|Institutional Source||Beutler Lab|
|Gene Name||cytochrome P450, family 4, subfamily x, polypeptide 1|
|Is this an essential gene?||Probably non essential (E-score: 0.072)|
|Stock #||R1426 (G1)|
|Chromosomal Location||115106323-115134281 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to A at 115112791 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000102155 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000051400] [ENSMUST00000106545]|
|Coding Region Coverage||
|Validation Efficiency||100% (40/40)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the cytochrome P450 superfamily of enzymes and is located within a cluster of genes belonging to this superfamily on chromosome 1. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The expression pattern of a similar rat protein suggests that this protein may be involved in neurovascular function in the brain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cyp4x1||
(F):5'- TGCTAAAGCACAGTGAAAGAGTGCC -3'
(R):5'- CTCCTTTGTCCTTACAGGGAACAGC -3'
(F):5'- GGCTGGAACCTAATAGCTCTC -3'
(R):5'- GCTGGATGAGATGTCATACACC -3'