Incidental Mutation 'R1426:Gsto1'
ID 162271
Institutional Source Beutler Lab
Gene Symbol Gsto1
Ensembl Gene ENSMUSG00000025068
Gene Name glutathione S-transferase omega 1
Synonyms GSTX, p28
MMRRC Submission 039482-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1426 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 47843412-47853229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 47846381 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 76 (E76G)
Ref Sequence ENSEMBL: ENSMUSP00000026050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026050]
AlphaFold O09131
Predicted Effect noncoding transcript
Transcript: ENSMUST00000026048
Predicted Effect probably damaging
Transcript: ENSMUST00000026050
AA Change: E76G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000026050
Gene: ENSMUSG00000025068
AA Change: E76G

DomainStartEndE-ValueType
Pfam:GST_N 22 95 1.6e-15 PFAM
Pfam:GST_N_3 26 101 9e-24 PFAM
Pfam:GST_N_2 31 96 2.2e-16 PFAM
Pfam:GST_C_2 89 204 5.1e-10 PFAM
Pfam:GST_C 106 209 1.3e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130157
Meta Mutation Damage Score 0.4674 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.3%
  • 20x: 86.1%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a mutant allele do not display abnormal arsenate metabolism following acute arsenate exposure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 A T 17: 46,635,361 (GRCm39) V214E probably damaging Het
Adh1 A G 3: 137,992,556 (GRCm39) D224G probably damaging Het
Arhgap28 C A 17: 68,164,459 (GRCm39) Q554H probably damaging Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Brat1 G A 5: 140,703,768 (GRCm39) V674I probably benign Het
Brd2 ATCTTCTTC ATCTTC 17: 34,332,981 (GRCm39) probably benign Het
Ccdc162 T C 10: 41,429,178 (GRCm39) D438G possibly damaging Het
Cyp4x1 T A 4: 114,969,988 (GRCm39) probably benign Het
Dip2a T C 10: 76,115,654 (GRCm39) probably benign Het
Eif2s1 A G 12: 78,927,942 (GRCm39) D206G probably benign Het
Elovl7 T A 13: 108,419,028 (GRCm39) I220N possibly damaging Het
Hspa14 A T 2: 3,509,858 (GRCm39) W12R probably damaging Het
L3mbtl2 T A 15: 81,560,518 (GRCm39) C260S possibly damaging Het
Lama3 G T 18: 12,614,155 (GRCm39) probably null Het
Lrrc34 T A 3: 30,697,728 (GRCm39) probably benign Het
Lrrc45 A T 11: 120,610,839 (GRCm39) Q525L probably benign Het
Lss T C 10: 76,372,137 (GRCm39) I164T probably damaging Het
Myh11 T A 16: 14,023,795 (GRCm39) K1527* probably null Het
Naip2 T C 13: 100,298,362 (GRCm39) E558G probably benign Het
Naip2 C T 13: 100,298,368 (GRCm39) G556D probably benign Het
Ncoa1 T A 12: 4,320,737 (GRCm39) probably benign Het
Or5an1c G T 19: 12,218,546 (GRCm39) Q160K possibly damaging Het
Or6c38 A T 10: 128,929,559 (GRCm39) C95S probably damaging Het
Pafah1b3 T C 7: 24,996,560 (GRCm39) E41G possibly damaging Het
Pnma8a C T 7: 16,694,909 (GRCm39) P255S possibly damaging Het
Prkar2b A T 12: 32,012,987 (GRCm39) probably benign Het
Rbck1 A T 2: 152,169,161 (GRCm39) probably benign Het
Rcor2 A G 19: 7,248,395 (GRCm39) S137G possibly damaging Het
Slc25a48 T A 13: 56,596,804 (GRCm39) probably benign Het
Slc7a4 A G 16: 17,391,808 (GRCm39) probably null Het
Tert T C 13: 73,790,472 (GRCm39) probably benign Het
Traf7 A T 17: 24,730,655 (GRCm39) I344N probably damaging Het
Vmn1r194 T A 13: 22,429,236 (GRCm39) F284L probably damaging Het
Xpc A G 6: 91,470,220 (GRCm39) M699T probably damaging Het
Zbtb5 T C 4: 44,993,968 (GRCm39) H472R possibly damaging Het
Zfp786 A G 6: 47,802,013 (GRCm39) V88A probably benign Het
Zkscan7 T C 9: 122,724,228 (GRCm39) I399T probably benign Het
Zyg11b G A 4: 108,108,009 (GRCm39) R466C probably damaging Het
Other mutations in Gsto1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00570:Gsto1 APN 19 47,846,375 (GRCm39) missense probably benign 0.24
R0277:Gsto1 UTSW 19 47,846,416 (GRCm39) missense probably damaging 0.98
R1733:Gsto1 UTSW 19 47,843,674 (GRCm39) missense probably damaging 1.00
R3418:Gsto1 UTSW 19 47,846,344 (GRCm39) missense probably benign 0.01
R3419:Gsto1 UTSW 19 47,846,344 (GRCm39) missense probably benign 0.01
R3710:Gsto1 UTSW 19 47,847,971 (GRCm39) critical splice donor site probably null
R4830:Gsto1 UTSW 19 47,852,830 (GRCm39) missense probably benign 0.01
R4953:Gsto1 UTSW 19 47,843,759 (GRCm39) missense probably damaging 1.00
R5567:Gsto1 UTSW 19 47,846,338 (GRCm39) missense probably damaging 1.00
R5570:Gsto1 UTSW 19 47,846,338 (GRCm39) missense probably damaging 1.00
R6448:Gsto1 UTSW 19 47,846,420 (GRCm39) missense probably benign 0.02
R7994:Gsto1 UTSW 19 47,847,899 (GRCm39) missense probably benign
R9029:Gsto1 UTSW 19 47,852,837 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTGGAATCGGGCCACACTAATTCAG -3'
(R):5'- TTTCAGGAAGGCAGCAGGTCCAAG -3'

Sequencing Primer
(F):5'- GGCCACACTAATTCAGGGAGAC -3'
(R):5'- AGTTAAGGTTCCCAGTGCCAG -3'
Posted On 2014-03-14