Incidental Mutation 'R1388:Kplce'
ID 162482
Institutional Source Beutler Lab
Gene Symbol Kplce
Ensembl Gene ENSMUSG00000090314
Gene Name KPRP N-terminal and LCE C-terminal like protein
Synonyms 2310050C09Rik
MMRRC Submission 039450-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R1388 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 92775666-92777512 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 92776356 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 109 (T109K)
Ref Sequence ENSEMBL: ENSMUSP00000126921 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000163439]
AlphaFold G5E8Z3
Predicted Effect probably damaging
Transcript: ENSMUST00000163439
AA Change: T109K

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000126921
Gene: ENSMUSG00000090314
AA Change: T109K

DomainStartEndE-ValueType
low complexity region 17 28 N/A INTRINSIC
internal_repeat_1 47 96 3.58e-12 PROSPERO
internal_repeat_1 104 151 3.58e-12 PROSPERO
low complexity region 152 171 N/A INTRINSIC
low complexity region 220 258 N/A INTRINSIC
Meta Mutation Damage Score 0.0908 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.9%
  • 20x: 88.1%
Validation Efficiency 98% (47/48)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot3 T G 12: 84,105,761 (GRCm39) H409Q possibly damaging Het
Adgra1 T C 7: 139,453,919 (GRCm39) V152A probably damaging Het
Arhgef6 T C X: 56,383,922 (GRCm39) M5V probably benign Het
Atxn7l3 C G 11: 102,183,261 (GRCm39) probably benign Het
Ccdc174 C A 6: 91,858,225 (GRCm39) probably null Het
Ccdc38 A T 10: 93,417,702 (GRCm39) probably benign Het
Clca4b A T 3: 144,622,415 (GRCm39) V550D probably benign Het
Dab2ip C T 2: 35,611,268 (GRCm39) probably benign Het
Gm17661 GA GAA 2: 90,917,709 (GRCm38) noncoding transcript Het
Gm2959 A T 14: 42,235,660 (GRCm39) noncoding transcript Het
Gmnc A G 16: 26,782,662 (GRCm39) L80P probably damaging Het
Gtf2ird1 T C 5: 134,424,564 (GRCm39) D394G probably damaging Het
Heatr1 T C 13: 12,432,328 (GRCm39) probably benign Het
Il1a T C 2: 129,148,501 (GRCm39) S70G possibly damaging Het
Kctd19 T C 8: 106,118,683 (GRCm39) S293G probably null Het
Klra4 T C 6: 130,039,198 (GRCm39) probably benign Het
Mr1 T C 1: 155,008,249 (GRCm39) E242G probably damaging Het
Mrnip C A 11: 50,087,772 (GRCm39) A98E probably benign Het
Mybpc3 C T 2: 90,953,219 (GRCm39) P155S probably benign Het
Myh14 A T 7: 44,314,546 (GRCm39) Y126N probably damaging Het
Nrbp1 T A 5: 31,403,157 (GRCm39) I210N probably damaging Het
Nup58 A T 14: 60,482,119 (GRCm39) probably benign Het
Or10g9 A G 9: 39,911,948 (GRCm39) S192P probably damaging Het
Or10j3 T C 1: 173,031,445 (GRCm39) V174A probably benign Het
Pnisr T C 4: 21,862,041 (GRCm39) M243T possibly damaging Het
Ptprr A G 10: 116,109,657 (GRCm39) S633G probably benign Het
Rasip1 T A 7: 45,279,656 (GRCm39) S300T probably damaging Het
Sbsn A T 7: 30,451,576 (GRCm39) H197L probably benign Het
Shf G A 2: 122,199,163 (GRCm39) P51S probably damaging Het
Sim1 T A 10: 50,772,090 (GRCm39) I33N probably damaging Het
Speg A G 1: 75,407,104 (GRCm39) D2878G probably damaging Het
Taf2 T A 15: 54,900,021 (GRCm39) N864I probably benign Het
Tmem43 G T 6: 91,455,785 (GRCm39) probably null Het
Ttn T C 2: 76,542,135 (GRCm39) E25290G probably damaging Het
Ush2a A G 1: 188,255,515 (GRCm39) probably benign Het
Usp53 T C 3: 122,751,277 (GRCm39) E260G probably damaging Het
Vmn2r12 T G 5: 109,240,840 (GRCm39) Y91S possibly damaging Het
Vmn2r59 A T 7: 41,695,133 (GRCm39) N426K probably benign Het
Whamm C A 7: 81,236,038 (GRCm39) L414I probably damaging Het
Zfhx4 A G 3: 5,466,447 (GRCm39) T2227A probably damaging Het
Zfp866 C T 8: 70,218,834 (GRCm39) R262Q probably benign Het
Other mutations in Kplce
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02056:Kplce APN 3 92,776,200 (GRCm39) missense probably benign 0.17
R0421:Kplce UTSW 3 92,776,291 (GRCm39) missense probably damaging 0.99
R2187:Kplce UTSW 3 92,775,922 (GRCm39) missense probably damaging 1.00
R4213:Kplce UTSW 3 92,776,434 (GRCm39) missense probably benign 0.01
R4240:Kplce UTSW 3 92,775,898 (GRCm39) missense possibly damaging 0.89
R5394:Kplce UTSW 3 92,776,005 (GRCm39) missense probably damaging 1.00
R6124:Kplce UTSW 3 92,776,365 (GRCm39) missense probably damaging 1.00
R6804:Kplce UTSW 3 92,776,354 (GRCm39) missense possibly damaging 0.67
R7293:Kplce UTSW 3 92,776,126 (GRCm39) missense probably benign 0.32
R8049:Kplce UTSW 3 92,776,202 (GRCm39) nonsense probably null
R9228:Kplce UTSW 3 92,775,951 (GRCm39) missense probably benign
R9663:Kplce UTSW 3 92,776,283 (GRCm39) missense probably benign 0.00
Z1176:Kplce UTSW 3 92,776,581 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CTGAGCCACTTGAAGAAGCCTGAG -3'
(R):5'- TGTGTGACCAACAGAAGCAGCC -3'

Sequencing Primer
(F):5'- CCACTTGAAGAAGCCTGAGTATAG -3'
(R):5'- TTTCAGGCCAGATCCAAGCTG -3'
Posted On 2014-03-17