Incidental Mutation 'R1432:Vmn2r85'
ID 162326
Institutional Source Beutler Lab
Gene Symbol Vmn2r85
Ensembl Gene ENSMUSG00000092048
Gene Name vomeronasal 2, receptor 85
Synonyms EG623734
MMRRC Submission 039487-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R1432 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 130253658-130266615 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130261155 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 394 (N394S)
Ref Sequence ENSEMBL: ENSMUSP00000128792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171811]
AlphaFold G3UW56
Predicted Effect possibly damaging
Transcript: ENSMUST00000171811
AA Change: N394S

PolyPhen 2 Score 0.736 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000128792
Gene: ENSMUSG00000092048
AA Change: N394S

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 9e-26 PFAM
Pfam:NCD3G 508 562 1.1e-18 PFAM
Pfam:7tm_3 595 831 3.7e-54 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.8%
  • 10x: 94.4%
  • 20x: 86.1%
Validation Efficiency 98% (90/92)
Allele List at MGI
Other mutations in this stock
Total: 88 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A G 12: 71,217,361 (GRCm39) probably null Het
9130401M01Rik A T 15: 57,892,256 (GRCm39) L117Q probably damaging Het
Abcb1b A G 5: 8,887,771 (GRCm39) K886E possibly damaging Het
Acaa2 A T 18: 74,920,198 (GRCm39) I9F probably damaging Het
Acap2 A T 16: 30,929,901 (GRCm39) S386T probably damaging Het
Acsm2 A T 7: 119,172,798 (GRCm39) I138F possibly damaging Het
Agl T C 3: 116,540,342 (GRCm39) Y1424C probably damaging Het
Aoc1l1 T A 6: 48,952,588 (GRCm39) F171Y probably damaging Het
Apc2 T C 10: 80,148,183 (GRCm39) V1079A probably benign Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Armc8 C T 9: 99,405,185 (GRCm39) probably benign Het
Catsperb A G 12: 101,588,476 (GRCm39) Y953C probably damaging Het
Cdk13 G A 13: 17,893,001 (GRCm39) A720V probably damaging Het
Chka T C 19: 3,924,809 (GRCm39) probably benign Het
Clcc1 T C 3: 108,575,418 (GRCm39) I165T probably benign Het
Cndp1 G A 18: 84,652,777 (GRCm39) probably benign Het
Dip2c C A 13: 9,603,340 (GRCm39) P297Q probably damaging Het
Dnah17 A T 11: 117,914,153 (GRCm39) W4429R probably damaging Het
Dram2 T C 3: 106,478,082 (GRCm39) V138A possibly damaging Het
Dus4l T C 12: 31,698,770 (GRCm39) N78S probably benign Het
Dync1h1 G A 12: 110,602,943 (GRCm39) E2195K probably benign Het
Ebf1 T C 11: 44,895,533 (GRCm39) probably benign Het
Epm2a T A 10: 11,266,587 (GRCm39) Y111N probably damaging Het
Gm773 T C X: 55,247,377 (GRCm39) T52A probably benign Het
Gpam C A 19: 55,067,693 (GRCm39) M483I probably damaging Het
Gpr12 T C 5: 146,520,235 (GRCm39) H229R probably damaging Het
Gpr149 T C 3: 62,438,439 (GRCm39) T573A probably damaging Het
Gtf3c3 C T 1: 54,456,937 (GRCm39) A488T probably damaging Het
Hells T A 19: 38,945,628 (GRCm39) probably null Het
Herc1 T A 9: 66,372,751 (GRCm39) N3102K probably benign Het
Herc3 A T 6: 58,893,827 (GRCm39) T968S possibly damaging Het
Ift88 A G 14: 57,674,736 (GRCm39) Y69C probably benign Het
Incenp G A 19: 9,862,890 (GRCm39) T388M unknown Het
Jrkl A G 9: 13,245,337 (GRCm39) F108S probably benign Het
Khdc1a A G 1: 21,420,542 (GRCm39) E54G possibly damaging Het
Kif6 T A 17: 49,927,728 (GRCm39) F58L probably damaging Het
Klk14 T C 7: 43,344,342 (GRCm39) S218P probably damaging Het
Kmt2e T C 5: 23,655,319 (GRCm39) M19T probably benign Het
Llgl1 G T 11: 60,599,380 (GRCm39) G454C probably damaging Het
Lyrm4 A G 13: 36,276,898 (GRCm39) V33A probably benign Het
Mcam C T 9: 44,052,588 (GRCm39) R606C probably damaging Het
Mgam T A 6: 40,733,301 (GRCm39) M692K probably damaging Het
Mmp28 C T 11: 83,333,765 (GRCm39) R392H probably damaging Het
Mpdz G A 4: 81,210,788 (GRCm39) T1699M probably damaging Het
Mrps11 T C 7: 78,433,310 (GRCm39) probably benign Het
Mrtfb A G 16: 13,218,866 (GRCm39) N504S probably benign Het
Msmo1 A G 8: 65,180,650 (GRCm39) probably benign Het
Mst1 A G 9: 107,961,403 (GRCm39) E571G probably benign Het
Myh14 T C 7: 44,265,723 (GRCm39) E1585G probably damaging Het
Myrfl A G 10: 116,613,332 (GRCm39) C824R probably damaging Het
Ncapd3 C T 9: 26,981,168 (GRCm39) probably benign Het
Nlrp4a G GGTTCTTC 7: 26,163,622 (GRCm39) probably null Het
Nos1 C T 5: 118,087,684 (GRCm39) probably benign Het
Notch3 T C 17: 32,383,198 (GRCm39) S47G probably benign Het
Npsr1 A G 9: 24,221,371 (GRCm39) Y122C probably damaging Het
Or10ak12 T C 4: 118,666,435 (GRCm39) M209V probably benign Het
Or1j11 C T 2: 36,311,655 (GRCm39) L82F probably damaging Het
Or5a1 G T 19: 12,097,603 (GRCm39) R158S possibly damaging Het
Or6c1b C T 10: 129,272,807 (GRCm39) T42I probably damaging Het
Or6k2 T A 1: 173,986,483 (GRCm39) V48E possibly damaging Het
Or8b9 T A 9: 37,766,548 (GRCm39) L145M possibly damaging Het
Otog G T 7: 45,950,007 (GRCm39) V2490F probably damaging Het
Pibf1 T C 14: 99,350,425 (GRCm39) V191A probably benign Het
Pip A G 6: 41,826,852 (GRCm39) M66V probably benign Het
Plxna2 C T 1: 194,449,771 (GRCm39) R830C probably benign Het
Prkca A T 11: 107,830,346 (GRCm39) V248E probably benign Het
Prmt7 T A 8: 106,963,916 (GRCm39) L253* probably null Het
Prrc2a G T 17: 35,372,888 (GRCm39) probably benign Het
Rasgrf1 A G 9: 89,894,853 (GRCm39) D1091G probably benign Het
Rbm7 C A 9: 48,401,245 (GRCm39) G161V probably benign Het
Scn1a A T 2: 66,152,773 (GRCm39) I736N probably damaging Het
Skint6 A G 4: 112,726,721 (GRCm39) probably benign Het
Slc22a2 C T 17: 12,803,195 (GRCm39) H10Y possibly damaging Het
Sned1 G A 1: 93,209,376 (GRCm39) V830M possibly damaging Het
Stam2 A G 2: 52,604,821 (GRCm39) probably benign Het
Stk40 T C 4: 126,030,626 (GRCm39) L282P probably damaging Het
Tas2r110 A G 6: 132,845,331 (GRCm39) N121D probably damaging Het
Tbc1d32 A G 10: 55,893,758 (GRCm39) Y1272H probably damaging Het
Thoc2l T C 5: 104,665,970 (GRCm39) F164S probably damaging Het
Tmem131l T C 3: 83,836,021 (GRCm39) D696G probably damaging Het
Trdmt1 T C 2: 13,524,657 (GRCm39) Y266C probably damaging Het
Trim5 G T 7: 103,928,726 (GRCm39) H72N probably benign Het
Trim5 A C 7: 103,928,728 (GRCm39) L71R probably benign Het
Twf2 T A 9: 106,092,012 (GRCm39) probably benign Het
Ubap2l T C 3: 89,926,635 (GRCm39) T580A probably benign Het
Ugt1a10 C T 1: 88,143,982 (GRCm39) R201C probably damaging Het
Unc5a A G 13: 55,152,285 (GRCm39) probably benign Het
Wrn A T 8: 33,809,169 (GRCm39) probably benign Het
Other mutations in Vmn2r85
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01160:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL01298:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL01361:Vmn2r85 APN 10 130,254,690 (GRCm39) missense probably benign 0.22
IGL02185:Vmn2r85 APN 10 130,254,561 (GRCm39) missense probably benign 0.13
IGL02505:Vmn2r85 APN 10 130,261,449 (GRCm39) missense probably damaging 1.00
IGL02607:Vmn2r85 APN 10 130,262,290 (GRCm39) missense possibly damaging 0.89
IGL02755:Vmn2r85 APN 10 130,261,381 (GRCm39) missense probably damaging 0.98
IGL03188:Vmn2r85 APN 10 130,254,612 (GRCm39) missense probably benign 0.16
IGL03366:Vmn2r85 APN 10 130,262,328 (GRCm39) missense probably benign 0.00
IGL03397:Vmn2r85 APN 10 130,261,263 (GRCm39) missense probably damaging 1.00
PIT4445001:Vmn2r85 UTSW 10 130,261,572 (GRCm39) missense probably benign 0.00
R0066:Vmn2r85 UTSW 10 130,261,770 (GRCm39) missense probably damaging 1.00
R0128:Vmn2r85 UTSW 10 130,255,054 (GRCm39) splice site probably benign
R0130:Vmn2r85 UTSW 10 130,255,054 (GRCm39) splice site probably benign
R0503:Vmn2r85 UTSW 10 130,258,609 (GRCm39) missense probably damaging 1.00
R0827:Vmn2r85 UTSW 10 130,265,387 (GRCm39) missense possibly damaging 0.89
R1521:Vmn2r85 UTSW 10 130,261,788 (GRCm39) missense probably damaging 0.99
R2029:Vmn2r85 UTSW 10 130,261,443 (GRCm39) nonsense probably null
R2034:Vmn2r85 UTSW 10 130,262,242 (GRCm39) splice site probably benign
R2852:Vmn2r85 UTSW 10 130,255,035 (GRCm39) missense probably benign 0.03
R2853:Vmn2r85 UTSW 10 130,255,035 (GRCm39) missense probably benign 0.03
R3084:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R3085:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R3430:Vmn2r85 UTSW 10 130,254,758 (GRCm39) missense probably damaging 0.97
R3694:Vmn2r85 UTSW 10 130,254,171 (GRCm39) missense probably damaging 0.99
R3932:Vmn2r85 UTSW 10 130,254,336 (GRCm39) missense probably damaging 1.00
R4207:Vmn2r85 UTSW 10 130,254,574 (GRCm39) missense probably damaging 1.00
R4628:Vmn2r85 UTSW 10 130,261,235 (GRCm39) missense probably benign 0.00
R4814:Vmn2r85 UTSW 10 130,254,567 (GRCm39) missense probably benign 0.12
R4948:Vmn2r85 UTSW 10 130,254,990 (GRCm39) missense probably damaging 1.00
R4951:Vmn2r85 UTSW 10 130,261,113 (GRCm39) missense probably damaging 1.00
R4959:Vmn2r85 UTSW 10 130,257,302 (GRCm39) missense probably damaging 1.00
R5336:Vmn2r85 UTSW 10 130,258,574 (GRCm39) missense possibly damaging 0.63
R5643:Vmn2r85 UTSW 10 130,262,343 (GRCm39) missense probably damaging 1.00
R6061:Vmn2r85 UTSW 10 130,261,531 (GRCm39) missense probably benign 0.09
R6115:Vmn2r85 UTSW 10 130,258,672 (GRCm39) missense probably damaging 1.00
R6190:Vmn2r85 UTSW 10 130,261,330 (GRCm39) missense possibly damaging 0.88
R6518:Vmn2r85 UTSW 10 130,265,281 (GRCm39) missense probably benign 0.00
R6533:Vmn2r85 UTSW 10 130,262,529 (GRCm39) missense probably benign 0.00
R6610:Vmn2r85 UTSW 10 130,261,838 (GRCm39) missense probably damaging 0.97
R6809:Vmn2r85 UTSW 10 130,261,795 (GRCm39) missense probably benign
R6962:Vmn2r85 UTSW 10 130,261,452 (GRCm39) missense probably damaging 0.99
R7075:Vmn2r85 UTSW 10 130,258,557 (GRCm39) missense probably benign 0.06
R7104:Vmn2r85 UTSW 10 130,262,376 (GRCm39) missense probably benign
R7424:Vmn2r85 UTSW 10 130,254,849 (GRCm39) missense probably damaging 1.00
R7516:Vmn2r85 UTSW 10 130,254,852 (GRCm39) missense probably damaging 1.00
R7537:Vmn2r85 UTSW 10 130,258,735 (GRCm39) missense probably benign 0.01
R7768:Vmn2r85 UTSW 10 130,254,562 (GRCm39) missense probably damaging 1.00
R7810:Vmn2r85 UTSW 10 130,261,081 (GRCm39) missense probably benign 0.00
R8078:Vmn2r85 UTSW 10 130,265,364 (GRCm39) nonsense probably null
R8115:Vmn2r85 UTSW 10 130,261,820 (GRCm39) missense probably benign 0.06
R8262:Vmn2r85 UTSW 10 130,254,738 (GRCm39) missense probably damaging 0.98
R8395:Vmn2r85 UTSW 10 130,261,797 (GRCm39) missense probably damaging 0.99
R8409:Vmn2r85 UTSW 10 130,261,257 (GRCm39) missense probably benign 0.16
R8547:Vmn2r85 UTSW 10 130,261,311 (GRCm39) missense probably damaging 1.00
R8875:Vmn2r85 UTSW 10 130,254,171 (GRCm39) missense probably damaging 0.99
R9035:Vmn2r85 UTSW 10 130,261,479 (GRCm39) missense probably benign
R9040:Vmn2r85 UTSW 10 130,254,311 (GRCm39) missense probably damaging 1.00
R9115:Vmn2r85 UTSW 10 130,254,153 (GRCm39) missense probably benign 0.00
R9182:Vmn2r85 UTSW 10 130,265,350 (GRCm39) missense probably benign 0.00
R9245:Vmn2r85 UTSW 10 130,261,534 (GRCm39) missense probably damaging 1.00
R9245:Vmn2r85 UTSW 10 130,255,033 (GRCm39) missense possibly damaging 0.92
R9405:Vmn2r85 UTSW 10 130,261,215 (GRCm39) missense probably damaging 0.99
R9502:Vmn2r85 UTSW 10 130,261,387 (GRCm39) missense probably damaging 0.99
R9520:Vmn2r85 UTSW 10 130,254,993 (GRCm39) missense probably benign
R9653:Vmn2r85 UTSW 10 130,261,694 (GRCm39) missense probably damaging 0.99
Z1176:Vmn2r85 UTSW 10 130,261,713 (GRCm39) missense probably damaging 0.99
Z1177:Vmn2r85 UTSW 10 130,254,776 (GRCm39) missense probably damaging 1.00
Predicted Primers
Posted On 2014-03-14