Incidental Mutation 'R1391:Farp1'
ID 162617
Institutional Source Beutler Lab
Gene Symbol Farp1
Ensembl Gene ENSMUSG00000025555
Gene Name FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms Cdep
MMRRC Submission 039453-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R1391 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 121272612-121521156 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to A at 121495378 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Stop codon at position 611 (W611*)
Ref Sequence ENSEMBL: ENSMUSP00000026635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026635]
AlphaFold F8VPU2
Predicted Effect probably null
Transcript: ENSMUST00000026635
AA Change: W611*
SMART Domains Protein: ENSMUSP00000026635
Gene: ENSMUSG00000025555
AA Change: W611*

DomainStartEndE-ValueType
B41 36 230 3.27e-68 SMART
FERM_C 234 324 3.87e-32 SMART
FA 328 374 6.07e-16 SMART
RhoGEF 546 732 2.07e-47 SMART
PH 763 861 1.05e-16 SMART
PH 936 1034 1.55e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130256
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137971
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.7%
  • 10x: 94.4%
  • 20x: 86.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Amer3 A T 1: 34,627,470 (GRCm39) T570S probably benign Het
Ank3 A T 10: 69,370,110 (GRCm39) K20I possibly damaging Het
Bmp10 G A 6: 87,410,740 (GRCm39) E178K probably benign Het
Brca1 T A 11: 101,417,372 (GRCm39) H254L possibly damaging Het
Cdon C T 9: 35,415,485 (GRCm39) S1241L possibly damaging Het
Cnst C A 1: 179,407,051 (GRCm39) P33T possibly damaging Het
Dnhd1 A G 7: 105,369,331 (GRCm39) Y4318C probably damaging Het
Fst C T 13: 114,590,815 (GRCm39) probably benign Het
Gapvd1 A G 2: 34,596,814 (GRCm39) L714P probably damaging Het
Hectd4 T G 5: 121,491,758 (GRCm39) L3732R possibly damaging Het
Lox A G 18: 52,661,891 (GRCm39) Y171H probably damaging Het
Magi3 T A 3: 103,922,374 (GRCm39) K1448* probably null Het
Med12l T A 3: 58,945,159 (GRCm39) I128N probably benign Het
Pkd1l2 T C 8: 117,781,673 (GRCm39) T791A possibly damaging Het
Prrt4 A G 6: 29,169,950 (GRCm39) V834A possibly damaging Het
Ptprz1 A G 6: 23,001,728 (GRCm39) S1273G probably benign Het
Slc13a4 A C 6: 35,248,597 (GRCm39) F517V probably damaging Het
Treh T C 9: 44,596,602 (GRCm39) V452A probably benign Het
Vmn2r83 T A 10: 79,314,931 (GRCm39) M393K probably damaging Het
Zfp931 T C 2: 177,709,984 (GRCm39) N134S probably benign Het
Other mutations in Farp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00584:Farp1 APN 14 121,474,561 (GRCm39) missense probably damaging 1.00
IGL01017:Farp1 APN 14 121,510,186 (GRCm39) missense possibly damaging 0.64
IGL02309:Farp1 APN 14 121,480,928 (GRCm39) missense probably benign
IGL02376:Farp1 APN 14 121,510,268 (GRCm39) missense probably damaging 0.98
IGL03018:Farp1 APN 14 121,339,581 (GRCm39) missense probably benign
IGL03400:Farp1 APN 14 121,444,733 (GRCm39) missense probably damaging 1.00
R0034:Farp1 UTSW 14 121,492,841 (GRCm39) missense probably benign 0.00
R0046:Farp1 UTSW 14 121,492,925 (GRCm39) missense probably benign 0.00
R0046:Farp1 UTSW 14 121,492,925 (GRCm39) missense probably benign 0.00
R0219:Farp1 UTSW 14 121,481,012 (GRCm39) missense possibly damaging 0.88
R0359:Farp1 UTSW 14 121,492,808 (GRCm39) splice site probably benign
R0616:Farp1 UTSW 14 121,514,434 (GRCm39) missense probably damaging 1.00
R0653:Farp1 UTSW 14 121,471,258 (GRCm39) critical splice donor site probably null
R0710:Farp1 UTSW 14 121,474,555 (GRCm39) missense probably damaging 1.00
R1791:Farp1 UTSW 14 121,494,157 (GRCm39) missense probably damaging 1.00
R1920:Farp1 UTSW 14 121,492,908 (GRCm39) missense probably benign 0.16
R1953:Farp1 UTSW 14 121,492,894 (GRCm39) missense probably benign
R1958:Farp1 UTSW 14 121,456,787 (GRCm39) critical splice acceptor site probably null
R2891:Farp1 UTSW 14 121,494,148 (GRCm39) missense probably damaging 1.00
R3121:Farp1 UTSW 14 121,460,138 (GRCm39) splice site probably benign
R4005:Farp1 UTSW 14 121,513,809 (GRCm39) missense probably damaging 0.99
R4257:Farp1 UTSW 14 121,492,891 (GRCm39) missense probably benign 0.00
R4559:Farp1 UTSW 14 121,510,213 (GRCm39) missense probably damaging 1.00
R4654:Farp1 UTSW 14 121,513,716 (GRCm39) missense possibly damaging 0.50
R4739:Farp1 UTSW 14 121,476,199 (GRCm39) missense probably damaging 1.00
R4831:Farp1 UTSW 14 121,514,469 (GRCm39) missense probably damaging 1.00
R4988:Farp1 UTSW 14 121,513,019 (GRCm39) missense probably damaging 1.00
R5379:Farp1 UTSW 14 121,494,169 (GRCm39) missense possibly damaging 0.88
R5463:Farp1 UTSW 14 121,472,489 (GRCm39) missense probably damaging 1.00
R5466:Farp1 UTSW 14 121,472,489 (GRCm39) missense probably damaging 1.00
R5467:Farp1 UTSW 14 121,472,489 (GRCm39) missense probably damaging 1.00
R5511:Farp1 UTSW 14 121,474,584 (GRCm39) missense probably damaging 0.98
R5520:Farp1 UTSW 14 121,472,489 (GRCm39) missense probably damaging 1.00
R5635:Farp1 UTSW 14 121,513,716 (GRCm39) missense possibly damaging 0.96
R5639:Farp1 UTSW 14 121,512,794 (GRCm39) missense probably damaging 1.00
R5954:Farp1 UTSW 14 121,460,079 (GRCm39) missense probably damaging 0.99
R6765:Farp1 UTSW 14 121,460,066 (GRCm39) missense probably benign 0.00
R7469:Farp1 UTSW 14 121,512,833 (GRCm39) missense probably damaging 1.00
R7549:Farp1 UTSW 14 121,472,589 (GRCm39) missense possibly damaging 0.89
R7660:Farp1 UTSW 14 121,514,334 (GRCm39) missense probably benign 0.00
R7752:Farp1 UTSW 14 121,495,359 (GRCm39) missense probably damaging 1.00
R7788:Farp1 UTSW 14 121,513,665 (GRCm39) missense probably benign 0.12
R7911:Farp1 UTSW 14 121,479,818 (GRCm39) missense probably damaging 1.00
R8013:Farp1 UTSW 14 121,479,813 (GRCm39) missense probably damaging 1.00
R8078:Farp1 UTSW 14 121,513,712 (GRCm39) missense probably benign 0.04
R8113:Farp1 UTSW 14 121,513,008 (GRCm39) missense probably benign 0.35
R8116:Farp1 UTSW 14 121,471,232 (GRCm39) missense probably damaging 1.00
R8716:Farp1 UTSW 14 121,479,855 (GRCm39) missense probably benign
R9103:Farp1 UTSW 14 121,509,104 (GRCm39) missense possibly damaging 0.55
R9190:Farp1 UTSW 14 121,492,988 (GRCm39) missense probably damaging 0.97
R9193:Farp1 UTSW 14 121,518,281 (GRCm39) missense probably benign 0.34
R9581:Farp1 UTSW 14 121,480,841 (GRCm39) missense probably benign 0.09
RF024:Farp1 UTSW 14 121,474,560 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTCAGAAACCCACGAGAAAGTG -3'
(R):5'- CTTGAAGAGTCCCCAGTCAAAGGC -3'

Sequencing Primer
(F):5'- AGAAAGTGCATGGTCTCCTGC -3'
(R):5'- GTCCCCAGTCAAAGGCAAAAAG -3'
Posted On 2014-03-17