm39) |
A69S |
probably damaging |
Het |
| Fbn1 |
A |
G |
2: 125,143,849 (GRCm39) |
V2760A |
probably benign |
Het |
| Fez1 |
GACAAACA |
GACA |
9: 36,781,845 (GRCm39) |
|
probably null |
Het |
| Fgl1 |
C |
G |
8: 41,663,496 (GRCm39) |
A11P |
possibly damaging |
Het |
| Fras1 |
T |
C |
5: 96,748,592 (GRCm39) |
V689A |
probably benign |
Het |
| Fry |
T |
A |
5: 150,304,324 (GRCm39) |
D571E |
probably damaging |
Het |
| Gm11232 |
T |
A |
4: 71,675,450 (GRCm39) |
R104* |
probably null |
Het |
| Gm1527 |
A |
G |
3: 28,972,199 (GRCm39) |
I439V |
possibly damaging |
Het |
| Gm4922 |
C |
A |
10: 18,659,640 (GRCm39) |
G361* |
probably null |
Het |
| Gm7052 |
T |
A |
17: 22,259,447 (GRCm39) |
|
probably benign |
Het |
| Gpatch8 |
A |
T |
11: 102,372,055 (GRCm39) |
S494R |
unknown |
Het |
| Grik4 |
G |
A |
9: 42,432,418 (GRCm39) |
H860Y |
probably benign |
Het |
| Gtpbp1 |
A |
C |
15: 79,591,930 (GRCm39) |
S93R |
probably damaging |
Het |
| Gucy2g |
C |
A |
19: 55,203,468 (GRCm39) |
|
probably benign |
Het |
| H2ac8 |
C |
A |
13: 23,755,221 (GRCm39) |
|
probably benign |
Het |
| Hmcn1 |
G |
A |
1: 150,485,451 (GRCm39) |
R4384C |
probably damaging |
Het |
| Hspa12b |
G |
C |
2: 130,987,112 (GRCm39) |
A678P |
probably damaging |
Het |
| Igsf21 |
T |
A |
4: 139,755,435 (GRCm39) |
N407Y |
probably damaging |
Het |
| Insig2 |
A |
G |
1: 121,234,885 (GRCm39) |
Y174H |
probably benign |
Het |
| Itpr3 |
T |
A |
17: 27,337,346 (GRCm39) |
M2413K |
probably benign |
Het |
| Kalrn |
A |
T |
16: 33,994,857 (GRCm39) |
I1322N |
probably damaging |
Het |
| Klk1b24 |
T |
A |
7: 43,840,890 (GRCm39) |
M106K |
possibly damaging |
Het |
| Krt81 |
G |
T |
15: 101,358,198 (GRCm39) |
Q352K |
probably benign |
Het |
| Lca5l |
A |
T |
16: 95,961,059 (GRCm39) |
S468T |
possibly damaging |
Het |
| Lvrn |
T |
C |
18: 47,015,452 (GRCm39) |
|
probably benign |
Het |
| Mcpt1 |
T |
A |
14: 56,256,621 (GRCm39) |
|
probably benign |
Het |
| Med13l |
T |
C |
5: 118,876,524 (GRCm39) |
M900T |
probably benign |
Het |
| Med16 |
A |
G |
10: 79,743,312 (GRCm39) |
|
probably benign |
Het |
| Megf6 |
G |
T |
4: 154,261,578 (GRCm39) |
V68L |
probably benign |
Het |
| Mep1a |
T |
C |
17: 43,802,563 (GRCm39) |
H154R |
probably damaging |
Het |
| Mrc2 |
A |
T |
11: 105,228,598 (GRCm39) |
D659V |
probably benign |
Het |
| Mroh8 |
T |
A |
2: 157,063,224 (GRCm39) |
E799V |
probably damaging |
Het |
| Mrpl21 |
A |
G |
19: 3,334,808 (GRCm39) |
Y50C |
possibly damaging |
Het |
| Msl1 |
A |
G |
11: 98,694,808 (GRCm39) |
|
probably benign |
Het |
| Myo1a |
C |
A |
10: 127,555,806 (GRCm39) |
Q932K |
probably benign |
Het |
| Nav3 |
A |
C |
10: 109,555,905 (GRCm39) |
S1675R |
probably damaging |
Het |
| Neurl2 |
A |
G |
2: 164,674,666 (GRCm39) |
V232A |
possibly damaging |
Het |
| Nfatc1 |
T |
A |
18: 80,708,482 (GRCm39) |
|
probably benign |
Het |
| Or2w4 |
C |
T |
13: 21,795,992 (GRCm39) |
C49Y |
probably benign |
Het |
| Or5k8 |
T |
A |
16: 58,645,039 (GRCm39) |
E11V |
probably null |
Het |
| P4hb |
A |
G |
11: 120,453,381 (GRCm39) |
|
probably benign |
Het |
| Papss1 |
T |
G |
3: 131,311,615 (GRCm39) |
I281S |
probably damaging |
Het |
| Pde10a |
A |
T |
17: 9,183,540 (GRCm39) |
D832V |
probably damaging |
Het |
| Pfkfb2 |
A |
T |
1: 130,635,927 (GRCm39) |
Y35N |
possibly damaging |
Het |
| Phaf1 |
T |
C |
8: 105,973,188 (GRCm39) |
|
probably null |
Het |
| Phf20l1 |
T |
A |
15: 66,476,662 (GRCm39) |
F253Y |
probably damaging |
Het |
| Pkhd1l1 |
G |
A |
15: 44,379,511 (GRCm39) |
V1046I |
probably benign |
Het |
| Plin3 |
C |
T |
17: 56,591,337 (GRCm39) |
A148T |
probably benign |
Het |
| Ppp1r8 |
T |
C |
4: 132,567,942 (GRCm39) |
|
probably benign |
Het |
| Ppp2r3d |
A |
G |
9: 101,088,511 (GRCm39) |
L604P |
probably damaging |
Het |
| Prdm5 |
T |
C |
6: 65,860,585 (GRCm39) |
V239A |
probably damaging |
Het |
| Prickle1 |
A |
G |
15: 93,398,519 (GRCm39) |
S770P |
probably damaging |
Het |
| Prl2c5 |
T |
A |
13: 13,365,310 (GRCm39) |
I155N |
probably benign |
Het |
| Prom1 |
T |
C |
5: 44,190,274 (GRCm39) |
|
probably benign |
Het |
| Psg25 |
C |
T |
7: 18,263,512 (GRCm39) |
G104R |
probably damaging |
Het |
| Rbm19 |
T |
C |
5: 120,282,094 (GRCm39) |
V817A |
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,741,908 (GRCm39) |
Y2091F |
probably damaging |
Het |
| Slc16a4 |
A |
G |
3: 107,208,248 (GRCm39) |
T253A |
probably benign |
Het |
| Smg7 |
A |
T |
1: 152,731,594 (GRCm39) |
|
probably null |
Het |
| Spink5 |
C |
A |
18: 44,140,786 (GRCm39) |
H662N |
probably benign |
Het |
| Taf2 |
A |
T |
15: 54,923,311 (GRCm39) |
M322K |
probably damaging |
Het |
| Tmc2 |
T |
C |
2: 130,090,682 (GRCm39) |
F676S |
probably damaging |
Het |
| Tmem177 |
A |
G |
1: 119,837,915 (GRCm39) |
S255P |
possibly damaging |
Het |
| Trim46 |
A |
T |
3: 89,142,375 (GRCm39) |
|
probably null |
Het |
| Tubb1 |
T |
A |
2: 174,292,596 (GRCm39) |
|
probably null |
Het |
| Upf1 |
T |
C |
8: 70,796,904 (GRCm39) |
T110A |
probably benign |
Het |
| Vmn2r9 |
T |
A |
5: 108,996,850 (GRCm39) |
I140L |
probably benign |
Het |
| Zfp638 |
T |
A |
6: 83,921,638 (GRCm39) |
H588Q |
probably damaging |
Het |
| Zfp780b |
T |
A |
7: 27,664,252 (GRCm39) |
N101I |
probably damaging |
Het |
| Zpld2 |
T |
C |
4: 133,924,144 (GRCm39) |
D467G |
probably benign |
Het |
|
| Other mutations in Gria2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00796:Gria2
|
APN |
3 |
80,618,097 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL00832:Gria2
|
APN |
3 |
80,614,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01086:Gria2
|
APN |
3 |
80,599,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01409:Gria2
|
APN |
3 |
80,615,004 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01924:Gria2
|
APN |
3 |
80,617,638 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL01999:Gria2
|
APN |
3 |
80,639,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02355:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02362:Gria2
|
APN |
3 |
80,614,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02389:Gria2
|
APN |
3 |
80,616,729 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL02444:Gria2
|
APN |
3 |
80,609,860 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02532:Gria2
|
APN |
3 |
80,614,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02991:Gria2
|
UTSW |
3 |
80,615,116 (GRCm39) |
nonsense |
probably null |
|
|
R0015:Gria2
|
UTSW |
3 |
80,615,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0148:Gria2
|
UTSW |
3 |
80,615,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0201:Gria2
|
UTSW |
3 |
80,615,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0411:Gria2
|
UTSW |
3 |
80,618,165 (GRCm39) |
splice site |
probably benign |
|
|
R0551:Gria2
|
UTSW |
3 |
80,639,333 (GRCm39) |
splice site |
probably benign |
|
|
R0655:Gria2
|
UTSW |
3 |
80,639,377 (GRCm39) |
nonsense |
probably null |
|
|
R0866:Gria2
|
UTSW |
3 |
80,629,331 (GRCm39) |
splice site |
probably benign |
|
|
R1393:Gria2
|
UTSW |
3 |
80,614,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1563:Gria2
|
UTSW |
3 |
80,598,704 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1771:Gria2
|
UTSW |
3 |
80,599,608 (GRCm39) |
nonsense |
probably null |
|
|
R1775:Gria2
|
UTSW |
3 |
80,598,645 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1902:Gria2
|
UTSW |
3 |
80,629,415 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1993:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1994:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R1995:Gria2
|
UTSW |
3 |
80,709,664 (GRCm39) |
missense |
probably benign |
|
|
R2001:Gria2
|
UTSW |
3 |
80,618,112 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2389:Gria2
|
UTSW |
3 |
80,609,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2520:Gria2
|
UTSW |
3 |
80,614,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2679:Gria2
|
UTSW |
3 |
80,648,260 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2869:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2870:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2871:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Gria2
|
UTSW |
3 |
80,609,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R3967:Gria2
|
UTSW |
3 |
80,618,084 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4285:Gria2
|
UTSW |
3 |
80,614,969 (GRCm39) |
intron |
probably benign |
|
|
R4611:Gria2
|
UTSW |
3 |
80,599,799 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4612:Gria2
|
UTSW |
3 |
80,639,358 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4616:Gria2
|
UTSW |
3 |
80,614,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4706:Gria2
|
UTSW |
3 |
80,648,297 (GRCm39) |
missense |
probably benign |
|
|
R4996:Gria2
|
UTSW |
3 |
80,614,448 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5502:Gria2
|
UTSW |
3 |
80,614,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5930:Gria2
|
UTSW |
3 |
80,614,556 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6142:Gria2
|
UTSW |
3 |
80,709,024 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6233:Gria2
|
UTSW |
3 |
80,614,510 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6317:Gria2
|
UTSW |
3 |
80,648,311 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6453:Gria2
|
UTSW |
3 |
80,648,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6526:Gria2
|
UTSW |
3 |
80,599,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6545:Gria2
|
UTSW |
3 |
80,648,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6574:Gria2
|
UTSW |
3 |
80,596,603 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6720:Gria2
|
UTSW |
3 |
80,709,611 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7009:Gria2
|
UTSW |
3 |
80,614,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7049:Gria2
|
UTSW |
3 |
80,596,634 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7191:Gria2
|
UTSW |
3 |
80,639,392 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7225:Gria2
|
UTSW |
3 |
80,709,938 (GRCm39) |
unclassified |
probably benign |
|
|
R7374:Gria2
|
UTSW |
3 |
80,648,383 (GRCm39) |
missense |
probably benign |
|
|
R7837:Gria2
|
UTSW |
3 |
80,618,095 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8034:Gria2
|
UTSW |
3 |
80,709,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8125:Gria2
|
UTSW |
3 |
80,614,550 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8189:Gria2
|
UTSW |
3 |
80,629,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8209:Gria2
|
UTSW |
3 |
80,616,764 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8362:Gria2
|
UTSW |
3 |
80,615,197 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8481:Gria2
|
UTSW |
3 |
80,708,998 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8500:Gria2
|
UTSW |
3 |
80,599,774 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8516:Gria2
|
UTSW |
3 |
80,614,294 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8918:Gria2
|
UTSW |
3 |
80,599,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8939:Gria2
|
UTSW |
3 |
80,618,170 (GRCm39) |
intron |
probably benign |
|
|
R8971:Gria2
|
UTSW |
3 |
80,615,200 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9229:Gria2
|
UTSW |
3 |
80,709,689 (GRCm39) |
start codon destroyed |
probably null |
0.60 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGCCATTGCTTACTGAGGCTG -3'
(R):5'- CTATGAGGTGGACATGCTTGGGAC -3'
Sequencing Primer
(F):5'- CTTACTGAGGCTGGGGATAATTC -3'
(R):5'- AACACTGCAAGCTGTGCTG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation