Incidental Mutation 'R1426:Pafah1b3'
ID |
162248 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Pafah1b3
|
Ensembl Gene |
ENSMUSG00000005447 |
Gene Name |
platelet-activating factor acetylhydrolase, isoform 1b, subunit 3 |
Synonyms |
mus[g], Pafahg |
MMRRC Submission |
039482-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R1426 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
24994473-24997377 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 24996560 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 41
(E41G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000120379
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005578]
[ENSMUST00000005583]
[ENSMUST00000080288]
[ENSMUST00000108410]
[ENSMUST00000148150]
[ENSMUST00000155118]
[ENSMUST00000163320]
[ENSMUST00000169266]
[ENSMUST00000164820]
|
AlphaFold |
Q61205 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000005578
|
SMART Domains |
Protein: ENSMUSP00000005578 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1065 |
1080 |
N/A |
INTRINSIC |
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
low complexity region
|
1135 |
1155 |
N/A |
INTRINSIC |
low complexity region
|
1223 |
1253 |
N/A |
INTRINSIC |
low complexity region
|
1280 |
1313 |
N/A |
INTRINSIC |
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000005583
AA Change: E41G
PolyPhen 2
Score 0.281 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000005583 Gene: ENSMUSG00000005447 AA Change: E41G
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
12 |
203 |
3.8e-13 |
PFAM |
Pfam:Lipase_GDSL
|
42 |
209 |
1.2e-8 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000080288
|
SMART Domains |
Protein: ENSMUSP00000104047 Gene: ENSMUSG00000058741
Domain | Start | End | E-Value | Type |
Pfam:Pro-rich_19
|
1 |
366 |
3.3e-196 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000108410
|
SMART Domains |
Protein: ENSMUSP00000104048 Gene: ENSMUSG00000005447
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
4 |
151 |
1.2e-23 |
PFAM |
low complexity region
|
155 |
166 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140093
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000148150
AA Change: E41G
PolyPhen 2
Score 0.779 (Sensitivity: 0.85; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000121250 Gene: ENSMUSG00000005447 AA Change: E41G
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
43 |
143 |
5.5e-14 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148828
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000155118
AA Change: E41G
PolyPhen 2
Score 0.910 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000120379 Gene: ENSMUSG00000005447 AA Change: E41G
Domain | Start | End | E-Value | Type |
Pfam:Lipase_GDSL_2
|
43 |
149 |
2.2e-12 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167379
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167162
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149634
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000163320
|
SMART Domains |
Protein: ENSMUSP00000126659 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1064 |
1079 |
N/A |
INTRINSIC |
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1154 |
N/A |
INTRINSIC |
low complexity region
|
1222 |
1252 |
N/A |
INTRINSIC |
low complexity region
|
1279 |
1312 |
N/A |
INTRINSIC |
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000169266
|
SMART Domains |
Protein: ENSMUSP00000132351 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
low complexity region
|
151 |
165 |
N/A |
INTRINSIC |
Pfam:DUF4819
|
249 |
346 |
1.8e-23 |
PFAM |
low complexity region
|
351 |
367 |
N/A |
INTRINSIC |
low complexity region
|
403 |
427 |
N/A |
INTRINSIC |
low complexity region
|
445 |
457 |
N/A |
INTRINSIC |
low complexity region
|
462 |
475 |
N/A |
INTRINSIC |
low complexity region
|
618 |
633 |
N/A |
INTRINSIC |
low complexity region
|
673 |
685 |
N/A |
INTRINSIC |
low complexity region
|
724 |
734 |
N/A |
INTRINSIC |
low complexity region
|
740 |
751 |
N/A |
INTRINSIC |
low complexity region
|
779 |
786 |
N/A |
INTRINSIC |
low complexity region
|
858 |
883 |
N/A |
INTRINSIC |
low complexity region
|
898 |
911 |
N/A |
INTRINSIC |
PDB:4J2L|D
|
930 |
955 |
5e-10 |
PDB |
low complexity region
|
1013 |
1027 |
N/A |
INTRINSIC |
low complexity region
|
1031 |
1045 |
N/A |
INTRINSIC |
HMG
|
1106 |
1176 |
1.24e-17 |
SMART |
low complexity region
|
1322 |
1338 |
N/A |
INTRINSIC |
low complexity region
|
1380 |
1393 |
N/A |
INTRINSIC |
low complexity region
|
1415 |
1428 |
N/A |
INTRINSIC |
low complexity region
|
1432 |
1462 |
N/A |
INTRINSIC |
low complexity region
|
1474 |
1490 |
N/A |
INTRINSIC |
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
low complexity region
|
1636 |
1647 |
N/A |
INTRINSIC |
low complexity region
|
1689 |
1710 |
N/A |
INTRINSIC |
low complexity region
|
1744 |
1766 |
N/A |
INTRINSIC |
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
low complexity region
|
1971 |
1986 |
N/A |
INTRINSIC |
low complexity region
|
2024 |
2038 |
N/A |
INTRINSIC |
low complexity region
|
2041 |
2061 |
N/A |
INTRINSIC |
low complexity region
|
2129 |
2159 |
N/A |
INTRINSIC |
low complexity region
|
2186 |
2219 |
N/A |
INTRINSIC |
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
low complexity region
|
2389 |
2400 |
N/A |
INTRINSIC |
low complexity region
|
2430 |
2453 |
N/A |
INTRINSIC |
low complexity region
|
2474 |
2509 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000163901
|
SMART Domains |
Protein: ENSMUSP00000127858 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
35 |
N/A |
INTRINSIC |
low complexity region
|
114 |
128 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000164820
|
SMART Domains |
Protein: ENSMUSP00000130146 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
low complexity region
|
22 |
36 |
N/A |
INTRINSIC |
low complexity region
|
39 |
57 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.1158 |
Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 94.3%
- 20x: 86.1%
|
Validation Efficiency |
100% (40/40) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an acetylhydrolase that catalyzes the removal of an acetyl group from the glycerol backbone of platelet-activating factor. The encoded enzyme is a subunit of the platelet-activating factor acetylhydrolase isoform 1B complex, which consists of the catalytic beta and gamma subunits and the regulatory alpha subunit. This complex functions in brain development. A translocation between this gene on chromosome 19 and the CDC-like kinase 2 gene on chromosome 1 has been observed, and was associated with mental retardation, ataxia, and atrophy of the brain. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009] PHENOTYPE: Homozygous null mice of both sexes are viable and fertile. However, in combination with homozygous disruptions in Pafah1b2, males become infertile. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 38 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcc10 |
A |
T |
17: 46,635,361 (GRCm39) |
V214E |
probably damaging |
Het |
Adh1 |
A |
G |
3: 137,992,556 (GRCm39) |
D224G |
probably damaging |
Het |
Arhgap28 |
C |
A |
17: 68,164,459 (GRCm39) |
Q554H |
probably damaging |
Het |
Atp8a2 |
T |
C |
14: 60,097,719 (GRCm39) |
K770E |
probably benign |
Het |
Brat1 |
G |
A |
5: 140,703,768 (GRCm39) |
V674I |
probably benign |
Het |
Brd2 |
ATCTTCTTC |
ATCTTC |
17: 34,332,981 (GRCm39) |
|
probably benign |
Het |
Ccdc162 |
T |
C |
10: 41,429,178 (GRCm39) |
D438G |
possibly damaging |
Het |
Cyp4x1 |
T |
A |
4: 114,969,988 (GRCm39) |
|
probably benign |
Het |
Dip2a |
T |
C |
10: 76,115,654 (GRCm39) |
|
probably benign |
Het |
Eif2s1 |
A |
G |
12: 78,927,942 (GRCm39) |
D206G |
probably benign |
Het |
Elovl7 |
T |
A |
13: 108,419,028 (GRCm39) |
I220N |
possibly damaging |
Het |
Gsto1 |
A |
G |
19: 47,846,381 (GRCm39) |
E76G |
probably damaging |
Het |
Hspa14 |
A |
T |
2: 3,509,858 (GRCm39) |
W12R |
probably damaging |
Het |
L3mbtl2 |
T |
A |
15: 81,560,518 (GRCm39) |
C260S |
possibly damaging |
Het |
Lama3 |
G |
T |
18: 12,614,155 (GRCm39) |
|
probably null |
Het |
Lrrc34 |
T |
A |
3: 30,697,728 (GRCm39) |
|
probably benign |
Het |
Lrrc45 |
A |
T |
11: 120,610,839 (GRCm39) |
Q525L |
probably benign |
Het |
Lss |
T |
C |
10: 76,372,137 (GRCm39) |
I164T |
probably damaging |
Het |
Myh11 |
T |
A |
16: 14,023,795 (GRCm39) |
K1527* |
probably null |
Het |
Naip2 |
T |
C |
13: 100,298,362 (GRCm39) |
E558G |
probably benign |
Het |
Naip2 |
C |
T |
13: 100,298,368 (GRCm39) |
G556D |
probably benign |
Het |
Ncoa1 |
T |
A |
12: 4,320,737 (GRCm39) |
|
probably benign |
Het |
Or5an1c |
G |
T |
19: 12,218,546 (GRCm39) |
Q160K |
possibly damaging |
Het |
Or6c38 |
A |
T |
10: 128,929,559 (GRCm39) |
C95S |
probably damaging |
Het |
Pnma8a |
C |
T |
7: 16,694,909 (GRCm39) |
P255S |
possibly damaging |
Het |
Prkar2b |
A |
T |
12: 32,012,987 (GRCm39) |
|
probably benign |
Het |
Rbck1 |
A |
T |
2: 152,169,161 (GRCm39) |
|
probably benign |
Het |
Rcor2 |
A |
G |
19: 7,248,395 (GRCm39) |
S137G |
possibly damaging |
Het |
Slc25a48 |
T |
A |
13: 56,596,804 (GRCm39) |
|
probably benign |
Het |
Slc7a4 |
A |
G |
16: 17,391,808 (GRCm39) |
|
probably null |
Het |
Tert |
T |
C |
13: 73,790,472 (GRCm39) |
|
probably benign |
Het |
Traf7 |
A |
T |
17: 24,730,655 (GRCm39) |
I344N |
probably damaging |
Het |
Vmn1r194 |
T |
A |
13: 22,429,236 (GRCm39) |
F284L |
probably damaging |
Het |
Xpc |
A |
G |
6: 91,470,220 (GRCm39) |
M699T |
probably damaging |
Het |
Zbtb5 |
T |
C |
4: 44,993,968 (GRCm39) |
H472R |
possibly damaging |
Het |
Zfp786 |
A |
G |
6: 47,802,013 (GRCm39) |
V88A |
probably benign |
Het |
Zkscan7 |
T |
C |
9: 122,724,228 (GRCm39) |
I399T |
probably benign |
Het |
Zyg11b |
G |
A |
4: 108,108,009 (GRCm39) |
R466C |
probably damaging |
Het |
|
Other mutations in Pafah1b3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00504:Pafah1b3
|
APN |
7 |
24,995,614 (GRCm39) |
missense |
probably benign |
0.02 |
IGL01351:Pafah1b3
|
APN |
7 |
24,994,570 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL01932:Pafah1b3
|
APN |
7 |
24,996,516 (GRCm39) |
missense |
probably benign |
0.02 |
R0626:Pafah1b3
|
UTSW |
7 |
24,996,554 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5056:Pafah1b3
|
UTSW |
7 |
24,994,764 (GRCm39) |
missense |
probably damaging |
1.00 |
R7177:Pafah1b3
|
UTSW |
7 |
24,994,657 (GRCm39) |
missense |
probably benign |
0.06 |
R7367:Pafah1b3
|
UTSW |
7 |
24,995,491 (GRCm39) |
missense |
probably benign |
0.01 |
R9045:Pafah1b3
|
UTSW |
7 |
24,996,898 (GRCm39) |
unclassified |
probably benign |
|
R9381:Pafah1b3
|
UTSW |
7 |
24,994,699 (GRCm39) |
missense |
probably benign |
0.08 |
|
Predicted Primers |
PCR Primer
(F):5'- AGGGCACACACTTCATTCTCAGC -3'
(R):5'- GTGACGGTTTCTAGTCTGCGAAAGG -3'
Sequencing Primer
(F):5'- ACATGGGGTTCTTAGATTCCTGC -3'
(R):5'- ATAGAACTGCTTCGTGACATCC -3'
|
Posted On |
2014-03-14 |