Incidental Mutation 'R1387:Agxt2'
ID 162457
Institutional Source Beutler Lab
Gene Symbol Agxt2
Ensembl Gene ENSMUSG00000089678
Gene Name alanine-glyoxylate aminotransferase 2
Synonyms
MMRRC Submission 039449-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R1387 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 10358618-10410239 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10380696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 196 (Y196H)
Ref Sequence ENSEMBL: ENSMUSP00000106171 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022858] [ENSMUST00000110541] [ENSMUST00000110542]
AlphaFold Q3UEG6
Predicted Effect probably damaging
Transcript: ENSMUST00000022858
AA Change: Y196H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022858
Gene: ENSMUSG00000089678
AA Change: Y196H

DomainStartEndE-ValueType
Pfam:Aminotran_3 76 228 4.5e-36 PFAM
Pfam:Aminotran_3 269 532 5.7e-60 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110541
AA Change: Y196H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106170
Gene: ENSMUSG00000089678
AA Change: Y196H

DomainStartEndE-ValueType
Pfam:Aminotran_3 86 219 1.7e-35 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110542
AA Change: Y196H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000106171
Gene: ENSMUSG00000089678
AA Change: Y196H

DomainStartEndE-ValueType
Pfam:Aminotran_3 87 443 1.3e-88 PFAM
Meta Mutation Damage Score 0.3408 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 95.1%
  • 20x: 88.4%
Validation Efficiency 99% (82/83)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a targeted allele exhibit reduced circulating L-citrulline, hypertension under terminal aesthesia and increased vasodilation maximal response following acetylcholine treatment. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610303G11Rik T A 9: 98,068,812 (GRCm39) noncoding transcript Het
4930447C04Rik C A 12: 72,962,208 (GRCm39) R52L probably benign Het
Abca13 C T 11: 9,632,085 (GRCm39) Q5002* probably null Het
Acacb T C 5: 114,338,573 (GRCm39) I761T probably benign Het
Acap3 G T 4: 155,983,937 (GRCm39) L134F probably benign Het
Adamtsl1 T C 4: 86,293,230 (GRCm39) probably benign Het
Adgrv1 A G 13: 81,641,295 (GRCm39) V3278A possibly damaging Het
Akap13 T C 7: 75,235,941 (GRCm39) V172A probably damaging Het
Aqp8 A G 7: 123,065,891 (GRCm39) I229V probably benign Het
Atp8a2 T C 14: 60,097,719 (GRCm39) K770E probably benign Het
Brd10 A G 19: 29,700,853 (GRCm39) I812T probably benign Het
Cacng8 T C 7: 3,463,672 (GRCm39) S275P possibly damaging Het
Catsperg1 T C 7: 28,906,289 (GRCm39) Y138C probably damaging Het
Ccdc93 T G 1: 121,418,918 (GRCm39) L491R probably damaging Het
Cntnap2 T C 6: 47,084,848 (GRCm39) V1103A probably benign Het
Col12a1 C T 9: 79,588,657 (GRCm39) probably benign Het
Col6a3 A G 1: 90,750,138 (GRCm39) probably benign Het
Csf2rb2 C T 15: 78,182,414 (GRCm39) A6T probably damaging Het
Cyp2j5 T A 4: 96,522,522 (GRCm39) S351C probably damaging Het
Cyth1 A G 11: 118,073,172 (GRCm39) probably benign Het
Dock2 A G 11: 34,223,309 (GRCm39) probably benign Het
Duoxa1 T A 2: 122,134,468 (GRCm39) I262F possibly damaging Het
Dync2h1 T C 9: 7,125,816 (GRCm39) D1930G probably benign Het
Eeig1 T C 2: 32,455,635 (GRCm39) S254P possibly damaging Het
Eno1 C T 4: 150,332,590 (GRCm39) probably benign Het
Fam98a T A 17: 75,845,264 (GRCm39) H494L unknown Het
Fcamr C A 1: 130,732,379 (GRCm39) T122K possibly damaging Het
Foxq1 A G 13: 31,743,288 (GRCm39) D130G probably damaging Het
Glb1 T A 9: 114,249,431 (GRCm39) W5R probably damaging Het
Gm17661 GA GAA 2: 90,917,709 (GRCm38) noncoding transcript Het
Gm5431 T A 11: 48,785,842 (GRCm39) R178W possibly damaging Het
Gys2 C T 6: 142,407,009 (GRCm39) V116M probably benign Het
Hif1a C T 12: 73,989,066 (GRCm39) T651I possibly damaging Het
Itgb5 T A 16: 33,720,885 (GRCm39) Y3* probably null Het
Kank3 A G 17: 34,035,205 (GRCm39) N7S possibly damaging Het
Kdm2b G T 5: 123,018,331 (GRCm39) H981Q probably damaging Het
Kdm6a C T X: 18,120,235 (GRCm39) probably benign Het
Kif1a A T 1: 92,983,672 (GRCm39) probably benign Het
Knl1 T A 2: 118,901,211 (GRCm39) S971T possibly damaging Het
Lcn6 T C 2: 25,567,149 (GRCm39) V50A possibly damaging Het
Llgl2 G T 11: 115,743,958 (GRCm39) V762F probably damaging Het
Lpcat4 T C 2: 112,075,021 (GRCm39) F342L probably benign Het
Lrp2 C A 2: 69,287,262 (GRCm39) G3725V probably damaging Het
Map1b T C 13: 99,569,158 (GRCm39) T1188A unknown Het
Mecp2 G A X: 73,079,394 (GRCm39) P362S possibly damaging Het
Mideas C A 12: 84,199,705 (GRCm39) R1005L probably damaging Het
Mmp13 T A 9: 7,282,033 (GRCm39) F445Y possibly damaging Het
Myo5b G T 18: 74,777,272 (GRCm39) probably benign Het
Myo7b A G 18: 32,116,805 (GRCm39) probably benign Het
Nadk2 C A 15: 9,106,870 (GRCm39) L384I possibly damaging Het
Napg A G 18: 63,119,283 (GRCm39) I98V possibly damaging Het
Ncoa1 G T 12: 4,324,790 (GRCm39) N1041K probably benign Het
Nmu A T 5: 76,497,992 (GRCm39) C64* probably null Het
Nobox T A 6: 43,284,132 (GRCm39) K13M probably damaging Het
Nos1 T C 5: 118,091,848 (GRCm39) probably benign Het
Nrg2 A G 18: 36,329,792 (GRCm39) V141A probably damaging Het
Or1b1 T G 2: 36,994,880 (GRCm39) I261L probably benign Het
Or2aj5 T C 16: 19,424,777 (GRCm39) I214V probably damaging Het
Or55b4 T A 7: 102,133,911 (GRCm39) I139L probably benign Het
Phldb2 C T 16: 45,646,357 (GRCm39) E71K possibly damaging Het
Pik3r4 T A 9: 105,521,490 (GRCm39) Y19N probably damaging Het
Pkhd1 A C 1: 20,625,447 (GRCm39) probably benign Het
Pogk G T 1: 166,227,707 (GRCm39) P148Q possibly damaging Het
Pten G T 19: 32,775,496 (GRCm39) A79S probably benign Het
Ptpdc1 A T 13: 48,739,796 (GRCm39) V545E possibly damaging Het
Qdpr G C 5: 45,607,480 (GRCm39) probably benign Het
Rhbdd3 T A 11: 5,054,121 (GRCm39) H83Q probably damaging Het
Rnf6 A G 5: 146,148,055 (GRCm39) V321A probably benign Het
Rtf1 T A 2: 119,536,126 (GRCm39) probably null Het
Serpina10 C T 12: 103,594,500 (GRCm39) V240I probably benign Het
Siah2 A G 3: 58,598,935 (GRCm39) V101A possibly damaging Het
Taok3 A G 5: 117,344,720 (GRCm39) K46R probably damaging Het
Tcaf2 A C 6: 42,601,512 (GRCm39) L849R probably damaging Het
Upf3a T C 8: 13,842,118 (GRCm39) F178S probably damaging Het
Vmn1r218 G A 13: 23,321,478 (GRCm39) G195D probably damaging Het
Vmn2r59 A G 7: 41,695,521 (GRCm39) V297A probably damaging Het
Vmn2r70 T A 7: 85,207,969 (GRCm39) Q836L probably benign Het
Zfp473 A G 7: 44,382,365 (GRCm39) V655A probably benign Het
Zic5 A G 14: 122,696,897 (GRCm39) S573P unknown Het
Other mutations in Agxt2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01958:Agxt2 APN 15 10,393,794 (GRCm39) splice site probably null
IGL02434:Agxt2 APN 15 10,358,686 (GRCm39) missense possibly damaging 0.83
IGL02824:Agxt2 APN 15 10,393,891 (GRCm39) missense probably null 0.96
IGL02929:Agxt2 APN 15 10,388,379 (GRCm39) splice site probably benign
IGL03368:Agxt2 APN 15 10,388,256 (GRCm39) nonsense probably null
PIT4810001:Agxt2 UTSW 15 10,399,151 (GRCm39) missense probably benign 0.00
R0179:Agxt2 UTSW 15 10,399,134 (GRCm39) missense possibly damaging 0.71
R0526:Agxt2 UTSW 15 10,373,948 (GRCm39) missense probably damaging 1.00
R1085:Agxt2 UTSW 15 10,388,338 (GRCm39) missense probably benign 0.00
R1173:Agxt2 UTSW 15 10,373,837 (GRCm39) missense probably damaging 1.00
R1174:Agxt2 UTSW 15 10,373,837 (GRCm39) missense probably damaging 1.00
R1642:Agxt2 UTSW 15 10,373,917 (GRCm39) missense probably damaging 1.00
R1938:Agxt2 UTSW 15 10,392,021 (GRCm39) missense probably damaging 1.00
R3439:Agxt2 UTSW 15 10,381,511 (GRCm39) missense probably benign 0.19
R4485:Agxt2 UTSW 15 10,378,968 (GRCm39) missense possibly damaging 0.89
R4698:Agxt2 UTSW 15 10,392,130 (GRCm39) critical splice donor site probably null
R5582:Agxt2 UTSW 15 10,399,245 (GRCm39) missense probably damaging 1.00
R6056:Agxt2 UTSW 15 10,378,963 (GRCm39) missense probably damaging 1.00
R6109:Agxt2 UTSW 15 10,377,508 (GRCm39) missense probably damaging 1.00
R6393:Agxt2 UTSW 15 10,393,894 (GRCm39) critical splice donor site probably null
R6868:Agxt2 UTSW 15 10,373,855 (GRCm39) missense probably damaging 1.00
R7206:Agxt2 UTSW 15 10,377,542 (GRCm39) missense probably damaging 0.99
R7275:Agxt2 UTSW 15 10,358,753 (GRCm39) missense probably benign 0.00
R7475:Agxt2 UTSW 15 10,409,623 (GRCm39) missense probably benign
R7792:Agxt2 UTSW 15 10,381,472 (GRCm39) missense probably damaging 1.00
R8722:Agxt2 UTSW 15 10,373,825 (GRCm39) missense probably benign
R8899:Agxt2 UTSW 15 10,378,900 (GRCm39) missense probably damaging 1.00
R8929:Agxt2 UTSW 15 10,393,830 (GRCm39) missense probably benign 0.02
R9229:Agxt2 UTSW 15 10,409,597 (GRCm39) missense probably damaging 1.00
R9311:Agxt2 UTSW 15 10,380,733 (GRCm39) missense probably damaging 0.96
R9608:Agxt2 UTSW 15 10,400,624 (GRCm39) missense possibly damaging 0.92
Predicted Primers PCR Primer
(F):5'- ACTTCCCAGTGACATTGAGCAGAAC -3'
(R):5'- TTACGCAGACTCCAAGGATGCTTC -3'

Sequencing Primer
(F):5'- gcacttgctgaccatgaac -3'
(R):5'- CTTGAATAAGTCCGATCAAGGC -3'
Posted On 2014-03-17