Incidental Mutation 'R1458:Med16'
ID 161896
Institutional Source Beutler Lab
Gene Symbol Med16
Ensembl Gene ENSMUSG00000013833
Gene Name mediator complex subunit 16
Synonyms Trap95, 95kDa, Thrap5
MMRRC Submission 039513-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R1458 (G1)
Quality Score 143
Status Validated
Chromosome 10
Chromosomal Location 79894708-79908923 bp(-) (GRCm38)
Type of Mutation unclassified
DNA Base Change (assembly) A to G at 79907478 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151887 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045628] [ENSMUST00000105378] [ENSMUST00000164705] [ENSMUST00000165684] [ENSMUST00000166964] [ENSMUST00000170409] [ENSMUST00000171416] [ENSMUST00000181321] [ENSMUST00000218970]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000045628
SMART Domains Protein: ENSMUSP00000044570
Gene: ENSMUSG00000035781

DomainStartEndE-ValueType
low complexity region 21 33 N/A INTRINSIC
Pfam:R3H-assoc 43 177 1.2e-35 PFAM
Pfam:R3H 181 244 7.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000105378
SMART Domains Protein: ENSMUSP00000101017
Gene: ENSMUSG00000013833

DomainStartEndE-ValueType
low complexity region 13 28 N/A INTRINSIC
WD40 94 133 1.05e-7 SMART
Blast:WD40 143 169 4e-8 BLAST
low complexity region 206 217 N/A INTRINSIC
WD40 226 267 1.53e2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163125
Predicted Effect probably benign
Transcript: ENSMUST00000164705
SMART Domains Protein: ENSMUSP00000129229
Gene: ENSMUSG00000013833

DomainStartEndE-ValueType
WD40 10 49 1.05e-7 SMART
Pfam:Med16 59 172 6.5e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165684
SMART Domains Protein: ENSMUSP00000129375
Gene: ENSMUSG00000013833

DomainStartEndE-ValueType
low complexity region 13 25 N/A INTRINSIC
WD40 95 134 1.05e-7 SMART
Blast:WD40 144 170 4e-8 BLAST
low complexity region 207 218 N/A INTRINSIC
WD40 227 268 1.53e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000166964
SMART Domains Protein: ENSMUSP00000128463
Gene: ENSMUSG00000013833

DomainStartEndE-ValueType
WD40 59 98 1.05e-7 SMART
Pfam:Med16 108 162 2.2e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000170409
SMART Domains Protein: ENSMUSP00000126729
Gene: ENSMUSG00000013833

DomainStartEndE-ValueType
WD40 10 49 1.05e-7 SMART
Pfam:Med16 59 105 1.1e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000171416
SMART Domains Protein: ENSMUSP00000132266
Gene: ENSMUSG00000035781

DomainStartEndE-ValueType
low complexity region 21 33 N/A INTRINSIC
Pfam:R3H-assoc 43 177 4.9e-39 PFAM
Pfam:R3H 183 243 1.1e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178620
Predicted Effect probably benign
Transcript: ENSMUST00000181321
Predicted Effect probably benign
Transcript: ENSMUST00000218970
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219358
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.3%
  • 20x: 92.8%
Validation Efficiency 98% (95/97)
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700036A12Rik A G 9: 60,769,761 (GRCm38) noncoding transcript Het
A430110L20Rik T A 1: 181,227,858 (GRCm38) noncoding transcript Het
Abce1 T C 8: 79,707,235 (GRCm38) K63R possibly damaging Het
Acp6 A G 3: 97,173,788 (GRCm38) probably benign Het
Adamts13 T A 2: 26,988,354 (GRCm38) L579Q probably damaging Het
Adamtsl3 T A 7: 82,523,320 (GRCm38) M497K probably damaging Het
Adgrb2 T A 4: 130,014,591 (GRCm38) M1042K possibly damaging Het
Akap12 A T 10: 4,353,693 (GRCm38) S168C probably damaging Het
Akap3 A T 6: 126,865,554 (GRCm38) M379L probably damaging Het
Aldh6a1 C T 12: 84,439,663 (GRCm38) M135I probably null Het
Arhgef12 A G 9: 42,988,998 (GRCm38) S860P probably damaging Het
Atp11b A C 3: 35,789,558 (GRCm38) T185P probably damaging Het
Bcas1 T C 2: 170,387,951 (GRCm38) D243G probably damaging Het
Cdhr2 T A 13: 54,717,872 (GRCm38) S228T probably damaging Het
Cic T C 7: 25,279,737 (GRCm38) probably benign Het
Cmya5 T A 13: 93,065,327 (GRCm38) I3376L probably benign Het
Ctrc C A 4: 141,846,224 (GRCm38) probably null Het
D230025D16Rik T C 8: 105,246,556 (GRCm38) probably null Het
Dchs1 G T 7: 105,755,244 (GRCm38) P2697Q probably damaging Het
Dmbt1 A G 7: 131,044,487 (GRCm38) probably benign Het
Drd2 G A 9: 49,402,212 (GRCm38) R227H probably damaging Het
Dscc1 C A 15: 55,086,764 (GRCm38) C195F probably damaging Het
Dzip1 T A 14: 118,922,713 (GRCm38) M28L probably benign Het
Edar A T 10: 58,607,366 (GRCm38) S313T probably benign Het
Eef1e1 C A 13: 38,656,123 (GRCm38) A69S probably damaging Het
Fbn1 A G 2: 125,301,929 (GRCm38) V2760A probably benign Het
Fez1 GACAAACA GACA 9: 36,870,549 (GRCm38) probably null Het
Fgl1 C G 8: 41,210,459 (GRCm38) A11P possibly damaging Het
Fras1 T C 5: 96,600,733 (GRCm38) V689A probably benign Het
Fry T A 5: 150,380,859 (GRCm38) D571E probably damaging Het
Gm11232 T A 4: 71,757,213 (GRCm38) R104* probably null Het
Gm1527 A G 3: 28,918,050 (GRCm38) I439V possibly damaging Het
Gm4922 C A 10: 18,783,892 (GRCm38) G361* probably null Het
Gm7052 T A 17: 22,040,466 (GRCm38) probably benign Het
Gm7534 T C 4: 134,196,833 (GRCm38) D467G probably benign Het
Gpatch8 A T 11: 102,481,229 (GRCm38) S494R unknown Het
Gria2 A T 3: 80,732,045 (GRCm38) V220E possibly damaging Het
Grik4 G A 9: 42,521,122 (GRCm38) H860Y probably benign Het
Gtpbp1 A C 15: 79,707,729 (GRCm38) S93R probably damaging Het
Gucy2g C A 19: 55,215,036 (GRCm38) probably benign Het
Hist1h2ae C A 13: 23,571,047 (GRCm38) probably benign Het
Hmcn1 G A 1: 150,609,700 (GRCm38) R4384C probably damaging Het
Hspa12b G C 2: 131,145,192 (GRCm38) A678P probably damaging Het
Igsf21 T A 4: 140,028,124 (GRCm38) N407Y probably damaging Het
Insig2 A G 1: 121,307,156 (GRCm38) Y174H probably benign Het
Itpr3 T A 17: 27,118,372 (GRCm38) M2413K probably benign Het
Kalrn A T 16: 34,174,487 (GRCm38) I1322N probably damaging Het
Klk1b24 T A 7: 44,191,466 (GRCm38) M106K possibly damaging Het
Krt81 G T 15: 101,460,317 (GRCm38) Q352K probably benign Het
Lca5l A T 16: 96,159,859 (GRCm38) S468T possibly damaging Het
Lvrn T C 18: 46,882,385 (GRCm38) probably benign Het
Mcpt1 T A 14: 56,019,164 (GRCm38) probably benign Het
Med13l T C 5: 118,738,459 (GRCm38) M900T probably benign Het
Megf6 G T 4: 154,177,121 (GRCm38) V68L probably benign Het
Mep1a T C 17: 43,491,672 (GRCm38) H154R probably damaging Het
Mrc2 A T 11: 105,337,772 (GRCm38) D659V probably benign Het
Mroh8 T A 2: 157,221,304 (GRCm38) E799V probably damaging Het
Mrpl21 A G 19: 3,284,808 (GRCm38) Y50C possibly damaging Het
Msl1 A G 11: 98,803,982 (GRCm38) probably benign Het
Myo1a C A 10: 127,719,937 (GRCm38) Q932K probably benign Het
Nav3 A C 10: 109,720,044 (GRCm38) S1675R probably damaging Het
Neurl2 A G 2: 164,832,746 (GRCm38) V232A possibly damaging Het
Nfatc1 T A 18: 80,665,267 (GRCm38) probably benign Het
Odf3l2 A T 10: 79,645,558 (GRCm38) probably benign Het
Olfr1362 C T 13: 21,611,822 (GRCm38) C49Y probably benign Het
Olfr175-ps1 T A 16: 58,824,676 (GRCm38) E11V probably null Het
P4hb A G 11: 120,562,555 (GRCm38) probably benign Het
Papss1 T G 3: 131,605,854 (GRCm38) I281S probably damaging Het
Pde10a A T 17: 8,964,708 (GRCm38) D832V probably damaging Het
Pfkfb2 A T 1: 130,708,190 (GRCm38) Y35N possibly damaging Het
Phf20l1 T A 15: 66,604,813 (GRCm38) F253Y probably damaging Het
Pkhd1l1 G A 15: 44,516,115 (GRCm38) V1046I probably benign Het
Plin3 C T 17: 56,284,337 (GRCm38) A148T probably benign Het
Ppp1r8 T C 4: 132,840,631 (GRCm38) probably benign Het
Ppp2r3a A G 9: 101,211,312 (GRCm38) L604P probably damaging Het
Prdm5 T C 6: 65,883,601 (GRCm38) V239A probably damaging Het
Prickle1 A G 15: 93,500,638 (GRCm38) S770P probably damaging Het
Prl2c5 T A 13: 13,190,725 (GRCm38) I155N probably benign Het
Prom1 T C 5: 44,032,932 (GRCm38) probably benign Het
Psg25 C T 7: 18,529,587 (GRCm38) G104R probably damaging Het
Rbm19 T C 5: 120,144,029 (GRCm38) V817A probably benign Het
Ryr2 T A 13: 11,727,022 (GRCm38) Y2091F probably damaging Het
Slc16a4 A G 3: 107,300,932 (GRCm38) T253A probably benign Het
Smg7 A T 1: 152,855,843 (GRCm38) probably null Het
Spink5 C A 18: 44,007,719 (GRCm38) H662N probably benign Het
Taf2 A T 15: 55,059,915 (GRCm38) M322K probably damaging Het
Tmc2 T C 2: 130,248,762 (GRCm38) F676S probably damaging Het
Tmem177 A G 1: 119,910,185 (GRCm38) S255P possibly damaging Het
Trim46 A T 3: 89,235,068 (GRCm38) probably null Het
Tubb1 T A 2: 174,450,803 (GRCm38) probably null Het
Upf1 T C 8: 70,344,254 (GRCm38) T110A probably benign Het
Vmn2r9 T A 5: 108,848,984 (GRCm38) I140L probably benign Het
Zfp638 T A 6: 83,944,656 (GRCm38) H588Q probably damaging Het
Zfp780b T A 7: 27,964,827 (GRCm38) N101I probably damaging Het
Other mutations in Med16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00977:Med16 APN 10 79,907,625 (GRCm38) start codon destroyed probably null 0.62
IGL02328:Med16 APN 10 79,907,542 (GRCm38) missense probably damaging 1.00
IGL03123:Med16 APN 10 79,896,833 (GRCm38) missense probably damaging 1.00
R0139:Med16 UTSW 10 79,896,801 (GRCm38) missense probably benign 0.17
R0254:Med16 UTSW 10 79,900,200 (GRCm38) missense possibly damaging 0.94
R1483:Med16 UTSW 10 79,903,100 (GRCm38) missense possibly damaging 0.88
R1524:Med16 UTSW 10 79,898,316 (GRCm38) missense probably damaging 1.00
R1612:Med16 UTSW 10 79,899,245 (GRCm38) missense probably damaging 1.00
R1700:Med16 UTSW 10 79,899,335 (GRCm38) missense probably benign 0.10
R1900:Med16 UTSW 10 79,898,931 (GRCm38) missense probably damaging 1.00
R1960:Med16 UTSW 10 79,907,095 (GRCm38) missense possibly damaging 0.94
R2120:Med16 UTSW 10 79,903,082 (GRCm38) missense possibly damaging 0.63
R2895:Med16 UTSW 10 79,903,171 (GRCm38) splice site probably null
R4419:Med16 UTSW 10 79,898,382 (GRCm38) missense probably benign
R4794:Med16 UTSW 10 79,900,117 (GRCm38) missense probably damaging 1.00
R4970:Med16 UTSW 10 79,907,037 (GRCm38) critical splice donor site probably null
R4975:Med16 UTSW 10 79,903,005 (GRCm38) missense possibly damaging 0.93
R5724:Med16 UTSW 10 79,895,409 (GRCm38) missense probably damaging 1.00
R5926:Med16 UTSW 10 79,902,528 (GRCm38) missense probably damaging 0.99
R6185:Med16 UTSW 10 79,896,363 (GRCm38) missense probably damaging 1.00
R7097:Med16 UTSW 10 79,903,343 (GRCm38) missense probably damaging 1.00
R7346:Med16 UTSW 10 79,908,816 (GRCm38) critical splice donor site probably null
R7350:Med16 UTSW 10 79,903,197 (GRCm38) missense probably damaging 1.00
R7808:Med16 UTSW 10 79,898,418 (GRCm38) missense probably damaging 1.00
R7877:Med16 UTSW 10 79,898,372 (GRCm38) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATAAGCTCCGCCATGCTGCTAGTC -3'
(R):5'- GCTCTCGCTGGAGAACATTCTAGAC -3'

Sequencing Primer
(F):5'- GCAGCCACATGTCTTAACATTG -3'
(R):5'- AGCTGCTATAGAGCACTGC -3'
Posted On 2014-03-14