Incidental Mutation 'R1364:Prl3b1'
ID 162862
Institutional Source Beutler Lab
Gene Symbol Prl3b1
Ensembl Gene ENSMUSG00000038891
Gene Name prolactin family 3, subfamily b, member 1
Synonyms mplII, PL, Pl-2, mPL-II, Pl2, prolactin-like, Csh2
MMRRC Submission 039429-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R1364 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 27426413-27433666 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 27427848 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 53 (A53T)
Ref Sequence ENSEMBL: ENSMUSP00000047680 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035273] [ENSMUST00000225089]
AlphaFold P09586
Predicted Effect probably benign
Transcript: ENSMUST00000035273
AA Change: A53T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000047680
Gene: ENSMUSG00000038891
AA Change: A53T

DomainStartEndE-ValueType
Pfam:Hormone_1 18 222 1e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000225089
AA Change: A53T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.6%
  • 20x: 90.8%
Validation Efficiency 100% (38/38)
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahi1 T A 10: 20,848,055 (GRCm39) L488I probably damaging Het
Bltp1 T C 3: 37,041,179 (GRCm39) F2519S probably damaging Het
Cobll1 A G 2: 64,956,654 (GRCm39) probably benign Het
Csn1s1 T C 5: 87,825,443 (GRCm39) probably benign Het
D430041D05Rik A T 2: 103,985,363 (GRCm39) S1920T possibly damaging Het
Dnah17 T A 11: 118,016,432 (GRCm39) probably benign Het
Fanca G A 8: 124,031,020 (GRCm39) probably benign Het
Fnbp1 T C 2: 30,949,043 (GRCm39) probably benign Het
Herc1 T A 9: 66,307,375 (GRCm39) L1023Q probably damaging Het
Hjurp T TN 1: 88,194,247 (GRCm39) probably null Het
Hycc1 T C 5: 24,170,351 (GRCm39) T333A probably benign Het
Kcnt1 A G 2: 25,798,106 (GRCm39) M906V probably damaging Het
Mfsd13a C T 19: 46,354,943 (GRCm39) T40I probably benign Het
Mid1 A C X: 168,769,090 (GRCm39) N215H probably damaging Het
Mug1 T A 6: 121,858,672 (GRCm39) L1130Q probably damaging Het
Nebl A T 2: 17,397,848 (GRCm39) probably benign Het
Or10q1b T C 19: 13,682,809 (GRCm39) V206A probably benign Het
Otud7b A G 3: 96,058,768 (GRCm39) D320G probably damaging Het
Piezo1 T C 8: 123,225,310 (GRCm39) E563G possibly damaging Het
Prkd3 T C 17: 79,264,687 (GRCm39) T643A probably damaging Het
Rasl10b G A 11: 83,308,665 (GRCm39) probably null Het
Ripk3 A C 14: 56,022,717 (GRCm39) probably null Het
Sgsm3 T C 15: 80,892,143 (GRCm39) F237S probably damaging Het
Slit3 G A 11: 35,560,934 (GRCm39) V960I probably benign Het
Sptbn2 T C 19: 4,782,693 (GRCm39) L543P probably damaging Het
Tll2 G A 19: 41,108,667 (GRCm39) R328C probably damaging Het
Unkl A G 17: 25,408,597 (GRCm39) I54V probably benign Het
Wdr75 A G 1: 45,838,222 (GRCm39) T44A probably benign Het
Other mutations in Prl3b1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02385:Prl3b1 APN 13 27,433,366 (GRCm39) missense possibly damaging 0.51
IGL02669:Prl3b1 APN 13 27,429,795 (GRCm39) missense probably benign 0.24
IGL03035:Prl3b1 APN 13 27,433,516 (GRCm39) unclassified probably benign
IGL03077:Prl3b1 APN 13 27,429,759 (GRCm39) missense probably benign 0.00
Gabby UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
peaches UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
Pits UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R2014_Prl3b1_632 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R0716:Prl3b1 UTSW 13 27,427,779 (GRCm39) missense probably benign 0.02
R0758:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0773:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0774:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R0775:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1366:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1367:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1368:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1530:Prl3b1 UTSW 13 27,427,848 (GRCm39) missense probably benign 0.00
R1884:Prl3b1 UTSW 13 27,431,886 (GRCm39) missense possibly damaging 0.95
R1990:Prl3b1 UTSW 13 27,429,775 (GRCm39) missense possibly damaging 0.94
R1991:Prl3b1 UTSW 13 27,431,895 (GRCm39) missense possibly damaging 0.60
R2014:Prl3b1 UTSW 13 27,431,948 (GRCm39) missense probably benign 0.00
R2885:Prl3b1 UTSW 13 27,433,505 (GRCm39) missense probably damaging 1.00
R4259:Prl3b1 UTSW 13 27,427,889 (GRCm39) splice site probably null
R4580:Prl3b1 UTSW 13 27,433,450 (GRCm39) missense possibly damaging 0.93
R4913:Prl3b1 UTSW 13 27,433,460 (GRCm39) missense probably damaging 0.99
R5897:Prl3b1 UTSW 13 27,429,858 (GRCm39) missense probably benign 0.08
R6235:Prl3b1 UTSW 13 27,431,928 (GRCm39) missense probably damaging 1.00
R6366:Prl3b1 UTSW 13 27,427,875 (GRCm39) missense probably benign 0.00
R6597:Prl3b1 UTSW 13 27,431,957 (GRCm39) critical splice donor site probably null
R7179:Prl3b1 UTSW 13 27,427,827 (GRCm39) missense probably benign 0.05
R7312:Prl3b1 UTSW 13 27,426,473 (GRCm39) start codon destroyed probably null 1.00
X0026:Prl3b1 UTSW 13 27,431,906 (GRCm39) missense probably benign 0.21
Z1177:Prl3b1 UTSW 13 27,427,742 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- GGACAGACAGTATAGCCTCTACAGTGT -3'
(R):5'- AGGGTTTGATGATTGCTCCATTGGAA -3'

Sequencing Primer
(F):5'- CAGTATAGCCTCTACAGTGTCATTTG -3'
(R):5'- ggaggaggtgagaggtgg -3'
Posted On 2014-03-17