Mutagenetix > Incidental Mutation

Incidental Mutation 'R1432:Plxna2'

162276

Institutional Source

Beutler Lab

Gene Symbol

Plxna2

Ensembl Gene

ENSMUSG00000026640

Gene Name

plexin A2

Synonyms

2810428A13Rik, OCT, PlexA2, Plxn2

MMRRC Submission

039487-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R1432 (G1)

Quality Score

183

Status

Validated

Chromosome

Chromosomal Location

194618218-194816869 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 194767463 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Cysteine at position 830 (R830C)

Ref Sequence

ENSEMBL: ENSMUSP00000027952 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027952]

AlphaFold

P70207

PDB Structure

Plexin A2 / Semaphorin 6A complex [X-RAY DIFFRACTION]
Mouse Plexin A2 extracellular domain [X-RAY DIFFRACTION]
Mouse Plexin A2, extracellular domains 1-4 [X-RAY DIFFRACTION]
Plexin A2 in complex with Semaphorin 6A [X-RAY DIFFRACTION]
Complex of mouse Plexin A2 - Semaphorin 3A - Neuropilin-1 [X-RAY DIFFRACTION]

Predicted Effect

probably benign
Transcript: ENSMUST00000027952
AA Change: R830C

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000027952
Gene: ENSMUSG00000026640
AA Change: R830C

Domain	Start	End	E-Value	Type
low complexity region	16	29	N/A	INTRINSIC
Sema	50	492	1.65e-132	SMART
PSI	510	560	8e-12	SMART
PSI	655	702	6.35e-6	SMART
PSI	803	856	1.24e-8	SMART
IPT	857	952	6.36e-21	SMART
IPT	953	1038	1.02e-24	SMART
IPT	1040	1140	1.48e-21	SMART
IPT	1142	1237	8.81e-6	SMART
transmembrane domain	1238	1260	N/A	INTRINSIC
Pfam:Plexin_cytopl	1311	1864	1.9e-261	PFAM

Predicted Effect

unknown
Transcript: ENSMUST00000135664
AA Change: R35C

SMART Domains

Protein: ENSMUSP00000118087
Gene: ENSMUSG00000026640
AA Change: R35C

Domain	Start	End	E-Value	Type
PSI	9	62	1.24e-8	SMART

Meta Mutation Damage Score

0.1388

Coding Region Coverage

1x: 98.9%
3x: 97.8%
10x: 94.4%
20x: 86.1%

Validation Efficiency

98% (90/92)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele show abnormal granule cell migration in the adult cerebellum and aberrant projection of mossy fibers in hippocampal slices. Mice homozygous for an ENU-induced allele are smaller and show granule cell migration defects and mild ataxia with incomplete penetrance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	A	G	12: 71,170,587 (GRCm38)		probably null	Het
9130401M01Rik	A	T	15: 58,028,860 (GRCm38)	L117Q	probably damaging	Het
Abcb1b	A	G	5: 8,837,771 (GRCm38)	K886E	possibly damaging	Het
Acaa2	A	T	18: 74,787,127 (GRCm38)	I9F	probably damaging	Het
Acap2	A	T	16: 31,111,083 (GRCm38)	S386T	probably damaging	Het
Acsm2	A	T	7: 119,573,575 (GRCm38)	I138F	possibly damaging	Het
Agl	T	C	3: 116,746,693 (GRCm38)	Y1424C	probably damaging	Het
Aoc1l1	T	A	6: 48,975,654 (GRCm38)	F171Y	probably damaging	Het
Apc2	T	C	10: 80,312,349 (GRCm38)	V1079A	probably benign	Het
Arhgef6	T	C	X: 57,338,562 (GRCm38)	M5V	probably benign	Het
Armc8	C	T	9: 99,523,132 (GRCm38)		probably benign	Het
Catsperb	A	G	12: 101,622,217 (GRCm38)	Y953C	probably damaging	Het
Cdk13	G	A	13: 17,718,416 (GRCm38)	A720V	probably damaging	Het
Chka	T	C	19: 3,874,809 (GRCm38)		probably benign	Het
Clcc1	T	C	3: 108,668,102 (GRCm38)	I165T	probably benign	Het
Cndp1	G	A	18: 84,634,652 (GRCm38)		probably benign	Het
Dip2c	C	A	13: 9,553,304 (GRCm38)	P297Q	probably damaging	Het
Dnah17	A	T	11: 118,023,327 (GRCm38)	W4429R	probably damaging	Het
Dram2	T	C	3: 106,570,766 (GRCm38)	V138A	possibly damaging	Het
Dus4l	T	C	12: 31,648,771 (GRCm38)	N78S	probably benign	Het
Dync1h1	G	A	12: 110,636,509 (GRCm38)	E2195K	probably benign	Het
Ebf1	T	C	11: 45,004,706 (GRCm38)		probably benign	Het
Epm2a	T	A	10: 11,390,843 (GRCm38)	Y111N	probably damaging	Het
Gm773	T	C	X: 56,202,017 (GRCm38)	T52A	probably benign	Het
Gpam	C	A	19: 55,079,261 (GRCm38)	M483I	probably damaging	Het
Gpr12	T	C	5: 146,583,425 (GRCm38)	H229R	probably damaging	Het
Gpr149	T	C	3: 62,531,018 (GRCm38)	T573A	probably damaging	Het
Gtf3c3	C	T	1: 54,417,778 (GRCm38)	A488T	probably damaging	Het
Hells	T	A	19: 38,957,184 (GRCm38)		probably null	Het
Herc1	T	A	9: 66,465,469 (GRCm38)	N3102K	probably benign	Het
Herc3	A	T	6: 58,916,842 (GRCm38)	T968S	possibly damaging	Het
Ift88	A	G	14: 57,437,279 (GRCm38)	Y69C	probably benign	Het
Incenp	G	A	19: 9,885,526 (GRCm38)	T388M	unknown	Het
Jrkl	A	G	9: 13,245,332 (GRCm38)	F108S	probably benign	Het
Khdc1a	A	G	1: 21,350,318 (GRCm38)	E54G	possibly damaging	Het
Kif6	T	A	17: 49,620,700 (GRCm38)	F58L	probably damaging	Het
Klk14	T	C	7: 43,694,918 (GRCm38)	S218P	probably damaging	Het
Kmt2e	T	C	5: 23,450,321 (GRCm38)	M19T	probably benign	Het
Llgl1	G	T	11: 60,708,554 (GRCm38)	G454C	probably damaging	Het
Lyrm4	A	G	13: 36,092,915 (GRCm38)	V33A	probably benign	Het
Mcam	C	T	9: 44,141,291 (GRCm38)	R606C	probably damaging	Het
Mgam	T	A	6: 40,756,367 (GRCm38)	M692K	probably damaging	Het
Mmp28	C	T	11: 83,442,939 (GRCm38)	R392H	probably damaging	Het
Mpdz	G	A	4: 81,292,551 (GRCm38)	T1699M	probably damaging	Het
Mrps11	T	C	7: 78,783,562 (GRCm38)		probably benign	Het
Mrtfb	A	G	16: 13,401,002 (GRCm38)	N504S	probably benign	Het
Msmo1	A	G	8: 64,727,616 (GRCm38)		probably benign	Het
Mst1	A	G	9: 108,084,204 (GRCm38)	E571G	probably benign	Het
Myh14	T	C	7: 44,616,299 (GRCm38)	E1585G	probably damaging	Het
Myrfl	A	G	10: 116,777,427 (GRCm38)	C824R	probably damaging	Het
Ncapd3	C	T	9: 27,069,872 (GRCm38)		probably benign	Het
Nlrp4a	G	GGTTCTTC	7: 26,464,197 (GRCm38)		probably null	Het
Nos1	C	T	5: 117,949,619 (GRCm38)		probably benign	Het
Notch3	T	C	17: 32,164,224 (GRCm38)	S47G	probably benign	Het
Npsr1	A	G	9: 24,310,075 (GRCm38)	Y122C	probably damaging	Het
Or10ak12	T	C	4: 118,809,238 (GRCm38)	M209V	probably benign	Het
Or1j11	C	T	2: 36,421,643 (GRCm38)	L82F	probably damaging	Het
Or5a1	G	T	19: 12,120,239 (GRCm38)	R158S	possibly damaging	Het
Or6c1b	C	T	10: 129,436,938 (GRCm38)	T42I	probably damaging	Het
Or6k2	T	A	1: 174,158,917 (GRCm38)	V48E	possibly damaging	Het
Or8b9	T	A	9: 37,855,252 (GRCm38)	L145M	possibly damaging	Het
Otog	G	T	7: 46,300,583 (GRCm38)	V2490F	probably damaging	Het
Pibf1	T	C	14: 99,112,989 (GRCm38)	V191A	probably benign	Het
Pip	A	G	6: 41,849,918 (GRCm38)	M66V	probably benign	Het
Prkca	A	T	11: 107,939,520 (GRCm38)	V248E	probably benign	Het
Prmt7	T	A	8: 106,237,284 (GRCm38)	L253*	probably null	Het
Prrc2a	G	T	17: 35,153,912 (GRCm38)		probably benign	Het
Rasgrf1	A	G	9: 90,012,800 (GRCm38)	D1091G	probably benign	Het
Rbm7	C	A	9: 48,489,945 (GRCm38)	G161V	probably benign	Het
Scn1a	A	T	2: 66,322,429 (GRCm38)	I736N	probably damaging	Het
Skint6	A	G	4: 112,869,524 (GRCm38)		probably benign	Het
Slc22a2	C	T	17: 12,584,308 (GRCm38)	H10Y	possibly damaging	Het
Sned1	G	A	1: 93,281,654 (GRCm38)	V830M	possibly damaging	Het
Stam2	A	G	2: 52,714,809 (GRCm38)		probably benign	Het
Stk40	T	C	4: 126,136,833 (GRCm38)	L282P	probably damaging	Het
Tas2r110	A	G	6: 132,868,368 (GRCm38)	N121D	probably damaging	Het
Tbc1d32	A	G	10: 56,017,662 (GRCm38)	Y1272H	probably damaging	Het
Thoc2l	T	C	5: 104,518,104 (GRCm38)	F164S	probably damaging	Het
Tmem131l	T	C	3: 83,928,714 (GRCm38)	D696G	probably damaging	Het
Trdmt1	T	C	2: 13,519,846 (GRCm38)	Y266C	probably damaging	Het
Trim5	A	C	7: 104,279,521 (GRCm38)	L71R	probably benign	Het
Trim5	G	T	7: 104,279,519 (GRCm38)	H72N	probably benign	Het
Twf2	T	A	9: 106,214,813 (GRCm38)		probably benign	Het
Ubap2l	T	C	3: 90,019,328 (GRCm38)	T580A	probably benign	Het
Ugt1a10	C	T	1: 88,216,260 (GRCm38)	R201C	probably damaging	Het
Unc5a	A	G	13: 55,004,472 (GRCm38)		probably benign	Het
Vmn2r85	T	C	10: 130,425,286 (GRCm38)	N394S	possibly damaging	Het
Wrn	A	T	8: 33,319,141 (GRCm38)		probably benign	Het

Other mutations in Plxna2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00227:Plxna2	APN	1	194,644,657 (GRCm38)	missense	probably damaging	1.00
IGL00332:Plxna2	APN	1	194,789,830 (GRCm38)	missense	probably damaging	0.98
IGL00392:Plxna2	APN	1	194,800,568 (GRCm38)	missense	probably damaging	1.00
IGL00432:Plxna2	APN	1	194,644,096 (GRCm38)	missense	probably benign	0.03
IGL00704:Plxna2	APN	1	194,751,461 (GRCm38)	missense	probably damaging	0.99
IGL00737:Plxna2	APN	1	194,746,239 (GRCm38)	splice site	probably benign
IGL01078:Plxna2	APN	1	194,786,693 (GRCm38)	unclassified	probably benign
IGL01354:Plxna2	APN	1	194,762,435 (GRCm38)	missense	probably benign	0.02
IGL01432:Plxna2	APN	1	194,644,318 (GRCm38)	missense	possibly damaging	0.58
IGL01459:Plxna2	APN	1	194,764,570 (GRCm38)	missense	probably benign	0.00
IGL01525:Plxna2	APN	1	194,712,311 (GRCm38)	missense	probably benign	0.00
IGL01656:Plxna2	APN	1	194,790,161 (GRCm38)	missense	possibly damaging	0.52
IGL01825:Plxna2	APN	1	194,788,902 (GRCm38)	missense	probably damaging	0.98
IGL01862:Plxna2	APN	1	194,643,950 (GRCm38)	missense	possibly damaging	0.87
IGL01899:Plxna2	APN	1	194,751,488 (GRCm38)	missense	probably damaging	1.00
IGL01996:Plxna2	APN	1	194,799,776 (GRCm38)	missense	probably damaging	0.99
IGL02123:Plxna2	APN	1	194,794,383 (GRCm38)	missense	probably damaging	1.00
IGL02226:Plxna2	APN	1	194,644,424 (GRCm38)	missense	probably damaging	1.00
IGL02227:Plxna2	APN	1	194,752,089 (GRCm38)	missense	probably damaging	1.00
IGL02415:Plxna2	APN	1	194,643,964 (GRCm38)	missense	probably damaging	1.00
IGL02440:Plxna2	APN	1	194,746,150 (GRCm38)	missense	probably benign	0.10
IGL02545:Plxna2	APN	1	194,786,690 (GRCm38)	unclassified	probably benign
IGL02553:Plxna2	APN	1	194,751,438 (GRCm38)	missense	probably benign	0.08
IGL02882:Plxna2	APN	1	194,762,570 (GRCm38)	missense	probably damaging	1.00
IGL02946:Plxna2	APN	1	194,749,309 (GRCm38)	splice site	probably benign
IGL03062:Plxna2	APN	1	194,762,550 (GRCm38)	missense	possibly damaging	0.72
IGL03095:Plxna2	APN	1	194,801,127 (GRCm38)	missense	probably damaging	1.00
IGL03293:Plxna2	APN	1	194,804,945 (GRCm38)	missense	probably damaging	0.99
G1Funyon:Plxna2	UTSW	1	194,790,175 (GRCm38)	missense	probably benign	0.01
PIT4514001:Plxna2	UTSW	1	194,794,937 (GRCm38)	missense	probably benign	0.00
R0024:Plxna2	UTSW	1	194,643,995 (GRCm38)	missense	possibly damaging	0.57
R0040:Plxna2	UTSW	1	194,643,896 (GRCm38)	missense	probably benign	0.13
R0040:Plxna2	UTSW	1	194,643,896 (GRCm38)	missense	probably benign	0.13
R0063:Plxna2	UTSW	1	194,644,939 (GRCm38)	missense	probably benign	0.00
R0063:Plxna2	UTSW	1	194,644,939 (GRCm38)	missense	probably benign	0.00
R0217:Plxna2	UTSW	1	194,644,598 (GRCm38)	missense	probably damaging	1.00
R0316:Plxna2	UTSW	1	194,644,150 (GRCm38)	missense	probably damaging	1.00
R0440:Plxna2	UTSW	1	194,644,404 (GRCm38)	nonsense	probably null
R0505:Plxna2	UTSW	1	194,644,348 (GRCm38)	missense	possibly damaging	0.93
R0568:Plxna2	UTSW	1	194,751,386 (GRCm38)	missense	probably benign	0.00
R0669:Plxna2	UTSW	1	194,788,837 (GRCm38)	missense	probably damaging	0.99
R0674:Plxna2	UTSW	1	194,649,475 (GRCm38)	missense	probably benign	0.00
R0885:Plxna2	UTSW	1	194,644,556 (GRCm38)	missense	probably benign
R0898:Plxna2	UTSW	1	194,797,024 (GRCm38)	missense	probably damaging	1.00
R0940:Plxna2	UTSW	1	194,800,555 (GRCm38)	missense	probably benign	0.01
R1061:Plxna2	UTSW	1	194,644,093 (GRCm38)	missense	probably damaging	1.00
R1067:Plxna2	UTSW	1	194,780,510 (GRCm38)	splice site	probably null
R1222:Plxna2	UTSW	1	194,800,649 (GRCm38)	missense	probably damaging	1.00
R1345:Plxna2	UTSW	1	194,644,486 (GRCm38)	missense	probably damaging	1.00
R1363:Plxna2	UTSW	1	194,804,939 (GRCm38)	nonsense	probably null
R1434:Plxna2	UTSW	1	194,751,540 (GRCm38)	splice site	probably benign
R1597:Plxna2	UTSW	1	194,749,306 (GRCm38)	splice site	probably benign
R1719:Plxna2	UTSW	1	194,644,370 (GRCm38)	missense	possibly damaging	0.93
R1778:Plxna2	UTSW	1	194,810,970 (GRCm38)	missense	probably benign	0.01
R1795:Plxna2	UTSW	1	194,806,303 (GRCm38)	missense	probably damaging	0.99
R1819:Plxna2	UTSW	1	194,790,186 (GRCm38)	missense	probably benign	0.03
R1926:Plxna2	UTSW	1	194,762,450 (GRCm38)	missense	probably benign	0.02
R1966:Plxna2	UTSW	1	194,644,700 (GRCm38)	missense	possibly damaging	0.91
R1987:Plxna2	UTSW	1	194,643,989 (GRCm38)	missense	probably damaging	1.00
R1988:Plxna2	UTSW	1	194,643,989 (GRCm38)	missense	probably damaging	1.00
R2034:Plxna2	UTSW	1	194,780,594 (GRCm38)	missense	probably benign	0.00
R2131:Plxna2	UTSW	1	194,644,750 (GRCm38)	missense	probably benign	0.01
R2171:Plxna2	UTSW	1	194,800,617 (GRCm38)	missense	probably damaging	1.00
R2217:Plxna2	UTSW	1	194,797,748 (GRCm38)	missense	probably damaging	1.00
R2311:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2340:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2342:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2423:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2424:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2425:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2842:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R2971:Plxna2	UTSW	1	194,797,731 (GRCm38)	missense	probably damaging	1.00
R3236:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R3731:Plxna2	UTSW	1	194,788,885 (GRCm38)	missense	probably benign	0.42
R3783:Plxna2	UTSW	1	194,807,521 (GRCm38)	missense	probably damaging	1.00
R3784:Plxna2	UTSW	1	194,644,617 (GRCm38)	missense	probably benign
R3787:Plxna2	UTSW	1	194,643,934 (GRCm38)	missense	probably benign	0.10
R3845:Plxna2	UTSW	1	194,793,790 (GRCm38)	missense	probably damaging	0.96
R3927:Plxna2	UTSW	1	194,746,157 (GRCm38)	missense	probably benign	0.02
R3930:Plxna2	UTSW	1	194,794,910 (GRCm38)	missense	probably benign	0.17
R3964:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R3980:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4067:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4120:Plxna2	UTSW	1	194,780,627 (GRCm38)	missense	probably damaging	1.00
R4231:Plxna2	UTSW	1	194,644,454 (GRCm38)	missense	probably damaging	1.00
R4257:Plxna2	UTSW	1	194,644,775 (GRCm38)	missense	probably damaging	1.00
R4396:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4397:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4418:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4444:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4446:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4482:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4487:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4489:Plxna2	UTSW	1	194,749,317 (GRCm38)	missense	probably damaging	1.00
R4571:Plxna2	UTSW	1	194,810,988 (GRCm38)	missense	possibly damaging	0.91
R4622:Plxna2	UTSW	1	194,812,150 (GRCm38)	missense	probably benign
R4623:Plxna2	UTSW	1	194,812,150 (GRCm38)	missense	probably benign
R4684:Plxna2	UTSW	1	194,762,594 (GRCm38)	missense	probably benign	0.42
R4688:Plxna2	UTSW	1	194,644,445 (GRCm38)	missense	probably damaging	1.00
R4855:Plxna2	UTSW	1	194,797,732 (GRCm38)	missense	probably benign	0.39
R4876:Plxna2	UTSW	1	194,643,775 (GRCm38)	missense	probably benign	0.02
R5161:Plxna2	UTSW	1	194,751,404 (GRCm38)	missense	probably benign
R5207:Plxna2	UTSW	1	194,788,899 (GRCm38)	missense	probably benign	0.19
R5479:Plxna2	UTSW	1	194,793,873 (GRCm38)	missense	probably benign
R5931:Plxna2	UTSW	1	194,810,870 (GRCm38)	missense	probably damaging	1.00
R6026:Plxna2	UTSW	1	194,799,814 (GRCm38)	missense	probably damaging	1.00
R6029:Plxna2	UTSW	1	194,799,575 (GRCm38)	missense	probably damaging	1.00
R6029:Plxna2	UTSW	1	194,794,427 (GRCm38)	missense	probably benign	0.00
R6059:Plxna2	UTSW	1	194,810,971 (GRCm38)	missense	possibly damaging	0.79
R6238:Plxna2	UTSW	1	194,790,196 (GRCm38)	missense	probably benign	0.01
R6322:Plxna2	UTSW	1	194,754,367 (GRCm38)	missense	possibly damaging	0.89
R6668:Plxna2	UTSW	1	194,810,088 (GRCm38)	missense	possibly damaging	0.68
R6709:Plxna2	UTSW	1	194,789,766 (GRCm38)	missense	probably benign	0.01
R6748:Plxna2	UTSW	1	194,794,182 (GRCm38)	splice site	probably null
R6838:Plxna2	UTSW	1	194,804,914 (GRCm38)	missense	possibly damaging	0.90
R6844:Plxna2	UTSW	1	194,793,828 (GRCm38)	missense	probably benign	0.08
R7069:Plxna2	UTSW	1	194,793,904 (GRCm38)	missense	possibly damaging	0.51
R7122:Plxna2	UTSW	1	194,644,568 (GRCm38)	nonsense	probably null
R7145:Plxna2	UTSW	1	194,649,522 (GRCm38)	missense	probably benign	0.31
R7189:Plxna2	UTSW	1	194,801,058 (GRCm38)	missense	possibly damaging	0.58
R7207:Plxna2	UTSW	1	194,644,019 (GRCm38)	missense	probably damaging	1.00
R7232:Plxna2	UTSW	1	194,712,260 (GRCm38)	missense	probably damaging	1.00
R7234:Plxna2	UTSW	1	194,806,390 (GRCm38)	missense	probably damaging	0.96
R7246:Plxna2	UTSW	1	194,644,282 (GRCm38)	missense	possibly damaging	0.74
R7255:Plxna2	UTSW	1	194,752,103 (GRCm38)	missense	probably benign	0.03
R7283:Plxna2	UTSW	1	194,644,883 (GRCm38)	missense	probably damaging	0.99
R7288:Plxna2	UTSW	1	194,796,919 (GRCm38)	missense	probably damaging	1.00
R7361:Plxna2	UTSW	1	194,799,779 (GRCm38)	missense	probably damaging	1.00
R7424:Plxna2	UTSW	1	194,806,339 (GRCm38)	missense	probably damaging	0.98
R7501:Plxna2	UTSW	1	194,643,895 (GRCm38)	missense	possibly damaging	0.95
R7528:Plxna2	UTSW	1	194,812,156 (GRCm38)	missense	probably damaging	1.00
R7529:Plxna2	UTSW	1	194,643,871 (GRCm38)	missense	probably benign	0.25
R7532:Plxna2	UTSW	1	194,644,819 (GRCm38)	missense	probably benign	0.13
R7959:Plxna2	UTSW	1	194,810,962 (GRCm38)	missense	probably damaging	1.00
R7959:Plxna2	UTSW	1	194,793,864 (GRCm38)	frame shift	probably null
R7960:Plxna2	UTSW	1	194,793,864 (GRCm38)	frame shift	probably null
R8261:Plxna2	UTSW	1	194,749,416 (GRCm38)	missense	probably damaging	1.00
R8301:Plxna2	UTSW	1	194,790,175 (GRCm38)	missense	probably benign	0.01
R8463:Plxna2	UTSW	1	194,644,046 (GRCm38)	missense	probably damaging	1.00
R8519:Plxna2	UTSW	1	194,793,958 (GRCm38)	missense	probably damaging	1.00
R8836:Plxna2	UTSW	1	194,796,935 (GRCm38)	missense	possibly damaging	0.94
R9010:Plxna2	UTSW	1	194,788,909 (GRCm38)	missense	possibly damaging	0.95
R9034:Plxna2	UTSW	1	194,793,889 (GRCm38)	missense	probably damaging	1.00
R9254:Plxna2	UTSW	1	194,810,166 (GRCm38)	missense	probably damaging	1.00
R9274:Plxna2	UTSW	1	194,788,828 (GRCm38)	missense	probably damaging	1.00
R9379:Plxna2	UTSW	1	194,810,166 (GRCm38)	missense	probably damaging	1.00
R9385:Plxna2	UTSW	1	194,749,416 (GRCm38)	missense	possibly damaging	0.95
R9422:Plxna2	UTSW	1	194,644,422 (GRCm38)	missense	probably damaging	1.00
R9451:Plxna2	UTSW	1	194,644,384 (GRCm38)	missense	probably benign	0.05
R9484:Plxna2	UTSW	1	194,644,894 (GRCm38)	missense	probably damaging	1.00
X0027:Plxna2	UTSW	1	194,644,433 (GRCm38)	missense	probably damaging	1.00
Z1088:Plxna2	UTSW	1	194,764,539 (GRCm38)	missense	probably benign	0.06
Z1088:Plxna2	UTSW	1	194,644,441 (GRCm38)	missense	possibly damaging	0.56

Predicted Primers

PCR Primer
(F):5'- GACTGCCTAAGGCACCCTATTCAC -3'
(R):5'- GACTCAGTCAACCTAGTCATGCAGC -3'

Sequencing Primer
(F):5'- GGGTGGTGACCCCAATG -3'
(R):5'- CATCAAATATTCCGTGTCCAGGG -3'

Posted On

2014-03-14