Incidental Mutation 'R1432:Or6k2'
ID 162275
Institutional Source Beutler Lab
Gene Symbol Or6k2
Ensembl Gene ENSMUSG00000055033
Gene Name olfactory receptor family 6 subfamily K member 2
Synonyms GA_x6K02T2P20D-20995211-20994246, MOR105-10, Olfr420
MMRRC Submission 039487-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R1432 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 173986288-173987333 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 173986483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 48 (V48E)
Ref Sequence ENSEMBL: ENSMUSP00000149052 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068403] [ENSMUST00000213748]
AlphaFold E9Q4G0
Predicted Effect possibly damaging
Transcript: ENSMUST00000068403
AA Change: V48E

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000069662
Gene: ENSMUSG00000055033
AA Change: V48E

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 9.9e-60 PFAM
Pfam:7tm_1 41 292 4.1e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213748
AA Change: V48E

PolyPhen 2 Score 0.672 (Sensitivity: 0.86; Specificity: 0.91)
Meta Mutation Damage Score 0.4821 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.4%
  • 20x: 86.1%
Validation Efficiency 98% (90/92)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A G 12: 71,217,361 (GRCm39) probably null Het
9130401M01Rik A T 15: 57,892,256 (GRCm39) L117Q probably damaging Het
Abcb1b A G 5: 8,887,771 (GRCm39) K886E possibly damaging Het
Acaa2 A T 18: 74,920,198 (GRCm39) I9F probably damaging Het
Acap2 A T 16: 30,929,901 (GRCm39) S386T probably damaging Het
Acsm2 A T 7: 119,172,798 (GRCm39) I138F possibly damaging Het
Agl T C 3: 116,540,342 (GRCm39) Y1424C probably damaging Het
Aoc1l1 T A 6: 48,952,588 (GRCm39) F171Y probably damaging Het
Apc2 T C 10: 80,148,183 (GRCm39) V1079A probably benign Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Armc8 C T 9: 99,405,185 (GRCm39) probably benign Het
Catsperb A G 12: 101,588,476 (GRCm39) Y953C probably damaging Het
Cdk13 G A 13: 17,893,001 (GRCm39) A720V probably damaging Het
Chka T C 19: 3,924,809 (GRCm39) probably benign Het
Clcc1 T C 3: 108,575,418 (GRCm39) I165T probably benign Het
Cndp1 G A 18: 84,652,777 (GRCm39) probably benign Het
Dip2c C A 13: 9,603,340 (GRCm39) P297Q probably damaging Het
Dnah17 A T 11: 117,914,153 (GRCm39) W4429R probably damaging Het
Dram2 T C 3: 106,478,082 (GRCm39) V138A possibly damaging Het
Dus4l T C 12: 31,698,770 (GRCm39) N78S probably benign Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
Ebf1 T C 11: 44,895,533 (GRCm39) probably benign Het
Epm2a T A 10: 11,266,587 (GRCm39) Y111N probably damaging Het
Gm773 T C X: 55,247,377 (GRCm39) T52A probably benign Het
Gpam C A 19: 55,067,693 (GRCm39) M483I probably damaging Het
Gpr12 T C 5: 146,520,235 (GRCm39) H229R probably damaging Het
Gpr149 T C 3: 62,438,439 (GRCm39) T573A probably damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Hells T A 19: 38,945,628 (GRCm39) probably null Het
Herc1 T A 9: 66,372,751 (GRCm39) N3102K probably benign Het
Herc3 A T 6: 58,893,827 (GRCm39) T968S possibly damaging Het
Ift88 A G 14: 57,674,736 (GRCm39) Y69C probably benign Het
Incenp G A 19: 9,862,890 (GRCm39) T388M unknown Het
Jrkl A G 9: 13,245,337 (GRCm39) F108S probably benign Het
Khdc1a A G 1: 21,420,542 (GRCm39) E54G possibly damaging Het
Kif6 T A 17: 49,927,728 (GRCm39) F58L probably damaging Het
Klk14 T C 7: 43,344,342 (GRCm39) S218P probably damaging Het
Kmt2e T C 5: 23,655,319 (GRCm39) M19T probably benign Het
Llgl1 G T 11: 60,599,380 (GRCm39) G454C probably damaging Het
Lyrm4 A G 13: 36,276,898 (GRCm39) V33A probably benign Het
Mcam C T 9: 44,052,588 (GRCm39) R606C probably damaging Het
Mgam T A 6: 40,733,301 (GRCm39) M692K probably damaging Het
Mmp28 C T 11: 83,333,765 (GRCm39) R392H probably damaging Het
Mpdz G A 4: 81,210,788 (GRCm39) T1699M probably damaging Het
Mrps11 T C 7: 78,433,310 (GRCm39) probably benign Het
Mrtfb A G 16: 13,218,866 (GRCm39) N504S probably benign Het
Msmo1 A G 8: 65,180,650 (GRCm39) probably benign Het
Mst1 A G 9: 107,961,403 (GRCm39) E571G probably benign Het
Myh14 T C 7: 44,265,723 (GRCm39) E1585G probably damaging Het
Myrfl A G 10: 116,613,332 (GRCm39) C824R probably damaging Het
Ncapd3 C T 9: 26,981,168 (GRCm39) probably benign Het
Nlrp4a G GGTTCTTC 7: 26,163,622 (GRCm39) probably null Het
Nos1 C T 5: 118,087,684 (GRCm39) probably benign Het
Notch3 T C 17: 32,383,198 (GRCm39) S47G probably benign Het
Npsr1 A G 9: 24,221,371 (GRCm39) Y122C probably damaging Het
Or10ak12 T C 4: 118,666,435 (GRCm39) M209V probably benign Het
Or1j11 C T 2: 36,311,655 (GRCm39) L82F probably damaging Het
Or5a1 G T 19: 12,097,603 (GRCm39) R158S possibly damaging Het
Or6c1b C T 10: 129,272,807 (GRCm39) T42I probably damaging Het
Or8b9 T A 9: 37,766,548 (GRCm39) L145M possibly damaging Het
Otog G T 7: 45,950,007 (GRCm39) V2490F probably damaging Het
Pibf1 T C 14: 99,350,425 (GRCm39) V191A probably benign Het
Pip A G 6: 41,826,852 (GRCm39) M66V probably benign Het
Plxna2 C T 1: 194,449,771 (GRCm39) R830C probably benign Het
Prkca A T 11: 107,830,346 (GRCm39) V248E probably benign Het
Prmt7 T A 8: 106,963,916 (GRCm39) L253* probably null Het
Prrc2a G T 17: 35,372,888 (GRCm39) probably benign Het
Rasgrf1 A G 9: 89,894,853 (GRCm39) D1091G probably benign Het
Rbm7 C A 9: 48,401,245 (GRCm39) G161V probably benign Het
Scn1a A T 2: 66,152,773 (GRCm39) I736N probably damaging Het
Skint6 A G 4: 112,726,721 (GRCm39) probably benign Het
Slc22a2 C T 17: 12,803,195 (GRCm39) H10Y possibly damaging Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Stam2 A G 2: 52,604,821 (GRCm39) probably benign Het
Stk40 T C 4: 126,030,626 (GRCm39) L282P probably damaging Het
Tas2r110 A G 6: 132,845,331 (GRCm39) N121D probably damaging Het
Tbc1d32 A G 10: 55,893,758 (GRCm39) Y1272H probably damaging Het
Thoc2l T C 5: 104,665,970 (GRCm39) F164S probably damaging Het
Tmem131l T C 3: 83,836,021 (GRCm39) D696G probably damaging Het
Trdmt1 T C 2: 13,524,657 (GRCm39) Y266C probably damaging Het
Trim5 G T 7: 103,928,726 (GRCm39) H72N probably benign Het
Trim5 A C 7: 103,928,728 (GRCm39) L71R probably benign Het
Twf2 T A 9: 106,092,012 (GRCm39) probably benign Het
Ubap2l T C 3: 89,926,635 (GRCm39) T580A probably benign Het
Ugt1a10 C T 1: 88,143,982 (GRCm39) R201C probably damaging Het
Unc5a A G 13: 55,152,285 (GRCm39) probably benign Het
Vmn2r85 T C 10: 130,261,155 (GRCm39) N394S possibly damaging Het
Wrn A T 8: 33,809,169 (GRCm39) probably benign Het
Other mutations in Or6k2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01394:Or6k2 APN 1 173,986,423 (GRCm39) missense probably damaging 1.00
IGL02479:Or6k2 APN 1 173,986,520 (GRCm39) nonsense probably null
IGL03190:Or6k2 APN 1 173,987,110 (GRCm39) missense probably damaging 0.99
IGL03270:Or6k2 APN 1 173,987,119 (GRCm39) missense probably benign 0.04
R0645:Or6k2 UTSW 1 173,986,920 (GRCm39) missense probably benign 0.00
R0834:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R1508:Or6k2 UTSW 1 173,986,930 (GRCm39) missense possibly damaging 0.55
R2351:Or6k2 UTSW 1 173,986,486 (GRCm39) missense probably damaging 0.99
R3440:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R3441:Or6k2 UTSW 1 173,986,746 (GRCm39) missense probably benign 0.14
R4571:Or6k2 UTSW 1 173,986,494 (GRCm39) missense possibly damaging 0.77
R5072:Or6k2 UTSW 1 173,986,527 (GRCm39) missense probably damaging 1.00
R6060:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
R6166:Or6k2 UTSW 1 173,986,659 (GRCm39) missense probably benign 0.43
R6228:Or6k2 UTSW 1 173,979,712 (GRCm39) missense probably benign 0.00
R6272:Or6k2 UTSW 1 173,986,741 (GRCm39) missense probably benign 0.02
R6298:Or6k2 UTSW 1 173,979,748 (GRCm39) missense probably benign 0.02
R6400:Or6k2 UTSW 1 173,986,830 (GRCm39) missense probably damaging 0.99
R7581:Or6k2 UTSW 1 173,986,337 (GRCm39) splice site probably null
R7677:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 1.00
R7823:Or6k2 UTSW 1 173,987,254 (GRCm39) missense probably benign 0.12
R7829:Or6k2 UTSW 1 173,986,425 (GRCm39) missense probably benign 0.00
R8077:Or6k2 UTSW 1 173,979,411 (GRCm39) unclassified probably benign
R8519:Or6k2 UTSW 1 173,986,614 (GRCm39) missense probably damaging 0.99
R9106:Or6k2 UTSW 1 173,986,369 (GRCm39) missense probably benign 0.00
R9205:Or6k2 UTSW 1 173,986,456 (GRCm39) missense probably benign 0.33
R9507:Or6k2 UTSW 1 173,986,552 (GRCm39) missense possibly damaging 0.94
R9797:Or6k2 UTSW 1 173,986,417 (GRCm39) missense probably benign
Z1187:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Z1192:Or6k2 UTSW 1 173,986,907 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGTGCAAGTGTCTTCTCAAAGCCTG -3'
(R):5'- AACCTCACTGATGCCTGTGGAATG -3'

Sequencing Primer
(F):5'- GTGGACACTTCCTGAAAAGCTTG -3'
(R):5'- CCTGTGGAATGGAAGAAATACATCTG -3'
Posted On 2014-03-14